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Molecular-cytogenetic characterization of head and neck cancer: Identification of novelprognostic factors and gene targets for therapy [double dissertation 2]

Wreesmann, V.B.; Singh, B.

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Citation for published version (APA):Wreesmann, V. B., & Singh, B. (2004). Molecular-cytogenetic characterization of head and neck cancer:Identification of novel prognostic factors and gene targets for therapy [double dissertation 2].

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Download date: 17 Jul 2020

Authors'' Publications

Volker tt B. Wreesmann M D PeerPeer Reviewed Publications 1.. Singh B, Lim D, Cigudosa JC, Ghossein R, Shaha AR, Poluri A,

Wreesmannn VB, Tuttle M, Shah JP, Rao PH. Screening for genetic aber-rationss in papillary thyroid cancer by using comparative genomic hybridization.. Surgery. 2000;128:888-93.

2.. Wreesmann VB, van Eijck CH, Naus DC, van Velthuysen ML , Jeekel J, Mooii WJ. Inflammatory pseudotumour (inflammatory myofibroblastic tumour)) of the pancreas: a report of six cases associated with obliterative phlebitis.. Histopathology. 2001;38:105-10.

3.. Wreesmann VB, Fokkens WJ, Knegt PP. Refractory chronic sinusitis: evaluationn of symptom improvement after Denker's procedure. Otolaryngoll Head Neck Surg. 2001;125:495-500.

4.. Wreesmann VB, Ghossein RA, Patel SG, Harris CP, Schnaser EA, Shaha AR,, Tuttle RM, Shah JP, Rao PH, Singh B. Genome-wide appraisal of thyroidd cancer progression. Am J Pathol. 2002;161:1549-56.

5.. Singh B, Wreesman VB, Pfister D, Poluri A, Shaha AR, Kraus DH, Shah JP,, Rao PH. Divergent pattern of genomic imbalances in patients with headd and neck squamous cell carcinoma based on severity of tobacco/alco-holl exposure. BMC Genet. 2002;3:22.

6.. Kutler DI , Wreesmann VB, Goberdhan A, Ben-Porat L, Satagopan J, Ngaii I, Huvos AG, Giampietro P, Levran O, Pujara K, Diotti R, Carlson D,, Huryn LA, Auerbach AD, Singh B. Human Papillomavirus DNA and p533 Polymorphisms in squamous cell carcinomas from Fanconi anemia patients.. J Natl Cancer Inst. 2003;95:1718-21.

7.. Wreesmann VB, Wang D, Goberdhan A, Prasad M, Ngai I, Schnaser EA, Sackss PG, Singh B. Genetic abnormalities associated with nodal metasta-siss in head and neck cancer. Head Neck. 2004;26:10-5.

8.. Wreesmann VB, Sieczka E, Socci ND, Hezel M, Belbin TJ, Childs G, Patell SG, Shah JP, Rao PH, Ghossein RA, Singh B.Genome-wide profil-ingg of papillary thyroid cancer identifies MUC1 as an independent prog-nosticc marker. Cancer Res. 2004;64:3780-9.

9.. Wreesmann VB, Ghossein RA, Hezel M, Banerjee D, Shaha AR, Tuttle RM,, Shah JP, Rao PH, Singh B. Follicular variant of papillary thyroid carcinoma:: genome-wide appraisal of a controversial entity. Genes Chromosomess Cancer. 2004;40:355-64.

10.. Wreesmann VB, Shi W, Thaler HT, Poluri A, Kraus DH, Pfister D, Shahaa AR, Shah JP, Rao PH, Singh B. Identification of novel prognostica-

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torss of outcome in squamous cell carcinoma of the head and neck. J Clin Oncol.. 2004;22:3965-72.

11.. Wreesmann VB, Ghossein RA, Omeroglu A, Bogdanova T, Dudas ME, Hooss A, Stojadinovic A, Shah JP, Rao PH, Tuttle RM, Singh B. Molecular-cytogeneticc characterization of Chernobyl-associated thyroid neoplasia.. Head Neck 2004 (In press).

