University of Toronto Interdepartmental Division of ...Care+Digital+Assets/... · University of Toronto Interdepartmental Division of Critical Care ... Message from Arthur S. Slutsky,

University of Toronto Interdepartmental Division of Critical Care

Annual Report

January 1 – December 31, 2012

Message from Arthur S. Slutsky, MD Director, Interdepartmental Division of Critical Care Medicine

Dear Members of the Interdepartmental Division of Critical Care Medicine, I am pleased to present the annual report for January 1 – December 31, 2012, which showcases the excellent work and effort on the part of our Division’s members. This has been another outstanding year for our Division. This report provides a summary of the academic and professional achievements of our Faculty. The publication impact factor analysis outlines publication productivity, as an introduction to the individual achievements of our members. Individual achievements are organized by publications (peer reviewed and non-peer reviewed), book chapters, abstracts, presentations, funding and creative professional achievements, including program development, teaching awards, educational development opportunities, and other major accomplishments. I congratulate all of you for your tremendous individual achievements and a collective commitment to excellence in Critical Care Medicine. Under the leadership of Drs Abrahamson and Scales, our Residency Training Program continues to be a national leader in training and producing the highest quality intensivists and leaders in critical care medicine. The program received Full Accreditation status following the external review by the Royal College of Physicians and Surgeons of Canada. This achievement is indicative of the high quality of the program, the dedication of the faculty and the hard work and efforts of our exceptional residents. I congratulate this year’s graduating class, wishing them success in their careers and I welcome the 2013 class as they embark on their residency training. Our Faculty had another very successful year in research. This year, the total number of unique peer-reviewed publications exceeded 225. I would like to thank Drs. Andrew Baker (St. Michael’s Hospital), Brian Cuthbertson (Sunnybrook), Peter Laussen (Hospital for Sick Children), and Niall Ferguson (Mt. Sinai and UHN) for their leadership. This year’s Canadian Critical Care Forum conference was held on October 28th to 31st. The conference was attended by over 1000 participants and featured 175 presentations covering many diverse topics including mechanical ventilation, sedation and analgesia strategies, and systems for improving quality and safety. I would like to thank the organizing committee (Brian P. Kavanagh (Chair, Organizing Committee); Niall D. Ferguson (Chair, Scientific Programme), Shelly Dev, Claudia Dos Santos; Rob Fowler; Stephen Lapinsky; John Marshall; and Damon Scales) for the ongoing success of this conference. As you are aware, I am stepping down as the Director of the Interdepartmental Division this year. Following a comprehensive search, I am pleased to welcome Dr. Laurent Brochard as the new Division Director. Dr. Brochard will be joining us from Geneva, where he was Professor of Critical Care Medicine at Geneva University and Head of the ICU at Geneva University Hospital. An outstanding physician and researcher, Dr. Brochard leads a clinical research program in mechanical ventilation and has published extensively in the areas of acute respiratory failure and mechanical ventilation. We are honoured to have him in Toronto and I look forward to the Division’s continued success under his leadership. Sincerely,

Arthur S. Slutsky, MD Director, Interdepartmental Division of Critical Care Medicine, University of Toronto

University of Toronto Residency Training Program (Damon C. Scales, MD PhD)

The University of Toronto Adult Critical Care Medicine Residency Training Program continues to lead the country in producing the highest quality intensivists and leaders in Critical Care Medicine. The 2012-2013 academic year marked several important successes. Most notably, our Program received Full Accreditation status following the external review by the Royal College of Physicians and Surgeons of Canada. This important distinction acknowledges the excellent quality of our training program and in particular the outstanding academic half-day organized by Dr. Simon Abrahamson, the dedication of our teaching faculty, and the exceptional and hard-working residents that we continue to attract. We congratulate last year’s graduating residents, who have all developed into highly trusted and competent intensivists: Drs. Alawi AlSaeedi, Andrew Beckett, Martin Betts, Jesse Delaney, Akash Girn, Terence Ip, Oleksa Rewa, Kit Stanley, Maude St-Onge, and Carolyn Tram. We are very proud of these impressive individuals, and look forward to following their continued career growth and success. We continue to attract some of the very brightest candidates, and welcome those that joined our program in July 2013: Drs. Jonathan Di Fabio, Ray Guo, Barbara Haas, Christina Katsios, Aleksandra Leligdowicz, Mark Maraschiello, and Warren Luksum. The residency program continues to offer novel educational opportunities to our trainees, thanks largely to the innovation and dedication of the Program’s Education Director, Dr. Simon Abrahamson. We would also like to thank Bernadette Slingerland for her help in organizing and scheduling these events and contributing to a truly excellent program. This past year we once again had a simulation series (Dr. Simon Abrahamson), National ACES course (Dr. Simon Abrahamson), Bronchoscopy course (Dr. Simon Abrahamson), Communication Course (Dr. James Downar), Leaders and Mangers Day (Dr. Andrew Beckett, Simon Abrahamson, Bernadette Slingerland), Career Night (Dr. Andrew Beckett, Bernadette Slingerland), ethics series (Drs. Neil Lazar), and a summer physiology series (Drs. Martin Betts, Elliott Owen, Simon Abrahamson). The excellent Transport Day (Drs. Maude St-Onge, Andrew Beckett, Simon Abrahamson) received media coverage in a CTV News video segment. Drs. Simon Abrahamson and Alberto Goffi continued to provide an ultrasound and echocardiography course. Dr. Eddy Fan led the monthly journal club to teach critical appraisal skills, and also organized a workshop on extracorporeal life support. Dr. Shelly Dev and Christie Lee organized the annual in-training oral exam to help us assess the progress of our residents. The UofT Annual CCM Residents’ Day (Drs. Chris Parshuram, Damon Scales, Maude St-Onge, Elliott Owen, Charles Larson, Srinivas Murthy; Meredith Malloy and Nicole De Berardinis) was a tremendous success, featuring plenary presentations from Drs. Taylor Thompson (Harvard University) and Peter Laussen (Sick Kids), and more than 50 posters and oral presentations from our residents. The recipients of the annual teaching awards were selected by the critical care residents to acknowledge outstanding faculty in the IDCCM. Dr. Simon Abrahamson once again received the John T. Granton Award for Outstanding Contributions to Teaching and Education (city-wide). The site winners for excellence in teaching were Dr. Thomas Stewart (Mount Sinai), Dr. Simon Abrahamson (St. Michael’s), Dr. Andre Amaral (Sunnybrook), Dr. Eddie Fan (Toronto General), Dr. Jeff Singh (Toronto Western), and Dr. Alvin Chang (UofT-affiliated community teaching hospitals, Toronto East General). We continue to improve the calibre of the overall training program with several exciting initiatives including a new ultrasound simulator and the appointment of Dr. Christie Lee as the Program’s Evaluation Director. The Visiting Professor series and Clinical Research in Progress Sessions, both organized by Dr. Gordon Rubenfeld and Meredith Malloy, have been tremendously successful by exposing our trainees to international leaders in critical care and providing our residents with support and feedback for on their scholarly projects. This was truly an outstanding and important year that culminated in our program being fully accredited once more by the Royal College of Physicians and Surgeons. We should all be very proud of this achievement, and continue to build on our strong reputation for training leaders in Critical Care Medicine.

Critical Care Canada Forum 2012 (Niall D. Ferguson, MD)

Critical Care Canada Forum (CCCF) is a 3-day conference organized by the Interdepartmental Division of Critical Care Medicine, which focuses on topics that are relevant to the individuals involved in the care of critically ill patients, wherever the patients are located. Internationally recognized, the Critical Care Canada Forum focuses on leading-edge science through informative and interactive sessions, dynamic speakers and numerous exhibitions. The CCCF is a place where doctors, nurses and respiratory therapists can collaborate on shared knowledge across disciplines, departments and institutions. This year Critical Care Canada Forum (CCCF) was held October 28-31, continuing this year in its new location at the Sheraton Centre Hotel & Convention Centre. These dates coincided with Canadian Intensive Care Week in Canada. The conference proper was preceded by several pre-congress courses, including the popular Residents’ Day (co-sponsored by the Canadian Critical Care Society) and workshops on ultrasound in the ICU. This year’s conference was attended by over 1000 participants and featured 175 presentations covering many diverse topics including mechanical ventilation, sedation and analgesia strategies, and systems for improving quality and safety. As usual we had presentations of a number of important randomized trials – including studies on fluid resuscitation in shock, high-frequency oscillation, and prone positioning in ARDS. In addition to the strong scientific programme, social aspects of the conference are also highly rated, including the Reception at the Top of the Sheraton. CCCF also has a number of affiliated meetings before and during conference period, including the Canadian Critical Care Society, the Canadian Critical Care Trials Group, and the Canadian Intensive Care Foundation. The organizing committee for Critical Care Canada Forum consists of: Brian Kavanagh (Chair, Organizing Committee); Niall Ferguson (Chair, Scientific Programme); Shelly Dev; Claudia Dos Santos; Rob Fowler; Stephen Lapinsky; John Marshall; Damon Scales; and Art Slutsky The conference in 2012 was a huge success, and planning is already underway for the upcoming year November 9-21, 2013. More details are available at www.criticalcarecanada.com. The Critical Care Canada Forum is where Canada’s intensivists put the latest science into practice.

An Update from the Department of Critical Care, St. Michael’s Hospital (Andrew J. Baker, MD)

In the past year, the Department of Critical Care at St. Michael’s Hospital has succeeded in its quest for excellence across all endeavors undertaken by its staff. In the areas of education, research and clinical activities, the hard work of the department has been recognized through various honours received throughout the past year. The St. Michael’s Hospital Critical Care Department is very happy to welcome Dr. John Laffey as a new member of the department’s faculty. In education, Dr. Simon Abrahamson and Dr. Natalie Wong continue to lead the Fellowship and Residency programs, respectively. Dr. Abrahamson again received the John Ganton Award from the University of Toronto and the Best Teacher Award from St. Michael’s Hospital for his excellent teaching capacity within in the hospital. In addition to the aforementioned education-based awards, other awards received by physicians within the department include: Dr. Simon Abrahamson was also presented with the University of Toronto Innovation Award for his work on the Simfocus Study. In addition, Dr. Andrew Baker and Dr. Arthur Slutsky were presented with the Queen Elizabeth II Diamond Jubilee Medal in commemoration of the 60th anniversary of her Majesty’s accession to the throne and in recognition of their contributions to Canada. Furthermore, Dr. Andrew Baker was awarded the inaugural Cara Phelan Chair of Critical Care Medicine at St. Michael’s Hospital in July 2012. Dr. Arthur Slutsky was also presented with the Anne & Neil McArthur Research Award from St. Joseph’s Healthcare as well as the prestigious 2012 American Thoracic Society Assembly on Critical Care Lifetime Achievement Award in May of 2012.Dr. Patricia Houston received the Award of Merit for Excellence in Interprofessional Teaching from the Department of Anesthesia in the Faculty of Medicine at the University of Toronto. Dr. Warren Lee was presented with an award for Best Poster at the Infectious Disease Research Day at the University of Toronto and an award for Best Oral Presentation at the Canadian National Medical Student Research Symposium as a supervisor for his graduate student Susan Armstrong. As a unit, the Critical Care Department’s Critical Care Response Team (CCRT) received the Values in Action Award, a testament to the strong sense of values and contributions to the hospital’s culture of caring, as exemplified by those within the department. The physicians in the Critical Care Department have continued their consistent contributions to the realm of research by publishing 108 articles in peer-reviewed journals in the past year. These publications were funded in part through a total of 26 research grants and awards received by the Critical Care Department staff this year. Peer-reviewed grants were received by – Drs. Andrew Baker, Karen Burns, Claudia dos Santos, Sara Gray, David Hall, Chris Hayes, John Laffey, Bernard Lawless, Warren Lee, John Marshall, and Arthur Slutsky. Non-peer reviewed grants were received by – Drs. David Hall, David Klein, David Mazer, and Natalie Wong. In order to present their own research and further their knowledge of new findings in similar research fields, Critical Care Department members traveled to a variety of conferences and presentations throughout the world. There were a total of 45 regional, 24 national and 58 international presentations by Critical Care Department physicians in the 2012 year.

An Update from the Department of Critical Care Medicine, The Hospital for Sick Children (Peter C. Laussen, MB, BS, FCICM)

The 2012 academic year in the Department of Critical Care Medicine at SickKids has been eventful and productive. We continue to be extremely busy with over 2,000 admissions to the Divisions of Paediatric Critical Care and Cardiovascular Critical Care. Outcomes remain excellent and comparable to any benchmark with respect to mortality and quality markers such as rate of inadvertent extubation, healthcare acquired infection and rate of readmission. However, there is always room for improvement and the Quality Program in the department is undergoing significant change with new appointments and managers to oversee a coordinated approach to quality and safety across the Intensive Care Unit. These will also be included in initiatives currently underway to broaden quality and safety measurement and practices across the Intensive Care Units in the GTA. Our new Chief, Dr. Peter Laussen, arrived from Boston in September of 2012 and has settled in nicely and embraced the culture that exists across SickKids. Over recent years, Dr. Laussen has led the development of an innovative web-based software application to facilitate capture of continuous physiologic data streams in the Critical Care environment. Called “T3” for Tracking, Trajectory and Trigger, the aims include improved visualization of continuous physiologic data with functions that enhances the integration and interactions with the data. A primary aim is to capture, store and share these large physiologic data sets to enable predictive modeling. The Resident and Fellow Training Program at SickKids underwent a successful review by the Royal College. Led by Dr. Kotsakis, we were well prepared and passed with flying colours in all domains. This was a major milestone and a great relief to receive full accreditation. The clinical research within the department has once again been very active, led by Dr. Jamie Hutchison. The work by Dr. Hutchison and Dr. Guerguerian related to traumatic brain injury continues to be at the forefront of this research in paediatric patients, and the Early Warning Score developed by Dr. Parshuram remains the only validated early warning score for paediatric patients and has now also received FDA approval; the multi-centre study continues to enroll patients and adoption of this Early Warning Score continues across Canada, the US and indeed the world. We remain extremely committed to teaching the next generation, and our education program for Residents and Fellows is a priority. In addition to our Canadian residents in the training program, our many Fellows from overseas who spend between 1-2 years with us really enhance the richness of our program. We successfully launched a Senior Fellowship position in our Cardiovascular Critical Care Unit in 2012, and this academic year have launched a Senior Neurocritical Care Fellow position. We also recognize the importance of maintaining connections and collaboration with the many Fellows we have trained over the years. Dr. Peter Cox is leading our inaugural SickKids Critical Care Alumni meeting during the Critical Care Canada Forum this coming November 2013, and will also be launching an Alumni Association. By doing so, we hope to maintain our connections with those Fellows who have trained with us, and also facilitate ongoing collaboration and communication between former Fellows as well. Finally, the Department received its second Endowed Chair, the David and Stacey Cynamon Chair in Paediatric Critical Care Medicine through the Hospital for Sick Children and the University of Toronto. This Endowed Chair is to support the Chief of the Department of Critical Care Medicine.

