Rosaura parisi ppt progetto

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<p>Cosa sono gli AMPs?</p> <p>CNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHMNVBICNJEWDUHFYGRYBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJCEDWHFYUGWIEGFIUWBJDSKLHJUGFHGJBVUCEDWHFYUGWIEGFIUWHEIGEOHEGFIUEGFIUEGFIUEGFIUEGFIU</p> <p>Search of novel moleculardescriptors for antimicrobial peptides</p> <p>Dottorato di Ricerca in Scienze del FarmacoXVI cicloTutorPhD candidateProf. Stefano PiottoRosaura Parisi</p> <p>GIGKFLHSAKKFGKAFVGEIMNS1Small peptides produced by multicellular organisms</p> <p>12-50 amino acids in their L-configuration</p> <p>-helix structure</p> <p>Amphipathic conformation</p> <p>Positively charged</p> <p>They are able to kill or to inhibit growth of various microorganisms</p> <p> Thanks peptide in FASTA formatTHANKSFORTHEATTENTIONFour models of interaction between cationic AMPs and cytoplasmic membrane</p> <p>a)Barrel-stave poreb)Carpet mechanismc) Toroidal pored) Disordered toroidal poreMechanism of action: proposed models</p> <p>Priddy, Kevin L., and Paul E. Keller.Artificial neural networks: an introduction. Vol. 68. SPIE Press, 2005.21</p> <p>PDB 2LGI PDB 4GU2</p> <p> Red experimental 3D structure Blue Predict 3D structure </p>