Cell Division: How Condensin Keeps Chromosome Arms Folded.

ANDScientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer

Cells.

Estefani La Rotta GallegoMedicine StudentMedellín, ColombiaUPB2011

INTRODUTION

Scientific methodology used to study DNA to find sites that break is fragile situations as

cancer.

Found in yeast, condensin protein tha

t keeps your arms bent and makes the transport of

chromosomes is much easier.

Cell Division: How Condensin Keeps Chromosome Arms Folded.

Cell Division: How Condensin Keeps Chromosome Arms Folded.

Cell division is and will always important in all

organisms, with the discovery of condensin

protein is intended that no errors occur during

the division.

Cell Division: How Condensin Keeps Chromosome Arms Folded.

The condensin has a ring that can surround different chromosome regions, functioning as a rope-stopper.

Cell Division: How Condensin Keeps Chromosome Arms Folded.

The condensin, manages to fold the arms of the chromosomes, it is known that the centromere is the one who moves and leaves the chromosome arms without any protection which causes damage that may occur at the time of division, in yeast has but you want to see this, this can be achieved in human bodies to prevent disease mutations or by a bad cell division.

OBSERVATION

Other agencies have served as experimentation, to develop drugs, vaccines or treatments that help solve diseases in other cases serve as a method of comparison with humans, in this case the yeast which has been found the condensin is a protein that would help prevent errors at the time of cell division . 

Scientists Identify Molecular Basis for

DNA Breakage, a Hallmark of Cancer Cells.

Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells.

DNA is important because it is one that contains our genetic information, when it breaks

may lead to changes in cellular function, leading to defects in the control of proliferation and

generate cancer.

Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells.

The DNA has certain regions more susceptible to the damage, in a

normal state, the cell tries to control the amount of damage. In cancer cells, this mechanism of

control cannot avoid the lesion of the DNA strand.

Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells.

Cancer not always results from the first lesion in the DNA strands, in

some cases, there are several damages before the cancer starts. Before the development of cancer,

the cell starts to divide trying to repair the damages, when this

mechanism fails, the cancer cell appears.

OBSERVATION

Are important scientific advances that have been made throughout history, the development of study could achieve significant reductions in the development of cancer and everything about this, thus ensuring that the cancer will become a thing of the past . 

MEDICAL UTILITY

The discovery of new molecules involved in the process of cell division helps us to understand better this mechanism in which are involved many regulatory steps and tries to avoid the posterior lesions.

MEDICAL UTILITY

With the discovery of unknown molecules appear new molecular targets for posterior treatments

in pathologies in which this protein has responsibility. A fail in

the activity of this protein may have an important roll in some

genetic disorders.

MEDICAL UTILITY

The second news is very important because it With the passage of time

has generated more diseases, climatic changes and the revolution that has

taken the world, humans are increasingly more prone t

o disease so that achieving DNA repair, would help in the

case cancer, possible to help people who are predisposed.

MEDICAL UTILITY

People every day are more likely develop and the development of different types of cancer, every day are more aggressive and kill people quickly, with this break through could make people with cancer and find a solution to their illness and avoid other treatments that cause damage so severe in their bodies, while opening up to other fields such as this would achieve a better result and a possible total eradication.

CANCER

REFERENCE:

Efrat Ozeri-Galai, Ronald Lebofsky, Ayelet Rahat, Assaf C. Bester, Aaron Bensimon, Batsheva Kerem. Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites. Molecular Cell, 2011. www.scienciedaily.com

Sara Cuylen, Jutta Metz, Christian H Haering. Condensin structures chromosomal DNA through topological links.Nature Structural & Molecular Biology, 2011. www.scienciedaily.com

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