An Update from the Departments of Critical Care Medicine, University Health Network/Mount Sinai Hospital

(Niall D. Ferguson, MD) Personnel: The leadership team for Critical Care at UHN/MSH remained largely unchanged in 2012. Dr. Niall Ferguson is Interim Director of Critical Care for UHN/MSH, with Drs. Neil Lazar, Jeff Singh, and Stephen Lapinksy serving as Site Directors for Toronto General, Toronto Western, and Mount Sinai, respectively. Our research leads are Drs. Margaret Herridge (UHN) and Geeta Mehta (MSH). Dr. Andrew Steel serves as the Director of our International Fellowship Programme. One of our education leads, Dr. Lisa Kenny, left UHN to pursue her career in her home province of Newfoundland, where we wish her every success. Research: This was another excellent year for our research group. Our grant and publications records were strong (see individual reports). We participated in numerous studies – some investigator-led from within our group OSCILLATE; Towards RECOVER), some investigator-initiated from other CCCTG collaborators (ABLE), and others industry trials (PROWESS-Shock; CONSCIOUS II). Education/Innovation: The International Fellowship Programme at UHN/MSH, under Dr. Andrew Steel’s direction, continues to flourish, despite positions for 7 fellows per year we are fortunate to receive many more strong applications than we can accommodate. In addition we continue to evolve our resident education programme at UHN/MSH, including Intensive Care University – a primer on essentials of critical care for new residents beginning their rotation. Other areas of quality improvement include a focus on reducing CLI and VAP, and new quality initiatives targeting delirium and also early mobility.

An Update from the Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (Dr. Brian Cuthbertson MB ChB, MD, FRCA)

The leadership team for Critical Care Medicine at Sunnybrook Health Sciences Centre remained unchanged in 2012. Dr. Brian Cuthbertson is the Chief of Critical Care Medicine, while Dr. Gordon Rubenfeld continues to serve as Chief of the Trauma, Emergency and Critical Care Program. Dr. Damon Scales remained the Program Director of the University of Toronto Adult Critical Medicine Training Program. Drs. Shelly Dev and Cameron Guest lead the education programme as our Residency Director and Co- Fellowship Directors of the International Fellowship Program. Research In research the department enjoyed a number of notable academic accomplishments. Brian Cuthbertson was the senior author on the TRAC-MAN trial in JAMA and the OSCAR trial on high-frequency oscillatory ventilation in the NEJM while continuing the first phases of the SuDDICU research program evaluating selective decontamination of the digestive tract and the METS (Measurement of Exercise Tolerance before Surgery) Study, both funded by CIHR. Gordon Rubenfeld completed his year as the American Thoracic Society Critical Care Assembly Chair while supporting numerous IDDCCM faculty research programs, playing a leading role on ARDS and Sepsis international guidelines and completing a multicenter trial of acute lung injury support tools. Avery Nathens is the principal investigator on numerous peer-funded trauma-focused research programs in addition to authoring two-dozen peer-reviewed manuscripts. Andre Amaral continues his focus on quality improvement with publications on patient “hand-offs” and sedation practices. Lorraine Tremblay is the Principal Investigator of the Implementation & Assessment of a Novel Multidisciplinary e-Discharge Summary to Improve Efficiency, Satisfaction, and Safety of Transfer of Care for Complex Patients. Damon Scales was an inaugural recipient of the Physicians’ Services Incorporated Fellowship Award in Translational Medicine (2012-2015), the scientific officer for the CIHR Health Services Research Panel, principal investigator of the CIHR-funded ICE-PACS Randomized Controlled Trial and Premature Termination of Resuscitation in Survivors of Cardiac Arrest (PremaTOR) study, in addition to authoring 14 peer-reviewed publications. Neill Adhikari is a consultant to the World Health Organization Global Influenza Program critical care training courses, lecturing in Indonesia and Vietnam in addition to authoring 16 peer-reviewed publications. Rob Fowler completed a Commonwealth Fund Harkness Fellowship and began a Heart and Stroke Foundation Mid-Career Clinician Scientist award (2013-2017), initiating a research program focused on end-of-life care and funded by CIHR, TVN Network Center of Excellence, and the University of Toronto. Martin Chapman is the project lead for the Ontario Neurotrauma Foundation-funded Knowledge Translation for Severe Traumatic Brain Injury (sTBI) Across Ontario and the Academic Health Sciences Centres Alternate Funding Plan Innovation Fund Transforming the Care Of Patients with Severe Traumatic Brain Injury (sTBI) In Toronto projects. Taz Sinuff authored numerous peer-reviewed publications on advance care planning, rationing in the ICU and quality improvement initiatives. Shannon Goddard and Vicki McCredie are new Clinical Associates and simultaneously enrolled in graduate studies in clinical epidemiology at HPME. The Visiting Professorship Program continues to be tremendously successful in bringing international experts in Critical Care to Sunnybrook and the city-wide Interdepartmental Division of Critical Care. The Clinical Research in Progress sessions continue to provide a supportive environment where investigators can bring research projects for critical evaluation and discussion. This past year we had 18 presenters which included an assortment of both city-wide staff and fellows. Nicole Marinoff, our Research Manager is currently leading 12 open industry studies that many are currently under review and pending publication. Several of our staff has received REB approval for retrospective data studies in 2012-2013.

Education and Quality Improvement We pride ourselves on our high quality clinical teaching and in the 2012-2013 academic year the Department has continued to receive high scores for teaching assessments from both resident and fellowship training attachments. We have continued to develop our problem based learning modules and have shared this teaching throughout the University of Toronto adult critical care centres. Dominique Piquette completes her PhD in simulation and supervision in medical education as part of a CIHR-funded fellowship award and has six papers accepted or under submission from her work. Shelly Dev is the Principal Investigator of a Validation Study of a Multimedia-Based Teaching Tool used for Bedside Teaching funded by the Education Development Fund, University of Toronto and continues her role as editor and contributor to the New England Journal of Medicine Videos in Clinical Medicine series. We are also continuing to develop simulation teaching in technical skills based competencies with increase success. Dr. Shelly Dev was contracted by Sunnybrook Health Sciences Centre to create a very popular educational video series around correct hand hygiene practices. Additionally, she collaborated with colleagues in the Department of Medicine to develop a video series for educators to learn about giving effective feedback to trainees. In Quality Improvement, the Department continues to collect data on key quality indicators reflecting our performance. A Process of Care Database was developed and validated, which monitors the quality of care provided in the ICU for these select quality indicators. The results are published internally on-line on a quarterly basis. We have initiated activities to improve compliance with lung protective ventilation, early rehabilitation and to decrease blood work. This year we also develop a biannual multi-professional quality meeting across all of critical care central with encouraging feedback. Dr Andre Amaral continues to work on hand over and clinical communication as quality improvement ventures.

Publication Analysis for the Year 2012

Number of unique publications: 228 Number of unique publications with impact factor greater than zero: 200 Mean impact factor (of those with an impact factor greater than zero): 6.30 Median impact factor (of those with an impact factor greater than zero): 4.27 Percentage of publications with impact factor greater than 7.00: 13.1%

Simon Abrahamson (St. Michael’s Hospital) Presentations/Lectures: 1. Ultrasound in Critical Care - you are blind without it. Canadian Critical Care Forum Residents Day,

October 2012. Abrahamson S, Goffi A, Hockmann E. 2. Mass casualty simulation for critical care residents - Poster Presentation, Canadian Critical Care

Forum, October 2012. St. Onge, Beckett A, Abrahamson S et al

3. Lung ultrasound for the diagnosis of acute cardiogenic dyspnea in the Emergency Department – a multicenter study. June 2012, University of Toronto CCM research day. Goffi A, Abrahamson S.

Neill KJ. Adhikari (Sunnybrook Health Sciences Centre) Peer Reviewed Publications:

1. Wald R, Friedrich JO, Bagshaw SM, Burns KEA, Garg AX, Hladunewich MA, House AA, Lapinsky S,

Klein D, Pannu NI, Pope K, Richardson RM, Thorpe K, Adhikari NK. Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI) - a pilot randomized controlled trial of hemofiltration versus hemodialysis: a Canadian Critical Care Trials Group project. Crit Care 2012 Oct 24;16(5):R205. Senior Responsible Author.

2. Odutayo A, Adhikari NKJ, Barton J, Burns KEA, Friedrich JO, Klein D, Lapinsky S, Litwin S, Meret A, Moineddin R, Richardson B, Richardson R, Zaltzman A, Hladunewich M, Wald R. The epidemiology of acute kidney injury in Canadian critical care units. Can J Anaesth 2012 Oct;59(10):934-942. Coauthor or Collaborator.

3. Clark E, Wald R, Levin A, Bouchard J, Adhikari NK, Hladunewich M, Richardson RM, James MT, Walsh MW, House AA, Moist L, Stollery DE, Burns KE, Friedrich JO, Barton J, Lafrance JP, Pannu N, Bagshaw SM; for the Canadian Acute Kidney Injury (CANAKI) Investigators. Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study. Can J Anaesth 2012 Sep;59(9):861-870. Coauthor or Collaborator.

4. Dainty KN, Adhikari NK, Kiss A, Quan S, Zwarenstein M. Electronic prescribing in an ambulatory care setting: a cluster randomized trial. J Eval Clin Pract 2012 Aug;18(4):761-7. Coauthor or Collaborator.

5. Friedrich JO, Wald R, Bagshaw SM, Burns KE, Adhikari NKJ. Hemofiltration compared to hemodialysis for acute kidney injury: systematic review and meta-analysis. Crit Care 2012, 16:R146. Senior Responsible Author.

6. Friedrich JO, Adhikari NK, Beyene J. Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulation. Stat Med 2012 Jul 30;31(17):1857-86. Coauthor or Collaborator.

7. Wilcox ME, Adhikari NKJ. The effect of telemedicine in critically ill patients: systematic review and meta-analysis. Crit Care 2012, 16:R127. Senior Responsible Author.

8. Wald R, Quinn RR, Adhikari NK, Burns KE, Friedrich JO, Garg AX, Harel Z, Hladunewich MA, Luo J, Mamdani M, Perl J, Ray JG. University of Toronto Acute Kidney Injury Research Group. Risk of chronic dialysis and death following acute kidney injury. Am J Med 2012 Jun;125(6):585-93. Coauthor or Collaborator.

9. Ganapathy A, Adhikari NK, Spiegelman J, Scales SC. Routine chest x-rays in intensive care units: a systematic review and meta-analysis. Crit Care 2012 Apr 27;16(2):R68 (Trainee publication, Ganapthy A, Spiegelman J). Senior Responsible Author.

10. Westcott M, Martiniuk ALC, Fowler RA, Adhikari NKJ, Dalipanda T. Critical care resources in the Solomon Islands: a cross-sectional survey. BMC Int Health Hum Rights 2012 Mar 1;12:1. Coauthor or Collaborator.

11. Duffett M, Burns KE, Adhikari NKJ, Arnold DM, Lauzier F, Kho ME, Meade MO, Hayani O, Koo K, Choong K, Lamontagne F, Zhou Q, Cook DJ. Quality of reporting of surveys in critical care journals: A methodologic review. Crit Care Med 2012 Feb;40(2):441-449. Coauthor or Collaborator

In Press: 1. WHO Global Influenza Programme Critical care training: Severe forms of influenza infection,

including severe pneumonia, acute lung injury, severe sepsis, and septic shock. WHO Press. In Press. Principal author for 6chapters; Editor of overall manual.

2. Gove S, McHarry K, Cohen H, Moodley N, Zuroweste E, Diaz J, Duncombe C, Chersich M, Jacob S. WHO IMAI District Clinician Manual: Guidelines for the management of common illnesses with limited resources Hospital Care for Adolescents and Adults. WHO Press, Geneva. Expert reviewer.

Abstracts: 1. Herridge MS, Chu LM, Matte AL, Chan L, Tomlinson G, Ferguson ND, Mehta S, Friedrich J, Adhikari

N, Fowler R, Lamontagne F, Rudkowski J, Meggison H, Ayas N, Skrobik Y, Batt JA, dos Santos CC, Flannery JF, Abbey SE, Rubenfeld G, Scales DC, Sinuff T, Cuthbertson B, Fan E, Slutsky AS, Leung G, Moody AR, Levasseur M, Marshall JC, Cook D, Cameron JI, in collaboration with the Canadian Critical Care Trials Group. Long-term patient outcomes after prolonged mechanical ventilation: the TOWARDS RECOVER study. Poster presentation at Critical Care Canada Forum, Toronto, Canada. Coauthor or Collaborator.

2. Cameron JI, Chan L, Czerwonka A, Chu LM, Matte A, Tomlinson G, Ferguson ND, Mehta S, Friedrich J, Adhikari N, Fowler R, Lamontagne F, Rudkowski J, Meggison H, Ayas N, Skrobik Y, Batt JA, dos Santos CC, Flannery JF, Abbey SE, Rubenfeld G, Scales DC, Sinuff T, Cuthbertson B, Fan E, Slutsky AS, Leung G, Moody AR, Levasseur M, Marshall JC, Cook D, Herridge MS, in collaboration with the Canadian Critical Care Trials Group. Long-term outcomes after prolonged mechanical ventilation: family caregiver outcomes from the TOWARDS RECOVER study. Poster presentation at Critical Care Canada Forum, Toronto, Canada. Coauthor or Collaborator.

3. Golan E, Vasquez D, Ferguson ND, Adhikari NK, Scales DC. Prophylactic magnesium for improving neurological outcome after aneurysmal subarachnoid hemorrhage: systematic review and meta-analysis. Intensive Care Med 2012; 38 (Suppl 1): S111 (Trainee publication, Golan E). Coauthor or Collaborator.

4. Duggal A, Ganapathy A, Ratnapalan M, Tsang J, Sinuff T, Burns KE, Meade MO, Adhikari N. A systematic review of pharmacotherapies for acute respiratory distress syndrome (ARDS). Intensive Care Med 2012; 38 (Suppl 1): S165 (Trainee publication, Golan E). Senior Responsible Author.

5. Douketis J, Pai M, Walsh M, Heels-Ansdell D, Zytaruk N, Cook D. Can Low-molecular-weight Heparin be Safely Used as Prophylaxis Against Venous Thromboembolism in Critically Ill Patients with End Stage Renal Disease? A Sub-group Analysis of the PROTECT Trial. Am J Hematol 2012;87(S1):S199. Author on poster but not on published abstract.

6. Sinuff T, Muscedere J, Adhikari N, Stelfox T, Rubenfeld G, Dodek PM, Pinto R, Heyland D, Cook D, Amaral AC, Piquette D, Cahill N, Lawless B, Scales DC, Garland A. The Quality Of Knowledge Translation Studies In Critical Care. Am J Respir Crit Care Med 185;2012:A1483. Coauthor or Collaborator.

