Restless Legs Syndrome and Niacin

  • Published on
    11-Apr-2017

  • View
    1.988

  • Download
    4

Embed Size (px)

Transcript

Restless Legs Syndrome and Niacin

Restless Legs Syndrome and NiacinK. Thomas PickardQuantified Self Show&Tell #21San Francisco, CAOctober 27, 2011

1

What is Restless Legs Syndrome (RLS)?Uncomfortable/unpleasant sensations in legsOften with periodic limb movements of sleep (PLMS)Symptoms usually worse at nightAffects 515% of the population

2

What can RLS look like?

3

Healthy Sleep PatternRLS PatientSource: Markus Mueller, RLS, Wikipedia

3

Restless Legs Syndrome and meHad it since early 20sDiagnosed at age 38Taking clonazepam 0.5 mg/dayStarted with 2.5 mg/day (!)

4

clonazepam

4

Some previous workDrug experiments (2002-2009)MBA and $1000 genome (2009)Coriell Personalized Medical Collaborative (2009)23andMe (2011)5

5

Genomera: QS + genomicsCrowd-sourcing health discoveryGenomics meets Facebook6

I am sharing my genome with everyoneSource: www.genomera.com/users/ktpickard

6

RLS/niacin study protocolSeth Roberts: blog post on RLS and niacin0 to 1000 mg/day niacin over four weeksTrack flush, RLS and PLMS severity, sleep hours dailyCheck cholesterol before and after (HDL benefit from niacin)7

Niacin Vitamin B3

7

Instruments on Genomera8

Niacin DosageFacial FlushingRLS SensationSource: www.genomera.com/studies/effects-of-niacin-on-restless-leg-syndrome

8

Data sharing on Genomera

9

Source: www.genomera.com/studies/effects-of-niacin-on-restless-leg-syndrome

9

I used some other instruments, too.10

For measuring sleepFor niacin remindersSources: www.fitbit.com, www.tonicselfcare.com

10

Meds go down, symptoms go up11

Source: bit.ly/pT1zok

11

Meds go down, symptoms go up12

Source: bit.ly/pT1zok

12

How well am I really sleeping?13

Lost fitbit in washing machineNormal trackingSensitive tracking

13

Talking about RLS with my doctor23andMe RLS variant: rs3923809 (AG)UpToDate.com has GWAS info!

Lets check your serum ferritin level.14

14

RLS and genetic factorsDominant inheritance: 40%Recent 23andMe RLS updateFor memixed results: 15

2 higher-risk markers1 lower-risk marker3 typical markersSource: www.diygenomics.org

15

What about ferritin?Hemoglobin carries O2 in blood13.818 g/dL for males12.115.1 g/dL for females My hemoglobin: 1516 g/dLFerritin stores iron30400 ng/mL for males13150 ng/mL for females My ferritin: 14 ng/mL16

Ferritin

Hemoglobin

16

Whats the theory?RLS patients may have diminished brain iron storesTested with CSF, MRI, US, autopsyIron therapy may improve symptoms17Source: www.rls.org/Document.Doc?&id=605

RLS

+=?

17

What did I learn?Niacin did not improve my RLSLow ferritin may be the causeWork with a quant-friendly docQS can be uncomfortableNew talk if iron therapy works

18

18

For more informationRLSwww.rls.org National Sleep Foundationwww.sleepfoundation.org/article/sleep-related-problems/restless-legs-syndrome-rls-and-sleepCureTogetherwww.curetogether.com

19

Source: www.curetogether.com

19

Questions?

K. Thomas Pickardktpickard [at] pickardexpress.com@kthomaspickardwww.linkedin.com/users/kthomaspickard

Disclosure statement: Nothing to disclose

Slides posted to: http://slideshare.net/kthomaspickard/restless-legs-syndrome-and-niacin

20

20