William Pomerantz, Ph.D Curriculum Vitae WILLIAM C ... Pomerantz, Ph.D Curriculum Vitae

William Pomerantz, Ph.D Curriculum Vitae

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WILLIAM C. POMERANTZ, Ph.D.

Phone: 612-624-9091 email: [email protected]

Group Site: http://www.chem.umn.edu/groups/pomerantz/

Education

University of Wisconsin-Madison

Ph.D. Organic Chemistry, 2008

Research Advisors: Professor Sam Gellman and Professor Nick Abbott

Swiss Federal Institute of Technology, ETH, Zürich, Switzerland

Seydel/Fulbright Fellow, Department of Chemistry 2002-2003

Research Advisors: Professor François Diederich and Professor Emeritus Jack Dunitz

Ithaca College B.S. Chemistry, Summa cum laude 2002

Research Advisor: Professor Heinz Koch

Appointments

University of Minnesota

Assistant Professor of Chemistry 2012-present

Department of Chemistry

McKnight Land Grant Professor 2016-present

Department of Medicinal Chemistry 2014-present

Graduate Faculty

University of Michigan

NIH NRSA Postdoctoral Research Fellow 2009-2012

Research Advisor: Professor Anna Mapp

Honors

Rising Star in Chemical Biology, International Chemical Biology Society Award 2016

Cottrell Research Scholar 2016

University of Minnesota Land-Grant McKnight Professor Award 2016

Eli Lilly $2500 honorarium 2015

NIH Grant mentoring workshop (NIGMS), travel award 2014

University of Minnesota College of Science and Engineering Teaching Fellow 2014

Phi Kappa Phi, Love of Learning Awards 2013, 2014

F32 NRSA NIH Postdoctoral Research Fellowship, NIGMS 2010-2012

Goering student fellowship, University of Wisconsin-Madison Chem. Dept. 2008

Samuel M. McElvain Fellowship, University of Wisconsin-Madison 2003

Fulbright Fellowship, Zürich, Switzerland 2002-2003

Grants

NIH 1R01GM121414-01 recommended for funding 2017-2022

Eli Lilly LRAP recommended for funding 2017-2019

American Heart Association, Scientist Development Grant, National Affiliate 2015-2019

Sidney Kimmel Cancer Foundation Scholar Award 2015-2017

NSF CAREER supplements (CHE-1542011), (CHE – 1638451) 2015,2016

NSF CAREER Award (CHE-1352091) 2014-2019

mailto:[email protected]

http://www.chem.umn.edu/groups/pomerantz/


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Masonic Cancer Center, Breast Cancer Translational Pilot Project 2014-2015

American Cancer Society IRG, Award #124166-IRG-58-001-52-IRG6 2013-2014

PUBLICATIONS Publications during independent position: * = corresponding author

Non-Refereed Articles

1. “Protein-observed 19

F NMR as a Ligand Discovery Tool” by W. C. K. Pomerantz, featured piece on Bruker’s online

website “The Resonance”

http://www.theresonance.com/2014/categories/structural-biology/protein-based-19f-nmr-as-a-ligand-discovery-tool

Refereed Journal Articles

Publications during independent position: * = corresponding author

In preparation

35. Pyridopyrimidine scaffolds as a new class of domain 1 isoform selective BET bromodomain inhibitor. S. Talluri, A.

Divakaran, A. Ayoub, J. Widen, N. K. Mishra, J. Zhu, E. Schnonnbrun, D. Harki, W. C. K. Pomerantz* manuscript in

preparation

34. Simultaneous fluorinated amino acid labeling of a transcription factor uncovers new small molecule binding site, C.

T. Gee. K.E. Arntson, E.J. Koleski, W. C. K. Pomerantz*manuscript in preparation

34. Bptf maintains chromatin accessibility and the self-renewal capacity of mammary gland stem cells. W. D.

Frey, A. Chaudhry, P. F. Slepicka, A. M. Ouellette, S. E. Kirberger, W. C. K. Pomerantz, G. J. Hannon, and C.

O. dos Santos* Stem Cell reports, manuscript submitted

33. “BET bromodomain inhibitors from a one-step multi-component synthesis discovered from a virtual screen.” L. M. L.

Hawk, A. Ayoub, R. Herzig, A. Wisniewski, J. Zhu, T. Scott, N. Berndt, C. T. Gee, J. Qi, J. E. Bradner, T. R. Ward, E.

