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Uterine leiomyoma (fibroid)

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Text of Uterine leiomyoma (fibroid)

  • 1.definition Prevalence Risk Factors classification Clinical Manifestations Diagnosis Management

2. Definition of Uterine leiomyomas (fibroids or myomas) are the most common pelvic tumor in women. They are benign monoclonal tumors arising from the smooth muscle cells of the myometrium. 3. Groosly ,Leiomyomas are pseudoencapsulated solid tumors, well demarcated from the surrounding myometrium. Microscopically, these appear as smooth muscle cells in longitudinal or cross-section intermixed with fibrous connective tissue. Vascular structures are few, and mitoses are rare. 4. Risk of Malignancy Leiomyosarcomas are found rarely in hysterectomy or myomectomy specimens (incidence 0.2%). 5. Uterine leiomyomas are the most common pelvic tumor in women. Leiomyomas have not been described in prepubertal girls, but they are occasionally noted in adolescents. Myomas are clinically apparent in approximately 12 to 25 percent of reproductive age women and noted on pathological examination in approximately 80 percent of surgically excised. Most, but not all, women have shrinkage of leiomyomas at menopause 6. Race Menstrual history & parity Hormonal contraception Ovulation induction agents others Early menarche (

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