ADVANCED ENGINEERING SOLUTIONS INC.
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AES Property/Confidential information1
AES Biomedical Capabilities
AES Biomedical Capabilities & Case Studies
ADVANCED ENGINEERING SOLUTIONS INC.
Innovative Steps to Excellence …
AES Property/Confidential information2
AES Biomedical Capabilities11/14/07
Advanced Engineering Solutions Inc. (AES), is one of the leading product design and engineering
consulting company providing product development and engineering solutions to major global companies.
• Aerospace
• Automotive
• Biomedical
• Chemical Industries
• Consumer Goods
• Electronic
• Environmental
• Energy
• Gas Turbine
• HVAC
• Industrial
• Oil & Gas
• Power Generation
• Process Industries
• Pumps
• Semiconductor
• Steam Turbine
• Turbo-machinary
ADVANCED ENGINEERING SOLUTIONS INC.
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AES Biomedical Capabilities
Flow Modeling Solutions for the Biomedical, Healthcare & Pharmaceutical Industries
• Visualization and prediction of physical phenomena for crucial information.
• Understanding the physics into delicate and often inaccessible areas
• Helping the designer in design and development of bio-medical systems.
• System studies include: Respiratory, Pharmaceutical, breath-activated device, Drug
delivery (inhalers, etc.), Blood handling (pumps, separators), In vivo blood and non-
blood flow etc.
ADVANCED ENGINEERING SOLUTIONS INC.
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AES Biomedical Capabilities
a. Troubleshooting: Diagnosing the problem and defects will be done faster, safer at less
cost.
b. Analyzing: Statically and Graphical data will reveal the cause/effect relationships to
improve performance and effectiveness.
c. Optimizing: Project viability and accuracy can be enhanced by doing number of changes
prior to laboratory testing to save time and money.
d. Understanding: Evaluate implications of changes in process variables to rapidly gain a
wider knowledge base at a low cost.
e. Reducing Development Time (Turn-around Time): Understanding the changes and
modifications for unsuccessful attempts before conducting time-consuming laboratory tests
and validations will be come down drastically and results in faster progress.
e. Reducing Development Cost
CFD Benefits
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AES Biomedical Capabilities
AES CFD Services
• Steady & Transient Flows
• Flow Distribution (Laminar & Turbulent ) using Different Turbulent Methods
• Incompressible and Compressible
• Swirling & Rotating Flows
• Conjugate Thermal Analysis
• Flow Through Porous Media
• Rotating Frames of Reference
• Multiple Species Transport,
• Multi-component & Multi Phase Flow- Mixing, Flashing, Reacting Evaporation
• Mixing
• Multiphase
• Fluid Structure Interaction (Including Deforming Grid),
• Radiation Modeling
• Cavitations
• Lagrangian Particle Tracking
• Forced & Natural Convection Heat Transfer
• Free Surfaces by VOF Method
• Deformable Meshes
• Design Optimization studies
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AES Biomedical Capabilities
Inhaler Performance
Design/Prototype Testing
Needles
Blood Processing Devices
Micro-Fluidic Diagnostic Devices
Manufacturing Process Optimization
Blood Pumps
Artificial Organs
CFD Applications -Medical Device Design & Performance
Inhaler
Inspiratory flow
Blood Pump
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AES Biomedical Capabilities
Medical Tubing Extrusion
Blow Molding of Medical Balloons
Micro-Electro-Mechanical Devices (MEMS)
3D Injection Molding
Compression Molding
Magnetic Drug Targeting
Blood flow within aneurysms Compression MoldingInjection
CFD Applications - Device Manufacturing Process
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AES Biomedical Capabilities
Diagnostic and Therapeutic Methods
Drug Delivery Modeling
Blood and Other Physiological Flows
Arteriosclerosis
Pathologies
Toxicology Research
Air Flow in Physiological Passages
Fluid Structure Interaction
Valve Modeling
Surgical Analysis
Complex Rheologies
Oxygenation
Multiphase Flow
Aerosol inhaler
Heart Throb
Bronchial tubes
CFD Applications - Physiological Transport Modeling
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AES Biomedical Capabilities
Presen
ted
to
Case Studies
on
Biomedical Pharmaceutical and healthcare
ADVANCED ENGINEERING SOLUTIONS INC.
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AES Biomedical Capabilities
Case Study for real-time visualization of tissue viability and function
Objective :
• Real-time visualization of tissue viability and function based on computer simulations that will provide a new tool for
doctors to help them in planning.