12.. Belbin TJ, Singh B, Wreesmann VB, Socci ND, Sanchez-Carbayo M., Prystowskyy M, Cordon-Cardo C, Childs G. Molecular profiling of tumor progressionn in head and neck cancer. Arch Otolaryngol Head Neck Surg. (Inn press).

13.. Singh B, Wreesmann VB, Socci N, Li RG, Shah JP, Bosl G, Rao PH, Pfisterr D. Prediction of chemoresponse in laryngopharyngeal cancer by hierarchicall clustering based on combination of biological parameters. (Manuscriptt submitted).

Books,Books, letters, reviews and monographs

1.. Kutler DI , Wreesmann VB, Singh B. RESPONSE: Re: Human papillo-maviruss DNA and p53 polymorphisms in squamous cell carcinomas from Fanconii anemia patients. J Natl Cancer Inst. 2004;96:968-9.

2.. Wreesmann VB, Singh B. Chromosomal aberrations in squamous cell carcinomass of the upper aerodigestive tract: biological insights and clini-call opportunities. J Oral Pathol Med 2004 (In press).

3.. Wreesmann VB, Singh B. Molecular basis of thyroid cancer. Head Neck (Manuscriptt submitted).

Bhuvaneshh Singh, M.D. PeerPeer Reviewed Publications

1.. Singh B, Santos V, Guffin TN, Jr., Alexis R, Har-El G. Giant cell variant off malignant fibrous histiocytoma of the head and neck. J Laryngol Otol. 1991;105:1079-81. .

2.. Singh B, Shaha A, Har-El G. Malignant fibrous histiocytoma of the head andd neck. J Craniomaxillofac Surg. 1993;21:262-5.

3.. Singh B, Lucente FE, Shaha AR. Substernal goiter: a clinical review. Am JJ Otolaryngol. 1994;15:409-16.

4.. Singh B, Shaha AR. Solitary malignant schwannoma invading the hypoglossall nerve. Ear Nose Throat J. 1994;73:842-4; 847-9.

5.. Singh B, Har-El G, Lucente FE. Kaposi's sarcoma of the head and neck in patientss with acquired immunodeficiency syndrome. Otolaryngol Head Neckk Surg. 1994;111:618-24.

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Authors'' Publications

6.. Singh B, Tolete-Velcek F, Alexis R. Pathological case of the month. Pilomatrixoma.. Arch Pediatr Adolesc Med. 1995;149:551-2,

7.. Singh B, Shaha A. Traumatic submandibular salivary gland fistula. J Oral Maxillofacc Surg. 1995;53:338-9.

8.. Singh B, Balwally AN, Shaha AR, Rosenfeld RM, Har-El G, Lucente FE. Upperr aerodigestive tract squamous cell carcinoma. The human immun-odeficiencyy virus connection. Arch Otolaryngol Head Neck Surg. 1996;122:639-43. .

9.. Singh B, Balwally AN, Nash M, Har-El G, Lucente FE. Laryngeal tuber-culosiss in HIV-infected patients: a difficult diagnosis. Laryngoscope. 1996;106:1238-40. .

10.. Singh B, Bhaya M, Stern J, et al. Validation of the Charlson comorbidity indexx in patients with head and neck cancer: a multi-institutional study. Laryngoscope.. 1997;107:1469-75.

11.. Singh B, Kantu M, Har-El G, Lucente FE. Complications associated with 3277 foreign bodies of the pharynx, larynx, and esophagus. Ann Otol Rhinoll Laryngol 1997;106:301-4.

12.. Balwally AN, Singh B, Sperling NM. Radiological case of the month. Subperiosteall abscess of the mastoid. Arch Pediatr Adolesc Med. 1997;151:201-2. .

13.. Singh B, Bhaya M, Shaha A, Har-El G, Lucente FE. Presentation, course, andd outcome of head and neck skin cancer in African Americans: a case-controll study. Laryngoscope. 1998;108:1159-63.

14.. Singh B, Balwally AN, Sundaram K, Har-El G, Kregin B. Branchial cleft cystt carcinoma: myth or reality? Ann Otol Rhinol Laryngol. 1998;107:519-24. .