Schonnbrun, G. I. Georg*, W. C. K. Pomerantz* J. Med. Chem. manuscript submitted

32. “Quantifying Protein Concentrations using Smartphone Colorimetry: A New Method for an Established Test” C. T.

Gee, E. Kehoe, W. C. K. Pomerantz* R. Lee Penn* J. Chem. Ed. submitted

31. “Comparative analysis of ligand-observed 1H NMR and protein observed

19F NMR methods for fragment screening,

A.K. Urick; J. Espinosa, J. P. Calle, H. Hu,* W. C. K. Pomerantz* ACS Chem. Biol. 2016, ASAP

30. Paramagnetic relaxation enhancement for protein-observed 19

F NMR as an enabling approach for efficient fragment

screening, L. M. Hawk, C. T. Gee, A. K. Urick, H. Hu. W. C. K. Pomerantz* RSC Advances, 2016, 6 95715-21.

29. “The Prediction of 19

F NMR in Proteins” W. C. Isley III,* A. K. Urick, W. C. K. Pomerantz* C. J. Cramer Mol.

Pharm., 2016, 13, 2376-238.

28. “Oxidation increases the strength of the methionine-aromatic interaction”, A. K. Lewis, A. Cembran, T. L. Senkow,

R. Mahling, G. T. Perell, M. R. McCarthy, C. Her, B. T. Horn, C. C. Valley, C. B. Karim, J. Gao, W. C. Pomerantz, D.

D. Thomas, A. Hinderliter, J.N. Sachs**, Nature Chem. Biol. In press

27. “Protein-Observed 19

F NMR for Fragment Screening, Affinity Quantification, and Druggability Assessment , “ C. T. Gee, K. E. Arntson, L.M. Hawk, A. Wisniewski, A.K. Urick, N. K. Mishra, W. C. K. Pomerantz*. Nat. Protoc.,

2016, 11, 1414-27

26. Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery, K. E. Arntson, W. C.

K. Pomerantz*, J. Med. Chem. Invited review, 2016, 59, 5158–71.

http://www.theresonance.com/2014/categories/structural-biology/protein-based-19f-nmr-as-a-ligand-discovery-tool


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25. Dual screening of BPTF and Brd4 using protein-observed fluorine NMR uncovers new bromodomain probe

molecules. Andrew K. Urick, Laura M. L. Hawk, Melissa K. Cassel, Neeraj K. Mishra, Shuai Liu, Neeta Adhikari, Wei

Zhang, Camila O. dos Santos, Jennifer L. Hall, and William C. K. Pomerantz* ACS. Chem. Biol. 2015, 10, 2246-56. Hear the interview at the 5:30 mark: http://pubs.acs.org/subscribe/journals/acbcct/audio/acbcctv10n10.mp3

24. “Fragment Screening and Druggability Assessment for the CBP/p300 KIX Domain Via Protein Observed 19

F NMR” C. T. Gee, E. J. Koleski W. C. Pomerantz*. Angew. Chem. Int. Ed. 2015 54. 3735-9. Read its coverage on Practical Fragments, http://practicalfragments.blogspot.com/2015/02/19f-target-based-screening-reduced-to.html

23. “Fluorinated aromatic amino acids are sensitive probes for bromodomain ligand interactions”, N. K. Mishra, A. K.

Urick, S. W. Ember, E. Schonbrunn, W. C. Pomerantz* ACS. Chem. Biol. 2014 9, 2755-60.

Publications prior to independent position: * = corresponding author

22. "FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions" J. M.

Lodge, J. T. Rettenmaier, J. A. Wells*, W. C. Pomerantz*, A. K. Mapp*, MedChemComm, 2014, 5, 370-375.

Recommended for special significance to the field by Faculty of 1000 on F1000prime and among the top ten most

downloaded articles in the journal from April to June 2014.

21. “Ordering a disordered protein via a small molecule stabilizer”, N. Wang, C. Y. Majmudar, W. C. Pomerantz, J. K.

Gagnon, J. D. Sadowsky, J. L. Meagher, T. K. Johnson, J. A. Stuckey, C. L. Brooks III, J. A. Wells, A K. Mapp, J. Am.

Chem. Soc. 2013, 135, 3363-3366 Featured as a JACS spotlight piece

20. “Sekikaic Acid and Lobaric acid target a dynamic interface of the coactivator CBP/p300” C. Y. Majmudar* J. W.

