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ORIGINAL ARTICLE
Varicocelectomy by means of subinguinal cremasteric compartmentdisruption and venous ligation
A technical critique
PARAG SHAH
Department of Male Infertility, Nowrosjee Wadia Hospital, Mumbai, India
AbstractObjective. To evaluate the efficacy of addition of disruption of the cremasteric compartment to venous ligation in infertilemen with varicocele and abnormal semen parameters. Material and methods. A prospective non-randomized study wasundertaken in 380 infertile men with varicocele and abnormal semen parameters. They were operated on using subinguinalvenous ligation with the addition of cremasteric compartment disruption on an outpatient basis. Results. Following surgery,the median values for each semen parameter were compared preoperatively and 1-year postoperatively using the Wilcoxonsigned rank test. The difference in the median values was significant for all the parameters. Over a minimum 2-year follow-up period, 304 men (80%) contributed to pregnancies leading to live births. Conclusions. The results suggest thatsubinguinal venous ligation with the addition of cremasteric compartment disruption is a physiological, economic and safeoption for varicocele repair in men with abnormal sperm parameters. A high rate of unassisted pregnancy compared toconventional isolated venous obliteration is achievable, with minimal morbidity and recurrence.
Key Words: Varicocele, infertility, cremasteric compartment complex, subinguinal approach, ambulatory surgery, pregnancy
outcome
Introduction
Varicocele is observed in 35�40% of men with
primary infertility [1,2] and in up to 80% with
secondary infertility [3,4]. Varicocele is the com-
monest treatable cause of infertility and its repair has
been demonstrated to improve semen quality and
fertility potential in men with abnormal semen
parameters [5,6].
Various outpatient techniques have been described
for the repair of varicocele, including microsurgery
[7,8], embolization [9,10] and laparoscopy [11,12].
These techniques have generated renewed interest in
the treatment of varicocele because they limit mor-
bidity, decrease recurrence rates and seem to be more
acceptable to patients. However, some investigators
[12�14] were unable to demonstrate improvement
among their own patients following varicocelectomy.
Numerous theories have been suggested for the
development of varicocele [15�18], including in
particular the absence of valves in the spermatic
vein and the so-called nut-cracker phenomenon.
While most of these theories suggest causes above
the deep inguinal ring, none of them explain the
clinical evidence of absence of venous tortuosity
above the deep inguinal ring. I believe that it is not
retrograde flow in the spermatic vein but venous
stasis induced by a tight cremasteric compartment
around the spermatic cord which leads to dilatation
and tortuosity of the spermatic veins. Based on the
above concept, I suggest the addition of complete
disruption of the cremasteric compartment to venous
ligation for the adequate treatment of varicocele.
Material and methods
Between January 1995 and October 2003, a total of
862 patients were referred to an outpatient clinic at a
Correspondence: Parag A. Shah, Shah Surgical Clinic, 11, Yogesh sadan, Hingwala Lane, Ghatkopar (East), Mumbai 400077, India. Tel: �/91 022 25137834.
Fax: �/91 22 25146521. E-mail: [email protected]
Scandinavian Journal of Urology and Nephrology, 2007; 41: 54�57
(Received 11 February 2006; accepted 24 May 2006)
ISSN 0036-5599 print/ISSN 1651-2065 online # 2007 Taylor & Francis
DOI: 10.1080/00365590600863996
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tertiary care unit dedicated to the treatment of
infertile men. A detailed history was obtained and
a complete physical examination was performed. A
minimum duration of infertility of 12 months,
defined as failure to cause pregnancy with appro-
priately timed and unprotected intercourse, was
required for entry into the study. Physical examina-
tion was performed by a single investigator.
The spermatic cords were observed and palpated
while the patient stood upright and performed a
Valsalva manoeuvre and testicular size was docu-
mented. Scrotal ultrasonography with colour Dop-
pler imaging was used to confirm the physical
findings and detect subclinical varicocele. Based on
these findings, the varicoceles were graded as either
large (visible and palpable), moderate (palpable) or
small (detected by Doppler reflux with a venous
diameter �/3 mm). For all patients, semen para-
meters (B/20 million sperm/ml semen; B/50%
motility or B/40% normal morphological forms)
were below threshold levels. Of the 862 infertile
men referred, 412 (42%) were detected to have
varicocele. A total of 517 varicocelectomies were
performed in 380 patients.
Surgical technique
All procedures were performed on an outpatient
basis. Oral atropine (0.6 mg) was given as premedi-
cation. The skin was infiltrated with 3�5 cm3 of a
1:1 mixture of 1% lignocaine and bupivacaine over
the external ring and into the spermatic cord. A
small (2-cm) incision was made over the external
ring, the subcutaneous tissue was separated by
sharp, blunt dissection and small band retrac-
tors exposed the spermatic cord. Local anaesthetic
(1�2 cm3) was injected under the cremasteric fascia
of the exposed spermatic cord. The anaesthetized
exposed segment of the spermatic cord was elevated
out of the incision by gentle traction and sharp
dissection. The band retractor was placed below the
spermatic cord for support, and dilated posterior
cremasteric veins, if present, were ligated and
transected. The cremasteric fascia and muscle en-
circling the exposed spermatic cord were completely
dissected and disposed. The vas deferens and artery
were observed and maintained out of the surgical
field. Only grossly dilated spermatic veins (�/3 mm
in diameter) were isolated, ligated and transected.