7. Goligher EC, Rubenfeld G, Adhikari N, Pinto R, Kavanagh BP, Cook D, Guyatt G, Jones GL, Granton J, Stewart T, Meade M, Ferguson ND. Oxygenation Response To Increased PEEP Predicts Mortality In Acute Lung Injury: A Secondary Analysis Of The Lung Open Ventilation Study (LOVS) Trial. Am J Respir Crit Care Med 185;2012:A1158 (Trainee publication, Goligher, EC). Coauthor or Collaborator.

8. Sinuff T, Garland A, Adhikari N, Stelfox T, Rubenfeld G, Dodek PM, Heyland D, Pinto R, Cook D, Amaral AC, Piquette D, Cahill N, Lawless B, Scales DC, Muscedere J. Knowledge Translation Interventions For Critically Ill Patients: A Systematic Review. Am J Respir Crit Care Med 185;2012:A2460. Coauthor or Collaborator.

9. Wilcox ME, Adhikari NK. Effect Of Telemedicine On Mortality In Critically Ill Patients: Systematic Review And Meta-Analysis. Am J Respir Crit Care Med 185;2012:A2867. Senior Responsible Author.

10. Cameron JI, Chan L, Czerwonka AI, Chu LM, Matte AL, Ferguson ND, Mehta S, Friedrich J, Adhikari N, Fowler R, Cook DJ, Rudkowski JC, Meggison H, Abbey SE, Batt JA, dos Santos C, Flannery J, Leung G, Marshall J, Moody A, Rubenfeld G, Scales DC, Sinuff T, Slutsky A, Lamontagne F, Levasseur M, Tomlinson G, Herridge MS. Long-Term Outcomes After Prolonged Mechanical Ventilation: Family Caregiver Outcomes From The Towards RECOVER Study. Am J Respir Crit Care Med 185;2012:A1090. Coauthor or Collaborator.

11. Clarke F, McDonald E, Smith O, Zytaruk N, Heels-Ansdell D, Watpool I, McArdle T, Matte A, Vallance S, Finfer S, Galt P, Crozier T, Fowler R, Arabi Y, Woolfe C, Orford N, Hall R, Adhikari N, Ferland MC, Marshall J, Foster D, Farias P, Cook DJ, Meade M. Enrolling Critically Ill Patients Into Multiple Studies: A Case Study Of A Thromboprophylaxis Trial. Am J Respir Crit Care Med 185;2012:A2458. Coauthor or Collaborator.

12. Herridge MS, Chu LM, Matte AL, Chan L, Tomlinson G, Ferguson ND, Mehta S, Friedrich J, Adhikari N, Fowler R, Cook DJ, Rudkowski JC, Meggison H, Abbey SE, Batt JA, dos Santos C, Flannery J, Leung G, Marshall JC, Moody AR, Rubenfeld G, Scales DC, Sinuff T, Slutsky A, Lamontagne F, Levasseur M, Cameron JI. Long-Term Patient Outcomes After Prolonged Mechanical Ventilation: The Towards RECOVER Study. Am J Respir Crit Care Med 185;2012:A2546. Coauthor or Collaborator.

13. Lamontagne F, Adhikari N, Cook D, Koo KK, Lauzier F, Burns KE, Douglas I, Turgeon AF, Quiroz H, Poulin Y, Choong K, Ferguson N, Kho ME, Duffet M, Chant C, Lesur O, Meade MO. Corticosteroids for critically ill patients: an international survey of intensivists [P101]. Crit Care 2012; 16(Suppl 1):S36. Coauthor or Collaborator.

Presentations/Lectures: 1. 2012 Oct 29 Invited Speaker. Targeting depression after lung injury. Critical Care,

Canada Forum. Toronto, Ontario, Canada. Presented in session “ICU Rehabilitation & Recovery”.

2. 2012 Oct 29 Chair. Session: “ICU Long-term Outcomes”. Critical Care Canada

Forum. Toronto, Ontario, Canada. 3. 2012 Jun 19 Chair. Oral abstract presentations: clinical. University of Toronto

Interdepartmental Division of Critical Care Medicine. Toronto, Ontario, Canada. 4. 2012 Feb 16 Invited Speaker. Acute respiratory distress syndrome. Division of

Cardiology, Sunnybrook Health Sciences Centre. Toronto, Ontario, Canada. Cardiology critical care rounds.

5. 2012 Feb 16 Invited Speaker. Weaning from mechanical ventilation. Division of

Cardiology, Sunnybrook Health Sciences Centre. Toronto, Ontario, Canada. Cardiology critical care rounds.

Research Funding: 1. 2012 Apr – 2013 Sep Co-Investigator. One day Point Prevalence Study of Acute

Rehabilitation in Ontario Intensive Care Units: Rates of, Barriers to and Facilitating Factors for Mobilization. Physicians’ Services Incorporated Foundation. PI: Koo, Karen. 58,234.9 CAD. [Grants]

2. 2012 Apr – 2013 Mar Co-Investigator. One-day Point Prevalence of Acute Rehabilitation in Canadian Intensive Care Units: Rates of, Barriers to and Facilitating Factors for Mobilization. Academic Medical Organization of Southwestern Ontario AFP Innovation Fund. PI: Koo, Karen. 102,183.9 CAD. [Grants]

3. 2011 Jul – 2013 Jun Co-Investigator. STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI). Canadian Institutes of Health Research (CIHR). PI: Wald, Ron; Bagshaw, Sean. 276,360 CAD. [Grants]

4. 2009 Sep – 2013 Sep Co-Investigator. The RECOVER Program: Phase I Towards RECOVER - Outcomes and Needs Assessment in Survivors of Prolonged Mechanical Ventilation and Their Caregivers. Canadian Institutes of Health Research (CIHR). PI: Herridge, Margaret. 704,367 CAD. [Grants]

5. 2009 Jul - 2014 Jun Co-Investigator. OSCILLation for ARDS Treated Early (OSCILLATE)Trial. Canadian Institutes of Health Research (CIHR). PI: Meade, Maureen; Ferguson, Niall. 3,791,391 CAD. [Grants]

Najma Ahmed (St. Michael’s Hospital) Peer Reviewed Publications: 1. Ahmed, N., Gotlib Conn, L., Chiu, M., Kurabi, B., Qureshi, A., Nathens, A., Kitto, S. Career

satisfaction among general surgeons in Canada: A qualitative study of enablers and barriers to improve recruitment and retention in general surgery. Academic Medicine 2012 Oct 87(1) p161-162 Trainee publication, Adnan Qureshi is a PGY1 resident in General Surgery). Principal Author

2. Doumouras A, Keshet I, Nathens AB, Hicks C, Ahmed N. A crisis of faith? A review of simulation in

teaching team-based, crisis management skills to surgical trainees. Journal of Surgical Education. J Surg Educ. 2012 May-Jun;69(3) (Trainee publication, Supervision of 2 medical students on this project). Co-Principal Author.

3. Gomez D, Haas B, Al-Ali K, Monneuse O, Nathens AB, Ahmed N. Controversies in the management

of splenic trauma. International Journal of the Cared of the Injured. J Care Injured 43 (2012) 55-61. Senior Responsible Author.

Presentations/Lectures:

1. Apr 2012 What do students think of the St. Michael’s Hospital ThinkFirst Injury Prevention Strategy for Youth? Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): A. Sorvari, J. Bridge, J. Topolovec-Vranic, J. Mauceri, E. Butorac, N. Ahmed, J. Holmes. Scientific paper. April 12, 2012.

2. Apr 2012 Trauma Surgery Case Review. Trauma Association of Canada. Ontario, Canada.

Presenter(s): Dr. Mohammed Bawazeer (fellow) and Dr.Najma Ahmed. April 21, 2012.

3. Apr 2012 97% of MTPs do not have a hemorrhage panel. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Mohammed Bawazeer (fellow), Avery Nathens, Katerina Pavenski, Najma Ahmed. April 12, 2012.

Andre Amaral (Sunnybrook Health Sciences Centre) Peer Reviewed Publications: 1. Andre CKB Amaral, Lars Kure and Angie Jeffs. Effects of increasing compliance with minimal

sedation on duration of mechanical ventilation: a quality improvement intervention. Crit Care. 16(3):R78 Study design and concept, data collection, data analysis, manuscript writing. Impact Factor 4.61. Principal Author.

Submitted Publications:

1. Bernardo S Barros, MD1; Camilla C P P Barros, MD1; Ruxandra Pinto, PhD (Stat)1; Gordon D Rubenfeld, MD, MSc1, 2; Andre C K B Amaral, MD1, 2. The effects of weekday nighttime coverage on clinical decisions in critically ill patients. Intensive Care Medicine. Data collection, study concept and design, data analysis, manuscript writing. Senior Responsible Author.

2. Andre C. K. B. Amaral1, Robert A. Fowler1, Ruxandra Pinto1, Gordon D. Rubenfeld1, Paul Ellis2, Brian Bookatz3, John Marshall4, Greg Martinka5, Sean Keenan6, Denny Laporta7, Daniel Roberts8, Anand Kumar8, and the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Patient and organizational factors associated with delays in antimicrobial therapy for septic shock. Am J Respir Crit Care Med. Study concept and design, data analysis, manuscript writing. Principal Author.

3. Ferreyro, Bruno; Angriman, Federico; Giunta, Diego; Lourdes, María; Martínez, Posadas; Vazquez, Fernando; Fernán, Gonzalez Bernaldo de Quirós; Amaral, Andre C. K. B. Scales, Damon C. A predictive score for estimating cancer and death after venous thromboembolism. Chest. Study design and concept, data analysis, manuscript writing. Coauthor or Collaborator.

4. Sinuff, Tasnim; Muscedere, John; Adhikari, Neil; Stelfox, Tom; Rubenfeld, Gordon; Dodek, Peter; Heyland, Daren; Cook, Deborah; Pinto, Ruxandra; Amaral, Andre; Monaharan, Venika; Garland, Allan. Knowledge Translation Interventions for Critically Ill Patients: A Systematic Review. Crit Care Med. Data collection, data analysis, manuscript writing. Coauthor or Collaborator.

In Press: 1. Amaral, Andre. The venous saturation paradox: measure it early, but leave it alone afterwards. Crit

Care Med. Review of original paper, editorial writing. In Press. Principal Author.

Presentations/Lectures: 1. 2012 Oct 31 Invited Speaker. In the midst of the night: challenges in handing over critically ill

patients. Critical Care Canada Forum. Toronto, Ontario, Canada. Presenter(s): Amaral, Andre.

2. 2012 May 26 Invited Speaker. Protocolized care. Hospital Alemao Oswaldo Cruz. Sao Paulo, São Paulo, Brazil. Presenter(s): Andre Amaral.

3. 2012 May 26 Invited Speaker. Conflicts in postoperative hemodynamic management. Hospital Alemao Oswaldo Cruz. Sao Paulo, São Paulo, Brazil. Presenter(s): Andre Amaral.

4. 2012 May 25 Invited Speaker. Handovers. Hospital Alemao Oswaldo Cruz. Sao Paulo, São Paulo, Brazil. Presenter(s): Andre Amaral.

5. 2012 May 23 Presenter. A Quality Improvement Process To Increase Compliance With A Minimal Sedation Protocol. American Thoracic Society. San Francisco, United States. Presenter(s): Andre Amaral.

6. 2012 May 23 Presenter. Improvement In Compliance With Minimal Sedation Protocol Decreases Length Of Mechanical Ventilation. American Thoracic Society. San Francisco, United States. Presenter(s): Andre Amaral.

7. 2012 Feb 14 Presenter. Quality Report for the Dept of Critical Care Medicine. Sunnybrook

Health Sciences Centre - Medical Advisory Committee. Toronto, Ontario, Canada.

8.2012 Jan 12 Presenter. Quality Report for the Dept of Critical Care Medicine. Sunnybrook

Health Sciences Centre - Quality Committee. Toronto, Ontario, Canada. Research Funding: 1. 2013 Jul – 2015 Jul Co-Investigator. Bridging the gap: Implementing a complex intervention

to improve communication and collaboration between surgeons and intensivists in a closed Intensive Care Unit. AFP. PI: Nathens, Avery B. Collaborators: Cuthbertson, Brian H; Coburn, Natalie; Nusdorfer, Linda; Amaral, Andre C.; Gotlib Conn, Lesley; Betts, Martin; Haas, Barbara. 92,126 CAD. [Grants] Study design, grant writing.

2. 2012 Mar – 2014 Feb Co-Investigator. Sepsis: Early antibiotics and resuscitation to control

infected patients in Emergency Departments (SEARCHED Study). Association of Fundraising Professionals (AFP). PI: Hayes, Chris. Collaborators: Bandiera, Glen; Gray, Sara; Barratt, Lee; Gaunt, Karen; Baker, Andrew; Amaral. Andre C K B; Lee, Jacques. 82,455 CAD. [Grants]

3. 2011 Jul – 2013 Jun Co-Investigator. Problem-based learning for postgraduate critical

care training: Implementation and dissemination of a new curriculum to promote CanMEDs roles. RCPSC. CanMEDs research and development grant. PI: Piquette, Dominique. Collaborators: Dev, Shelly; Amaral, Andre. 24,876 CAD. [Grants] Study design, grant writing.

Andrew Baker (St. Michael’s Hospital) Peer Reviewed Publications: 1. Siddiq I, Park E, Liu E, Spratt SK, Surosky R, Lee G, Ando D, Giedlin M, Hare MTG, Fehlings

MG, Baker AJ. Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A. J Neurotrauma. 29(17):2647-59. 2012 Nov SRA 2. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Shiu MY, Baker AJ, Li L, Shek PN, Hoyt DB,

Bulger EM. Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline - without dextran - inhibits neutrophil and endothelial cell activation. J Shock.

2012 Oct; 38(4):341-50. Presentations/Lectures: 1. Nov 2012 Neuro Critical Care. The 9th Annual Krembil Neuroscience Symposium, Toronto. 2. Nov 2012 Park K, Park E, Baker AJ. Cultured endothelial progenitor cells protect ischemic axons

from degenerating after brain injury. Neurotrauma 2012 Symposium. Phoenix, AZ 3. Oct 2012 Understanding Mild Traumatic Brain Injury. Critical Care Forum, Toronto, Ontario.

October 30, 2012. 4. Oct 2012 Moderator: Caring for the Brain-Injured Patient. Critical Care Canada Forum, Toronto,

Ontario. October 30, 2012 5. Oct 2012 Moderator: When ICU admission may not be helpful. CCCF/CCCS Residents Day,

Toronto, Ontario. October 28, 2012. 6. May 2012 Traumatic brain injury and brain protection. Neuroanesthesia Lectures, Toronto, Ontario.