• Pressure load calculations on the tissue walls and flow paths and directions at different locations of blood vessel (arteries)
CFD Modeling :
• Flow is 3D laminar, Steady and Incompressible & Conjugate heat transfer problem.
Task Executed:
• The model is created in Unigraphics. Tetrahedral meshing is carried out using ICEM. Analysis is carried out in CFX after
applying the material properties and different boundary conditions. Different plots are provided in the technical report using
CFX- Post-processing.
Conclusion & Reliability :
• our 3-D simulation models employing computational fluid dynamics (CFD) calculations of flow in blood vessels and
facilitates by improving our whole organ thermal modeling by developing an improved understanding of tissue perfusion,
metabolism, and vasculature blood flow under surgical or emergency conditions. .
CAD Model MeshPressure Contours for the blood vessel
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AES Biomedical Capabilities
CAD ModelMesh
Case Study for High Pressure Gas & Low Quantity Fluid Nozzle StudyObjective :
• CFD analysis to predict the flow pattern in the nozzle system.
• To predict the static pressure & total pressure distribution , velocity and mass flow distribution of liquid in the nozzle
system.
• To optimise the design.
CFD Modeling :
• Isothermal, Turbulent and steady incompressible flow in 3D Domain is solved in Ansys CFX 11 parallel solver.
Task Executed:
• The model is created in Unigraphics. Hexahedral meshing is carried out using ICEM. Analysis is carried out in CFX after
applying the material properties and different boundary conditions. Different plots are provided in the technical report using
CFX- Post-processing.
Conclusion & Reliability :
•From the Analysis, the static pressure, total pressure, mach number, static temperature, mass fractions of fluids at different
location and velocity components are plotted. Based on the analysis, the liquid gas ratio and performance are optimized
for the given design as per the SOW. Customer verified the initial results as well as optimized results obtained by CFD
analysis with the experimental data.
Contours : Stream lines, Velocity and mass fraction
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AES Biomedical Capabilities
Case Study for MEB mobile charger head coil assembly thermal analysisObjective :
• Neuro-modulation CFD Analysis describing the transient thermal performance of the MEB mobile charging head coil assembly in
multiple simulated cases is to simulate test conditions used during design verification testing. .
• Thermal performance includes the temperature distribution throughout the entire assembly to outer surface temperature.
• To estimate response times to reach the specified temperature by the sensors
CFD Modeling :
• Flow is 3D laminor, Steady and Incompressible & Conjugate heat transfer problem.
•Natural convection has been accounted.
Task Executed:
• The model is created in Unigraphics. Tetrahedral meshing is carried out using ICEM. Analysis is carried out in CFX after
applying the material properties and different boundary conditions. Different plots are provided in the technical report using
CFX- Post-processing.
Conclusion & Reliability :
• Performance of MEB mobile charging head coil assembly was estimated and suggestions on design changes made for the
improvement.
Cost Savings :
• Performance of MEB mobile charging head coil assembly validated before incurring heavy cost of prototyping and testing.
CAD ModelMesh
Surface Temperature Contours for the individual parts
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AES Biomedical Capabilities
Case Study for Vacuum Pressure Syndion Chamber Reactive Flow StudyObjective :
• Side injection simulation for predicting the flow patterns in the vacuum pressure chamber with reactions of SiF4 and F2.
• Realize the flow pattern and pressure distribution in the Syndion chamber.
• Use the simulation data as a tool to design and optimize gas injection and chamber geometry.
• Forecast the etch uniformity with the simulated data.
CFD Modeling :
• Flow is 3D Turbulent , Steady and Incompressible & reactive and species transport problem.• Chemistry: Si + 4F SiF4 & F+F F2 (All Walls)• Low pressure gas flow between 20 to 300 mTorr.
Task Executed:
• The model is created in Unigraphics. Hexahedral meshing is carried out using ICEM. Analysis is carried out in Fluent after
applying the material properties and different boundary conditions. Different plots are provided in the technical report using
Fluent Post processing.
Conclusion & Reliability :
• Optimization was achieved for the uniform etching by doing iterative flow studies by varying the angle of flow, flow rate and
chamber operative pressure .
Cost Savings :
• Performance Syndion chamber validated before incurring heavy cost of multiple cases of testing.
CAD Model Mesh Surface Mass Fraction , Reaction , Velocity vectors and Stream lines
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AES Biomedical Capabilities11/14/07