João Andrade | 2014

International Stem Cell BankLondon | Madrid | Porto

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widecells.com

Mission Statement

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!“wideCELLS is focused on accelerating the development of proprietary cellular therapies and becoming a single source for collection, storage, manufacturing, therapeutic development and transportation of cells for cell based medicine and regenerative science globally.”

“Larger than life.”

Who is wideCELLS?!✓wideCELLS, Ltd was formed in 2012!✓Head-Offices in London, UK !✓Stem Cell processing and storage!✓Boast State-of-the-art dedicated clean-room laboratory processing & testing facilities located in the UK and Portugal!✓Fully Accredited and licensed by HTA, DGS, Infarmed, SMS and APMS!✓International Presence in Spain and Portugal!

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wideCELLS Differentiation!✓wideCELLS is leading world authority on private stem cell banking with the knowledge and resources to process and store stem cells from 5 different sources in the body.!✓Fully-licensed in all territories: HTA, DGS, APMS, Infarmed and SMS!✓wideACADEMY – organic unity integrated in wideCELLS focused on R&D and training programs!✓Clinical Applications: wideCELLS provides access to a internacional HCP’s network!

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Executive Team

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Lopes Gil!Chief Financial

Officer!!

BA Mba Finance

João Andrade!Chief Executive

Officer!!

BA IM Mkt Admin.

Prof. Peter Hollands!Chief Scientific !

Officer!!

BSC PHD CSCI FIBMS

wideACADEMY: !Innovation, training and R & D;

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!✓Dean: Prof. Peter Hollands !✓Collaboration with Leading Academic !Institutions (e.g. Westminster University; !Instituto Pedro Nunes) !ensuring the continuous redevelopment of products!processes and services!✓International Scientific and Medical Network!✓E-Learning Platform – Stem Cell Biology for HCP’s!

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• Founders of wideCELLS initial research on the Stem Cell Industry

• Founders of wideCELLS involved in Europe's fastest-growing Stem Cell Banking Start-Up

wideCELLS Timeline

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2012 2013 2014

• Incorporation of wideCELLS, Ltd in the UK!

• Scientific Development of New Services: Teeth, Adipose Tissue and Bone Marrow

• DGS Full license as Tissue Bank!

• International Expansion for Portugal!

2007!

2010!

!• International

Expansion for Spain: Acquisition of Nacersauld, S.L. SMS License as tissue Bank!

• Partnership with UK Lab; HTA License;!!

Transport

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Transportation of Samples:!✓Validated and tested Collection Kits designed and specially made for wideCELLS !✓Agreements with International Human Tissue transport companies:!✓DHL!✓BioExpress!

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Collection Kit <UN 3373>

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wideCELLS Services & Pipeline

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Services

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Cord Blood – Hematopoietic Stem Cells!• The collection of umbilical cord blood is a procedure extremely

simple and totally free of risk either for Mom or for the newborn.!• After delivery, the umbilical cord is usually discarded, despite

being a rich source of stem cells. During the past 20 years, blood transfusions have been performed from the umbilical cord blood with an excellent safety profile and clinical use proven.!

• Currently, stem cells from umbilical cord blood are being used for treatment of an increasingly wide range of diseases.!

• Seventy percent of patients who need stem cell transplant specialist in the formation of blood, do not find a matching donor within the family, so they have to resort to the public register of donors.!

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Cord Tissue – Mesenchymal Stem Cells!• Such as the collection of cord blood, collecting the tissue

takes place through a simple and free of any risk not only to mum, but also for newborn. !

• While the cord blood may contain trace amounts of mesenchymal stem cells, it is difficult to isolate these cells. The efficiency of processing and isolating mesenchymal stem cells from umbilical cord tissue is 100%.!

• The vast majority of our customers choose to store the umbilical cord tissue for the baby together with the storage of umbilical cord blood, which brings many advantages, including the level of costs.!!

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Services

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TeethCELLS – Mesenchymal Stem Cells!•Normally exfoliated (naturally fallen out) baby teeth, healthy wisdom teeth and permanent teeth extracted for orthodontic purposes all contain dental pulp. Dental pulp contains unique stem cells that have the ability to regenerate and develop into many different kinds of cells. !•These stem cells can potentially be used to replace diseased and damaged tissues in the body without rejection.!• There are over 500,000 extractions performed in the UK(e.g) every year. Baby teeth naturally fall out typically between 6-11 years old with a set of twenty teeth.!

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Services

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LipoCELLS – Mesenchymal Stem Cells!•Thousands of liposuction procedures are performed every year, and in the vast majority of cases, the adipose tissue is simply discarded. The vast amounts of adipose tissue (depots of fat for storing energy) by sheer volume of availability ensure vast numbers of stem cells ranging in the millions per unit volume. !•lipoCELLS stem cells are extremely similar to stem cells isolated from bone marrow (BMSCs).!• The similarities in profile between the two types of stem cells range from morphology to growth to transcriptional and cell surface phenotypes. Their similarity extends also to their developmental behaviour both in vitro and in vivo. This has led to suggestions that adipose-derived stem cells are in fact a mesenchymal stem cell fraction present within adipose tissue.!

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Bonelike

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The Novel Synthetic Bone Graft that Mimics Human Bone

wideCELLS – R&D programs!•KTP: Knowledge Transfer Partnerships : UK-wide programme supporting wideCELLS improve its competitiveness and productivity through the better use of knowledge, technology and skills that reside within the UK Knowledge Base!!•UKTi; UK Trade & Investment: Gateway to Global Growth: application for a UKTI grant which will support wideCELLS diversify into new markets!!!

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wideCELLS – Laboratories

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• State-of the-Art Laboratory – UK & PT

• Processing & Testing Facilities

• Samples currently Stored = +20000

• UCB, UCT, AT, DP and PB Technologies

• Operates 24/7

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wideCELLS – Strategic Org. Chart

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wideCELLS Sales Channels!✓Hospitals (e.g. exclusivity with Unit. Healthcare in PT)!✓Maternities!✓Obstetrics and gynecology clinics!✓Pharmacies (POS – point of sale)!✓E-commerce!✓Sales Representatives!✓Events!✓Workshop’s!✓SMM!✓Blog’s!

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wideCELLS Strategic Alliances

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Partnership Model !wideCELLS intends to offer all Strategic Allies a chain of added value:!• Win / Win Relationship!• Synergistic Alliance: based on Cooperation &

Collaboration!• Strategic & Systemic Innovation!• Shared vision for growth!• Seeking breaktroughs!• Cross-functional teams!

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<Holistic Multidisciplinary approach>

(M)Any Questions?