May 9, 2012. Research Funding: 1. 2012 - 2015 Development and innovation of a clinical biomarker for diagnosis of outcome

following mild and moderate traumatic brain injury using endothelial progenitor cell specific markers. Ontario China Research and Innovation Fund, Ministry of Economic Development and Innovation. Role: Principal Investigator. Total Amount: $250,000 CAD.

2. 2012 – 2014 Clinical Evaluation of Blood Biomarkers for Discrimination of Posttraumatic

Stress Disorder and Traumatic Brain Injury Comorbidity. National Defence Research and Development Canada. Role: Principal Investigator. Total Amount: $125,000 CAD

3. 2009-2016 Canadian Institutes of Health Research. From bench to bedside to curbside

Baker AJ: Co-investigator $1,057,000

4. 2011-2016 National Institutes of Health Resuscitation Outcomes Consortium- Core Training

Grant Baker AJ: Co-investigator $335,000

Karen Burns (St. Michael’s Hospital) Peer Reviewed Publications: 1. Wald R, Friedrich O, Bagshaw S, Burns KEA, Garg AX, Hladunewish M, House A, Lapinsky S, ,

Klein D, Pannu NI, Pope K, Richardson I, Thorpe K, Adhikari NKJ. Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI): A randomized controlled pilot trial of hemofiltration vs hemodialysis. Journal of Critical Care. Crit Care. 2012 Oct 24;16(5):R205. [Epub ahead of print].

2. Odutayo A, Adhikari N, Barton J, Burns K, Friedrich JO, Klein D, Lapinsky S, Litwin S, Meret A, Moineddin R, Richardson B, Richardson R, Zaltzman A, Hladunewich M, Wald R. The Epidemiology of Acute Kidney Injury in Canadian Critical Care Units. Can J Anaesth. 2012 Oct; 59(10):934-942.

3. Clark E, Barton J, Bouchard J, Burns KEA, Friedrich JO, Hladunewich M, House A, James MT, Lafrance JP, Levin A, Moist L, Pannu N, Stollery DE, Wald R, Walsh MW, Bagshaw SM for the Canadian Acute Kidney Injury (CANAKI) Investigators. Timing of Renal Replacement Therapy Initiation for Acute Kidney Injury in Canadian Intensive Care Units. Can J Anaesth 2012; 59 (9): 861-70.

4. Friedrich JO, Wald R, Bagshaw SM, Burns KE, Adhikari NKJ for the University of Toronto Acute Kidney Injury Research Group. Hemofiltration compared to hemodialysis for acute kidney injury: systematic review and meta-analysis. Crit Care Med 2012.16(4):R146.

5. Lutz K, Wilton K, Zytaruk N, Julien L, Hall R, Harvey J, Skrobik Y, Vlahakis N, Meade L, Matte A, Meade M, Burns K, Albert M, Barlow Cash B, Vallance S, Klinger JR, Heels- Ansdell D, Cook DJ. Research Ethics Board Approval for an International Thromboprophylaxis Trial. For the Protect Investigators in Collaboration with the CCTG and ANZICS. Journal of Critical Care 2012;27:225-31.

6. Wald R, Quinn R, Adhikari N, Burns K, Friedrich JO, Garg ZX, Harel Z, Hladunewich M, Luo J, Mamdani M, Perl J, Ray JG for the University of Toronto Acute Kidney Injury Research Group. The Risk of Chronic Dialysis Among Acute Kidny Injury Survivors. Am J Med. Am J Med. 2012 Jun;125(6):585-93. Epub 2012 Apr 18.

7. Rose L, Gray S, Burns K, Atzema C, Kiss A, Worster A, Scales D, Rubenfeld G, Lee J. Emergency department length of stay for patients requiring mechanical ventilation: a prospective observational study. Scand J Trauma Resusc Emerg Med. 2012 Apr 11;20:30.

8. Duffett M, Burns KE, Adhikari NK. Quality of reporting of surveys in critical care journals: A methodologic review. Crit Care Med 2012; 40:441-449.

9. Menon K, Ward RE, Gaboury I, Thomas M, Joffe A, Burns K, Cook D. Factors affecting consent in pediatric critical care research. Intensive Care Med. 2012 Jan;38(1):153-9. doi: 10.1007/s00134-011-2412-0. Epub 2011 Nov 26.

10. McMullen SM, Meade M, Rose L, Burns KEA, Mehta S, Doyle R, Henzler D. Partial Ventilatory Support Modalities in Acute Respiratory Failure: A Systematic Review. Plos One 2012:7(8):e40190.

Non-Peer Reviewed Abstracts: 1. Chant C, Burns K. Effect of intravenous β-2 agonist treatment on clinical outcomes in acute

respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial. ACP Journal Club. 2012;156(5):JC5-6

2. Mehta S, Devlin J, Meade M, Cook D, Skrobik Y, Fergusson D, Steinberg M, Granton J, Ferguson N, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafsonj K, Keenan S, Reynolds S, Kusogiannis J, Mallick R, Burry L. Delirium, Sub-syndromal delirium, Antipsychotic Use and Associated Clinical Outcomes for Critically Ill Mechanically Ventilated patients Participating in the SLEAP Multicentre Randomized Trial. Intensive Care Medicine. Intensive Care Medicine 2012; 38(1):S128.

Presentations/Lectures: 1. The Approach Trial. Canadian Critical Care Trials Group. Toronto, Ontario, Canada. November 2,

2012.

2. Practices in End of Life Care and Mechanical Ventilation Discontinuation: A Nested Study Within an International Observational Study. Canadian Critical Care Trials Group. Toronto, Ontario, Canada. November 2, 2012

3. Consent Issues in Critical Care Research. Critical Care Canada Forum. Toronto, Ontario. October 30, 2012

4. Deferred Consent in ICU/Resuscitation Research. St Michael’s Hospital Clinical and Population Health Rounds. Toronto, Ontario, Canada. February 16, 2012.

Research Funding: 1. One Day Point Prevalence of Acute Rehabilitation: Rates of, Barriers to and Facilitating Factors for

Mobilization in Canadian Intensive Care Units. Academic Medical Organizaiton of Southwestern Ontario. AFP Innovation Fund. Role: Co-Investigator. Total amount: $102,183.9.

2. One Day Point Prevalence of Acute Rehabilitation: Rates of, Barriers to and Facilitating Factors for

Mobilization in Canadian Intensive Care Units. Physician Services Incorporated. Role: Co-Investigator. Total amount: $58,000.

3. Clinician Scientist – Phase 2 salary support renewal. Canadian Institutes of Health Research.

$180,000 CAD. Toronto, Ontario

Martin Chapman (Sunnybrook Health Sciences Centre) Abstracts: 1. Barriers To Implementing EEG Monitoring Technology In Critical Care: A Scoping Review Of ICU

Available Neuromonitoring Technology C Davies-Schinkel, AGagliardi, GB Young, M Chapman, A Capone, R Pinto, D Zygun, R Fowler (Presented at ATS 2012, San Francisco) Am J RespirCrit Care Med 2012;185:A1619

2. Barriers To Implementing EEG Monitoring Technology In Critical Care: A Dichotomy Between Perceived Need And Clinical Practice C Davies-Schinkel, A Gagliardi, M Chapman, R Pinto, A Capone, GB Young, C Hahn, D Zygun, R Fowler (Presented at ATS 2012, San Francisco) Am J RespirCrit Care Med 2012;185:A1618

Robert Chen (St. Michael’s Hospital) Peer Reviewed Publications: 1. Chen R. (Book and New Media Reviews). Clinical Anesthesiology Guide- Cardiac Anesthesia &

Transesophageal Echocardiography. Wasnick JD et al (eds.) McGraw Hill Lange 2011. Can J Anaesth. 2012 May

2. Hu R, Tousignant C, Chen R. Flow velocity patterns in the pulmonary artery and pulmonary

hypertension. Can J Anaesth. 2012 Apr 19 Presentations/Lectures: 1. October 28, 2012, Canadian Critical Care Forum, Toronto ON. Workshop: FOCUS TTE.

Demonstrator

2. September 23, 2012, Canadian Association of Pediatric Surgeons Annual Meeting, Victoria BC. Workshop: Screening ultrasound for surgeons. Course director and demonstrator.

3. June 18, 2012, Canadian Anesthesiologists’ Association Annual Meeting. Quebec QC Chair: Interesting TEE cases

4. June 16, 2012, Canadian Anesthesiologists’ Association Annual Meeting, Quebec QC, Workshop: Bedside resuscitation ultrasound (Lecturer and demonstrator)

5. May 27, 2012, Canadian Critical Care Ultrasound Society meeting: Hemodynamics 2012. Lecture and Hands-on demonstration: Transcranial Doppler

Michael Christian (Mount Sinai Hospital) Peer Reviewed Publications: 1. Talbot M, Meunier B, Trottier V, Christian M, Hillier T, Berger CW, Taylor JES. 1 Canadian Field

Hospital in Haiti: Surgical experience in earthquake relief. Can J Surg. 2012 Aug;55(4):271-4. doi: 10.1503/cjs.001411. Review. Coauthor or Collaborator.

2. Katsios CM, Burry L, Nelson S, Bell CM, Jivraj T, Lapinsky SE, Wax RS, Christian M, Mehta S, Morris AM. An Antimicrobial Stewardship Program Improves Antimicrobial Treatment by Culture Site and the Quality of Antimicrobial Prescribing in Critically Ill Patients. Critical Care. 2012 Nov 5;16(6):R216. Coauthor or Collaborator.

Non-Peer Reviewed Publications: 1. Christian MD. Collateral impact of a hospital outbreak of Clostridium difficile: an unrecognized surge

event requiring a system-level response. Healthc Q. 2012;15(3):66-72. Principal Author.

Presentations/Lectures: 1. 2012 Oct 29 Co-Author/Presenter. Mass casualty simulation for critical care residents. Critical Care

Canada Forum 2012. Toronto, Ontario, Canada. Presenter(s): Maude St. Onge. St-Onge M, Beckett A, Abrahamson S, Mazurik L, Piquette D, Hawryluck L, Scales D, Thompson M, Christian M University of Toronto.

2. 2012 Aug Co-Author. Trainee Satisfaction with a Blended Learning Experience as Part of a Simulation-Based Advanced Cardiac Life Support Recertification Course. Association for Medical Education in Europe (AMEE). Presenter(s): Dr. Luke Devine

3. 2012 Jul 13 Facilitator. Disaster/Humanitarian Relief. Advanced Military Trauma Resuscitation Program - Canadian Forces Trauma Training. Montreal, Quebec, Canada.

4. 2012 Jul 13 Facilitator. Mass Casualty Simulations. Advanced Military Trauma Resuscitation Program - Canadian Forces Trauma Training. Montreal, Quebec, Canada

5. 2012 Jul 12 Facilitator. Simulations. Advanced Military Trauma Resuscitation Program - Canadian Forces Trauma Training. Montreal, Quebec, Canada.

6. 2012 Jul 9 Facilitator. Airway Skills. Advanced Military Trauma Resuscitation Program - Canadian Forces Trauma Training. Montreal, Quebec, Canada..

7. 2012 Jul 9 Facilitator. Mechanical Ventilation Skills. Advanced Military Trauma Resuscitation Program - Canadian Forces Trauma Training. Montreal, Quebec, Canada.

8. 2012 Mar 16 Invited Speaker. SARS - Lessons for Emergency Preparedness. Argerich Hospital. Buenos Aires, Argentina.

9. 2012 Mar 9 Facilitator. Course Instruction. Advanced Military Trauma Resuscitation Program - Canadian Forces Trauma Training. Montreal, Quebec, Canada.

Research Funding: 1. 2011 Oct - 2012 Mar Principal Investigator. Planning Meeting for the PREEDICCT Study.

Canadian Institute for Health Research. Planning Grannts. MPI-117659. Collaborators: R Fowler, D Fisman, D Zygun, J Marshall. 23,842 CAD. [Grants].

Peter Cox (Hospital for Sick Children) Peer Reviewed Publications: 1. Drake M., COX, PN: End of Life Decision Making in a Pediatric Patient with SMA Type 2: The

Influence of the Media, Neurology, 2012

Presentations/Lectures: 1. 2012 Aug Invited Speaker. Quality of Care , Communication, Early de-intensifcation- who and

how? Critical 4 Africa Conference. South Africa.

2. 2012 Aug Invited Lecturer. Evolution & Adaptation, Respiratory mechanics in ARDS. IX Pediatric & Neonatal Mechanical Ventilation Symposium. Sao Paolo, Brazil.

3. 2012 Feb Invited Speaker. Pulmonary Pathophysiology. 28th Annual CNMC Symposium: ECMO & the Advanced Therapies for Respiratory Failure. Keystone.

4. 2012 Feb Organizing Committee // Invited Speaker. Social Media - getting on the right side of it! Annual Canadian Critical Care Conference. Whistler, British Columbia.

Brian H. Cuthbertson (Sunnybrook Health Sciences Centre) Peer Reviewed Publications: 1. Reader, TW, Cuthbertson BH, Challenges in using high-fidelity simulation to improve learning and

patient safety. Resuscitation. 2012 Nov; 83(11): 1317-1318.

2. Islam R , Tinmouth AT , Francis JJ , Brehaut JC , Born J ,Stockton C ,Stanworth SJ , Eccles MP , Cuthbertson BH, Hyde C , Grimshaw, JM. A cross-country comparison of intensive care physicians' beliefs about their transfusion behaviour: A qualitative study using the theoretical domains framework. Implementation Science: IS. 2012 Sept; 7: 1-16.

3. Biccard BM , Lurati Buse GA , Burkhart C, Cuthbertson BH, Filipovic M , GibsonSC , Mahla E, Leibowitz DW , Rodseth RN. The influence of clinical risk factors on pre-operative B-type natriuretic peptide risk stratification of vascular surgical patients. Anaesthesia. 2012 Jan; 67(1): 55- 59.

Abstracts: 1. Seppelt I, Marshall A,Dan A, Cole L,Weisbrodt L, Glass P,Myburgh J, Finfer S,Lipman J, Paterson D,

Francis J, Cuthbertson BH. An InternationalDELPHI Study examining thepercevied risks, benefits and barriers to the use of selective decontamination of the digestive tract (SDD) in Intensive Care.

2. Vanniyasingam T, Rodseth R, Lurati Buse G, Bolliger D, Burkhart C, Cuthbertson BH, Gibson S, Mahla E, Leibowitz D, Bicca B. Using the Minimum P-Value Method to Predict the Occurrence of Cardiovascular Complications within 30 Days of Vascular Surgery. June 2012. Statistical Society of Canada Annual Meeting.