15.. Singh B, Balwally AN, Har-El G, Lucente FE. Isolated cervical tuberculo-siss in patients with HIV infection. Otolaryngol Head Neck Surg. 1998;118:766-70. .

16.. Singh B, Bhaya M, Zimbler M, et al. Impact of comorbidity on outcome off young patients with head and neck squamous cell carcinoma. Head Neck.. 1998;20:1-7.

17.. Carew J, Spiro R, Singh B, Shah JP. Treatment of recurrent pleomorphic adenomaa of the parotid grand. Otolaryngol Head Neck Surg. 1999;121:539-42. .

18.. Cordeiro PG, Shah K, Santamaria E, Gollub MJ, Singh B, Shah JP. Bariumm swallows after free jejunal transfer: should they be performed rou-tinely?? Plast Reconstr Surg. 1999;103:1167-75.

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19.. Tami TA, Ferlito A, Rinaldo A, Lee KC, Singh B. Laryngeal pathology in acquiredd immunodeficiency syndrome: Diagnostic and therapeutic dilem-mas.. Ann Otol Rhinol LaryngoL 1999;108:214-220.

20.. Sundaram K, Singh B, Har-El G. Nasopharyngeal mucosa-associated lym-phoidd tissue lymphoma in patients infected with the human immunodefi-ciencyy virus. Am J Otolaryngol. 1999;20:56-8.

21.. Singh B, Cordeiro PG, Santamaria E, Shaha AR, Pfister DG, Shah JP. Factorss associated with complications in microvascular reconstruction of headd and neck defects. Plast Reconstr Surg. 1999;103:403-11.

22.. Carew J, Singh B, Kraus D. Hemangiopericytoma of the head and neck. Laryngoscope.. 1999; 109:1409-1141.

23.. Singh B, Sabin S, Rofim O, Shaha AR, Har-El G, Lucente FE. Alterations inn head and neck cancer occurring in HIV infected patients: Preliminary resultss of a longitudinal prospective study. ACTA Oncologica.. 1999;38:1047-50.

24.. Singh B, Shaha AR, Trivedi H, Carew JF, Poluri A, Shah JP. Coexistent Hashimoto'ss thyroiditis with papillary thyroid carcinoma: Impact on presentation,, management, and outcome. Surgery. 1999;126:1070-77.

25.. Singh B, Alfonso A, Sabin S, Shaha AR, Sundaram K, Har-El G, Lucente FE.. Outcome differences in younger and older patients with laryngeal cancer:: A retrospective case-control study. Am J Otolaryngology. 2000;21:92-97. .

26.. Singh B, Poluri A, Shaha AR, Carew J, Micularat P, Har-El G, Lucente FE.. Head and neck manifestations of non-Hodgkin's lymphoma in HIV infectedd patients. Am J Otolaryngol. 2000;21:10-3.

27.. Paulino A, Singh B, Carew J, Shah JP, Huvos A. Ebstein Barr virus infec-tionn in anterior nasal cavity carcinomas. Ann Diagnostic Pathol. 2000;4:7-10. .

28.. Poluri A, Singh B, Sperling N, Har-El G, Lucente FE. Retropharyngeal abscesss secondary to perforating foreign bodies. J Cranio-Maxillofacial Surg.. 2000;28:243-246.

29.. Friedlander P, Caruana S, Singh B, Shaha A, Kraus D, Harrison L, McKiernann J, Sloan J, Polyak T, Shah JP. Functional status after primary radiotherapyy for squamous cell carcinoma of the base of tongue. Head and Neck.. 2002;24:111-4.

30.. Paulino A, Singh B, Shah JP, Huvos A. Basaloid squamous carcinoma of thee head and neck region. Laryngoscope. 2000;110:1479-82.

31.. Singh B, Kim S, Carew JC, Yu I, Shaha AR, Wholden S, Boyle JO, Shah

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Authors'' Publications

JP,, Rao PH. Genome wide screening for radiation response factors in head andd neck cancer. Laryngoscope. 2000;110:1251-1256.

32.. Stojadinovic A, Karpoff H, Antonescu CR, Shah JP, Singh B, Spiro RH, Dumornayy W, Shaha AR. Head and neck dermatofibrosarcoma protuber-ans.. Ann Surg Oncol. 2000;7:696-704.