No attempt was made to ligate all vessels and
spermatic veins. No sclerosing agent was used and
surgery was done without the use of an operative
microscope. The spermatic cord was replaced in its
bed and the incision was closed with an absorbable
suture.
Results
A total of 517 procedures were performed in 380
patients. There were 362 cases of primary and 18 of
secondary infertility. The mean9/SD age of the
patients was 28.79/6.3 years (range 21�46 years).
The varicocele were left-sided in 152 patients (40%),
right-sided in 91 (24%) and bilateral in 137 (36%).
The mean9/SD duration of infertility was 26.39/
16.5 months (range 12�120 months). The varico-
cele were large in 136 cases (36%), moderate in 194
(51%) and small in 50 (13%). A history of smoking
was reported by 23 patients (6%) and these patients
were advised to stop smoking. Although all patients
reported a reduction in the number of cigarettes per
day, none of them completely abandoned smoking.
A total of 15 couples (4%) had concomitant female
factor infertility which was independently treated.
All operations were performed on an outpatient
basis and the mean operative time was 15 min (range
10�25 min) per side. In 53 patients (14%) only
cremasteric compartment disruption was performed
as these patients did not have grossly dilated veins
(�/3 mm in diameter).
The commonest problem was transient local
discomfort, which was reported by 26 patients
(7%). There were only two cases of hydrocele; no
recurrence was palpable over a 2-year follow-up
period and there was no testicular atrophy. Semen
specimens were collected and evaluated according to
WHO criteria [19]. The median values for each
semen parameter were compared preoperatively and
1 year postoperatively using the Wilcoxon signed
rank test. The differences in the median values were
significant for all parameters (Table I). The 1-year
pregnancy rate was 64% (n�/244), and this in-
creased to 80% (n�/304) over a 2-year period.
Discussion
Varicocele is the commonest identifiable, surgically
correctable lesion associated with male infertility.
Surgical correction of varicocele, whether uni- or
bilateral, results in improvement not only in semen
parameters but also in spontaneous and assisted
pregnancy rates. The results of this study showed
that semen parameters were improved for most men
and that 80% contributed to an unassisted preg-
nancy. Infertility and oligoasthenozoospermia were
the main criteria in selecting patients with varicocele
for surgery. The grade of varicocele was considered
to be of secondary importance. Subclinical varico-
cele probably indicated a tight cremasteric compart-
ment. Venous dilatation may evolve in such patients
with time.
Technical critique of varicocelectomy 55
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In this study, a decision was taken to perform
surgery on an outpatient basis under local anaesthe-
sia, as this is associated with less risk than the general
anaesthesia required for the laparoscopic and retro-
peritoneal approaches [11,12,20]. I believe that a
tight cremasteric compartment encircling the sper-
matic cord causes venous stasis and subsequent
tortuosity of the spermatic veins in a localized area
up to the deep ring. Histochemical study of the
human cremasteric compartment in patients with
long-standing varicocele showed small group atro-
phy due to local tissue hypoxemia and denervation
[21,22]. I believe that atrophy of the cremasteric
compartment occurs as nature’s response to long-
standing varicocele and this emphasizes the need for
complete disruption of the cremasteric fascia and
muscle in order to achieve the desired results.
In this study, only abnormally dilated veins were
transected, with no emphasis being placed on
complete venous occlusion. As major dissection is
not required, the chances of damaging the artery,
with subsequent testicular atrophy (0% in this
series), or damaging the lymphatics, with subsequent
formation of hydrocele (0.3% in this series),
are minimized. Others [20] have reported an in-
cidence of hydrocele formation of up to 7.2% after
varicocelectomy using the inguinal and retroperito-
neal approach. The commonest complaint following
modified subinguinal varicocelectomy was wound
discomfort; this was easily managed by means
of conservative measures such as administration
of non-steroidal anti-inflammatory drugs. The pa-
tient usually returned to work within 24 h after
surgery.
The morbidity associated with this procedure was
less than that with the inguinal or retroperitoneal
approaches, which require dissection of the muscle
layers of the inguinal canal. Laparoscopic varicoce-
lectomy may have lowered the morbidity rate but the
technique requires intraperitoneal exploration and
has the potential for significant complications, such
as bowel perforation and bleeding [23,24]. The
operative time in the present series was 15 min per
side, which was significantly less than in some
laparoscopic cases, for which the operative time has
been reported to be as long as 177 min [11]. The
high ligation and retroperitoneal approaches are
subject to high recurrence rates ranging from 1%
to 8% [24�26]. As meticulous dissection and liga-
tion are not advocated in the present approach it
might be concluded that there would be a high rate
of recurrence; however, no palpable recurrences
were demonstrated over a 2-year follow-up period.
Analysing the reports of different investigators, it
was observed that those who used the subinguinal
approach for varicocele repair had better pregnancy
rates (30�60%) compared to those who adopted
other approaches (6�8%) [25�27]. It is inferred that
subinguinal varicocelectomy results in partial or
complete disruption of the cremasteric fibres, lead-
ing to better results. Theoretically, cremasteric
compartment disruption without venous ligation
would be the best surgical option for eliminating a
tight cremasteric compartment. The venous dilata-
tion which occurred subsequent to a tight cremas-
teric compartment would regress spontaneously.
However, in the absence of a suitable animal model,
with a standing posture, for varicocele, it is not
possible to document this prior to human experi-
mentation.
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