of 10/10
UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM Mochamad Fahlevi Rizal

UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM

  • View
    135

  • Download
    0

Embed Size (px)

DESCRIPTION

UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM. Mochamad Fahlevi Rizal. Infeksi akibat biofilm. Perkembangan teori biofilm. Skema biofilm. Properti biofilm. Fungsi komponen saliva. Jalur metabolik spesifik dan mekanisme transport S. mutans. Salivary Mucin MG2. .5. .4. .3. .2. - PowerPoint PPT Presentation

Text of UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM

UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM

UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM

Mochamad Fahlevi RizalInfeksi akibat biofilm

Perkembangan teori biofilm

Skema biofilm

Properti biofilmGeneral propertyDental plaque exampleOpen architecturePresence of channels and voidsProtection from host defences, desiccation etc.Production of extracellular polymers to form a functional matrixEnhanced resistance to antimicrobialsIncreased resistance to chlorhexidine and antibioticsNeutralization of inhibitors-lactamase production by neighbouring cells to protect sensitive organismsNovel gene expressionSynthesis of novel proteins; up-regulation of gtfBCCo-ordinated gene responsesProduction of cell-cell signaling molecules (e.g. CSP, autoinducer 2)Spatial and environmental heterogeneitypH and O2 gradients; co-adhesionBroader habitat rangeObligate anaerobes in an overtly aerobic environmentMore efficient metabolismComplete catabolism of complex host macromolecules (e.g. mucins) by consortiaFungsi komponen saliva

Jalur metabolik spesifik dan mekanisme transport S. mutansSalivary Mucin MG2 deft1614121086420-2.5.4.3.2.10.0-.1ObservedCubicTerima Kasih