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2. INTRODUCTION Lung cancer is largely a disease of modern man. Rare before 1900, with fewer than 400 casesdescribed in the medical literature. Raymond Pearl's landmark 1938 report conclusivelyestablished the devastating impact smoking has on longevity.: Abeloff's Clinical Oncology, 4th ed. 3. Tobacco consumption is the primary cause of lung cancer. More than 60% of new lung cancers occur in- Never smokers (smoked