3. Herridge M, Chu LM, Matte AL, Chan L, Tomlinson G, Ferguson ND, Sinuff T, Cuthbertson BH, Fan E, Slutsky AS, Leung G, Moody AR, Levasseur M, Marshall JC, Cook D, Cameron JI, et al. Long-Term Patient Outcomes After Prolonged Mechanical Ventilation: The Towards RECOVER Study. May 2012. American Thoracic Society Conference.

4. Herridge M, Chu LM, Matte AL, Chan L, Tomlinson G, Ferguson ND, Sinuff T, Cuthbertson BH, Fan E, Slutsky AS, Leung G, Moody AR, Levasseur M, Marshall JC, Cook D, Cameron JI, et al. Long-Term Outcomes After Prolonged Mechanical Ventilation: Family Caregivers Outcomes from the Towards RECOVER Study, May 2012. American Thoracic Society Conference.

Presentations/Lectures: 1. 2012 May 15 ICU Short and Long Term Outcomes. ICU Resident Seminar Series –

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre. Toronto, ON.

2. 2012 Mar 3 Results of the FOCCUS study. Intensive Care & Emergency Medicine

Symposium. Belgium. 3. 2012 Mar 20 Long Term Outcomes. Intensive Care & Emergency Medicine

Symposium. Belgium. Research Funding: 1. 2012 Apr – 2016 Mar Principal Investigator. The METS (Measurement of Exercise Tolerance

before Surgery) Study: An International Multicentre Prospective Cohort Study of Cardiopulmonary Exercise Testing For Improving Preoperative Risk Stratification for Major Non-Cardiac Surgery. $987, 066 CAD [Grant]

2. 2012 Oct – 2013 Sept Co-Investigator. A Systematic and Methodological Review of Neuromuscular Electrical Stimulation in the Intensive Care Unit. Canadian Institutes of Health Research (CIHR) $99,996 CAD [Grant]

3. 2011 Oct – 2012 Oct Co-Investigator. SuDDICU Study of Selective Decontamination of the

Digestive Tract in ICU. Australian and New Zealand Intensive Care Foundation. $40,000 CAD [Grant]

4. 2011 Jan – 2012 Jun Co-Investigator. SuDDICU Study of Selective Decontamination of the

Digestive Tract in ICU. Australian and New Zealand Intensive Care Foundation. $80,000 CAD [Grant]

5. 2010 Nov – 2012 May Principal Investigator. SuDDICU Study of Selective Decontamination of

The Digestive Tract in ICU. Canadian Institutes of Health Research (CIHR) $198,322 CAD [Grant]

6. 2010 Jan – 2012 Jan Principal Investigator. SuDDICU Study of Selective Decontamination of

The Digestive Tract in ICU. Health Technology Assessment. $480,000 CAD. [Grant]

Shelly P. Dev (Sunnybrook Health Sciences Centre) In Press: 1. SP Dev, A Stefan, S Lee. Videos in Clinical Medicine: Intraosseous Needle Insertion in the Adult. N

Engl J Med. In Review. In Press. Principal Author.

2. SP Dev, A Stefan, S Lee. Videos in Clinical Medicine: Intraosseous Needle Insertion in the Adult. N Engl J Med. In Review. In Press. Principal Author.

Presentations/Lectures: 1. 2012 Dec Invited Speaker. Nothing to LOL About: Multimedia, Education & One

Teacher’s Quest to Reach the Millennial Learner. Grand Rounds, Department of Medicine, Sunnybrook Health Sciences Centre. Ontario, Canada.

2. 2012 Sep Interviewee. Profiling Distinguished Alumni. Interviewer: Our Kids: The Trusted

Source. Our Kids: The Trusted Source. Ontario, Canada. present. Available from: http://www.ourkids.net/tv/video-detail/shelly-dev-–-the-creative-doctor/148.

3. 2012 May Invited Speaker. Finger on the Pulse: What’s New in Critical Care. Critical Care

Department Education Practice Council, Sunnybrook Health Sciences Centre. Toronto, Ontario, Canada. Presentation to Critical Care Nurses at their Annual Education Retreat. (Continuing Education).

4. 2012 May Facilitator. Intensive Care Unit Procedures, Ultrasound and New Devices.

American Thoracic Society. San Francisco, California, United States. 5. 2012 May Presenter. Little Brother is Watching: Understanding the Hidden Curriculum.

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre. Toronto, Ontario, Canada. Grand Rounds Presentation.

Research Funding: 1. 2012 Jul - present Consultant/Producer. Numbers and Narratives: Examining the effects of

two types of structured feedback on internal medicine residents’ recall and subsequent generation of learning goals after feedback. University of Toronto, Department of Medicine. Educational Scholarship & Research Competition. PI: Stroud, Lynfa. 10,000 CAD. [Contracts]

2. 2012 Jul – present Consultant/Producer. Just Wash Your Hands. Sunnybrook Health Sciences Centre. Infection Control. Collaborator(s): De Mendonca, Ben. 30,000 CAD. [Contracts]

3. 2011 Mar - present Principal Investigator. Is a Multimedia-Based Teaching Tool as Effective As Bedside Teaching? Proposal for a Validation Study. Education Development Fund, University of Toronto. Educational Development Fund Grant. Collaborator(s): Chow, Chi-Ming and Bandiera, Glenn. 4,993 CAD. [Grants]

Claudia Dos Santos (St. Michael’s Hospital) Peer Reviewed Publications: 1. Dos Santos CC, Batt J. ICU-acquired weakness: mechanisms of disability. Curr Opin Crit

Care. 2012 Oct;18(5):509-17.

2. Srinivas Murthy, Pingzhao Hu, Yuexin Shan, Jack Haitsma, Shirley Mei, Duncan Stewart, Conrad Liles. Network analysis of transcriptional responses induced by mesenchymal stem cell treatment of experimental sepsis. Am J Pathol. 2012 Nov;181(5):1681-92. doi: 10.1016/j.ajpath.2012.08.009

3. Smeding L, Leong-Poi H, Hu P, Shan Y, Haitsma JJ, Horvath E, Furmli S, Masoom H, Kuiper JW, Slutsky AS, Parker TG, Plötz FB, dos Santos CC. Salutary effect of resveratrol on sepsis-induced myocardial depression. Critical Care Medicine. Crit Care Med. 2012 Jun;40(6):1896-907. doi: 10.1097/CCM.0b013e31824e1370

4. Dos Santos CC. The role of the inflammasome in ventilator-induced lung injury. Am J Respir Crit Care Med. 2012 Jun 1;185(11):1141-4. doi: 10.1164/rccm.201204-0649ED

5. Oyaizu T, Fung SY, Shiozaki A, Guan Z, Zhang Q, Dos Santos CC, Han B, Mura M, Keshavjee S, Liu M. Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury. Intensive Care Med. 2012 May;38(5):894-905. doi: 10.1007/s00134-012-2498-z. Epub 2012 Feb 17

6. Rocco PR, Dos Santos C, Pelosi P. Pathophysiology of ventilator-associated lung injury. Curr Opin Anaesthesiol. 2012 Apr;25(2):123-30. PMID: 22395439.

7. Aslami H, Haitsma JJ, Hofstra JJ, Florquin S, Dos Santos C, Streutker C, Zhang H, Levi M, Slutsky AS, Schultz MJ. Plasma-derived human antithrombin attenuates ventilator-induced coagulopathy but not inflammation in a Streptococcus pneumoniae pneumonia model in rats. J Thromb Haemost. 2012 Mar;10(3):399-410. doi: 10.1111/j.1538-7836.2012.04622.

Presentations/Lectures: 1. Transcriptional regulation in VILI. Canadian Critical Care Forum, Toronto, Ontario. November 15,

2012 2. MSC in the treatment of experimental sepsis. Canadian Critical Care Forum, Toronto, Ontario.

November 15, 2012 3. Omics in ALI/ARDS: identification of novel targets for therapy. Canadian Critical Care Forum,

Toronto, Ontario. November 14, 2012 4. Role of ATF3 in ALI/VILI-induced apotosis. European Society of Intensive Care Medicine. Lisbon,

Portugal. October 15, 2012 5. Overview of translational medicine research program. University of Toronto, Toronto, Ontario.

September 28, 2012 6. Microarray meta-analysis identifies clinically relevant acute lung injury. 11th International Conference

on Complexity in Acute Illness (ICCAI) 2012. Ottawa, Ontario. September 7, 2012 7. Identifying molecular markers of clinically relevant acute lung injury. 11th International Conference on

Complexity in Acute Illness (ICCAI) 2012. Ottawa, Ontario. September 7, 2012

8. Neuroimmune regulation of ALI/VILI. Spanish Critical Care Society Meeting. Santander, Spain. June 11, 2012.

9. Application of genomic technology to AL. Spanish Critical Care Society Meeting. Santander, Spain. June 11, 2012

10. Genomica de la lesion pulmonary aguda. Spanish Critical Care Society Meeting. Santander, Spain.

June 10, 2012.

11. Oxygen therapy in critically ill patients. European Respiratory Society Online Course on OxygenTherapy. Canada. May 22, 2012

12. Transcriptional responses induced by MSCs in experimental sepsis. American Thoracic Society

Meeting. San Francisco, USA. May 21, 2012

13. Discussion facilitator for thematic poster discussion. American Thoracic Society Meeting. San Francisco, USA. May 20, 2012

14. Systems approach to identifying novel molecular targets for VILI. Hospital for Sick Children Critical

Care Research Rounds. Toronto, Ontario. April 27, 2012

15. The role of ATF3 in acute and ventilator induced lung injury. Pulmonary Grand Rounds. Philadelphia, USA. February 15, 2012

16. Systems approach to identifying novel molecular targets for VILI. Visiting Scientist. Philadelphia,

USA. February 15, 2012

17. Transcriptional responses induced by MSC administration in experimental sepsis. Cardiovascular repair using enhanced stem cell therapy (CREST) project meeting. Ottawa, Canada. February 13, 2012

18. Biomarkers for Oscillate. Canadian Critical Care Translational Biology Group Meeting. Lake Louise, Canada. January 26, 2012

19. Biomarkers for RECOVER. Canadian Critical Care Translational Biology Group Meeting. Lake Louise, Canada. January 22, 2012

20. Expression profiling provides new insights into sepsis induced myocardial depression. Cardiology Research Rounds. Toronto, Ontario. January 18, 2012.

Research Funding: 1. Informed discovery of novel targets for therapy. Canadian Institutes of Health Research (CIHR).

Role: Principal applicant. Total amount: 562,000. March 2012 – March 2017.

2. Student Award -St. Michael’s Hospital – Li Ka Shing Knowledge Intitute Scholarship. St. Michael’s Hospital, Toronto. Role: Principal applicant. Total amount: 10,000. June 2012 – May 2013.

Eddy Fan (Mount Sinai Hospital) Peer Reviewed Publications: 1. Fan E. Critical illness neuromyopathy and early rehabilitation in the chronically critically ill.

Respiratory Care. 2012;57:933-946. Principal Author.

2. Fan E, Gifford JM, Chandolu S, Colantuoni E, Pronovost PJ, Needham DM. The functional comorbidity index had high inter-rater reliability in patients with acute lung injury. BMC Anesthesiology. 2012;12:21. Principal Author.

3. Ferguson ND, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, Rhodes A, Slutsky AS, Vincent JL, Rubenfeld GD, Thompson BT, Ranieri VM. The Berlin definition of ARDS: An expanded rationale, justification, and supplementary material. Intensive Care Medicine. 2012;38:1573-1582. Coauthor or Collaborator.

4. Fan E, Checkley W, Stewart TE, Muscedere J, Lesur O, Granton JT, Freitag AP, Jacka M, Ferguson ND, Meade MO. Complications from recruitment maneuvers in patients with acute lung injury: secondary analysis from the Lung Open Ventilation study. Respiratory Care. 2012;57:1842-1849. Principal Author.

5. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS, for the ARDS Definition Task Force. Acute respiratory distress syndrome: The Berlin definition. Journal of the American Medical Association. 2012;307:2526-2533. Coauthor or Collaborator.

6. Lee CM, Fan E. ICU-acquired weakness: What is preventing rehabilitation in the awake, calm, cooperative and mobile patient? BMC Medicine. 2012;10:115. Senior Responsible Author.

Review Articles, Letters& Editorials: 1. Patterson T, Fan E. Recruitment maneuvers in patients with acute lung injury. European Respiratory

Monograph. 2012;55:40-53. (Trainee publication, Supervised Dr. Tim Patterson). Senior Responsible Author.

2. Fan E and Guerguerian AM. Extracorporeal life support for acute respiratory failure: Now and moving forward. Critical Care Rounds. 2012;8(6):1-8. Co-Principal Author.

In Press: 1. Rahimi RA, Skrzat J, Reddy DR, Zanni JM, Fan E, Stephens RS, Needham DM. Physical

rehabilitation of intensive care patients requiring extracorporeal membrane oxygenation: a small case series. Phys Ther. 2012. In Press. Coauthor or Collaborator.

2. Kho ME, Truong AD, Brower RG, Palmer JB, Fan E, Zanni JM, Ciesla ND, Feldman DR, Korupolu R, Needham DM. Neuromuscular electrical stimulation for ICU-acquired weakness: protocol and methodological implications for a randomized, sham-controlled phase II trial. Physical Therapy Journal. In Press. Coauthor or Collaborator.


1. Fan E, Dowdy DW, Colantuoni, E, Mendez-Tellez PA, Sevransky JE, Shanholtz C, Himmelfarb CRD, Desai SV, Ciesla N, Herridge MS, Pronovost PJ, Needham DM. Physical complications in acute lung injury survivors: a 2-year longtudinal prospective study. Am J Respir Crit Care Med. Submitted. Principal Author.

2. Fan E, Brower R, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, Hopkins R, Hough T, Kress JP, Latronico N, Moss M, Needham D, Rich M, Stevens R, Winkleman C, Zochodne D, Ali N, on behlaf of the ATS Consensus Panel on Definitions and Assessments for ICU-Acquired Weakness. An Official ATS Clinical Practice Guideline: The diagnosis of intensive care unit acquired weakness. Am J Respir Crit Care Med. Submitted. Principal Author.

3. Fan E, Villar J, Slutsky A. Novel approaches to minimize ventilator-induced lung injury. BMC Med. 2012. Principal Author.

4. Fan E, Brower R, Cheek F, Chlan L, Gosselink R, Hart N, Herridge M, Hopkins R, Hough T, Kress JP, Latronico N, Moss M, Needham D, Rich M, Stevens R, Winkleman C, Zochodne D, Ali N, on behalf of the ATS Consensus Panel on Definitions and Assessments for ICU-Acquired Weakness. An Official ATS Clinical Practice Guideline: The diagnosis of intensive care unit acquired weakness. Am J Respir Crit Care Med. Principal Author.

5. Wilcox ME, Chong CAKY, Niven DJ, Rubenfeld GD, Rowan KM, Wunsch H, Fan E. Intensivist staffing pattern and mortality in critically ill patients: a systematic review with meta-analysis. Crit Care Med. Senior Responsible Author.

