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DNA REPLICATIONJUAN PABLO RUIZ RODRIGUEZ
MEDICINE STUDENT
DNA
REPLICATION
It´s a process where one mother DNA molecule can synthesize two new molecules of DNA with an identicalsequences
A defence
protein that
causes cancer.
Boston University Medical
Center
(2016, january 28).
A defence
protein that
causes cancer
APOBEC IS A PROTEIN THAT
WORK AS PROTECTING
AGENT AGAINST VIRAL
INFECTION
A defence
protein that
causes cancer
APOBEC CAN CHANGE THE
DNA REPLICATION PROCESS
A defence
protein that
causes cancer
APOBEC CAUSE DNA MUTATIONS AND CAN CAUSE
CANCER
A defence
protein that
causes cancer.
Student
observation:
IT´S INCREDIBLE HOW AFTER THE PERFECT MECHANISM OF DNA REPLICATION , CAN BE FAILURES MADE BY JUST A SIMPLE VIRAL INFECTION. IT´S IMPORTANT TO KNOW HOW IT WORKS TO RESEARCH MECHANISMS TO PREVENT CANCER.
Researchers
tease apart a
pathway certain
cancer cells use
to replicate.Université de Genève
(2016, january 22)
Researchers
tease apart a pathway
certain cancer cells use
to replicate
CANCER CELLS HAVE MECHANISMS TO OVERCOME PROGRESSIVE TELOMERE SHORTENING AND BYPASS THIS GROWTH ARREST. CANCER CELLS CAN MAINTAIN THEIR TELOMERE LENGTH BY PRODUCING TELOMERASE OR USING ALTERNATIVE LENGTHENING OF TELOMERES PATHWAY (ALT)
RESEARCHERS FROM BOSTON
UNIVERSITY SCHOOL OF
MEDICINE (BUSM) IDENTIFIED
THAT THE REPLICATION STRESS
RESPONSE PROTEIN SMARCAL1
IS A KEY TO THE ALT PATHWAY
Researchers
tease apart a pathway
certain cancer cells use
to replicate
IN THE ABSENCE OF SMARCAL1, THE ACCUMULATION OF REPLICATION STRESS AT ALT TELOMERES LEADS TO THE FORMATION OF DNA DOUBLE STRAND BREAKS AND CONSEQUENTLY, DRIVES MASSIVE GENOMIC INSTABILITY
Researchers
tease apart a pathway
certain cancer cells use
to replicate
THIS RESEARCH IS IMPORTANT TO MEDICINE BECAUSE THIS STUDY ALLOWS TO KNOW HOW THE HUMANS CAN TREAT OR CAN TRY TO TREAT THE CANCER AND GENOMIC INSTABILITY.
Researchers
tease apart a
pathway certain
cancer cells use to
replicate.
Student
observation:
Medical utility
Medical Utility
Identifying new players regulating the ALT pathway
may lead to the identification of new targeted
therapies for cancers that currently have limited
treatment options
Medical Utility
Identifyig the process that include the appear
of APOBEC and what it comes before its a big
oportunity to modify that protein and his all
mechanism .
Medical Utility
Analyze the all process of DNA
replication it´s important because
the researches can detect and
prevent DNA mutations and study
the factors that cause all this
mutations.
Bibliography
· Boston University Medical Center .(2016, january
28).Researchers tease apart a pathway certain cancer
cells use to replicate. ScienceDaily.
https://www.sciencedaily.com/realeses/2016/01/16012813
2016.htm
· Université de Genève . (2016, january 22) A defense
protein that causes cancer. ScienceDaily.
https://www.sciencedaily.com/releases/2016/01/16012210
3826.htm
• Martinez Sanchez, Lina Maria. Biologia molecular. 7.ed .
Medellin :UPB. Fac. Medicina .
