Silybum marianum

Silybum marianum

Introduction

Chemical Constitu

entsUses

Mechanism of Action

Side effects Toxicity Dosage

Contraindication

s

Drug Interacti

ons

INTRODUCTION

Family: Asteraceace

Botanical Name: Sillybum marianum

English Name: Milk thistle Urdu Name: Oont Katara

Part Used: Seeds, leaves, flowers and roots

CHEMICAL CONSTITUENTS

Silibinin

Silychristin

Silydianin

Tocopherols

Fatty acids

Silymarin

USESSilibinin is used as anti-oxidant and anti-neoplastic

Silychristin is used as anti-inflammatory

Silydianin is also used as anti-oxidant

Silibinin is used as hepato-protective agent

It is used as anti-depressant

It is used as demulcent

It is used as laxative

Tocopherols prevent from brain stroke

MECHANISM OF ACTION

Silymarin

• Hinder inflammatory process by inhibiting by inhibiting neutrophil migration and kuppfer cells inhibition

• Also inhibit the inhibitory mediators, i.e., prostaglandins and leukotrienes, release of histamine from basophils

Silymarin

• Protect live from Hepato-toxins and thus increase regenerative capacity of liver• Block the Hepato toxins binding site

Tocopherol• Tocopherol inhibit the platelets to from blood clot thus prevent the brain stroke

MECHANISM OF ACTION

Silychristin• Inhibit the prostaglandin synthetase to treat inflammation

Silymarin

• Increases the hepatic content of glutathione (Both oxidized and reduced)

• Glutathione is a powerful oxidant, detoxify a number of contents

TOXICITY

Appears to be lowToxic

SIDE EFFECTS

Increased bile flow

Laxative effect

Slow rate of clotting

May cause

mild loose stools

DOSAGE

Typical dose is 240-900mg twice or thrice a day of the extract

Take 2ml of the tincture thrice a day

DRUG INTERACTIONS

May cause interactions with

Anti Psychotics

butyrophenones

Phenothiazines

Phenytoin Halothane Anti allergic drugs

Fexofenadine

Anti-hyperlipidemic

drugs

Lovastatin

Anti-anxiety drugs

Alprazolam

Anti platelet or Anti-coagulant

Warfarin

CONTRAINDICATIONS

Should be avoided during

pregnancy and breast feeding

Should be avoided by

people allergic to this plant

Must be avoided in

case of hormone related cancers

Must be avoided in hemophilia

END