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Page 1: Dna replication

DNA REPLICATI

ON

Universidad Pontificia Bolivariana

María Paulina Henao ZuluagaMedicine Student3rd Semester

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INTRODUCTIONAn essential property of the genetic material is

its ability to make exact copies of itself.

ENZYMES •DNA Polymerases,•DNA Ligase •Primase •SSDPB (Single Strand DNA BindingProtein)•Topoisomerases,•RNAse- H

DIRECTION

5’---- 3’

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HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS

FOR DNA BREAKAGEBIOLOGY & NATURE

(July 19, 2011)  

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HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE

DNA

Responsibly for saving the

genetic information

Proper functioning o

f the cells

In charge of the protein synthesis

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HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE

Discover bases of DNA breakage

The cell increase proliferation  process

 Later cells enters in stress on DNA replication

“FRAGILE SITES “ are created in the

early cancer stages

CANCER

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HEBREW U. SCIENTISTS IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE

“Fragil sites”

DNA replicatio

n becomes

much slower or even stop

The breakdown of DNA

DNA of damage

Daughter cells are

born defective.

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OBSERVATION

Is very important that

every day do this kind of research on

the structure of DNA because

any little thing to do in the

future will be a base and a great

help for the treatment of many

diseases

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SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF

SOME CANCERS BIOLOGY & NATURE

(July 7, 2011)  

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SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF

SOME CANCERS

In normal conditions

When an error occurs during cell division

Cells sends a signal to stop replication

Checkpoints

Prevent excessive growth

Survival of the genome

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SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF

SOME CANCERS

Uncontrolled and excessive proliferation

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SCIENTISTS FIND 'BRAKE-OVERRIDE' PROTEINS THAT ENABLE DEVELOPMENT OF

SOME CANCERS

Cells  continuous playback

with the damaged genome

Cks 1 and Cks 2 proteins Avoid the

checkpoint in the

STAGE ”S”

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OBSERVATION

This is a great discovery, because

these proteins could be

detained in animals suggesting that in the not too distant future we

can apply it to humans, which I think would be

a good option for finding an effective

treatment against cancer .

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MEDICAL

UTILITY

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MEDICAL UTILITY

With the discovery of protein function Cks1 and Cks2 may be finding new ways of treatment and prevention against cancer by preventing the large increase of these in the early stages of disease development, improving the quality of life for thousands of people.

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MEDICAL UTILITY

With the discovery of the molecular basis of DNA breakage, are disclosed new features of the structure of DNA that promote the development of cancer, identifying the initial cancer processes such as fragile sites. This can be used to prevent cancer development through genetic modification.

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MEDICAL UTILITY

All these studies that realize about the operation, structure and application of DNA, serve as the basis for many other studies and provide valuable information in front of a cure for some diseases that affect millions of people such as cancer. Those discovers help  to preserve the quality of life and the people.

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BIBLIOGRAFHY

Scientists find “brake-override” proteins that enable development of some cancers.URL:http://esciencenews.com/articles/2011/07/07/scientists.find.brake.override.proteins.enable.development.some.cancers .(Biology & Nature).

 MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed.

Medellín: UPB. Fac. de Medicina, 2006. 208 p.

Hebrew U. scientists identify molecular basis for DNA breakage. URL: http://esciencenews.com/articles/2011/07/19/hebrew.u.scientists.identify.molecular.basis.dna.breakage. (Biology & Nature) .

 

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THANKS


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