Index No 0000026619

M W Niranjan Somathilaka

Country Manager

Teva Pharmaceuticals

Teva Pharmacuticals

Mission ::We commit ourselves to total customer care by delivering world-class products and services

Vision ::To be the

leader in the

pharmaceutical

industry.

Main anti diabetic products available in the sriLankan market Gliclazide

Glimpiride

SitaGliptin

Sitagliptin is the one of best selling anti diabetic product in sri Lankan market today.

Brand Name Manufacture Local Agent Pack size Strength

Sita CCL,Pakisthan CCL 2x7 50/100mg

Januvia Merck sharp,UK Baurs 4x7 100mg

Sitaglip Acme,Banglahesh Mega Pharma 3x7 100mg

Sitaglu Hilton pharma,Pakisthan Sunshine 2x7 25mg

Inosita Pharmaevo,Pakisthan CIC 1x10 100mg

Sitagil50 Incepta,Bangladesh Citihealth 1x10 50mg

Mode of action of Sitagliptin Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-

4). This enzyme breaks down the incretins GLP-1and GIP, gastrointestinal hormones released in response to a meal. By preventing GLP-1 and GIP inactivation, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas. This drives blood glucose levels towards normal. As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an "overshoot" and subsequent low blood sugar (hypoglycemia) which is seen with some other oral hypoglycemic agents

Ideal packaging for sitagliptin would be 3 cards of 10 Tablets.

Anti Hypertensive drugs

Olmesartan Medoxomil (Angiotensin II receptor antagonists

Perindropil (Angiotensin-converting enzyme (ACE) inhibitors

Atenolol (Beta-adrenoceptor antagonists)

Olmesartan Is a one of latest molecule in the market

There are 14 olmesartan products in the market (10/20mg)

Brand Name Manufacture Local Agent Pack size Strenth

Benitec 20 Glaxo India GSK 10X10S 20mg

Orion Ferosons,Bangladesh

Emmachemi 1x10s 10/20mg

Omsana Hilton,pakisthan

Sunshine 1x14 20mg

Olesta Searle,Pakisthan J L Morison 1x10 20mg

Olmecar SqurePharma,Bangladesh

Pharma Ace 10x3 20mg

Mode of action Olmesartan blocks the receptors that angiotensin II acts on, and so prevents its

actions. The main result of this is that the peripheral blood vessels are allowed to widen, which means that there is more space and less resistance in these blood vessels. This is the main mechanism by which the pressure in the blood vessels is lowered.

Blocking the actions of angiotensin II also reduces the action of aldosterone on the kidneys. The result of this is an increase in the amount of fluid removed from the blood by the kidneys. This decreases the amount of fluid in the blood vessels, which also lessens the resistance and pressure in the blood vessels.

Ten card of Ten tablets per a Pack

Acute pain management products available sri lanka

Naproxen

Diclofenac potassium/Sodium

Codeine Phosphate Naproxen is used to relieve pain from various conditions such as headaches, muscle

aches, tendonitis, dental pain, and menstrual cramps. It also reduces pain, swelling, and joint stiffness caused by arthritis, bursitis, and gout attacks.

Brand Name Manufacturer Local Agent Strength Pack size

Neoprox Merck,Pakisthan

Emmachemi 250/500mg 3x10

Genoxen Genix,Pakisthan Ceyoka 500mg 2x10

Xenobid Sherya,India Emmachemi 550mg 10x10

Naprofred Fredum,India George Stuert 500mg 3x10

Naprozim Zim labs,India Tabrane 250mg 3x10

Naxen Dougles,Newzealend

Farnell ceylon 250mg 10x10

Ticoflex 250 Incepta,India Citihealth 250mg 5x10

Mechanism Of Action

Naproxen has analgesic, anti-inflammatory, and antipyretic properties.The mechanism of action of NAPRELAN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase(COX-1 andCOX-2).

Naproxen sodium is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen sodium concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because naproxen sodium is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues

Packaging12x20 s,12x 11 sBig packs

Dry Eye Products Main dry eye combinations available in market as follow

• Carboxy methylcellulose(0.05% w/v)

carboxymethylcellulose, dextran, glycerin, hypromellose, polyethylene glycol 400

carboxymethylcellulose, dextran, glycerin, hypromellose, polyethylene glycol 400 (PEG 400), polysorbate, polyvinyl alcohol, povidone, or propylene glycol,

Methylcellulose and Gylcerin contain products has shown some unique benefits than other combinations.

Mode of Action

Wetting and lubricating the eye surface

eye lubricants keep the eye moist, help to protect the eye from injury and infection, and decrease symptoms of dry eyes such as

burning, itching, and feeling as if something is in the eye.

Brand Name Ingrediants Manufacture Lontcal Age Packing

Tears Naturale DEXTRAN 70 0.1% HYDROXYPROPYLMETHYLCELULOSE 0.3%

Alocon,Belgium J L Morison 15ml plasticdropper

Refresh CARBOXYMETHYLCELLULOSE SODIUM EYE DROPS 1%

Allergan,USA Hemas 15ml

Add Tears CARBOXYMETHYLCELLULOSE SODIUM LUBRICANT EYE DROPS 1%

Cipla India BreathFree 10ml

Task 02Field Manager

Total Field Experience

Related product experience/Product Knowledge

Interpersonal Skills

I. Personality

II. Communication

Leadership

Confidence

Team Handling

Documentation Skills(Power point/Excell)

Team Members

Previous Field Experience

Communication

Area Knowledge

Doctor Rapport

Paper qualification in Marketing

For Anti diabetic product Endocrinologist Physician General Practitioners

Diabetic patients are mainly treated by these three doctors

its low incidence of hypoglycemia, Sitagliptin has a low incidence of adverse events, consisting of stomach

discomfort, diarrhea, upper respiratory infection, stuffy or runny nose, sore throat and headache.

Unlike many other drugs used to treat diabetes, sitagliptin does not cause weight gain.

Animal studies have shown that it can help prevent ß-cell apoptosis and improve ß-cell functioning

For Anti Hypertensive Product Cardiologist

Physicians

General Practitioners

Calcium channel blockers cause numbness or sharp pain in fingers or toes

Dizziness upon rising quickly from a sitting or lying position.

Diuretic may cause dry eyes, mouth and throat.

Nightmares or sleeping difficulties with Diuretic

ACE inhibitor may cause cough in patients.

Patients who have asthma can not use beta-adrenoceptorantagonists.

For Pain management Product

Rheumatologist

Dental Surgeons

GPs

Advantages of naproxen

One of the advantages of naproxen sodium is rapid action, along with long-lasting

relief. For patients with pain which can be managed by naproxen sodium, the

drug lasts for hours and the pain relief remains very consistent.

This drug has also been shown to be useful in post-operative pain management.

Patients who are given a dose of the drug before surgery experience less

inflammation and pain after surgery, which keeps them more comfortable and can

speed the healing time from surgery

Dry Eye products Ophthalmologist Physicians GPs

Improves tear film interface stability and corneal surface wettability

More effective than Hydroxypropylmethylcellulose in controlling dry eye symptoms

Well tolerated and improves symptoms of dry eyes

Improve corneal wound healing

Has access to both aqueous and lipid portion of the eye