Hojfeldt,* C. Arevang, W.C. Pomerantz, P.J. Schultz, J. K. Gagnon, L. C. Cesa, C. H. Doss, S. P. Rowe, T. Cierpicki, C.

L. Brooks III, D. H. Sherman, A. K. Mapp, Ang. Chem. Int. Ed. 2012, 51, 11258 *rated as a “Highly Important Paper”

19. “Profiling the Dynamic Interfaces of Fluorinated Transcription Complexes for Ligand Discovery and

Characterization” W.C. Pomerantz, N. Wang; R. Wang, A. K. Lipinksi, T. Cierpicki, A. K. Mapp. ACS. Chem. Biol.,

2012, 7, 1345-50. See “Highlighting our Authors” in the same issue

18. “Lyotropic Liquid Crystals from ACHC-Rich β-peptides”, W. C. Pomerantz, V. M. Yuwono, R. Drake, J. D.

Hartgerink, N. L. Abbott, S. H. Gellman, J. Am. Chem. Soc. 2011, 133, 13604-13.

17. “Lyotropic liquid crystalline phases from helical β-peptides as alignment media”, C. Thiele; W. C. Pomerantz, N. L.

Abbott; S. H. Gellman, Chem. Comm., 2011, 47, 502-4

16. “Transcriptional Tools: Small Molecules for Modulating CBP KIX-dependent Transcriptional Activators”, C. A.

Bates; W. C. Pomerantz; A. K. Mapp; Biopolymers, 2011, 95, 17-23

15. ”Streamlined monitoring of backbone thioester exchange by

19F NMR” W. C. Pomerantz,

* E. B. Hadley,

* C. G. Fry,

S. H. Gellman, * These authors contributed equally. ChemBioChem 2009,10, 2177-81.

14. “Pre-clinical development of a bi-functional, cancer cell homing, PKC-epsilon inhibitory peptide for treatment of head

and neck cancer.” L. W. Bao, M. A. Gorin, M. Zhang, A. C. Ventura, W. C. Pomerantz, S. D. Merajver, T. N. Teknos, A.

K. Mapp, Q. Pan Cancer Res. 2009, 69, 5829-34.

13. “Effect of sequence and structural properties on 14-helical β-peptide activity against Candida albicans planktonic cells

and biofilms” A. J. Karlsson, W. C. Pomerantz, K. J. Neilsen, S. H. Gellman, S. P. Palecek, ACS Chem. Biol. 2009, 4,

567-79.

12. “A Rationally Designed Aldolase Foldamer” M M. Müller, M. A. Windsor, W. C. Pomerantz, S. H. Gellman, D. Hilvert, Angew. Chem. Int. Ed. 2009, 48, 922-5.

http://pubs.acs.org/subscribe/journals/acbcct/audio/acbcctv10n10.mp3

http://practicalfragments.blogspot.com/2015/02/19f-target-based-screening-reduced-to.html


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11. “Characterization of nanofibers formed by self-assembly of β-peptide oligomers using small angle x-ray scattering.”

C. L. Pizzey, W. C. Pomerantz, B.-J. Sung, V. M. Yuwono, J. D. Hartgerink, A. Yethiraj, S. H. Gellman, N. L. Abbott, J.

Chem. Phys., 2008, 129, 095103-1-8.

10. “Distinctive circular dichroism signature for 14-helix-bundle formation by β-peptides.” W. C. Pomerantz, T. L.

Grygiel, J. R. Lai, S. H. Gellman, Org. Lett. 2008, 10, 1799-1802.

9. “Nanofibers and lyotropic liquid crystals from a class of self-assembling β-peptides” W. C. Pomerantz, C. L. Pizzey,

V. M. Yuwono, J. D. Hartgerink, N. L. Abbott, S. H. Gellman, Angew. Chem., 2008, 47, 1241-4.

8. “Comparisons of design strategies for promotion of 14-helix stability in water”, E. Vaz, W.C. Pomerantz, M. Geyer,

S. H. Gellman, L. Brunzveld, ChemBioChem, 2008, 9, 2254-59.

7. “Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in β-peptides.” M.-R. Lee, T. L. Raguse, M.

Schinnerl, W. C. Pomerantz, X. Wang, P. Wipf, S. H. Gellman, Org. Lett. 2007, 9, 1801-4.

