New Patents

A pyridylketoxime ether compound of the for- mula: See Patent for Chemical Structure (I) wherein Ar is a phenyl, naphthyl, or heterocyclic group unsubstituted or substituted by a C1-C8 alkyl group, a C1-C8 alkylamino group, a C1-C8 alkoxy group, a C1-C8 alkoxycarbonyl group, a trifluoromethyl group, a nitro group or a halogen atom, X is a -(CH2)m- group wherein m is an integer of from 1 to 5, a -(CH2)m-Y- group wherein Y is an oxygen or sulfur a tom and m is as defined above, or a -CH2-(CH double bondCH)n- group wherein n is an integer of 1 or 2, and R is a phenyl, naphthyl, C3-C8 cycloalkyl or heterocyclic group unsubstituted or sub- stituted by a CI-C8 alkyl group, a C1-C8 alkylamino group, a C1-C8 alkoxy group, a C1- C8 akloxycarbonyl group, a trifluoromethyl group, a nitro group or a halogen atom, or a salt thereof.

4973470

SUSTAINED RELEASE PHARMACEUTICAL

COMPOSITIONS

Nancy L Mills, Michael R Harris, Russell U Nesbitt assigned to Warner-Lamber t Company

A sustained release oral pharmaceutical com- position consists essentially of a recompressed mixture of a water-sensitive pharmaceutical a- gent, a high molecular weight hydrophilic cel- lulose polymer, and a lubricant. The mixture is compressed into a unitary mass, comminuted, and recompressed into tablets without the use of solvents.

4973504

PHARMACEUTICAL ELASTOMERIC COATING

Val Romberg, Patty Kiang, Wayne Curry as- signed to The West Company Incorporated

An elastomeric member for use with a container and in contact with pharmaceutically pure con- tents therein. The elastomeric member has an elastomeric base and a continuous polyparaxyly- lene coating on the base. The coating ranges from about 0.5 microns to about 2.0 microns in thickness. The closure member has a coefficient of friction of less than 1.0 and is capable of sub- stantially preventing metal extraction from said elastomers.

4973576

BISPHOPHONIC ACID DERIVATIVES AND PHARMACEUTICAL

COMPOSITIONS CONTAINING THE SAME

Shuichi Sakamoto, Makoto Takeuchi, Yasuo Isomura, Kunihiro Niigata, Tetsushi Abe, Kousei Kawamuki , Masafumi Kudou, Tokyo, Japan assigned to Yamanouchi Pharmaceutical Co Ltd

Novel bisphosphonic acid derivatives, and a bone resorption-inhibitor and an anti-arthritis containing a bisphosphonic acid derivative represented by the formula (I): See Patent for Chemical Structure (I) wherein R2 represents a hydrogen atom, an alkyl group, etc., R2 represents a hydrogen a tom or a lower alkanoyl group, R3, R4, R5 and R6

4973480

TAMPER EVIDENT PHARMACEUTICAL CAPSULE

Marc S Hermelin, Mitchell I Kirschner, George N Paradissis assigned to K V Pharmaceutical Co

A tamper evident pharmaceutical capsule which contains an active agent. The capsule is coated on its external surfaces to provide an indication of tampering.

4973580

DEPOLYMERIZED DERMATAN SULFATES ENDOWED WITH AN

ANTITHROMBOTIC, FIBRINOLYTIC,

ANTIINFLAMMATORY ACTIVITY AND PHARMACEUTICAL

COMPOSITIONS CONTAINING SUCH

Giuseppe Mascellani, Pietro Bianchini, Corlo, Italy assigned to Opocrin S p A Laboratorio Farmacobiologico