Introduction to Functional Magnetic Resonance ImagingFunctional Magnetic Resonance Imaging
PSY 992, Section 601# of Credits: 3
http://www.msu.edu/~zhuda
Meeting date and time: gTuesday and Thursday: 10:20-11:40 AM
346 Giltner Hall
Tentative office hours: Tuesday and Thursday:12 PM - 1 PM
358 Giltner Hall
David C. Zhu, Ph.D.Associate Professor of Psychology and Radiology
Cognitive Imaging Research Center
For undergraduate students, please talk with me.
Grading
Grading will be based on:
1 Att d L t /Di i i (10%)1. Attend Lecture/Discussion sessions. (10%)
2. Attend Lab sessions. (10%)
3. Homework assignments. (50%)
4. Project: Students will help to design and implement an fMRI project. Pilot data will be
ll t d d i th f thi t d St d tcollected during the course of this study. Students will analyze and summarize the results as their final project. (30%)
Traditional Imaging
T1-weighted
T2-weighted
Blood flow Cerebral blood flow (perfusion)(perfusion)
Ventricle movement
Cerebrospinal fluid dynamics
Zhu DC, Xenos M, Linninger AA and Penn RD. D i f l t l t i l d b i l fl id iDynamics of lateral ventricle and cerebrospinal fluid in normal and hydrocephalic brains. J Magn Reson Imaging. 2006;24:756-770.
Carotid Plaque Hemorrhage Detection and Characterization
ith 3D SHINE
≥ 28 ms T2*
with 3D SHINE
14 ms
21 ms
3D SHINE & T2* map 3D SHINE & T2* map
14 ms
7 ms
0 ms
Type II
(b) (c)(a)
Type I
( ) ( )
Zhu DC, Vu AT, Ota H, DeMarco JK. Magn Reson Med. 2010;64:1341-1351.
The following images show the brain activation when a subject watched movies and pictures:
The following images show the brain activation when you tapped the fingers of your left hand:
Motor area
M tMotorarea
The following movie shows the brain activation h bj h d i i dwhen a subject watched movies or pictures and
pressed his finger at the same time:
A contrast study of scene vs face base on a group of 14 subjects:
Scene Processing
A contrast study of scene vs. face base on a group of 14 subjects:Red and yellow regions show preferential activation to scene.Blue regions show preferential activation to face.
H d JM L CL Zh DC F ll S d ti ti thHenderson JM, Larson CL, Zhu DC. Full Scenes produce more activation than close-up scenes and scene-diagnostic objects in parahippocampal and retrosplenial cortex: an fMRI study. Brain Cogn. 2008;66:40-49.
Scene Processing
The following regions show preferential activation of indoor over outdoor scenes based on group analysis of 17 subjects:
Henderson JM, Larson CL, Zhu DC. Cortical activation to indoor versus outdoor scenes: an fMRI study.Exp Brain Res. 2007;179:75-84.
The following regions show preferential activation of
Emotional Processing
g g pdownward triangles over upward triangles based on group analysis of 17 subjects:
Larson CL, Aronoff J, Sarinopoulos IC, Zhu DC. Recognizing threat: a simple geometric shape activates neural circuitry for threat detection. J Cogn Neurosci. 2009 Aug;21(8):1523-35.
Left TPJ activity in verbal working memory: Implications for storage- and sensory-specific models of short term memory
1 1
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High Object
High Verbal
Low Object
Low Verbal0.4
0.6
0.8
1a Left IFG/MFG d SMAd
t sig
nal c
hang
e
t sig
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Low Verbal
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0 4 8 12 16 20 24 28 32 36 40
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Perc
ent
Perc
ent
Enc Mt Ret Enc Mt Ret
0.4
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1b Left motor e Left insula/IFG
nt s
igna
l cha
nge
nt s
igna
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Perc
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Perc
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Enc Mt RetEnc Mt Re
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f Right cerebellum
Ravizza SM, Hazeltine E, Ruiz S, Zhu DC. Neuroimage. 2011;55:1836-46.
Flanker Study: “>>> < >>> - >>>>>>>”, “Incongruent Congruent” Contrast
Aging Study
“Incongruent – Congruent” Contrast
Investigate the network for interference resolution.
65
>
(voxel based p ≤ 0.005, whole brain corrected p ≤ 0.021)
543210-1-2
Younger adults Older adults
2-3-4-56-6<
Zhu DC, Zacks RT, Slade JM. Brain activation during interference resolution in young and older adults: an fMRI study. Neuroimage. 2010;50:810-817.
Diffusion Tensor Imaging
The Integration of Structural (DTI) and
Seed Region #1: pC/rsp (posterior cingulate/retrosplenial cortex)
Functional (Resting-State fMRI) Connectivity Analyses
Group Integration(17 subjects): pC/rsp( j )Whole-brain corrected P < 0.0325 for fMRI.
pC/rsp
Mean structural normalized connectivity distribution > 10-4
MeFC/ACC(Medial Frontal Cortex/Anterior Cingulate Cortex)
distribution > 10 4.
Zhu DC and Majumdar S. Journal of Neuroimaging. In Press.
A happy volunteer after surviving an fMRI session
Data acquisitionPulse sequence development
Type of Research Focus
- Pulse sequence development- Image reconstruction technique development- Coil development
Data analysis- Statistical method- Data mining- Resting state
Visualization- Pattern recognition- Human-computer interfacesHuman computer interfaces
Applications- Normal aging Resting state Alzheimer- Normal aging, Resting state, Alzheimer.-Visual, Language, Executive processing, Memory- …………
http://www.circ.msu.edu
Investigators
How would I get around to start an fMRI project?How would I get around to start an fMRI project?
Engineering ProcessEngineering Process
Cognitive Neuroscience Question
fMRI Q ti
Experimental Design
fMRI Question Looping
D t A i iti
Pilot Data
F ll
Data Analysis
Data AcquisitionFull
Time & $
Experimental Design
Implementation
Quality Assurance (QA)
iIntegration Test
First Subjectj
Review Result
Three or Four more Subjects
Evaluate Preliminary ResultsEvaluate Preliminary Results
Full data collection
Some Paper Works for a New fMRI Project
• IRB approval.
• Reviewed by the MRI Review Committee in
Radiology. Please contact Scarlett Doyle (our MR
research technologist) for paper work.
S f tS f tSafetySafety
Reading assignment for this week:
Chapters 1-2Chapters 1 2.