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© Strand Life Sciences 1
Dr. Sowmya Raghavan
© Strand Life Sciences
Strand - an Introduction
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• Strand is a technology innovation company offering Scientific Intelligence solutions for use in discovery research
• Strand’s proprietary award-winning data-analysis and visualization software platform, AVADIS reflects 400 person years of continuous innovation evident. It powers several leading informatics products like GeneSpring, Sarchitect, Bioblox and WebChemistry.
• Strand offers “Virtual Lab” services - Computational biology/chemistry and informatics services to address pharma industry challenges
• Key IP and technology in AVADIS and Liver Toxicity Prediction
• $5M investment from Indian government to build and operate a genomic applications and informatics technologies labs
© Strand Life Sciences
Bioblox – A platform for Systems Modeling
© Strand Life Sciences
Bioblox enables biologists analyze their systems quantitatively
• GUI based model building
• Enables biologists test their hypotheses without employing “hardcore” math
• Enables collaboration and knowledge management within an enterprise
© Strand Life Sciences 5
Translate Biology into Mathematical ModelsCreate information-rich networks of
interactions
Model System
Model Network
Model System
© Strand Life Sciences
Design Experimentsfor disease evolution, clinical protocols, therapeutic regimens
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Parameter Set - Values
Input formats
Simulation Results
Homeostasis Disease
© Strand Life Sciences
Gain insights into model behaviorby hypothesis generation and testing
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Parameter Sensitivity
Compare Results from Multiple Hypotheses
Detect Events of Interest
Steady State Continuation
© Strand Life Sciences
Analyze and interpret resultswith a suite of dynamically linked visualizations
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© Strand Life Sciences
Increase Biological understandingby simplifying networks visually
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Clone
Collapse
© Strand Life Sciences
Share Biological insights and datawith context specific annotations
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Manage Experiments; Store, Retrieve Results
Experiment Details
References
© Strand Life Sciences
Develop and analyze complex modelsmodularly enabling collaborations
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Analyze model components in isolation
Integrate Models Seamlessly
© Strand Life Sciences
Manage multiple projects Track model(s) evolution with versioning, user-access control
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Track multiple model builders, versions and use history
© Strand Life Sciences
Thank You
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