6. “Sequence dependent behavior of amphiphilic β-peptides on gold surfaces.” W. C. Pomerantz, K. D. Cadwell, Y.-J.

Hsu, S. H. Gellman, N. L. Abbott, Chem. Mater. 2007, 19, 4436-41.

5. “Practical synthesis of enantiomerically pure β-amino acids via proline-catalyzed diastereoselective aminomethylation

of aldehydes.” Y. Chi, E. P. English, W. C. Pomerantz, W. S. Horne, L. A. Joyce, L. R. Alexander, W. S. Fleming, E. A.

Hopkins, S. H. Gellman, J. Am. Chem. Soc. 2007, 129, 6050-5.

4. “Antifungal activity from 14-helical β-peptides.” A. J. Karlsson, W. C. Pomerantz, S. H. Gellman, S. P. Palecek, J.

Am. Chem. Soc. 2006, 128, 12630-1.

3. “Lyotropic liquid crystals from designed helical β-peptides.” W. C. Pomerantz, S. H. Gellman, N. L. Abbott, J. Am.

Chem. Soc. 2006, 128, 8730-1.

2. “Donor-substituted cyanoethynylethenes: pi-conjugation and band-gap tuning in strong charge-transfer chromophores.”

N. N. P. Moonen; W. C. Pomerantz, R. Gist, C. Boudon, J.-P. Gisselbrecht, T. Kawai, A. Kishioka, M. Gross, M. Irie, F.

Diederich, Chem. Eur. J., 2005, 11, 3325-41.

1. “Comparing isotope effects and rates for the methanolic sodium methoxide reactions of 9-R-fluorene to those for p-

CF3C6H4CHClR (R = CH2Cl, CH2F and CF3).” H. F. Koch, W. C. Pomerantz, E. L. Ruggles, M. Van Laren, A.-M. Van

Roon, CCCC., 2002, 67, 1505-16.

PATENTS

3. “β-Peptide lyotropic liquid crystals.” W. C. Pomerantz, S. H. Gellman, N. L. Abbott, U.S. patent application filed,

2007 Approved 2011, US8021570B2

2. “Helical β-peptides with antifungal activity.”A. J. Karlsson, W. C. Pomerantz, S. H. Gellman, S. P. Palecek, U.S.

patent application filed, 2007, Approved 2008 US2008/0166388 A1

1. “Practical synthesis of enantiomerically pure β-amino acids via proline-catalyzed enantioselective and

diastereoselective aminomethylation” Y. Chi, E. P. English, W. C. Pomerantz, W. S. Horne, S. H. Gellman, U.S. patent

application filed, 2007, Approved 2012 US 8269039 B2

PRESENTATIONS

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Biorganic GRC, Proctor

Academy Scheduled June 11th 2017

“TBD” ACS, MI, Scheduled Spring National Meetnig, ACS, San Francisco April 2-6, 2017


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“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” New York University, NY,

Scheduled April 25, 2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Albert Einstein College of

Medicine, NY, Scheduled April 24, 2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” University of Michigan, MI,

Scheduled March 17th 2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” University of Wisconsin-

Madison, Madison WI, Scheduled March 9th 2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Duke University, NC

Scheduled March 3rd

2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” University of North Carolina

NC, Scheduled March 2nd

2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” BYU, UT, Scheduled Feb

16th 2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Colorado State University, CO,

Scheduled Feb 5th 2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” University of Washington, WA

Scheduled Feb. 2nd

2017

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” University of Illinois at

Urbana-Champagne, IL Scheduled November 28th 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Tufts, MA Scheduled

November 15th 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” MIT, MA Scheduled

November 14th 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Boston University, MA

Scheduled October 31st 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Univ. Kansas KS Scheduled

October 20th 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” UC-Irvine, Irvine CA

Scheduled October 12th 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” UCSD, CA Scheduled October

10th 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” University of Pittsburgh, PA

Scheduled Sept 15th 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” St. Jude’s Research Hospital,

Memphis TN, May 19th 2016


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“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Epigenetics Research

Symposium, University of Minnesota, April 29th 2016

"Protein-Observed Fluorine NMR for Fragment Screening" Drug Discovery Chemistry, San Diego California, Invited

Talk April 20 2016

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” Division of Biological

Chemistry, young investigator series, Spring ACS National Meeting, March 13, 2016