33.. Singh B. Lim D, Cigudosa JC, Ghossein R, Shaha AR, Poluri A, Wreesmannn VB, Tuttle M, Shah JP, Rao PH. Screening for genetic aberra-tionss in papillary thyroid cancer using comparative genomic hybridiza-tion.. Surgery. 2000;128:888-94.

34.. Singh B, Li R, Xu L, Poluri A, Shaha AR, Pfister D, Sherman E, Hoffmann RM, and Shah JP. Prediction of survival of patients with head andd neck cancer by the histoculture drug response assay. Head and Neck. 2002;24:437-442. .

35.. Singh B, Gogineni S, Sachs P, Shah JP, Stoffel A, Rao PH. Molecular-cytogeneticc characterization of head and neck squamous cell carcinoma andd refinement of 3q amplification. Cancer Research 2001;61:4506-4513.

36.. Singh B, Gogineni S, Sachs P, Shah JP, Stoffel A, Rao PH. Spectral Karyotypingg (SKY) analysis of head and neck squamous cell carcinoma celll lines. Laryngoscope. 2001;111:1545-1550.

37.. Pfister D, McCaffrey J, Zahalsky AJ, Schwartz GK, Lis E, Gerald W, Huvoss A, Shah JP, Kraus DK, Shaha AR, Singh B, Wolden S, Zelefsky M,, Palgi I. A phase II trial of Bryostatin-1 in patients with metastatic or recurrentt squamous cell carcinoma of the head and neck. Invest New Drugs.. 2002;20:123-7.

38.. Osman I, Sherman E, Singh B, Zelefsky M, Scher H, Carlos Cordon-Cardoo C, Pfister D. Alterations of p53 pathway in squamous cell carcino-maa of the head and neck: impact on treatment outcome in patients treated withh larynx preservation intent. J Clin Oncol. 2002;20: 2980-2987.

39.. Belbin TJ, Singh B, Barber IB, Wenig B, Smith R, Prystowsky M, Childs G.. Molecular classification of head and neck squamous cell carcinoma usingg cDNA microarrays. Cancer Res 2002;62:1184-90.

40.. Stojadinovic A, Ghossein RA, Hoos A, Urist M, Spiro RH, Shah JP, Brennann MF, Shaha AR, Singh B. Hiirthle cell carcinoma: A critical histopathologicall appraisal. J Clin Oncol. 2001; 19:2616-2625.

41.. Hoos A, Stojadinovic A, Singh B, Dudas M, Leung DHY, Shaha AR, Shahh JP, Brennan M, Cardon-Cardo, C, Ghossein R. Clinical significance off molecular expression profiles of Hiirthle cell tumors of the thyroid glandd analyzed via tissue microarrays. Am J Pathol. 2002;160:175-183.

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42.. Stojadinovic A, Shaha AR, Orlikoff RF, Nissan A, Kornak MF, Singh B, Boylee JO, Shah JP, Brennan MF, Kraus DH. Prospective functional voice assessmentt in patients undergoing thyroid surgery. Ann Surg. 2002; 236:823-32. .

43.. Patel SG, Escrig M, Shaha AR, Singh B, Shah JP. Management of well-differentiatedd thyroid carcinoma presenting within a thyroglossal duct cyst.. J Surg Oncol 2001;79:134-139.

44.. Rao SR, Shaha AR, Singh B, Rinaldo A, Ferlito A. Management of cancer off the parathyroid. Acta Oto-Laryngologica. 2002;122:448-452.

45.. Singh B, Reddy PG, Goberdhan A, Dao S, Ngai I, Walsh C, O-charoenrat P,, Chou TC, Rao PH, Levine AJ, Stoffel A. PI3KCA is an oncogene in epitheliall carcinomas that is regulated by p53. Genes Development 2002;16:984-993. .

46.. Minhas K* , Singh B*, Sidransky D, Califano JA. Chromosomal instabili-tyy in head and neck squamous cell carcinomas. Int J Cancer. 2003; 107: 46-52.. (*equal contributors).