Abstracts:

1. Farias P, Wheeler K, Mew E, Fan E, Singh JM. Challenges in assessing delirium in the neurointensive care unit. American Journal of Respiratory and Critical Care Medicine. 2012;185:A4015. Coauthor or Collaborator.

2. Mew E, Farias P, Wheeler K, Fan E, Singh JM. A quality improvement initiative to screen for ICU delirium, improve sedation practices, and ensure timely liberation from mechanical ventilation. American Journal of Respiratory and Critical Care Medicine. 2012;185:A1614. Coauthor or Collaborator.

3. Pearmain L, Steel A, Lazar N, Pierre A, Hawryluck L, Fan E, Chu LM, Chan L, Matte AL, Cameron JI, Herridge MS. Venoarterial extracoroporeal membrane oxygenation (ECMO) for hemodynamic collapse from toxic shock syndrome and H3N2 influenza. American Journal of Respiratory and Critical Care Medicine. 2012, 185:A6018. Coauthor or Collaborator.


1. 2012 Dec 3 Invited Speaker. To Breathe or Not to Breathe - Spontaneous Breathing in ARDS. Mount Sinai Hospital RT Education Day. Toronto, Ontario, Canada.

2. 2012 Oct 31 Invited Speaker. Delirium: Quality of Care Can Prevent It - A Tale of Two Institutions. Canada Critical Care Forum. Ontario, Canada.

3. 2012 Oct 30 Facilitator. Ventilation - Monitoring and Spontaneous Breathing. Canada Critical Care Forum. Toronto, Ontario, Canada.

4. 2012 Oct 30 Facilitator. Systematic Reviews - Scientific Poster Session Adjudicator. Canada Critical Care Forum. Toronto, Ontario, Canada.

5. 2012 Oct 30 Facilitator. Assessing and Preventing Delirium. Canada Critical Care Forum. Toronto, Ontario, Canada.

6. 2012 Oct 30 Invited Speaker. Mechanical Ventilation for Patients on ECMO - How, Why, Future Studies. Canada Critical Care Forum. Ontario, Canada

7. 2012 Oct 29 Invited Speaker. ICU-Acquired Weakness in Survivors of Critical Illness. Canada Critical Care Forum. Ontario, Canada.

9. 2012 Oct 20 Distinguished Speaker. Improving Outcomes After Critical Illness - The Awake, Calm, Cooperative, and Mobile ICU Patient. Cardiorespiratory Physical Therapy and Early Mobility Skills in Acute Care. Toronto, Ontario, Canada.

10. 2012 Aug 15 Speaker. Building the Future – One Breath at a Time…. Department of Medicine Grand Rounds, University Health Network and Mount Sinai Hospital. Toronto, Ontario. (Continuing Education).

11. 2012 Jul 25 Invited Speaker. Get ‘Em Moving – Early Mobility for Ventilator-Dependent Patients. American Association for Respiratory Care Professor’s Rounds. Dallas, Texas, United States

12. 2012 Jun 28 Invited Speaker. Pro-Con: HFO or VV ECMO for Severe ARDS. International Course of ECMO and Short Term Circulatory/Respiratory Support. Paris, France.

13. 2012 May 21 Facilitator. Intensive Care Unit Physiotherapy and Weaning: Mind over Muscle? Thematic Poster Session Adjudicator. American Thoracic Society International Meeting. San Francisco, California, United States.

14. 2012 May 21 Invited Speaker. Extracorporeal Gas Exchange as a Bridge to Lung Transplant. American Thoracic Society International Meeting. San Francisco, California, United States.

15. 2012 May 19 Invited Speaker. Physical Complications in Survivors of Acute Lung Injury: 2 Year Follow Up. 5th International Meeting of Physical Medicine and Rehabilitation in the Critically Ill. San Francisco, California, United States

16. 2012 Apr 27 Invited Speaker. Long Term Outcomes in Survivors of Sepsis. Clinical Focus – Sepsis-Related Respiratory Failure. Society for Critical Care Medicine. Boston, Massachusetts, United States.

17. 2012 Apr 27 Invited Speaker. Mobilization and Ambulation of the Mechanically Ventilated Patient. Clinical Focus – Sepsis-Related Respiratory Failure. Society for Critical Care Medicine. Boston, Massachusetts, United States.

18. 2012 Apr 26 Invited Speaker. Approaches to Refractory Hypoxemic Respiratory Failure. Clinical Focus – Sepsis-Related Respiratory Failure. Society for Critical Care Medicine. Boston, Massachusetts, United States

19.2012 Apr 3 Invited Speaker. Wake Up, Get Up, and Get Out Early: ICU-Acquired Weakness and Early Mobility in the ICU. St. Joseph’s Health Centre. Toronto, Quebec, Canada.

20. 2012 Mar 22 Invited Speaker. ICU-Acquired Weakness in 2012. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

21.2012 Mar 22 Invited Speaker. Delirium – Quality of Care Can Prevent It. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

22.2012 Mar 22 Facilitator. Ventilator-Associated Pneumonia. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

23. 2012 Mar 20 Facilitator. Poster Session Adjudicator. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

24. 2012 Mar 20 Invited Speaker. Refractory Hypoxemia in ARDS. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

25. 2012 Jan 29 Invited Speaker. Mechanical Ventilation. Ontario Thoracic Society. Toronto, Ontario, Canada. Ontario Respiratory Resident’s Symposium – Better Breathing Conference.

26. 2012 Jan 12 Invited Speaker. Wake Up, Get Up, and Get Out Early: ICU-Acquired Weakness and Early Mobility in the ICU. Mississauga Halton LHIN. Oakville, Ontario, Canada.

Research Funding: 1. 2012 Mar - 2013 Jul Co-Investigator. One Day Point Prevalence Study of Barriers to Acute

Rehabilitation in Ontario Intensive Care Units. Physician Services Incorporated (PSI) Foundation. PI: Koo KKY. 58,234.9 CAD. [Grants]

2. 2012 Mar - 2013 Feb Co-Investigator. One Day Point Prevalence Study of Barriers to Acute Rehabilitation in Ontario Intensive Care Units. Academic Health Sciences Centre AFP Innovation Fund. Academic Medical Organization of Southwestern Ontario -AMOSO. PI: Koo KKY. 102,183.9 CAD. [Grants]

3. 2012 Jan - 2013 Dec Principal Investigator. Understanding Barriers to Early Rehabilitation in the Intensive Care Unit Using the Toronto ICU Registry (TICUR) Project. University of Toronto. Department of Medicine Strategic Planning Innovation Fund. 75,000 CAD. [Grants]

4. 2011 Jul - 2014 Jun Co-Investigator. Understanding Long-Term Mechanical Ventilation in Canada: A Programmatic Approach. Canadian Institutes of Health Research (CIHR). Partnerships for Health Systems Improvement (PHSI). PI: Rose, L. 349,863 CAD. [Grants]

5. 2011 May – 2012 Apr Co-Investigator. A Prospective Evaluation of the Association Between

Psychoactive Medications and Delirium In Critically Ill Adults. University of Toronto. Leslie Dan Faculty of Pharmacy. PI: Burry, Lisa. 25,000 CAD. [Grants]

6. 2008 Jul – 2012 Jun Co-Investigator. Improving Long-Term Physical and Mental Health

Outcomes After Acute Lung Injury. National Heart, Lung, and Blood Institute (NHLBI) (USA). R01 HL088045-01. PI: Pronovost PJ and Needham DM. 1,911,194 USD. [Grants]

7. 2007 Jul – 2012 Jun Principal Investigator. Corticosteroids and Long-Term Weakness After

Acute Lung Injury. Canadian Institutes of Health Research (CIHR). Fellowship Award #MFE-81972. 300,000 CAD. [Grants] Supervisor: Pronovost PJ, Johns Hopkins University.

Niall Ferguson (Mount Sinai Hospital) Peer Reviewed Publications: 1. Golan E, Vasquez DN, Ferguson ND, Adhikari NK, Scales DC. Prophylactic magnesium for

improving neurological outcome after aneurysmal subarachnoid hemorrhage: systematic review and meta-analysis. Journal of Critical Care. 2012. Co-Principal Author.

2. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gardlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD, for the PROWESS-SHOCK Study Group. Drotrecogin Alfa (Activated) in Adults with Septic Shock. New England Journal of Medicine. 366:2055-64. Collaborator.

3. Ferguson ND, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, Rhodes A, Slutsky AS, Vincent JL, Rubenfeld GD, Thompson BT, Ranieri VM. The Berlin Definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Medicine. 2012; 38:1573-1582. Intensive Care Medicine. 2012; 38:1573-1582. Principal Author.

4. The NICE-SUGAR Study Investigators. Hypoglycemia and Risk of Death in Critically Ill Patients. New England Journal of Medicine. 2012; 367:1108-1118. Collaborator.

5. Mehta S, Burry L, Cook DJ, Fergusson D, Steinberg M, Granton JT, Herridge MS, Ferguson ND, Devlin J, Tanois M, Dodek P, Fowler RA, Burns K, Jacka M, Olafson K, Skrobik Y, Hebert P, Sabri E, Meade MO for the SLEAP Investigators and Canadian Critical Care Trials Group. Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for with a Sedation Protocol: A Randomized Trial. JAMA. Nov 21;308(19):1985-92. Co-Principal Author.

6. Barrett KA, Ferguson ND, Athaide V, Cook DJ, Friedrich JO, McDonald E, Pinto R, Smith OM, Stevenson J, Scales DC. Surrogate Decision Makers’ Attitudes Towards Research Decision-Making for Critically Ill Patients. Intensive Care Medicine. 38:1616-1623. Senior Responsible Author.

7. The ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camproto L, Slutsky AS. Acute Respiratory Distress Syndrome: The Berlin Definition. JAMA. 307:2526-2533. Co-Principal Author.

8. Goligher EC, Ferguson ND, Kenny LP. Core Competency in Mechanical Ventilation: Development of Educational Objectives Using the Delphi Technique. Critical Care Medicine. 40:2828-2832. Senior Responsible Author.

9. Fan E, Checkley W, Stewart TE, Meade MO, Ferguson ND. Complications from Recruitment Maneuvers in Patients with Acute Lung Injury: Secondary Analysis from the Lung Open Ventilation Study. Respiratory Care. 57:1842-1849. Senior Responsible Author.

10. Terblanche M, Kruger P, di Gangi S, Gearay S, Gilfeather L, Ferguson ND, Pearse R, Beale R, Rhodes A, Brett S, McAuley DF. Risk factors to acute organ failure in ICU patients who receive respiratory support in the absence of non-respiratory organ failure: an international, prospective cohort study. Critical Care. 2012; 16:R61. Co-Principal Author.

Review Articles, Letters, and Editorials: 1. Goligher EC, Ferguson ND. Utility of Draining Pleural Effusions in Mechanically Ventilated Patients.

Current Opinion in Pulmonary Medicine. Narrative Review 2012;18:359-65. Senior Responsible Author

2. Ferguson ND. Low Tidal Volumes for All? JAMA. 2012; 308:1689-1690. Principal Author.

Abstracts: 1. J.I. Cameron, L. Chan, A.I. Czerwonka, L.M. Chu, A.L. Matte, N.D. Ferguson, S. Mehta, J. Friedrich,

N. Adhikari, R. Fowler, D.J. Cook, J.C. Rudkowski, H. Meggison, S.E. Abbey, J.A. Batt, C. Dos Santos, J. Flannery, G. Leung, J. Marshall, A. Moody, G. Rubenfeld, D.C. Scales, T. Sinuff, A. Slutsky, F. Lamontagne, M. Levasseur, G. Tomlinson, M.S. Herridge. Long-Term Outcomes After Prolonged Mechanical Ventilation: Family Caregiver Outcomes From The Towards RECOVER Study. American Journal of Respiratory & Critical Care Medicine. 2012; 185:A1090.

2. E.C. Goligher, G. Rubenfeld, N. Adhikari, R. Pinto, B.P. Kavanagh, D.J. Cook, G. Guyatt, G.L. Jones, J. Granton, T. Stewart, M. Meade, N.D. Ferguson. Oxygenation Response To Increased PEEP Predicts Mortality In Acute Lung Injury: A Secondary Analysis Of The Lung Open Ventilation Study (LOVS) Trial. American Journal of Respiratory & Critical Care Medicine. 2012; 185:A1158.

3. N. Zytaruk, M. Meade, S. Mehta, R. Hall, J. Granton, N.D. Ferguson, A. Freitag, J. Muscedere, R. Fowler, Y. Skrobik, M. Jacka, J. Marshall, F. Lauzier, F. Lamontagne, A. Turgeon, N. Vlahakis, J.R. Klinger, P. Devereaux, M. Ostermann, O. Berwanger, K. Khwaja, L. Burry, J. Freidrich, K.E.A. Burns, M. Herridge, D.J. Cooper, A. Bersten, D. Heels-Ansdell, D.J. Cook. Risk Factors For Pulmonary Embolism In Medical-Surgical ICU Patients. American JoJournal of Respiratory & Critical Care Medicine. 185:A2359.

4. M.S. Herridge, L.M. Chu, A.L. Matte, L. Chan, G. Tomlinson, N.D. Ferguson, S. Mehta, J. Friedrich, N. Adhikari, R. Fowler, D.J. Cook, J.C. Rudkowski, H. Meggison, S.E. Abbey, J. Batt, C. Dos Santos, J. Flannery, G. Leung, J.C. Marshall, A.R. Moody, G. Rubenfeld, D.C. Scales, T. Sinuff, A. Slutsky, F. Lamontagne, M. Levasseur, J. Cameron. Long-Term Patient Outcomes After Prolonged Mechanical Ventilation: The Towards RECOVER Study. American Journal of Respiratory & Critical Care Medicine. 185:A2546.

5. L. Hand, D.J. Cook, T. Karachi, P. Park, K. Brierley, A.C. Arroliga, S. Cormier, M. Meade, N.D. Ferguson. Airway Pressure Release Ventilation In OSCILLATE Trial Centres: A Self Reported Survey. American Journal of Respiratory & Critical Care Medicine. 2012; 183:A3184.

6. S. Mehta, L. Burry, D.J. Cook, M. Steinberg, D. Fergusson, P. Hebert, M.S. Herridge, J. Granton, N.D. Ferguson, J.W. Devlin, M. Tanios, R. Fowler, P.M. Dodek, K.E.A. Burns, M. Jacka, K. Olafson, S. Reynolds, S. Keenan, Y. Skrobik, J. Kutsogiannis, K. Antoni, M. Meade. SLEAP: A Multicenter Randomized Trial Of Daily Awakening In Critically Ill Patients Being Managed With A Sedation Protocol. American Journal of Respiratory & Critical Care Medicine. 2012; 185:A3882.

