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Lecture 24 from a college level neuropharmacology course taught in the spring 2012 semester by Brian J. Piper, Ph.D. ([email protected]) at Willamette University.
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Inhalants
Brian J. Piper, Ph.D.
Commonly Abused Products• Gases– Nitrous oxide, helium, refrigerants, propane
• Cleaning Agents– Spot remover, degreaser
• Solvents and Fuels– Butane propane, nail polish remover, paint
thinner/remover, correction fluid, permanent markers, gasoline, engine octane boosters
Commonly Abused Products• Aerosols– Spray paint, hair spray, air freshener, deodorant, fabric
protector
• Adhesives– Model airplane glue, rubber cement, PVC cement
• Foods– Cooking spray, aerosol whipped cream toppings
MtF: Epidemiology
MtF: Epidemiology
Sudden Sniffing Death Syndrome
Functional Resiliency• MRI & neurobehavioral tests
of adolescent toluene and polysubstance abusers (N=50/group)
Rosenberg et al. (2002). Clinical Toxicology, 40, 21-34.
White matter hyperintensities
Functional Resiliency• MRI & neurobehavioral tests
of adolescent toluene and controls (N=50/group)
Rosenberg et al. (2002). Clinical Toxicology, 40, 21-34.
Neurobehavioral TestsTest Use(s)
Wisconsin Card Sorting Test Schizophrenia/Alzheimer’s (Frontal lobe)
Continuous Performance Test ADHD
Tower of London Alzheimer’s
Trail Making Test Alzheimer’s
Novel Places & Faces ?
Concluding Thoughts
• Beyond dichotomies• Pharmacokinetics• Pharmacodynamics• Neurobehavioral Methods