47.. Patel SG, Prasad ML , Escrig M, Singh B, Shaha AR, Kraus DH, Boyle JO,, Huvos AG, Busam K, Shah JP. Primary mucosal malignant melanoma off the head and neck. Head Neck 2002;24:247-57.

48.. Stojadinovic A, Hoos A, Ghossein RA, Urist MJ, Leung DH, Spiro RH, Shahh JP, Brennan MF, Singh B, Shaha AR. Hiirthle cell carcinoma: a 60-yearr experience. Ann Surg Oncol 2002; 9:197-203.

49.. Patel SG, Coit DG, Shaha AR, Brady MS, Boyle JO, Singh B, Shah JP, Krauss DH. Sentinel lymph node biopsy for cutaneous head and neck melanomas.. Arch Otolaryngol Head Neck Surg 2002;1283:285-91

50.. Franco RA, Singh B, Har-El G. Laryngeal Chondroma. J Voice. 2002;16:92-95. .

51.. Wreesmann VB, Ghossein RA, Patel SG, Schnaser EA, Shaha AR, Tuttle RM,, Shah JP, Rao PH, Singh B. Genome-wide appraisal of thyroid cancer progression.. Am J Pathol. 2002;161:1549-56.

52.. Singh B, Stoffel A, Gogineni S, Poluri A, Shaha AR, Pfister D, Patak A, Bosll G, Cordon-Cardo C, Shah J, Rao PH. Impact of 3q amplification on tumorr progression and clinical outcome in patients with head and neck cancer.. Am J Pathol. 2002;161:365-371.

53.. Li n DT, Patel SG, Shaha AR, Singh B, Shah JP. Incidence of inadvertent pa.rathyroidd removal during thyroidectomy. Laryngoscope 2002;112:608-11. .

54.. Singh B, Wreesmann V, Pfister D, Poluri A, Shaha AR, Kraus D, Shah

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Authors'' Publications

JP,, Rao, PH. Divergent pattern of genomic imbalances in patients with headd and neck squamous cell carcinoma based on severity of tobacco/alco-holl exposure. BMC Genetics 2002; 3:22.

55.. Patel SG, Meyers P, Huvos AG, Wolden S, Singh B, Shaha AR, Boyle JO, Pfisterr D, Shah JP, Kraus DH. Improved outcomes in patients with osteogenicc sarcoma of the head and neck. Cancer. 2002; 95:1495-503.

56.. Shaha AR, Patel SG, Singh B. Minimally invasive parathyroidectomy: the rolee of radio-guided surgery. Laryngoscope. 2002; 112:2166-9.

57.. Kutler DI, Auerbach AD, Satagopan J, Giampietro PF, Batish SD, Huvos AG,, Goberdhan A, Shah JP, Singh B. High incidence of head and neck squamouss cell carcinoma in patients with Fanconi anemia. Arch Otolaryngoll Head Neck Surg. 2003;129:106-12.

58.. Stojadinovic A, Hoos A, Nissan A, Dudas ME, Cordon-Cardo C, Shaha AR,, Brennan MF, Singh B, Ghossein RA. Parathyroid neoplasms: clini-cal,, histopathological, and tissue microarray-based molecular analysis. Humm Pathol. 2003; 34: 54-64.

59.. Harris CP, Lu XY, Narayan G, Singh B, Murty VVVS, Rao PH. Comprehensivee molecular cytogenetic characterization of cervical carcino-maa cell lines. Genes Chromosomes Cancer. 2003; 36:233-241.

60.. Kutler D, Singh B, Satagopan J, Batish, SD, Berwick M, Giampietro PF, Auerbachh A. A 20 year perspective of the international Fanconi anemia registryy study. Blood. 2003;101:1249-1256.

61.. Estilo CL, O-charoenrat P, Ngai I, Patel SG, Shaha AR, Kraus DK, Boyle JO,, Wong RW, Pfister DG, Zlotolow IM, Shah JP, Singh B. The role of novell oncogenes squamous cell carcinoma-related oncogene and phos-phatidylinositoll 3-kinase pllOalpha in squamous cell carcinoma of the orall tongue. Clin Cancer Res. 2003;9:2300-2306.