“Teflon Proteins: Chemical Biology Tools for Probing Protein-Protein Interactions.” Carleton College, MN Jan. 22rd

2016

“Teflon Proteins: Chemical Biology Tools for Probing Protein-Protein Interactions.” W.C.K. Pomerantz Pacifichem,

Hawaii Dec. 19th 2015

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” W.C. K. Pomerantz,

Pacifichem, Hawaii Dec. 16th 2015

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” W.C. K. Pomerantz,

University of Nebraska-Lincoln, Oct. 12th 2015

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” W.C.K. Pomerantz,

University of Nebraska, Kearney, Oct. 9th 2015

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” W.C. K. Pomerantz

Eli Lilly, Indianapolis, Aug. 27th, 2015

“Aromatic Amino Acids: Privileged Side-Chains For PPI Inhibitor Discovery”, High Throughput Chemistry and

Chemical Biology Gordon Research Conference, invited talk W. C. K. Pomerantz June 14-19th, 2015

“Aromatic Amino Acids: Privileged Side-Chains For Protein-Protein Interaction Inhibitor Discovery”, W.C. K.

Pomerantz, Dept. Chemical biology Training Grant Student Symposium invited talk May 19th 2015

“19

F NMR as a Ligand Discovery Tool for Epigenetic Proteins” W.C. Pomerantz, UMN Kickoff Epigenetics Consortium

Meeting, May 8th, 2015

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” W.C. Pomerantz,

National Cancer Institute, NIH March. 10th 2015

“Aromatic Amino Acids: Privileged Side-Chains For Protein-Protein Interaction Inhibitor Discovery”, W.C. Pomerantz,

Dept. Pharamcology UMN Talk Feb 13th 2015

Aromatic Amino Acids: Privileged Side-Chains For Protein-Protein Interaction Inhibitor Discovery”, W.C. Pomerantz,

University of Minnesota Duluth Talk Jan. 30th 2015


Ripon College, Dec. 5th 2014


Cortland University Talk Oct. 13th 2014


Ithaca College Talk Oct. 14th 2014


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Fall American Chemical Society National Meeting, San Francisco, CA Selected Talk Aug. 12th, 2014


Drug Discovery Chemistry, San Diego California, Invited Talk, April 24, 2014

“Teflon Proteins: Chemical Biology Tools for Probing Protein-Protein Interactions.” W.C. Pomerantz, Cancer Center,

University of Minnesota, Minneapolis Minnesota April 1, 2014

“Teflon Proteins: Chemical Biology Tools for Probing Protein-Protein Interactions.” W.C. Pomerantz, Gustavos

Adolphus University, St. Peter, MN, March 21, 2014

“Teflon Proteins: Chemical Biology Tools for Probing Protein-Protein Interactions.” W.C. Pomerantz, Hamline College,

Chemistry Department, Minneapolis Minnesota rescheduled Sep. 10th 2014

“Teflon Proteins: Chemical Biology Tools for Probing Protein-Protein Interactions.” W.C. Pomerantz, Macalester,

Chemistry Department, St. Paul Minnesota Feb. 19th 2014

“Teflon Proteins: Chemical Biology Tools for Probing Protein-Protein Interactions.” W.C. Pomerantz, Univ. of

Minnesota, “Bio-Group” in the Department Chemical Engineering Materials Science, Dec. 6th 2013

“Teflon Proteins: Chemical Biology Tools for Probing Protein-Protein Interactions.” W.C. Pomerantz, Univ. of St.

Thomas, St. Paul Minnesota, Nov. 1st 2013

“Inspiration from fluorination, drugging the undruggable using 19

F NMR” W.C. Pomerantz, Univ. of Minnesota,

Department of Medicinal Chemistry, Oct. 15th 2013


F NMR” W.C. Pomerantz, Univ. of Mayaguez,

Mayaguez Puerto Rico, Oct. 2nd

2013


F NMR” W.C. Pomerantz, invited talk at 3M

April 30th, 2013


F NMR” W.C. Pomerantz, Chemical Biology Interest

Group Meeting, U of Mn April 18th, 2013

“Fluorine “Odd Man In” in Chemical Biology” W.C. Pomerantz, Invited research talk: U of MN Masonic Cancer

Center Feb. 13

th 2013

“Fluorine “Odd Man In” in Chemical Biology” W.C. Pomerantz, Invited research talk: U of MN Chemical Biology

Colloquium Sept. 24th 2012

“Fluorine “Odd Man in” in Chemical Biology” W.C. Pomerantz, Invited research talk at the U of MN Alumni Lunch and

Learn, Oct. 3rd

2012

PrOF”iling transcriptional complexes via Protein observed 19

F NMR”, W.C. Pomerantz, invited research seminar,

University of Vermont, VT 2012.