7. A.L. Matte, N.D. Ferguson, A.S. Slutsky, A.C. Arroliga, D.J. Cook, I.S. Douglas, J. Granton, M. Sen, K.K. Koo, Q. Zhou, M.O. Meade. Patterns Of Neuromuscular Blockade In An International Trial Of HFO For Adults With ARDS. American Journal of Respiratory & Critical Care Medicine. 2012; 185:A5443.

8. A.C. Arroliga, F. Frutos-Vivar, A. Anzueto, O. Penuelas, N.D. Ferguson, F. Rios, P. Amin, M. Soares, H. Bulow, S. Maggiore, A. Thille, K. Raymondos, M. Gonzalez, D. Bin, J. Hurtado, A. Esteban. The Use Of Sedatives And Analgesics In Patients Receiving Non-Invasive Positive Pressure Mechanical Ventilation (NPPV). American Journal of Respiratory & Critical Care Medicine. 2012; 185:.A6490.

9. F Lamontagne, N Adhikari, D Cook, KK Koo, F Lauzier, KE Burns, I Douglas, AF Turgeon, H Quiroz, Y Poulin, K Choong, ND Ferguson, ME Kho, M Duffett, C Chant, O Lesur, MO Meade. Corticosteroids for critically ill patients: an international survey of intensivists. Critical Care. 2012, 16(Suppl 1):P101

10. M Ostermann, L McIntyre, F Lauzier, J Alhashemi, I Qushmaq, S Langevin, P Dodek, M Albert, K Khwaja, J Kutsiogiannis, L Burry, J Granton, J Friedrich, ND Ferguson, J Marshall, S Finfer, D Heels-Ansdell, N Zytaruk, D Cook, J Sheppard, T Warkentin, M Crowther. Consequences of suspected heparin-induced thrombocytopenia in the ICU. Critical Care. 2012, 16(Suppl 1):P423.

Presentations/Lectures: 1. 2012 Nov 19 Invited Speaker. The OSCILLATION for ARDS Treated Early Trial (OSCILLATE).

OSCAR Trial Investigators Meeting, Oxford University. London, City of, United Kingdom

2. 2012 Oct 31 Invited Speaker. The OSCILLATION for ARDS Treated Early Trial (OSCILLATE). Critical Care Canada Forum 2012. Toronto, Canada.

3. 2012 Oct 30 Invited Speaker. Quality Adjusted Life Years as an Outcome for Critical Care Trials. Critical Care Canada Forum 2012. Toronto, Canada.

4. 2012 Oct 29 Invited Speaker. Exploring the Berlin Definition of ARDS. Critical Care Canada Forum 2012. Toronto, Canada.

5. 2012 Oct 28 Invited Speaker. Should We Use Low Tidal Volumes in Everybody? Absolutely Not! Physiology Debates, Residents’ Day, Critical Care Canada Forum 2012. Toronto, Canada.

6. 2012 Oct 28 Invited Speaker. ARDS Diagnosis: How Berlin Changes Everything…. Physiology Debates, Residents’ Day, Critical Care Canada Forum 2012. Toronto, Canada.

7. 2012 Oct 26 Invited Speaker. QALYs as an Outcome Measure in Critical Care Trials. 30th Congress of The Chilean Society of Intensive Care Medicine. Coquimbo, Chile.

8. 2012 Oct 26 Invited Speaker. The Role of APRV in Severe ARDS. 30th Congress of The Chilean Society of Intensive Care Medicine. Coquimbo, Chile.

9. 2012 Oct 25 Invited Speaker. The Role of HFO in Adults with ARDS. 30th Congress of The Chilean Society of Intensive Care Medicine. Coquimbo, Chile.

10. 2012 Oct 24 Invited Speaker. The Future of Critical Care: Challenges & Opportunities. Congress Opening Plenary Address. 30th Congress of The Chilean Society of Intensive Care Medicine. Coquimbo, Chile.

11. 2012 Oct 20 Invited Speaker. Weaning from Mechanical Ventilation. V International Symposium on Mechanical Ventilation for Experts – Island Congress. Panamerican & Iberic Federation of Societies of Intensive and Critical Care Medicine. Island of Barú, Colombia.

12. 2012 Oct 20 Invited Speaker. How to Set PEEP – Review of the Evidence. V International Symposium on Mechanical Ventilation for Experts – Island Congress. Panamerican & Iberic Federation of Societies of Intensive and Critical Care Medicine. Island of Barú, Colombia.

13. 2012 Oct 19 Invited Speaker. Patient-Ventilator Interactions. V International Symposium on Mechanical Ventilation for Experts – Island Congress. Panamerican & Iberic Federation of Societies of Intensive and Critical Care Medicine. Island of Barú, Colombia.

14. 2012 Aug 6 Invited Speaker. Ventilación de Alta Frecuencia Oscilatorio y el Ensayo OSCILLATE - OSCILLATE Trial Update [Spanish]. Department of Anaesthesia and Critical Care, Fundación Santa Fe de Bogotá, Universidad de Los Andes. Bogotá, Distrito Capital de Bogotá, Colombia.

15. 2012 Jul 24 Invited Lecturer. ‘Basic’ Mechanical Ventilation. Interdepartmental Division of Critical Care Medicine Lecture Series, University of Toronto. Toronto, Ontario, Canada.

16. 2012 Jul 6 Invited Speaker. Definitions and Epidemiology of ARDS – Exploring the Berlin Definition. 15th International Forum on Mechanical Ventilation and Sepsis. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Mexico City, México, Mexico.

17. 2012 Jul 6 Invited Speaker. Non-Conventional Modes of Mechanical Ventilation. 15th International Forum on Mechanical Ventilation and Sepsis. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Mexico City, México, Mexico.

18. 2012 Jul 5 Invited Speaker. High-Frequency Oscillation – Hands-on Workshop. 15th International Forum on Mechanical Ventilation and Sepsis. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Mexico City, México, Mexico.

19. 2012 Jul 5 Invited Speaker. When to Drain a Pleural Effusion in a Mechanically Ventilated Patient. 15th International Forum on Mechanical Ventilation and Sepsis. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Mexico City, México, Mexico.

20. 2012 Jun 2 Invited Speaker. Current State of ARDS and its Ventilatory Management. 5th International Course on Basic & Advanced Respiratory Support (SORBA), Hospital Universitario Fundación Santa Fe de Bogotá, Colombian Association of Critical Care Medicine. Bogota, Distrito Capital de Bogotá, Colombia.

21. 2012 Jun 1 Invited Speaker. When and How Should We Use High-Frequency Oscillation? 5th International Course on Basic & Advanced Respiratory Support (SORBA), Hospital Universitario Fundación Santa Fe de Bogotá, Colombian Association of Critical Care Medicine. Bogota, Distrito Capital de Bogotá, Colombia.

22. 2012 Jun 1 Invited Speaker. Patient-Ventilator Interactions. 5th International Course on Basic & Advanced Respiratory Support (SORBA), Hospital Universitario Fundación Santa Fe de Bogotá, Colombian Association of Critical Care Medicine. Bogota, Distrito Capital de Bogotá, Colombia.

23. 2012 Jun 1 Invited Speaker. High-Frequency Oscillation – Hands-on Workshop. 5th International Course on Basic & Advanced Respiratory Support (SORBA), Hospital Universitario Fundación Santa Fe de Bogotá, Colombian Association of Critical Care Medicine. Bogota, Distrito Capital de Bogotá, Colombia.

24. 2012 May 29 Invited Lecturer. Respiratory Dysfunction. Critical Care Review – Canadian Critical Care Society RCPSC Critical Care National Exam Review Course. Mississauga, Ontario, Canada.

25. 2012 May 29 Invited Lecturer. Weaning from Mechanical Ventilation. Critical Care Review – Canadian Critical Care Society RCPSC Critical Care National Exam Review Course. Mississauga, Ontario, Canada.

26. 2012 May 21 Invited Speaker. ARDS – The Berlin Definition. American Thoracic Society International Conference. San Francisco, California, United States.

27. 2012 May 21 Presenter. SLEAP: A Multicenter Randomized Trial Of Daily Awakening In Critically Ill Patients Being Managed With A Sedation Protocol. American Thoracic Society International Conference. San Francisco, California, United States. S. Mehta, L. Burry, D.J. Cook, M. Steinberg, D. Fergusson, P. Hebert, M.S. Herridge, J. Granton, N.D. Ferguson, J.W. Devlin, M. Tanios, R. Fowler, P.M. Dodek, K.E.A. Burns, M. Jacka, K. Olafson, S. Reynolds, S. Keenan, Y. Skrobik, J. Kutsogiannis, K. Antoni, M. Meade.

28. 2012 May 22 Presenter. The Use Of Sedatives And Analgesics In Patients Receiving Non-Invasive Positive Pressure Mechanical Ventilation (NPPV). American Thoracic Society

International Conference. San Francisco, California, United States. A.C. Arroliga, F. Frutos-Vivar, A. Anzueto, O. Penuelas, N.D. Ferguson, F. Rios, P. Amin, M. Soares, H. Bulow, S. Maggiore, A. Thille, K. Raymondos, M. Gonzalez, D. Bin, J. Hurtado, A. Esteban.

29. 2012 Apr 13 Invited Speaker. Alphabet Soup for ALI/ARDS: HFO/APRV/NAVA/PAV. Acute Respiratory Failure: New Insights from Around the World – A tribute to Dr. Andrés Esteban. Hospital Universitario de Getafe. Madrid, Spain.

30. 2012 Mar 22 Invited Speaker. When to Drain a Pleural Effusion. 32nd International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium.

31. 2012 Mar 21 Invited Speaker. How to Set PEEP – Review of the Evidence. 32nd International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium.

32. 2012 Mar 21 Invited Speaker. Non-conventional Ventilation - Tutorial. 32nd International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium.

33. 2012 Mar 21 Invited Speaker. When & How to do a Tracheostomy – Round table. 32nd International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium.

34. 2012 Mar 20 Invited Speaker. Non-conventional Ventilation - Overview. 32nd International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium

35.2012 Feb 28 Invited Speaker. Current State and Future Opportunities in the Management of Adult Respiratory Failures. 39th Annual Meeting of the Japanese Society of Intensive Care Medicine. Chiba, Japan. Presenter(s): Dr. Niall Ferguson.

36. 2012 Feb 9 Invited Speaker. Recruitment and Retention. University of Toronto, Department of Health Policy, Management and Evaluation Course. Toronto, Canada. Presenter(s): Dr. Niall Ferguson. Pragmatic Issues in Conduct of Controlled Trials

37.2012 Mar 22 Invited Speaker. Delirium – Quality of Care Can Prevent It. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

38.2012 Mar 22 Facilitator. Ventilator-Associated Pneumonia. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

39. 2012 Mar 20 Facilitator. Poster Session Adjudicator. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

40. 2012 Mar 20 Invited Speaker. Refractory Hypoxemia in ARDS. 32nd International Symposium of Intensive Care and Emergency Medicine. Brussels, Belgium.

41. 2012 Jan 29 Invited Speaker. Mechanical Ventilation. Ontario Thoracic Society. Toronto, Ontario, Canada. Ontario Respiratory Resident’s Symposium – Better Breathing Conference.

42. 2012 Jan 12 Invited Speaker. Wake Up, Get Up, and Get Out Early: ICU-Acquired Weakness and Early Mobility in the ICU. Mississauga Halton LHIN. Oakville, Ontario, Canada.

Research Funding: 1. 2012 Jan – 2014 Dec Co-Investigator. Understanding Barriers to Early Rehabilitation in the

ICU Using the 2012-2014 Toronto ICU Registry (TICUR) Project. University of Toronto. Department of Medicine Strategic. PI: E Fan. Collaborators: ND Ferguson, DC Scales, GR Rubenfeld. 75,000 CAD. [Grants]

2. 2012 Jan – 2013 Dec Co-Investigator. A Phase 1 Study: The Determination of the Maximum Tolerable Dosage of Sodium Nitroprusside in Adult Acute Lung Injury. The Physicians’ Services Incorporated Foundation. PI: Ip, T; Mehta, S. 20,000 CAD. [Grants]

3. 2011 Feb – 2012 Jan Co-Investigator. Daily Sedation Interruption versus No Daily Sedation Interruption for Critically Ill Adult Patients Requiring Invasive Mechanical Ventilation: A Systematic Review. Canadian Society of Hospital Pharmacists (CSHP). CSHP - Research and Education Foundation. PI: Lisa Burry. 3,500. [Grants]

4. 2011 Jan - 2013 Dec Principal Investigator. Acute Lung Injury in the ICU: Scope of the Problem and Focus on Prevention. Physicians Services Incorporated Foundation (The) (PSI). Collaborators: JM Singh, AC Steel, SE Lapinsky. 39,595 CAD. [Grants] Co-Principal Investigator - Galvin, Imelda.

5. 2010 Oct – 2012 Sept Co-Investigator. Weaning and Variability Evaluation (WAVE)- a multicenter evaluation of altered heart rate and respiratory rate variability to predict extubation failure. Canadian Institutes of Health Research (CIHR). PI: Seely A. Collaborators: ND Ferguson, D Fergusson, J Hooper, F Lellouche, JC Marshall, D Maziak, L MacIntyre, T Ramsay, GD Rubenfeld, P Wilkes, DC Scales, R Zarychanski. 650,000 CAD. [Grants]

6. 2012 Oct – 2012 Sept Co-Investigator. The efficacy, cost-effectiveness and ecological impact of Selective Decontamination of the Digestive tract in critically ill patients treated in the Intensive Care Unite (The SuDDICU Study). Canadian Institutes of Health Research (CIHR). PI: Cuthbertson BH. Collaborators: KE Burns, DJ Cook, P Dodek, ND Ferguson, J Francis, J Grimshaw, R Hall, B Johnson, S Kanji, JC Marshall, L MacIntyre, J Muscedere, G Pagliarello, L Rose, F Webster, C Weijer. 240,390 CAD. [Grants]

Alejandro Floh (Hospital for Sick Children) Submitted Publications: 1. Floh AA, La Rotta G, Wermelt JZ, Bastero-Minon P, Sivarajan VB, Humpl T Validation of a New

Method Based on Ultrasound Velocity Dilution to Measure Cardiac Output in Paediatric Patients. (Submitted for Publicaiton)

In Press: 1. Floh AA, Krawczeski CD, Schwartz SM. Peri-Operative Care of the Child with Congenital Heart

Disease. In: Wheeler, D.S., Wong H.S., Shanley, T.P. (eds): Pediatric Critical Care Medicine: Basic Science and Clinical Evidence London: Springer-Verlag, (In Press).

2. Lieppman, K., Floh, A., Schwartz, S.M.: Developing Techniques: The Future of Monitoring. In: Cruz,

E.d.; Dunbar-Davy, I., Hraska, V.; Jaggers, J. (eds): Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. London: Springer-Verlag Limited. (In Press).

