Plegable : Biología Molecular - Medicina UPB

Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial Cells and

Sex Chromosome Shocker: The 'Female' X a Key Contributor to Sperm Production

Deisy Tatiana Sánchez ZapataMedicine Estudent – Molecular Biology

UPB

FOLDING

FOLDING

INTRODUCTION

The cell cycle is the basis for the reproduction of organisms

The cell cycle is the basis for the reproduction of organisms

The X chromosome has a close relationship with sperm cells

The X chromosome has a close relationship with sperm cells

Flip of Mitotic Spindle Has Disastrous Consequences for

Epithelial Cells

Science Daily(July. 21, 2013)

Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial Cells

•Human epithelial cells are anchored to the extracellular matrix

and other cells by specialized proteins and for this property has

a significant role in the maintenance of epithelial cell polarity,

however in metastatic cancer cells this property is absent

•Binding complexes are of great importance for maintaining

cellular integrity even in the event of cell division


Apoptosis is a fundamental process that is altered in malignant neoplastic processes


Current research shows that if you directly disrupts the mitotic spindle, cells begin to detach from the epithelium, it was concluded that when researchers used fluorescence, this technique showed that the mitotic spindle poles are very close molecular contact regions of a cell with other cells.

OBSERVATION


Science Daily(July. 21, 2013)


• The X chromosome has a close relationship with male reproductive health.

• The Y chromosome has several regions of large palindromes while chromosome x presents ampliconic regions and genes associated with sperm production.

The gene expression sequences ampliconic in the X chromosome is largely restricted to the testis. At present it is known at this time that these genes are only expressed in spermatogenic cells themselves.


The content of X chromosome genes is conserved and shared among mammals.


Human X chromosomes in relation to the mouse X chromosomes have a ratio of 95% in the studied was identified that there are 340 genes that are identical between the two species


OBSERVATION

MEDICAL UTILITY

MEDICAL UTILITY


The recent advances in the process of cell division, allow to identify and understand in a better way the genesis of tumors, is why this type of research open a great outlook for multifactorial process of cancer.

MEDICAL UTILITY


This type of research have great contribution in reproduction and male infertility also through several studies it was concluded that several genes present on the X chromosome are linked to cancer of the testis, these recent developments are of great utility to men's health

BIBLIOGRAPHY

• Gibson Matt. Flip of Mitotic Spindle Has Disastrous Consequences for Epithelial Cells. Science Daily[Internet News]; 2013[July, 21]. Web Site: http://www.sciencedaily.com/news/health_medicine/

• Hahn B-S, Labouesse M. Tissue integrity: Hemidesmosomes and resistance to stress. Science Direct [October 2011], Edition (11); 2013[July, 26].Web Site: http://www.sciencedirect.com/science/article/

• Fearer Matt. Sex Chromosome Shocker: The 'Female' X a Key Contributor to Sperm Production. Bio- Medicine[Internet News]; 2013[July 21]. Web Site: http://www.bio-medicine.org/biology-news-1/Sex-chromosome-shocker-3A-The-female-X-a-key-contributor-to-sperm-production-31099-2/

Health & Medicine

Plegable : Biología Molecular - Medicina UPB