University of Kansas, KS 2012.



University of Minnesota, MN 2012.


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“Structural Paradigms: PrOF”iling transcriptional complexes via Protein observed 19

F NMR”, W.C. Pomerantz, invited

research seminar, Aileron Pharmaceuticals, MA 2011.

“Structural Paradigms: PrOF”iling transcriptional complexes via Protein observed 19

F NMR”, W.C. Pomerantz, invited

research seminar, Janelia Farms, VA 2011.

“PrOF”iling transcriptional complexes via Protein observed 19

F NMR”, W.C. Pomerantz; C. Majmudar, N. Wang, A.

Lipinski, J. D. Sadowsky. T. Cierpicki, J. A. Wells, A. K. Mapp, Oral presentation, Fall ACS National Meeting, Denver,

CO, 2011.

“Probing the Function and Mechanism of Small Molecule Artificial Transcriptional Regulators”, W.C. Pomerantz,

selected talk for at the Keystone Conference: New Directions in Small Molecule Drug Discovery, Whistler, BC, Canada,

2010

“Association behavior of ACHC-rich β-peptide foldamers: Rules, tools, and nanostructure“ W. C. Pomerantz, Oral

presentation, Ithaca College 2009.

“New strategies in molecular self-assembly: Lyotropic liquid crystals from designed helical β-peptides” W. C.

Pomerantz, Oral presentation, Materials Research Society Meeting Fall 2007.

“Lyotropic liquid crystals from designed helical β-peptides” W. C. Pomerantz, C. L. Pizzey, V. Yuwono, J. D.

Hartgerink, N. L. Abbott, S. H. Gellman, Oral presentation, annual NSF site visit Spring, 2005-2007

“Lyotropic liquid crystals from designed helical β-peptides” W. C. Pomerantz, C. L. Pizzey, N. L. Abbott, S. H.

Gellman, Poster presentation, International Liquid Crystal Conference, Keystone, CO, July 2006

“Mechanistic Investigation of Proton Transfer in a Highly П-Delocalized System”. W. C. Pomerantz, oral presentation,

National Conference for Undergraduate Research, (NCUR), Whitewater, WI, 2002

“Kinetic Study of Proton Transfer in Highly Conjugated and Aromatic Systems" W. C. Pomerantz, oral presentation,

James J. Whalen Student Symposium, Ithaca, NY 2001

“Functional Polymers for Electronic Microactuators and Removable Foam Encapsulants” W. C. Pomerantz, L.

Whinnery, J. McElhanon, Abstract for poster, Sandia National Laboratories 2nd

Annual Student Symposium, oral

presentation for Sandia’s 8700 Materials and Microsystems Division. Livermore, CA, 2001

Posters:

“Choosing the Right Halogen, Fluorinated Bromodomains for Small Molecule Discovery” W.C. Pomerantz,

Bioorganic Gordon Research Conference, poster presentation, June 5, 2015


Bioorganic Gordon Research Conference, poster presentation, June 8, 2014


F NMR” W.C. Pomerantz, poster presentation at the

High-Throughput Chemistry and Chemical Biology GRC, June 2th-7

th New London, NH, 2013

“Small Molecule Modulators of KIX-Dependent Transcriptional Activators” W.C. Pomerantz; C. Majmudar, N. Wang,

A. Lipinski, J. D. Sadowsky. T. Cierpicki, J. A. Wells, A. K. Mapp, Poster presentation: GRC: High Throughput

Chemistry and Chemical Biology, New London, NH, 2011.

“Probing the Function and Mechanism of Small Molecule Artificial Transcriptional Regulators”, W.C. Pomerantz; C. A.

Bates; L. N. Makley; A M. Bopra; A. K. Mapp, Poster presentation: GRC: High Throughput Chemistry and Chemical

Biology, Les Diablerets, Switzerland, 2010.


