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1 | Proprietary and GenTegra Confidential | 2/11/2014 LLC Redefining Ambient Stabilization February 2014

Gentegra Ambient Stabilization Technologies for DNA RNA 3 3_14

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1 | Proprietary and GenTegra Confidential | 2/11/2014

LLC

Redefining Ambient Stabilization

February 2014

2 | Proprietary and GenTegra Confidential | 2/11/2014

As a researcher, the value of your results is our most important priority. Allowing you to protect your biosamples, from the earliest stage possible, through long-term storage is what we offer.

RNA can be protected immediately after being isolated and purified, through short and long term storage.

DNA can be protected either without purification for biobanking, or as purified for transport and storage.

3 | Proprietary and GenTegra Confidential | 2/11/2014

GenTegra DNA & GenTegra RNA product lines

Stabilization and storage of

purified/extracted DNA & RNA

GenPlates & Archives

High density stabilization

and storage of blood &

biosamples

GenSolve

High yield recovery of

stored blood and

biosamples on FTA paper

Product Overview

4 | Proprietary and GenTegra Confidential | 2/11/2014

Products

GenTegra-RNA • Immediate and long-term protection of RNA

GenTegra-DNA • Long-Term protection of DNA

GenTegra is the only truly DRY state

storage method available, providing

a better and more risk free storage.

5 | Proprietary and GenTegra Confidential | 2/11/2014

GenTegra-RNA

RNA: unstable as it is being purified

GenTegra-RNA: immediate protection for the RNA while being

processed

When dried the RNA is given long term protection at ambient

temperature

Target users:

Epigenomics, Proteomics

Targeted sequencing,

NGS in general,

Cancer genetics, etc.

6 | Proprietary and GenTegra Confidential | 2/11/2014

GenTegra-DNA

DNA is more stable than RNA and is relatively safe in liquid for

normal processing times.

GenTegra-DNA provides long-term stabilization of the DNA when the

solution is dried and stored at ambient temperature with data for 9

years of storage and accelerated data equivalent to 30 years.

Target users:

NGS in general

epigenomics

targeted sequencing

cancer genetics

etc.

7 | Proprietary and GenTegra Confidential | 2/11/2014

Products

GenPlates • Long-term, high density storage of blood, blood products and biosamples

GenSolve • High yield extraction of biosamples from FTA and other paper

Archive cabinets • High density dry GenPlate storage at ambient temperature

8 | Proprietary and GenTegra Confidential | 2/11/2014

GenPlates & GenSolve Products

GenPlates • High density method of storing blood (and biologicals) of FTA paper

• Universally accepted FTA disc of 6 mm diameter

• Guthrie cards, other papers

• GenTegra offers 5 configurations for user; 1, 3, 6, 12, 24 regions

• All in a 384 half-height SBS microplate

• Really a choice of how many replicates the user needs/wants

Target Markets • Small genome project (State of Alaska Salmon project)

• Targeted human studies

• Species projects for endangered animals

• Ag and vet studies

9 | Proprietary and GenTegra Confidential | 2/11/2014

GenPlates

1 Region, 384 elements

3 Region, 96 elements

6 Region, 40 elements

12 Region, 16 elements

24 Region, 4 elements

Every GenPlate is barcoded

and hermetically sealed in a

silvered mylar bag.

GenPlates shelf life is

essentially unlimited before

opening and decades after

opening if properly stored in

low humidity environment.

10 | Proprietary and GenTegra Confidential | 2/11/2014

GenTegra Products

Personal Archive cabinet • High density convenient GenPlate storage at ambient temperature

• Holds 1176 GenPlates or half that number of standard microplates

• Dehumidifier and Barcode scanner included

• GenConnect software for sample tracking, optional

11 | Proprietary and GenTegra Confidential | 2/11/2014

Products

GenSolve • High yield extraction of biosamples from FTA and other paper

• No commercial competitive product

• Generic protocols for DO-IT-YOURSELF

• GenSolve significantly improves quantity of extracted DNA

12 | Proprietary and GenTegra Confidential | 2/11/2014

Redefining Ambient Stabilization

13 | Proprietary and GenTegra Confidential | 2/11/2014

LLC

Contacts: James Nelson, PhD Bruce Jamieson

+1 925-461-3010 +1 408-813-2344

[email protected] [email protected]

www.gentegra.com