62.. Matsuo JM, Patel SG, Singh B, Wong RJ, Boyle JO, Kraus DH, Shaha AR,, Zelefsky MJ, Pfister DG, Shah JP. Clinical nodal stage is an inde-pendentlyy significant predictor of distant failure in patients with squa-mouss cell carcinoma of the larynx. Ann Surg. 2003: 238: 412-421.

63.. Carvalho AL , Singh B, Spiro RH, Kowalski LP, Shah JP. Differences in orall cancer in developing and developed nations: a multi-institutional study.. Head Neck. 2004; 26: 31-38.

64.. Wong RJ, Chan M, Kim T, Bhargava A, Stiles B, Horsburgh BC, Shah JP, Singhh B, Fong Y. Effective intravenous therapy for murine pulmonary metastasiss with oncolytic herpes virus expression IL-12. Clin Cancer Res. 2004;10:: 251-9.

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65.. Kutier Dl, Goberdhan A, Ben-Porat L, Satagopan J, Ngai I, Huvos AG, Giampietroo PF, Levran O, Pujara K, Diotti R, Auerbach AD, Singh B. Higherr levels of human papilloma virus integration and lack of p53 muta-tionss in squamous cell carcinoma from patients with Fanconi anemia. J Nationall Cancer Inst. 2003; 95: 1718-1721.

66.. Disa JJ, Polvora VP, Pusic AL, Singh B, Cordeiro PG. Dextran-related complicationss in head and neck microsurgery: do the benefits outweigh thee risks? A prospective randomized analysis. Plast Reconstr Surg. 2003; 112:: 1534-1539.

67.. Patel SG, Singh B, Polluri A, Bridger PG, Cantu G, Cheesman AD, deSa GM,, Donald P, Fliss D, Gullane P, Janecka I, Kamata SE, Kowalski LP, Krauss DH, Levine PA, dos Santos LR, Pradhan S, Schramm V, Snydermann C, Wei WI, Shah JP. Craniofacial surgery for malignant skull basee tumors: report of an international collaborative study. Cancer. 2003; 98:: 1179-1187.

68.. Beal KP, Singh B, Kraus D, Yahalom J, Portlock C, Wolden SL. Radiationn induced salivary gland tumors: A report of 18 cases and review off the literature. Cancer J. 2003;9:467-71.

69.. Wreesmann VB, Sieczka E, Socci ND, Hezel M, Belbin TJ, Childs G, Patell SG, Prystowsky MB, Shaha AR, Shah JP, Rao PH, Ghossein R, Singhh B. Independent prognostic significance of MUC1 alterations in well-differentiatedd papillary thyroid carcinoma. Cancer Res. 2004; 40:355-64. .

70.. Wreesmann VB, Ghossein RA, Hezel M, Banerjee D, Shaha A, Tuttle RM, Shahh JP, Rao PH, Singh B. Follicular variant of papillary thyroid carcino-ma:: Genome-wide appraisal of a controversial entity. Genes Chromosomes Cancer.. 2004; 40: 355-364.

71.. Wreesmann VB, Wang D, Goberdhan A, Prasad M, Ngai I, Schnaser EA, Sackss PG, Singh B. Genetic abnormalities associated with nodal metasta-siss in head and neck cancer. Head Neck. 2004;26: 10-15.

72.. Talbot SG, O-Charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiroo CN, Wong RJ, Kri s MG, Rusch VW, Singh B. Squamous Cell Carcinomaa Related Oncogene Regulates Angiogenesis through Vascular Endotheliall Growth Factor-A. Ann Surg Oncol 2004;11:530-4

73.. Ostroff J, Ross S, Steinglass P, Ronis-Tobin V, Singh B. Interest in and barrierss to participation in multiple family groups among head and neck cancerr survivors and their primary family caregivers. Family Process. 2004;43:195-208. .

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Authors'' Publications

74.. Cohen EG, Patel SG, Lin O, Boyle JO, Kraus DH, Singh B, Wong RJ, Shahh JP, Shaha AR. Fine-needle aspiration biopsy of salivary gland lesionss in a selected patient population. Arch Otolaryngol Head Neck Surg.. 2004;130:773-8.

