SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE, A HALLMARK OF CANCER CELLS AND DNA HELPS GLUCOSE METERS MEASURE MORE THAN SUGAR

María Antonia VelásquezMedicine student

FOLDING

FOLDING

• The nuecelus is the most important structure of the cell, beacause its to pass the gentic material ti the duaghter cells , and to this form complte the division and the cell’s proliferation

• If the genetic material of the cell suffers some alteration very probably million of cells will be damaged and they were causing serious pathologies as the cancer

• The glucose is one of the most important substances for all the activities realized by the organism every day, for what his measurement in blood is so fundamental

• A few scientists have invented the possibility of measuring the glucose and likewise other present substances that can obstruct the development of a healthy life

INTRODUCTION

SCIENTISTS INDENTY MOLECULAR BASIS FOR DNA BREAKAGE, A HALLMARK OF CANCER CELLS

(ScienceDaily, July 19 2011)

• Study of single DNA molecules• study the basis for

the specific sensitivity of the fragile sites

NEW METHODOLOGY

• are the new light for discoveries in the DNA• They were helping to etender great part of the development of the cancerFRAGILE SITIES

• In early stages of the development of the cancer, the cells are forced to proliferate, this stress to which they are submitted leads them to breaking his DNA

IN THE CANCE

R

• The cell takes mechanisms of repair that they use always in conditions as these, nevertheless in early stages of cancer, she does not have any more instruments to conquer the tension and the breaks.STRESS

• The results of this study reveal the molecular mechanism that promotes cancer developmentRESULTS

• This investigation studied since the replication of the DNA is regulated along the fragile sites in the earliest stages of the cancer.

RESULTS

OPINION

see new structures of our genetic material

To learn more on the molecular mechanisms of

the cancer

know exactly that the cell under great

stress breaks the DNA

new therapeutic approaches to restrain and/or treat cancer.

POCKET CHEMISTRY: DNA HELPS GLUCOSE METERS MEASURE MORE THAN SUGAR

(ScienceDaily, July 25 2001)

• Low cost• High

portabilityADVANTAGES

• It improves in the medical diagnosis and in the environmental monitoringADBANTAGES

02/08/11

• not only it answers to glucose, but also to present substances in the environment, blood between othersNEW

TECHNOLOGY

• It answers with sensors of DNA

• use short segments of DNA that bind to specific targetsFUNCTIONAL

02/08/11

• This " meter of glucose " has the Immobilizer segments of DNAs in magnetic particles and Attached to the the enzyme invertase

INNOVATIVE

• On having put a sample of blood, whey or water the DNA it is liberated as the enzyme, there being identified the molecule and the level of the glucoseINNOVATIVE

• The DNA joins the molecule recognizing her and to the caress time liberates the enzyme that this one stuck to herMECHANISM

• The enzyme sticks of the saccharose turning her into glucose

• They diminish the levels of enzyme and increase the levels of glucoseMECHANISM

02/08/11

OPINION

This method means to expand the aims of the persons who use

meters of glucose

This will extend the coverage for the

patients

It will improve the quality of persons' life that does not

have easy access to the resources

There will improve the health of all the

persons not only those who must use

the meter.

MEDICAL UTILITY

• To reduce in a future the number of affected by the cancer

MEDICAL UTILITY

• To promote the early diagnosis and for consequently the reduction of complications and deaths for cancer

MEDICAL UTILITY

• Initially to improve the used treatments, in order that they are less invasiveMEDICAL

UTILITY

• to facilitate the medical diagnosis and the environmental monitoring

MEDICAL UTILITY

• To promote the good quality of life of the persons with diabetes that does not have good accesses to health• To facilitate the medical

diagnosis and the environmental monitoring

MEDICAL UTILITY

• To give him more than one use to the technological advances helping furthermore to the quality of lifeMEDICAL

UTILITY

BIBLIOGRAPHY

MARTÍNEZ S, Lina María. Biología. 4 ed. Medellín. Upb. Facultad de medicinA. 45p, 53p

1.McPherson & Pincus: Henry's Clinical Diagnosis and Management by Laboratory Methods, 21st ed.

THANKS