Glycyrrhiza glabra

CONTENTIntroductionUsesConstituentsSide EffectsMechanism of ActionToxicityDosageDrug InteractionsContraindications

INTRODUCTIONFAMILY LEGUMINACEAEBOTANICAL NAME

GLYCERYIZA GLABRA L.

ENGLISH NAME LIQUORICEURDU NAME MULHATIPART USED ROOTS,RHIZOME

CONSTITUENTS

Other Components

Glycyrrhizinic Acid 20%

GlycrrhizinGlabranin A & B

GlycyrrhetolGlabrolideIsoflavonesCoumarins

Triterpene Sterols

Active ingriedients

Glycyrrhizinic Acid 10%

TOXICITYHypokalemic

ParalysisCardiac Myopathy

Metabolic AlkalosisHypoxemia

Pseduoaldosteronism

USESAntiviral Anti-cancer Anti-inflammatory

Cardiac Dental Diabetes

GI ComplaintsHormonal EffectsHepatoprotection

MECHANISM OF ACTION

Hypocholester-olemic action

Anti mutagenic Activity

Decrease Lipid Peroxidation

Stimulate Hormones

Free Radical Scavenging

Activity

SIDE EFFECTSSalt Retention Water Retention

Low Potassium levelHypertensi

onCardiac

dysfunctionsDisturbance in cortisol

level

DOSAGE

LICORICE ROOTS

• Licorice Roots Doses Varies Between 2-15 g

for Ulcer And Gastritis

•Glycyrrhizin Is Suggested To Be 0.2 Mg/Kg/Day

DRUG INTERACTIONInteraction

With Warfarin

Licorice Decreases Effectiveness Of Warfarin Increasing Risk Of Clotting

Interaction With Digoxin

Licorice Decreases Potassium Levels Which Increase Side

Effects Of Digoxins

It May Altar Prednisolone Plasma Concentration

CONTRAINDICATIONSSurgery: Licorice might interfere with blood pressure control

during and after surgery. Stop taking licorice at least 2 weeks before a scheduled surgery.

It may also cause problems in the kidneys.so do not take licorice during

kidney problems.

It may lower the potassium levels in the blood causing hypokalemia.

Licorice can store water in the body, thus cause a severe congestive heart failure.so be

careful while using.

REFERENCESwww.herblist.com

www.ncbi.nlm.nih.gov

www.drhmeo.com

www.henrietess-herb.com

book of medical pharmacology

American medicinal plants

 

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