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Dr. Paresh Doshi Director of Neurosurgery Director Stereotactic and Functional Neurosurgery Dept. Jaslok Hospital and Research Centre Mumbai DEEP BRAIN STIMULATION (DBS) FOR TREATMENT RESISTANT DEPRESSION (TRD) DR. PARESH DOSHI

Dbs for depression

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Deep brain stimulation surgery at Jaslok hospital for treatment resistant depression.

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Page 1: Dbs for depression

Dr. Paresh Doshi

Director of Neurosurgery

Director Stereotactic and Functional Neurosurgery Dept.

Jaslok Hospital and Research Centre

Mumbai

DEEP BRAIN STIMULATION (DBS) FOR TREATMENT RESISTANT DEPRESSION (TRD)

DR. PARESH DOSHI

Page 2: Dbs for depression

Dr. Paresh Doshi

FIRST CASE IN ASIAN- AUSTRALIAN CONTINENTS

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Page 3: Dbs for depression

Dr. Paresh Doshi

• History of Psychiatric disorders surgery

MGH lesional experience

Also include other indication being OCD 25 publications and 130 cases

From where do claim this, world ns paper of mayberg

Papers published in IJP

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Page 4: Dbs for depression

Dr. Paresh Doshi

DEEP BRAIN STIMULATON

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Page 5: Dbs for depression

Dr. Paresh Doshi

ABOUT FUNCTIONAL NEUROSURGERY DEPT

• Started in 1998

• Offers treatment for Parkinson’s disease, movement disorders, epilepsy, pain, spasticity and psychiatric disorders

• Pioneer in performing several surgeries for the first time in India

• Largest experience of Deep brain stimulation (>250) in India

• Member of board of directors on Asian and the World societies for functional neurosurgery.

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Page 6: Dbs for depression

Dr. Paresh Doshi

WHAT IS SUBGENUAL CINGULATE GYRUS (SCCG)

• Located in the frontal lobe

• At the base of the brain

• Close to the midline

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Brain Target

Page 7: Dbs for depression

Dr. Paresh Doshi

WHY SCCG

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Inc activity in depression

Page 8: Dbs for depression

Dr. Paresh Doshi

MAY 2009- PSYCHOSURGERY CONSENSUS GROUP MEETING

Page 9: Dbs for depression

Dr. Paresh Doshi

GUIDELINES

• OCD and Depressionas the only confirmed indication

• Accept published inclusion and exclusion criteria for pt. selection

• Selection to be done with a 100% consensus of one neurosurgeon and two psychiatrists

• Selected case to be further reviewed and confirmed by independent neurologist, neurosurgeon and psychiatrist

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Doshi PK, Indian J Psych, 2009

Page 10: Dbs for depression

Dr. Paresh Doshi

WSSFN PSYCHIATRIC FORUM MEETING-SHANGHAI 2011

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Dr. Paresh Doshi

LONG TERM RESULTS

• 62% -1yr

• 42% -2yrs

• 75% -3yrs

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Kennedy HS, Lozano et al. Am J Psychiatry 2011; 168:502–510

Page 12: Dbs for depression

Dr. Paresh Doshi

BEN’S JOURNEY

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23rd September, 2013

Page 13: Dbs for depression

Dr. Paresh Doshi

DAY 1

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Page 14: Dbs for depression

Dr. Paresh Doshi

DAY 2

• Picture of consensus group with names tagged

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Page 15: Dbs for depression

Dr. Paresh Doshi

DAY 3 : FRAME FIXATION

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Page 16: Dbs for depression

Dr. Paresh Doshi

DAY 3: PLANNING

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Dr. Paresh Doshi

DAY 3: SURGICAL SETUP

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Page 18: Dbs for depression

Dr. Paresh Doshi

DAY3: INTRAOPERATIVE ASSESSMENT

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Dr. Paresh Doshi

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Page 20: Dbs for depression

Dr. Paresh Doshi

DAY 3: FINAL REWARD, BEN SMILING!!!

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Page 21: Dbs for depression

Dr. Paresh Doshi

THANK YOU

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