016 VGKC LIMBIC ENCEPHALITIS—A CASE SERIES

Matthew Knight,1 Mi Sun Choung,1 Mark Willis,2 Khalid Hamandi2. 1CardiffUniversity School of Medicine; 2University Hospital of Wales

10.1136/jnnp-2014-309236.16

Introduction Limbic encephalitis associated with voltage-gatedpotassium channel antibodies (VGKC-LE) is becoming

A4 J Neurol Neurosurg Psychiatry 2014;85(10):A1–A57

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increasingly recognised. However, only a few case series havebeen reported with the clinical phenotype known to vary widely.We aimed to establish a case series of patients with positiveVGKC antibodies to investigate their clinical, radiological andbiochemical features.Methods All patients with a positive VGKC antibody resultfrom University Hospital of Wales up until June 2012 were iden-tified. Medical records were subsequently reviewed and data col-lected using a standardised proforma.Results 25 patients were identified. Clinical presentationsincluded memory impairment (76%), seizures (56%), confusion(52%), behavioural changes (36%), and sleep disturbances (24%).6 patients presented with hyponatraemia. 10 patients had a diag-nosis of VGKC-LE although 15 patients satisfied the diagnostic cri-teria. A number of other diagnoses were associated with positiveantibodies including CJD and frontotemporal dementia. MRImainly demonstrated changes in the temporal region. All patientsthat received immunotherapy (n=12) made some improvement.Conclusion We show that the majority of patients with positiveVGKC antibodies satisfy the diagnosis for VGKC-LE but anti-bodies may also be present in a range of other diagnoses.

J Neurol Neurosurg Psychiatry 2014;85(10):A1–A57 A5

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doi: 10.1136/jnnp-2014-309236.16 2014 85: e4J Neurol Neurosurg Psychiatry

 Matthew Knight, Mi Sun Choung, Mark Willis, et al. SERIES

A CASE−−VGKC LIMBIC ENCEPHALITIS

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