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Presentation on …

Chlamydia

Presented by …

Sayed Abdullah – Al – MamunDept. of MicrobiologyRoll No : 130343Session : 2013-14Jessore University of Science & Technology

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What is Chlamydia ???

Chlamydia is a genus of bacteria ; that are non motile , coccid & obligate intracellular parasites . They contain DNA , RNA & ribosomes . They have cell wall but peptidoglycan is absent .

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Discovery of Chlamydia

Chlamydia was discovered by Stanislaus Von Prowazek, a Czech scientist , in 1907 . Before this time , Chlamydia was recognized as a disease , but the causative agent was not known . In fact , many thought that gonorrhea was actually responsible for the symptoms and didn’t realize there were two different pathogens .

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Chlamydial Chlamydial MorphologiesMorphologies

Elementary bodyElementary body– 0.25 - 0.3 um diameter0.25 - 0.3 um diameter– electron-dense nucleoidelectron-dense nucleoid– Released from ruptured infected cells , Released from ruptured infected cells ,

human to human & bird to human .human to human & bird to human . Reticulate BodyReticulate Body

– Intracytoplasmic form 0.5 - 1.0 umIntracytoplasmic form 0.5 - 1.0 um– Replication and growth without a dense Replication and growth without a dense

center. center.

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Evolution of Evolution of Chlamydia Chlamydia Gram-negative cocci Gram-negative cocci Facultative intracellular parasites of mammals Facultative intracellular parasites of mammals

Obligate intracellular parasites Obligate intracellular parasites Host range restricted to rodents Host range restricted to rodents Restricted virulence (compact inclusions) Restricted virulence (compact inclusions) Folates synthesized (sulfonamide susceptible) Folates synthesized (sulfonamide susceptible) Glycogen synthesized and deposited in Glycogen synthesized and deposited in

inclusionsinclusions

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Developmental Cycle of Developmental Cycle of ChlamydiaChlamydia

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Species of ChlamydiaChlamydia trachomatis

Chlamydia muridarum

Chlamydia suis

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Diseases by Chlamydia

Chlamydia trachomatis :

It only infects humans .

It causes trachoma ; infection to eyes , which can lead to blindness .

It also causes urethritis , pelvic inflammatory disease , ectopic pregnancy , neonatal pneumonia , and neonatal conjunctivitis .

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Chlamydia muridarum :

It naturally infects only members of the family Muridae (includes both mice and hamsters) .

Chlamydia suis :

It only infects swine . It causes conjunctivities , enteritis and pneumonia in swine

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