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WHI Investigators Meeting May 3-4, 2012

WHI Investigators Meeting

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WHI Investigators Meeting. May 3-4, 2012. Status of follow-up: Extension II. WHI Productivity-Ancillary Studies. Funding success. 2009 – 38 submitted, 17 funded, 45% 2010 – 40 submitted, 16 funded, 40% 2011 – 41 submitted, 7 funded 17% with 11 still pending. Robert Brunner, - PowerPoint PPT Presentation

Text of WHI Investigators Meeting

WHI Investigators Meeting

WHI Investigators MeetingMay 3-4, 2012Status of follow-up: Extension IIResponse to mailingsOverall ResponseF33OverallMRCSRCOverallMRCSRCYear 191.7%87.9%92.9%97.2%96.5%97.4%Year 2 89.1%86.0%90.2%WHI Productivity-Ancillary Studies

Funding success2009 38 submitted, 17 funded, 45%2010 40 submitted, 16 funded, 40%2011 41 submitted, 7 funded 17% with 11 still pending

Robert Brunner, Chair, Ancillary Studies CommitteeASC members

Co-chair, Marian NeuhouserGarnet AndersonTim AssimesBette CaanCharles EatonGerardo HeissLi JiaoKaren JohnsonLew KullerJennifer LinSimin LiuGloria SartoEric WhitselPublications and Presentations

Cynthia ThomsonBarbara Howard

P&P MembersPeggye Dilworth-Anderson Hoda Anton-Culver Rowan Chlebowski Laura Coker Jennifer Hays-Grudo Keri Monda Kari North Mary Jo OSullivan Ross Prentice Stephen Rapp Sylvia Smoller Lesley Tinker Robert Wallace Jean Wactawski-Wende

Linda Van Horn Shirley BeresfordGiselle Corbie-SmithMark Espeland Nora FranceschiniMargery Gass Jane Kotchen Andrea LaCroixSimin Liu Yvonne Michael Jacques Rossouw Michael Simon Sally Shumaker Marcia Stefanick

Top 10 lead authors:Rowan Chlebowski, Ross Prentice, Geoffrey Kabat, Judith Hsia, JoAnn Manson, Jacques Rossouw, Zhao Chen, Mark Espeland, Barbara Howard, Karen Margolis

Outcomes Advisory CommitteeMarian Limacher, ChairKaren Margolis, Co-chairMatt Allison Charles Eaton Susan Heckbert Charles Kooperberg Joyce Noonan (OC Rep.) Marcia Ko Andrea LaCroix Kamakshi Lakshminarayan Shari Ludlam Bernedine Lund Jennifer Robinson

Outcomes statusExtension I cases adjudication complete exceptRetrospective DVT cases (N=300, target completion, 8/2012)HFAll 11,000 cancer Extension I cases have been codedSince 10/01/10 7990 outcomes identified 5992 cases were sent forward adjudicationElectronic adjudication has been implemented for CVD/fracture/death outcomesAbstraction of HF cases is moving forward at UNC

Cancers identified in WHICancer SiteNBreast7787Lung2246Colorectal2211Endometrial1321Lymphoma1133GU804Melanoma (skin)769Ovary685Other GI606Leukemia575Pancreas559Thyroid345Multiple Myeloma342Other Gyn274Brain201Head and Neck114Other/unknown/Ill-defined791Total20763AdjudicatorsCarl CheliusEric Whitsel George HessJudith HsiaKaren MargolisKathryn RexrodeKim MillerLinda LoesMarcia KoMarian LimacherMaurizio TrevisanStephanie ConnellySteve SidneySusan HeckbertBeth LewisCharles EatonMatt AllisonStrokeAmie HsiaBrian SilverEnrique LeiraJana WoldJose Merino Kamakshi LakshminarayanLenore OcavaJohn Lynch

New InitiativesLong-Life Study (CCC)/OPACH (Andrea LaCroix, PI)Consent mailings started in February1602 consentedVisits started in March381 completed, 532 scheduledProjected completion of visits by second quarter 2013

Clinical Trial working group (Mark Espeland, chair)Reviewed 19 concept proposalsSelected 2 to support for studywide effortManson and SessoFactorial design of 2 dietary supplements, alpha linoleic acid and cacao10,000 women at elevated CVD riskStefanickA pragmatic trial of physical activity

ResourcesSharepointAccess at www.whiscience.org

Data enclavePhysical enclave in placeSeeking CMS/IRB approval for virtual enclave

Medicare dataCCC has files covering 1991-2010Application for Part D has been developedAnnual updates expected

Regional Center AnalystsScientific Interest Groups & ChairsAging: Stephen RappBone, Fracture and Body Composition: Carolyn Crandall, Jean Wactawski-WendeCancer: Bette Caan, Ross Prentice, Rowan Chlebowski Cardiovascular Disease: Marcia StefanickGenetics, Proteomics & Biomarkers: Rebecca JacksonHealth Services: Karen MargolisMinorities and Health Disparities: Laura CokerScientific Interest Groups & ChairsNutrition/Energy Balance: Marian NeuhouserDiabetes and Obesity: Lesley Tinker, Jean Wactawski-WendePhysical and Built Environment: Eric WhitselPhysical Activity: Marcia StefanickPsychosocial & Behavioral Health: Sally Shumaker

Rebecca Jackson, SRWG chair