75.. Wong RJ, Chan MK, Yu Z, Ghossein RA, Ngai I, Adusumilli PS, Stiles BM,, Shah JP, Singh B, Fong Y. Angiogenesis inhibition by an oncolytic herpess virus expressing interleukin 12. Clin Cancer Res. 2004;10:4509-16.

76.. O-charoenrat, Rusch V, Talbot S, Sarkaria I, Socci N, Viale A, Rao PH, Singhh B. Gene expression profiling is a predictor of outcome in patients withh squamous cell carcinoma of the lung. Clin Cancer Research 2004;10:5792-803. .

77.. Pao W, Miller VA, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelann R, Rusch V, Fulton LA, Mardis ER, Kupfer DM, Wilson RK, Kri ss MG, Varmus HE. EGF receptor gene mutations correlate with sensi-tivit yy of lung cancers to gefitinib (Iressa®) and erlotinib (TarcevaTM) andd are common in adenocarcinomas from "never smokers." Proc Natl Acadd Sci U S A. 2004;101:13306-11.

78.. Stoffel A, Chaurushiya M, Singh B, Levine AJ. The oncogenic API2/MALT 11 fusion products activate NF-kB and inhibit p53 mediated apoptosis.. Proc Natl Acad Sci USA. 2004;101:9079-84.

79.. Wreesmann WB, Shi W, Thaler HT, Poluri A, Kraus DH, Pfister D, Shahaa AR, Shah JP, Rao PH, Singh B. Identification fo novel prognostica-torss of outcome in squamous cell carcinoma of the head and neck. J Clin Oncol.. 2004;22:3965-72.

80.. Yu Z, Eisenberg DP, Singh B, Shah JP, Fong Y, Wong RJ. Treatment of aggressivee thyroid cancer with an oncolytic herpes virus. Int J Cancer. 2004;112:525. .

81.. Sarkaria IS, Talbot SG, Stojadinovic A, Pham D, Hoos A, Dudas M, Shahaa A, Shah JP, Brennan MF, Ghossein RA, Singh B. Squamous cell carcinomaa related oncogene (SCCRO) is highly expressed in normal humann adrenal tissue but not in aggressive adrenocortical carcinomas (ACC).. Surgery. (In press).

82.. Sarkaria IS, Pham D, Ghossein RA, Hezel M, Ebright MI , Memoli N, Zakowskii MF, Chuai S, Venkatraman ES, Miller VA, Kri s MG, Rusch VW,, Singh B. SCCRO expression correlates with invasive progression in bronchioloalveolarr carcinoma. Ann Thoracic Surg. (In press).

83.. Belbin TJ*, Singh B*, Wreesmann VB, Socci ND, Sanchez-Carbayo M, Mastersonn J, Smith R, Patel S, Cordon-Cardo C, Prystowsky MB, Childs

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G.. Molecular profiling of tumor progression in head and neck cancer. Archh Otolaryngol Head Neck Surg (*Equal Contributors; In press).

84.. Talbot SG, Estilo C, Maghami E, Sarkaria IS, Pham D, O-chorenrat P, Soccii N, Ngai I, Carlson D, Ghossein R, Viale A, Park B, Rusch V, Singh B.. Gene expression profiling allows distinction between primary and metastaticc squamous cell carcinomas in the lung. Cancer Res. (In revi-sion). .

85.. O-charoenrat P, Sarkaria N, Talbot S, Reddy PG, Ngai I, Maghami E, Levinee A, Rao PH, Stoffel A, Singh B. Modulation of hedgehog signaling byy the novel oncogene SCCRO (squamous cell carcinoma related onco-gene)) leads to squamous cell carcinogenesis. (Manuscript submitted).

86.. Singh B, Wreesmann VB, Socci N, Li RG, Shah JP, Bosl G, Rao PH, Pflsterr D. Prediction of chemoresponse in laryngopharyngeal cancer by hierarchicall clustering based on combination of biological parameters. (Manuscriptt submitted).

Books,Books, letters, reviews and monographs

1.. Singh B, Har-El G. Merkel cell carcinoma. Southern Med J. 1991;84:1285-1286. .

