Low dose vs high-dose

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Why Low-dose is more efficient than High-dose when it comes to iron

Restoring iron counts

Restoring iron values takes a while, just like the onset and development of iron deficiency doesn't happen overnight. It is a question of balance where the uptake of iron needs to match the losses.

Natural losses include for instance loss of blood through menstruation and natural intake is based on the diet.

Natural dose

The regular amount of iron we need in a mixed diet is 12 - 18 mg in total per day.

In healthy individuals the average iron demand is 1 mg daily for men, 1.5 - 2.5 mg daily for women and during pregnancy 2-3 mg daily.A heme iron tablet with a dose of 18 mg will yield up to 4 mgs for bodily needs, whereas a non-heme tablet of 100 mg will yield 2 mg. The rest is reactive and remains in the gut.

The body will absorb no more than it needs of heme iron and the rest is completely inert no stomach problems.

Iron absorption

Most of the daily iron will be in non-heme form, which is bound in plants or bound chemically in the regular syntethic supplements. Non-heme iron is not very bioavailable, so more than 95 % will not be absorbed.

Heme-Iron is taken up at a significantly higher rate, 20 -40 % and will not produce side-effects like the syntethic supplements. It is also not affected by other simultaneously ingested food or drink.

Uptake of non-heme iron

30 days of supplementation with 100 mg Fe++ non-heme iron at a bio-availablity of 2 % theoretically gives 60 mg absorbed iron. At 4 %, which is unusual, the amount is 120 mg.

Non-heme supplements at 100 mg Fe++ per dose regularly have an incidence of side-effects leading to termination of the therapy of around 30 %.

Uptake of Heme-iron

Supplementation with 18 mg of heme iron for thirty days with a bio-availability/uptake of 20 % gives 108 mg of absorbed iron.

Heme iron is very well tolerated and is known to have a side-effects ratio as placebo. This means a higher therapy success rate.

This is why heme iron tablets with a dose of 18 mg Fe++ cancompete with non-heme tablets of 100 mg Fe++.

More than 60 mg non-heme stops zinc uptake

A dose of more than 60 mg of non-heme iron per day will block the uptake of Zinc, which is an essential trace element vital for many biological functions and that has a crucial role in the enzyme system in the body.

Heme-Iron will not affect the uptake of Zinc.

Syntethic supplements with high doses

There is a clear tendency to use non-heme iron supplements in very large doses because many believe a strong deficiency situation should be cured as quickly as possible.

However there is a large risk for therapy-ruining side-effects and a normal uptake will not permit a large change quickly.

A steady therapy with an efficient and well tolerated iron, such as Heme-Iron in tablet form, is therefore always preferable.

The OptiFer Series is the nr. 1 Heme-Iron formula available internationally

-The OptiFer series is safe. No reported cases of serious side-effects or poisonings after long-time massive use of heme iron in Scandinavia.