2003-2004 Antineoplastics 1 February 2016 3:08 AM

2003-2004Antineoplastics

May 3, 202306:01 PM

Alemtuzumab

Antineoplastic

Anti-CD52 antibody

Aminoglutethimide

AntineoplasticImmunosuppressive

Glucocorticoid antagonistAromatase inhibitor

(decreases steroid synthesis)

Amsacrine

Antineoplastic

Miscellaneous

Anastrozole

AntineoplasticAntiestrogen

Aromatase inhibitor

L-asparaginase

Antineoplastic

Protein synthesis inhibitor

Azathioprine

ImmunosuppressiveAntineoplastic

Antimetabolite(“pseudofeedback inhibition” of

HGPRT and PRP)

Bleomycin

Antineoplastic

Natural productAntibiotic

Busulfan

Antineoplastic

Alkylating Agent

Carmustine (BCNU)

Antineoplastic

Alkylating Agent

Cisplatin

Antineoplastic

MiscellaneousCross-linking agent

Cyclophosphamide

Antineoplastic

Alkylating Agent

Cyclosporine

ImmunosuppressiveAntineoplastic

Binds cyclophilinInhibits calcineurin

Cyproterone acetate

AntiandrogenAntineoplastic

androgen receptor antagonist

Cytarabine (AraC)

Antineoplastic

Antimetabolite

Dacarbazine

Antineoplastic

Alkylating Agent

Dactinomycin

Antineoplastic

Natural productAntibiotic

Daunorubicin

Antineoplastic

Anthracycline antibiotic Natural product

Dexamethasone

AdrenocorticosteroidGlucocorticoidAntineoplastic

Anti-inflammatory steroidNot by inhalation

Doxorubicin

Antineoplastic

Anthracycline antibioticNatural product

Etoposide

Antineoplastic

Natural productPlant alkaloid

Exemestane

AntineoplasticAntiestrogen

Aromatase Inhibitor

5-Fluorouracil

Antineoplastic

AntimetaboliteThymidylate synthase inhibitor

Fulvestrant

AntineoplasticAntiestrogen

Estrogen receptor antagonist

Gemtuzumab

Antineoplastic

Anti-CD33 antibody

Goserelin

AntineoplasticGonadotropin releasing

hormone(GnRH) agonist

Hydroxyurea

Antineoplastic

MiscellaneousRibonucleotide reductase

inhibitor

Ibritumomab

Antineoplastic

Anti-CD20 antibody

Imatinib

Antineoplastic

MiscellaneousTyrosine kinase inhibitor

Interleukin 2

Cytokine Antineoplastic

Interleukin 11

Cytokine Antineoplastic (supporting

agent)

Iressa

Antineoplastic

MiscellaneousTyrosine kinase inhibitor

Letrozole

AntineoplasticAntiestrogen

Aromatase Inhibitor

Leucovorin

Antineoplastic (supporting agent)

Folic acid analogue(used in methotrexate rescue)

Leuprolide

AntineoplasticGonadotropin releasing hormone (GnRH) agonist

Lomustine (CCNU)

Antineoplastic

Alkylating Agent

Mechlorethamine

Antineoplastic

Alkylating Agent

Melphalan

Antineoplastic

Alkylating Agent

6-Mercaptopurine

Antineoplastic

Antimetabolite(“pseudofeedback inhibition” of

HGPRT and PRP – purine synthesis)

Mesna

Antineoplastic (supporting agent)

Prevent hemorrhagic cystitisdue to cyclophosphamide

Methotrexate

ImmunosuppressiveAntineoplastic

Folic acid antagonistDihydrofolate reductase

inhibitor

Mitomycin C

Antineoplastic

Natural productAntibiotic

Paclitaxel

Antineoplastic

Natural productPlant alkaloid (taxane)

Pentostatin

Antineoplastic

MiscellaneousEnzyme inhibitor

(blocks purine synthesis)

Rituxumab

Antineoplastic

Anti-CD20 antibody

Tacrolimus

ImmunosuppressiveAntineoplastic

Binds FKBP (FK506 binding protein)

Inhibits calcineurin

Thalidomide

Antineoplastic

Anti-angiogenicAnti-TNF

Leprosy (not antibiotic)

6-Thioguanine

Antineoplastic

Antimetabolite (“pseudofeedback inhibition” of

HGPRT and PRP – purine synthesis)

Thiotepa

Antineoplastic

Alkylating agent

Trastuzumab

Antineoplastic

Anti-HER2 antibody

Tumor necrosis factor

CytokineAntineoplastic

Vinblastine

Antineoplastic

Vinca alkaloidNatural product

Vincristine

Antineoplastic

Vinca alkaloidNatural product