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“Identification and Characterization of Binding Partners of Artificial Transcriptional Activators via NMR and Photo

Cross-linking” C. A. Bates, W. C. Pomerantz, S. Buhrlage, A. K. Mapp, Poster presentation Steenbock Symposium,

Madison, WI, 2009.

“Lyotropic liquid crystals from designed helical β-peptides” W. C. Pomerantz, C. L. Pizzey, V. Yuwono, S. Paramanov,

J. D. Hartgerink, N. L. Abbott, S. H. Gellman, Poster presentation, American Peptide Society Conference, Montreal,

Canada, June 2007

“Toward cyano-substituted donor-acceptor expanded radialenes and vinylic tricyanoethene systems: Fine tuning the

electronic band gap.” W. C. Pomerantz, N. P. Moonen, C. Boudon, J.- P. Gisselbrecht, M. Gross, F. Diederich, Poster

presentation, 6th International Symposium on Functional П-Systems, Ithaca, NY 2004

PROFESSIONAL SERVICE

American Chemical Society Biomolecular and Biophysical Processes Symposium Session Co-Chair with Rick

St. John (Genentech) on Protein Structure and Function, Spring National Meeting, San Diego 2016

American Chemical Society Division of Biological Chemistry Session Chair, Young investigator symposium,

Spring National Meeting, San Diego 2016

Elected as an American Peptide Society Nominating Committee Member 2015-2017

American Chemical Society Organic Division Session Chair, Molecular Recognition and Self-assembly Fall

National Meeting, 2014

Gordon Research Seminar (GRS) chair: High-Throughput Chemistry and Chemical Biology GRS-2011

Panelist for the ACS postdoc to faculty workshop (2012-16). Preparing postdoctoral fellows for the academic

job market via critiquing research proposals, mock interviews, and panels on teaching, writing and work

balance.

Journal Reviewers for Angew. Chemie, J. Am. Chem. Soc., ACS Chem. Biol., J. Med. Chem., Chem. Comm.,

ACS Macro Lett., J. Biol. Inorg. Chem. Biorg. Med. Chem. Lett., Org. Biomol. Chem., Mol. Pharm. Chemistry

and Biology, Anal. Chem.

SCIENTIFIC AFFILIATIONS

Member of Sigma Xi, Phi Kappa Phi, Oracle Society, American Chemical Society, American Peptide Society

(Nominating committee member), Gordon Research Conference for High Throughput Chemistry and Chemical

Biology

OUTREACH

“Chemical Biology in the Pomerantz Laboratory Part III” Chemistry to Modern Medicine: Changing the way

we “dye” for the Osher Life Long Learning Institute. Scheduled August 16th, 2016

“Chemical Biology in the Pomerantz Laboratory Part II” One-day chemical biology short course on imaging,

discussion and hands-on lab, and laboratory tour for the Osher Life Long Learning Institute. June, 2014

“Chemical Biology in the Pomerantz Laboratory” One-day chemical biology short course, discussion and

hands-on lab, and laboratory tour for the Osher Life Long Learning Institute. June 19th

, 2013


10

Science day at the West 7th

Community Center. Hands-on demonstrations and activities for children grades K-

9. Developed hands-on DNA extraction and fingerprint detection activity for solving a science mystery 2012,

2013.

RESEARCH INTERESTS

I am interested in modulating the function of protein-protein interactions through the use of small molecules

and bio-inspired peptide scaffolds as well as designing molecular imaging agents with reduced environmental

impact using peptide-based fluorochemicals. 19

F is a bioorthogonal nucleus that can be incorporated sequence

selectively into proteins and peptides resulting in simplified 1D-NMR spectra devoid of background signals.

My research interests exploit this bioorthogonality and the hypersensitivity of fluorine to changes in chemical

environment for probing important protein-protein interactions for epigenetic regulatory proteins and to

ultimately explore their behavior in cells and whole organisms (in-cell NMR and 19

F MRI). Given that

transcription factors represent a major class of potential drug targets, our proposed 19

F NMR approach to study

protein-ligand interactions could significantly increase the repertoire of new targets and thereby open up new

avenues for drug/probe discovery. From an environmental standpoint, as new fluorochemicals are designed, the

assessment of environmental persistence and toxicity will be essential for informing on the creation of new

materials that are “benign by design”.

Documents

William Pomerantz, Ph.D Curriculum Vitae WILLIAM C ... Pomerantz, Ph.D Curriculum Vitae