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Chronic kidney disease

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Text of Chronic kidney disease

CHRONIC KIDNEY DISEASE

CHRONIC KIDNEY DISEASETHUSHARA C1ST YEAR. M PHARM PHARMACY PRACTICE

CONTENTSDEFINITIONSTAGES OF CKDETIOPATHOGENESISCLINICAL FEATURESDIAGNOSTIC TEST RESULTSTHERAPY

DEFINITION

Chronic renal failure is a syndrome characterized by progressive and irreversible deterioration of renal function due to slow destruction of renal parenchyma, eventually terminating in death when sufficient number of nephrons have been damaged.Acidosis is the major problem in CRF with development of biochemical azotaemia and clinical uraemia syndrome.

CKD is categorized by the level of kidney function, based on glomerular filtration rate (GFR), into stages 1 to 5, with each increasing number indicating a more advanced stage of the disease, as defined by a declining GFR. This classification system from the National Kidney Foundations Kidney Dialysis Outcomes and Quality Initiative (K/DOQI) also accounts for structural evidence of kidney damage.

STAGES OF CKDSTAGEGFRDESCRIPTIONTREATMENT190+Normal kidney function, but urine findings or structural abnormalities or genetic trait point to kidney disease Observation, control of blood pressure.260-89Mildly reduced kidney function, and other findings (as for stage 1) point to kidney disease Observation, control of blood pressure and risk factors.

3A3B45-5930-44Moderately reduced kidney functionObservation, control of blood pressure and risk factors 415-29Severely reduced kidney functionPlanning for end stage renal failure5