Painful bladder syndrome ppt

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  1. 1. / , , , .
  2. 2. Painful bladder syndrome/interstitial cystitis (PBS/IC) , . , , , . , , . , .
  3. 3. IC 19 Joseph Parrish, , 1836 "tic doloureux of the bladder." 1887 Skene interstitial cystitis , . 20- , Guy Hunner , , 17 . , "Hunner's ulcer." 1949 Hand 223 IC, . 1978 Walsh glomerulations , Hand-. 1978 Stamey IC , , IC . Dr. Vicki Ratner, , , 1984 .
  4. 4. , , , PBS/IC PBS/IC . .
  5. 5. 1. , 6 2. 7 3. 4. , , in situ 5. 6. , , 3 7. , , , 8. 3 9. 3 10. 3 11. 12. 13. ( , , - , , , ) 14. ( ) 15. , 3 16. 3 17. , , 3 18. , , , . 19. 12 French
  6. 6. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1. 350 mL . 2. 100 mL 150 mL 3. 4. 9 5. 6. , , . 7. 8 . 8. 3 9. 10. 11. 12. 13. / 14. 18 15. , , 16. 17. 18.
  7. 7. . 20,000 100,000 1,2 100,000 . 100,000 : 15-24,000 : 7 : 10.6-450 : 1.2 = 5:1 -?
  8. 8. 8 / / , 3-4 , . , , , , .
  9. 9. 9 / , / 14%
  10. 10. ,
  11. 11. 11 , - , - /
  12. 12. / , , ,- . . . , - . , , - . "
  13. 13. 13 ( 70%). E.Coli () , , . . , .. .
  14. 14. / / /. , ? : . - .
  15. 15. 15 CD34 +, . IgE- IgE . , KIT, . 100
  16. 16. , , , . , . , , , , .
  17. 17. / Parsons , ,- . (): , , , 4- 6-, , . . , , , , ,-, . : ,- .
  18. 18. 18 (AQP) -3 (UT) . Puneet Khandelwal et al. Am J Physiol Renal Physiol 2009;297:F1477-F1501 . . , . , , . , . UT-B () () . AQP-3 () , . (UC). [Spector et al. (192).]
  19. 19. 19 Ricardo Saban et al. Am J Physiol Renal Physiol 2008;295:F1613-F1623 (IF) . 2 NRP2 VEGF- 1 IF . (A), (), (C), IF (D). VEGF-1 NRP2 . (P