Rosaura parisi ppt progetto

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Text of Rosaura parisi ppt progetto

Cosa sono gli AMPs?

CNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHEGFIUEGFIUEGFIUEGFIUEGFIU

Search of novel moleculardescriptors for antimicrobial peptides

Dottorato di Ricerca in Scienze del FarmacoXVI cicloTutorPhD candidateProf. Stefano PiottoRosaura Parisi

GIGKFLHSAKKFGKAFVGEIMNS1Small peptides produced by multicellular organisms

12-50 amino acids in their L-configuration

-helix structure

Amphipathic conformation

Positively charged

They are able to kill or to inhibit growth of various microorganisms

Thanks peptide in FASTA formatTHANKSFORTHEATTENTIONFour models of interaction between cationic AMPs and cytoplasmic membrane

a)Barrel-stave poreb)Carpet mechanismc) Toroidal pored) Disordered toroidal poreMechanism of action: proposed models

Priddy, Kevin L., and Paul E. Keller.Artificial neural networks: an introduction. Vol. 68. SPIE Press, 2005.21

PDB 2LGI PDB 4GU2

Red experimental 3D structure Blue Predict 3D structure