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Page 1: Low dose vs high-dose

Why Low-dose is more efficient than High-dose when it comes to iron

Page 2: Low dose vs high-dose

Restoring iron counts

• Restoring iron values takes a while, just like the onset and development of iron deficiency doesn't happen overnight. It is a question of balance where the uptake of iron needs to match the losses.

• Natural losses include for instance loss of blood through menstruation and natural intake is based on the diet.

Page 3: Low dose vs high-dose

Natural dose

• The regular amount of iron we need in a mixed diet is 12 - 18 mg in total per day.

• In healthy individuals the average iron demand is 1 mg daily for men, 1.5 - 2.5 mg daily for women and during pregnancy 2-3 mg daily.

• A heme iron tablet with a dose of 18 mg will yield up to 4 mgs for bodily needs, whereas a non-heme tablet of 100 mg will yield 2 mg. The rest is reactive and remains in the gut.

• The body will absorb no more than it needs of heme iron and the rest is completely inert – no stomach problems.

Page 4: Low dose vs high-dose

Iron absorption

• Most of the daily iron will be in non-heme form, which is bound in plants or bound chemically in the regular syntethic supplements. Non-heme iron is not very bioavailable, so more than 95 % will not be absorbed.

• Heme-Iron is taken up at a significantly higher rate, 20 -40 % and will not produce side-effects like the syntethic supplements. It is also not affected by other simultaneously ingested food or drink.

Page 5: Low dose vs high-dose

Uptake of non-heme iron

• 30 days of supplementation with 100 mg Fe++ non-heme iron at a bio-availablity of 2 % theoretically gives 60 mg absorbed iron. At 4 %, which is unusual, the amount is 120 mg.

• Non-heme supplements at 100 mg Fe++ per dose regularly have an incidence of side-effects leading to termination of the therapy of around 30 %.

Page 6: Low dose vs high-dose

Uptake of Heme-iron

• Supplementation with 18 mg of heme iron for thirty days with a bio-availability/uptake of 20 % gives 108 mg of absorbed iron.

• Heme iron is very well tolerated and is known to have a side-effects ratio as placebo. This means a higher therapy success rate.

This is why heme iron tablets with a dose of 18 mg Fe++ cancompete with non-heme tablets of 100 mg Fe++.

Page 7: Low dose vs high-dose

More than 60 mg non-heme stops zinc uptake

• A dose of more than 60 mg of non-heme iron per day will block the uptake of Zinc, which is an essential trace element vital for many biological functions and that has a crucial role in the enzyme system in the body.

• Heme-Iron will not affect the uptake of Zinc.

Page 8: Low dose vs high-dose

Syntethic supplements with high doses

• There is a clear tendency to use non-heme iron supplements in very large doses because many believe a strong deficiency situation should be cured as quickly as possible.

• However there is a large risk for therapy-ruining side-effects and a normal uptake will not permit a large change quickly.

• A steady therapy with an efficient and well tolerated iron, such as Heme-Iron in tablet form, is therefore always preferable.

Page 9: Low dose vs high-dose

The OptiFer® Series is the nr. 1 Heme-Iron formula available internationally

-The OptiFer® series is safe. No reported cases of serious side-effects or poisonings after long-time massive use of heme iron in Scandinavia.


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