2.. Singh B, Sherry SH, Lanza JT. Moh's micrographic surgery in the man-agementt of soft tissue sarcomas of the extremities. Surgery 1992;111:718-719. .

3.. Singh B. Multicentric granular cell tumors. Southern Med J. 1993;86:1446-1447. .

4.. Singh B, Shaha A. Cutaneous granular cell tumor. Surgical Rounds.l995;18:68-69. .

5.. Singh B, Velcek FT, Alexis R. Pathology Case of the Month: Pilomatrixoma.. Arch Ped Adolescent Med. 1995; 149:551-552.

6.. Singh B, Carew J, Shaha AR. Laryngeal cancer in patients with acquired immunodeficiencyy syndrome. Am J Clin Oncol. 1998;21:623-4.

7.. Carew J, Singh B, Shaha AR. Head and neck sarcoma: Current manage-ment.. Current Concept Otolaryngol. (In press).

8.. Lucente FE, Singh B, Har-El G. Cancer of the Head and Neck in HIV Infectedd Patients. In Meyers EN, Seun JY (eds): Cancer of the Head and Neck-- Third Edition. W. B. Saunders Company. Orlando, Florida. 1996; 625-643. .

9.. Singh B, Shah JP. Controversies in the management of the NO neck. In Penzakk M Ed. Controversies in Otolaryngology. Thieme Medical

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Authors'' Publications

Publishers.. 2001;14-19. 10.. Singh B. Quality of lif e and rehabilitation. Shah JP and Patel SG (eds.).

Cancerr of the Head and Neck- American Cancer Society Atlas of Clinical Oncology.. B.C. Decker Inc. London. 2001; 467-477.

11.. Singh B, Shah JP. Skin cancer. Shah JP and Patel SG (eds.). Cancer of the Headd and Neck- American Cancer Society Atlas of Clinical Oncology. B.C.. Decker Inc. London. 2001; 75-99.

12.. Singh B. Cervical lymph nodes and unknown primary. Bland KI , Shah JP (Eds.).. The Practice of General Surgery. W. B. Saunders. 2002;279-297.

13.. Carew J, Singh B, Shah JP. Clinical evaluation and differential diagnosis. Inn Shah JP, Batsakis, Johnson N (Eds.) Oral Cancer. Martin Dunitz. 2003: 183-198. .

14.. Carew J, Singh B, Shah JP. Workup and staging. In Shah JP, Batsakis, Johnsonn N (Eds.) Oral Cancer. Martin Dunitz. 2003; 199-206.

15.. Carew J, Singh B, Shah JP. Factors effecting choice of treatment. In Shah JP,, Batsakis, Johnson N (Eds.) Oral Cancer. Martin Dunitz. 2003; 207-212. .

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19.. Carew J, Singh B, Shah JP. Complications and of treatment and their management.. In Shah JP, Batsakis, Johnson N (Eds.) Oral Cancer. Martin Dunitz.. 2003; 365-370.

20.. Singh B, Kacker A. Cancer of the Head and Neck in HIV Infected Patients.. In Meyers EN, Seun JY Myers JN, Hanna EYN (eds): Cancer of thee Head and Neck- Third Edition. W. B. Saunders Company. Orlando, Florida.. 2003; 581-600.

21.. Singh B. Basic science of head and neck cancer. In Shah JP and Patel S. Headd and Neck Surgery (Third ed.). 2003; 679-694.

22.22. Singh B. Quality of lif e and functional outcome in head and neck cancer. Inn Shah JP and Patel S. Head and Neck Surgery (Third ed.). 2003; 673-678. .

23.. Ganly I, Singh B. Topical ONYX-015 in the Treatment of Premalignant Orall Dysplasia: Another Role for the Cold Virus? J Clin Oncol. 2003; 21:

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4476-8. . 24.. Kutier Dl, Wreesmann V, Singh B. RESPONSE: Re: Human papillo-

maviruss DNA and p53 polymorphisms in squamous cell carcinomas from Fanconii anemia patients. J Natl Cancer Inst. 2004;96:968-9.