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ADCT, CRT sign agreements to develop ADCs against cancer AND Secrets of

Parasites' Replication Unraveled

David Cano QuinteroMedical student III

UPBAugust 13 2012

INTRUDUCTION

The mitosis is the more important part in the DNA

replication and in it, we find the principal step of the regulation

Cancer is the most important problem of the DNA and involve the replication, mediate by the

DNA polymerase.

ADCT, CRT sign agreements to develop ADCs against cancer

Cancer Research Technology (CRT), the commercial arm of

Cancer Research UK, and Switzerland-based ADC

Therapeutics Sarl (ADCT) announce today that they

have signed agreements to develop cancer treatments

called Antibody Drug Conjugates (ADCs) using

CRT antibodies and peptides, and ADCT's 'warhead' and

linker chemistries.ADCT, CRT sign agreements

to develop ADCs against cancer

News Medical July 6 2012


Its important in the investigation of

cancer treatment

which are internalized into the cancer cell

while avoiding damage to healthy

tissue

The antibody component selectively

targets the cancer cells to deliver tumor-destroying chemicals


ADCT's toxic chemicals interact with DNA without disrupting the double helix structure

which avoids triggering DNA repair processes - with the prospect that this will prevent drug resistance


• Once inside the cancer cell, the linker degrades and the active toxin is released, binding to the cell's DNA and killing the cancer cell.

1

• ADCT's toxic chemicals interact with DNA without disrupting the double helix structure which avoids triggering DNA repair processes - with the prospect that this will prevent drug resistance

2

• ADCT's warheads are based on proprietary pyrrolobenzodiazepines (PBDs) technology developed by London-based Spirogen Limited

3

OBSERVATION

I think that this new is very relevant in the way that is a big base to future studies of cancer and all types of treatments about it and with that they can be a beginning to help a lot of lives

Secrets of Parasites' Replication Unraveled

Advances have not come easily, in part because

these parasites have the most complex mitochondrial genome structure in nature,

say Klingbeil and Concepción-Acevedo

Klingbeil says, "so if we can inhibit the replication

process and take away the kDNA, the parasites will die. That's one way we might be

able to kill them.“ScienceDaily July 10, 2012


They finally could have an idea

around how can do more

investigations about DNA taking

part of the parasities

Advances have not come easily, in part because these parasites have the most

complex mitochondrial

genome structure in

nature

report the first detailed characterization of the way key proteins in the

model parasite Trypanosoma

brucei organize to replicate its

mitochondrial DNA


Klingbeil says, "so if we can inhibit the replication process and take away the kDNA, the parasites will die. That's one way we might be able to kill them."

kDNA is found as a nucleoid in the mitochondrion, where it holds many copies of catenated or networked minicircles and maxicircles

These molecules pass information on to daughter cells via DNA polymerases whose job it is to copy all circles in the network

Trypanosomes have six mtDNA polymerases, while humans have just

one

To figure out how these trypanosomal polymerases know when to initiate DNA replication set up immunofluorescence

experiments focused on tracking mtDNA polymerase ID (POLID)

Their ultimate success would be to find a chemical to inhibit POLID from

carrying out its role during replication and target all parasites with kDNA

structures


OBSERVATION

In my opinion this new start to take relevance in the way that use this investigation in parasites, to make more studies about the mitochondrial DNA but in humans and with that can make some important findings

MEDICAL UTILITY

This provides a very promising and rapid route to develop ADCs for cancer therapy

ADCT, CRT sign agreements to develop

ADCs against cancer

MEDICAL UTILITY

Potent PBD-based warheads combined with CRT's leading tumor-targeting antibodies and peptides

ADCT, CRT sign agreements to develop

ADCs against cancer

MEDICAL UTILITY

It is an important step to do investigation about the hereditary obesity in humans

The mitochondrial DNA is relationship with this hereditary problem


MEDICAL UTILITY

This important discovery explains how POLID engages in kDNA replication and opens up new avenues to study and intervene in mitochondrial protein dynamics


BIBLIOGRAPHY

Martinez S, Lina Maria. Biología Molecular. 7 ed Medellín: UPB. Fac Medicina

ADCT, CRT sign agreements to develop ADCs against cancer. News Medical. (July 6, 2012)

Secrets of Parasites' Replication Unraveled. ScienceDaily. (July 10, 2012)

THANKS