Presentations/Lectures: 1. A Pro-Inflammatory, Elevated Insulin State, Not Hyperglycemia, is Associated with Adverse

Outcomes after Pediatric Heart Surgery. Annual Scientific Sessions of the American Heart Association, Los Angeles, CA, USA

2. Augustinavicius, J, Floh AA, Jacques F, Kim DJ, Hawkins C, Frndova H, Stockoe J, Guergueria AM,

Cerebral Hemorrhage in Children Supported with Extracorporeal Membrane Oxygenation. Critical Care Canada Forum. Toronto, Ontario

3. Floh AA, La Rota G, Humpl T. Active Circulation Volume as a Volumetric Marker for Routine Bedside Use with Pediatric ICU Patients. Society of Critical Care Medicine Congress, Houston, TX, USA

Rob Fowler (Sunnybrook Health Sciences Centre) Peer Reviewed Publications: 1. Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J,

Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hebert P, Sabri E, Meade M. Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol: A Randomized Controlled Trial. JAMA. Coauthor or Collaborator.

2. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gardlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B and Williams MD. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012 May 31;366(22):2055-64. Epub 2012 May 22. Coauthor or Collaborator.

3. Mandourah Y, Al-Radi A, Ocheltree AH, Ocheltree SR and Fowler R. Clinical and Temporal Patterns of Severe Pneumonia Causing Critical Illness during Hajj. BMC Infect Dis. 2012 May 16;12(1):117. Senior Responsible Author.

4. Dodek PM, Wong H, Heyland DK, Cook DJ, Rocker GM, Kutsogiannis DJ, Dale C, Fowler R, Robinson S, Ayas NT. The Relationship between Organizational Culture and Family Satisfaction in Critical Care. Crit Care Med. 40(5):1506-12. Coauthor or Collaborator.

5. Thirugnanam S, Pinto R, Cook DJ, Geerts WH, Fowler R. Economic Analyses of venous thromboembolism prevention strategies in hospitalized patients: a systematic review. Critical Care. 16(2):R43. Senior Responsible Author.

6. Mandourah Y, Ocheltree A, Al Radi A and Fowler R. The epidemiology of Hajj-related critical illness: lessons for deployment of temporary critical care services*. Crit Care Med. 2012 Mar;40(3):829-34. Senior Responsible Author.

7. Dodek PM, Wong H, Jaswal D, Heyland DK, Cook DJ, Rocker GM, Kutsogiannis DJ, Dale C, Fowler R and Ayas NT. Organizational and safety culture in Canadian intensive care units: relationship to size of intensive care unit and physician management model. J Crit Care. 2012 Feb;27(1):11-7. Epub 2011 Sep 29. Coauthor or Collaborator

8. You J, Fowler R, Heyland DK. Goals of care determination for hospitalized patients: advance care planning for the inpatient setting. CMAJ. 2012. In Press. Coauthor or Collaborator.

9. Westcott M, Martiniuk AL, Fowler R, Adhikari NK and Dalipanda T. Critical care resources in the Solomon Islands: a cross-sectional survey. BMC Int Health Hum Rights. 2012 Mar 1;12:1. Coauthor or Collaborator.

10. Chalkidou K, Tunis S, Whicher D, Fowler R, Zwarenstein M. The role for pragmatic randomized controlled trials (pRCTs) in comparative effectiveness research. Clinical Trials. 2012; 0:1-11. Coauthor or Collaborator.

Submitted Publications: 1. Fowler RA, Efobi CA, Bhagwanjee S, Kissoon N, Rubenfeld G, Adhikari N. Perspectives on the care

of the critically ill world wide: our own flobal crisis. Principal Author.

2. McGaughey J, Fowler R, Mayhew A. Outreach and Early Warning Systems (EWS) for the prevention of death or need for intensive care admission for adult patients on general hospital wards. Coauthor or Collaborator.

In Press: 1. Chalkidou K, Tunis S, Whicher D, Fowler R, Zwarenstein M. The role for pragmatic randomized

controlled trials (pRCTs) in comparative effectiveness research. Clinical Trials. 2012; 0:1-11. Coauthor or Collaborator.

2. Alali A, Kiss A, Fowler R, Scales D, Ray J, Mainprize T, de Mestral C, Nathens A. Intracranial Pressure Monitoring in Severe Traumatic Brain Injury: Results from the American College of Surgeons Trauma Quality Improvement Program. J Neurotrauma. 2013. In Press. Coauthor or Collaborator.

3. Williamson D, Albert M, Heels-Ansdell D, Arnold D, Lauzier F, Zarychanski R, Crowther M, Warkentin T, Dodek P, Cade J, Lesur O, Lim W, Fowler R, Lamontagne F, Langevin S, Freitag A, Muscedere J, Friedrich J, Geerts W, Burry L, Alhashemi J, Cook D. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest. 2013. In Press. Coauthor or Collaborator.

4. Fowler R, Hammer M. End-of-Life Care in Canada. Clinical Investigative Medicine. In Press. Principal Author.

5. Daneman N, Scales DC, Blount V, Lawless B, Fowler R. Infection Prevention and Control in the Intensive Care Unit: Open Versus Closed Models of Care. Infection Control and Hospital Epidemiology. In Press. Senior Responsible Author.

6. Lamontagne F, Quiroz H, Adhikari N, Cook DJ, Koo K, Lauzier F, Turgeon A, Kho ME, Burns K, Chant C, Fowler R, Douglas I, Poulin Y, Choong K, Ferguson N, Meade M. Corticosteriod Use in the Intensive care unit - a survey of intensivists. Can J Anesthes. In Press. Coauthor or Collaborator.

7. Hammer M, Melberg HO, Fowler R. International Variation in End-of Life Care. Handbook of Health Services Research. In Press. Senior Responsible Author.

8. Hammer M, Fowler R. International Variation on End of Life Care. In Press. Senior Responsible Author.

9. Fowler R, Thirugnanam S, Sud S. Prophylaxis in the ICU. In Press. Principal Author.

10. Duggal A, Fowler R. Pandemic Management: Patient Care and ICU Management During Viral Respiratory Outbreaks and Pandemics. In Press. Senior Responsible Author.

Abstracts: 1. Rac VE, Dorian P, Slutsky AS, Abramson B, Fowler R, Parsons J, Kiss A, Dainty K, Zwarenstein M,

Zhan C, Morrison LJ. Does Gender Matter for Post Arrest Care? American Heart Association with Resuscitation Symposium Meeting. Los Angeles, California. November 2012. Coauthor or Collaborator.

2. Aoyama K, Lapinsky S, Scales DC, Pinto R, Fowler R. Incidence characteristics and outcomes of pregnancy related critical illness over time in Canada. Senior Responsible Author.

3. Sadler E, Hales B, Myers J, Wynnychuk L, Taggar R, Henry B, Fowler R. Quality Dying Initiative: Family Satisfaction with End-of -Life care. Senior Responsible Author.

4. Guo, Downar J, Dhalla I, Fowler R. Characterization of Research Involvement of Critically Ill Patients. Senior Responsible Author.

5. Maraschiello M, Amaral A, Fowler R. Physician order discrepancies during patient transfer from the intensive care unit to an alternate level of care. Senior Responsible Author.

6. Aoyama K, Lapinsky S, Scales DC, Pinto R, Fowler R. Incidence characteristics and outcomes of pregnancy-related critical illness over time in Canada. Senior Responsible Author.

7. Aoyama K, Lapinsky S, Fowler R. Incidence of peripartum cardiomyopathy in Canada. Senior Responsible Author.

8. Sanwar S, Daneman N, Fowler R, Cuthbertson B. Impact of selective decontamination on antibiotic resistance in the intensive care unit: A system review and meta-analysis. Coauthor or Collaborator.

9. Hill AD, Pinto R, Nathens AB, Fowler R. Regional patterns in acess to trauma centre care in Canada; the plight of the elderly. Senior Responsible Author.

10. Cameron JI, Chan L, Czerwonka A, Chu LM, Matte A, Tomlinson G, Ferguson ND, Mehta S, Friedrich J, Adhikari N, Fowler R, Lamontagne F, Rudkowksi J, Meggison H, Ayas N, Skrobik Y, Batt JA, Dos Santos CC, Flannery JF, Abbey SE, Rubenfeld G, Scales DC, Sinuff T, Cuthbertson B, Fan E, Slutsky AS, Leung G, Moody AR, Levasseur M, Marshall JC, Cook D, Herridge MS in collaboration with the Canadian Critical Care Trials Group. Long-Term Outcomes after Prolonged Mechanical Ventilation: Family Caregiver Outcomes from the Towards RECOVER Study. Critical Care Canada Forum, Toronto, Ontario, Canada. October 2012. Coauthor or Collaborator.

11. Herridge MS, Chu LM, Matte AL, Chan L, Tomlinson G, Ferguson ND, Mehta S, Friedrich J, Adhikari N, Fowler R, Lamontagne F, Rudkowski J, Meggison H, Ayas N, Skrobik Y, Batt JA, Dos Santos CC, Flannery JF, Abbey SE, Rubenfeld G, Scales DC, Sinuff T, Cuthbertson B, Fan E, Slutsky AS, Leung G, Moody AR, Levasseur M, Marshall JC, Cook D, Cameron JI in collaboration with the Canadian Critical Care Trials Group. Long-Term Patient Outcomes After Prolonged Mechanical Ventilation: The TOWARDS RECOVER Study. Critical Care Canada Forum, Toronto, Ontario, Canada. October 2012. Coauthor or Collaborator.

12. Teodoro da Luz L, Roehrig C, Fowler R, Papia G. Forty Cats + Pasteurella + a Human Host = a Case of Fulminant Sepsis. University of Toronto Residents’ Day, Toronto, Canada. June 2012. Coauthor or Collaborator.

13. Aoyama K, Lapinsky S, Scales DC, Pinto R, Fowler R. Incidence, Characteristics and Outcomes of Pregnancy-Related Critical Illness Over Time in Canada. University of Toronto Residents’ Day, Toronto, Canada. June 2012. Coauthor or Collaborator.

14. Zytaruk N, Meade M, Mehta S, Hall R, Granton J, Ferguson N, Freitag A, Muscedere J, Fowler R, Skrobik Y, Jacka M, Marshall J, Vlahakis N, Klinger J, Ostermann M, Berwanger O, Khwaja K, Burry L, Friedrich J, Cooper J, Berstein A, Heels-Asdell D, Cook D, for the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Risk Factors for Pulmonary Embolism in Medical-Surgical ICU Patients. Am J Resp Crit Care Med 2012. Coauthor or Collaborator.

15. Lauzier F, Arnold D, Rabbat C, Heels-Ansdell D, Dodek P, Ashley BJ, Albert M, Khwaja K, Ostermann M, Skrobik Y, Fowler R, McIntyre L, Nates J, Karachi T, Renato L, Zytaruk N, Crowther M for the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. In Medical-Surgical ICU Patients, Major Bleeding is Common, But Independent of Heparin Prophylaxis. Critical Care 2012:P435. Coauthor or Collaborator.

16. Zytaruk N, Meade M, Mehta S, Hall R, Granton J, Ferguson N, Freitag A, Muscedere J, Fowler R, Skrobik Y, Jacka M, Marshall J, Lauzier, F, Lamontagne A, Turgeon A, Vlahakis N, Klinger JR, Devereaux P, Ostermann M, Berwanger O, Khwaja K, Burry L, Friedrich J, Burns K, Herridge M, Cooper J, Berstein A, Heels-Asdell D, Cook D, for the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Risk Factors for Pulmonary Embolism in Medical-Surgical ICU Patients. American Thoracic Society 2012. Coauthor or Collaborator.

17. Clarke F, McDonald E, Smith O, Zytaruk N, Heels-Ansdell D, Watpool I, McArdle T, Matte A, Vallance S, Finfer S, Galt P, Crozier T, Fowler R, Arabi Y, Woolfe C, Orford N, Hall R, Adhikari N, Ferland MC, Marshall J, Foster D, Farias P, Cook D, Meade M. Enrolling Critically Ill Patients Into Multiple Studies: A Case Study of A Thromboprophylasis Trial. B15: American Thoracic Society 2012. Coauthor or Collaborator.

18. Mehta S, Burry L, Cook D, Steinbert M, Fergusson D, Hebert P, Herridge M, Granton J, Ferguson N, Devlin J, Tanios M, Fowler R, Dodek P, Burns K, Jacka M, Olafson K, Reynolds S, Keenan S, Skrobik Y, Kutsogiannis J, Antoni K, Meade M, for the SLEAP Investigators and Canadian Critical Care Trials Group. SLEAP: A multicenter randomized trial of daily awakening in critically ill patients being managed with a sedation protocol. Am J Respir Crit Care Med 2012; 185: A3882. Coauthor or Collaborator.

19. Cameron JI, Chan L, Czerwonka AI, Chu LM, Matte AL, Ferguson NK, Mehta S, Friedrich J, Adhikari N, Fowler R, Cook DJ, Rudkowski JC,Meggison H, Abbey SE, Batt JA, dos Santos C, Flannery J, Leung G, Marshall J, Moody A, Rubenfeld G, Scales DC, Sinuff T, Slutsky A, Lamontagne F, Levasseur M, Tomlinson G, Herridge M. Long-Term OUtcomes After Prolonged Mechanical Ventilation: Family Caregiver Outcomes From The Towards RECOVER Study. Am J Respir Crit Care Med; 185: A1090. Coauthor or Collaborator.

20. Herridge MS, Chu LM, Matte AL, Chan L, Tomlinson G, Ferguson ND, Mehta S, Friedrich J, Adhikari N, Fowler R, Cook DJ, Rudkowski JC, Meggison H, Abbey SE, Batt J, Dos Santos C, Flannery J, Leung G, Marshall JC, Moody AR, Rubenfeld G, Scales DC, Sinuff T, Slutsky A, Lamontagne F, Levasseur M, Cameron J. Long-Term Patient OUtcomes After Prolonged Mechanical Ventilation: The Towards RECOVER Study. Am J Respir Crit Care Med; 185: A2546. Coauthor or Collaborator.

Presentations/Lectures: 1. 2012 Oct 31 Invited Speaker. CCCF-CCCS Frank Rutledge Symposium. Critical Care

Canada Forum. Toronto, Ontario, Canada. Presenter(s): Fowler RA, Granton JG (moderators).

2. 2012 Oct 30 Invited Speaker. Decision-making near the end of life ( Part 1 and Part

2). Critical Care Canada Forum. Toronto, Ontario, Canada. Presenter(s): Fowler RA, Carstairs S ( moderators).

3. 2012 Oct 30 Invited Speaker. Does ICU Capacity Influence End of Life Decision-

Making? Critical Care Canada Forum. Toronto, Ontario, Canada. Presenter(s): Fowler RA.

4. 2012 Oct 29 Invited Speaker. William J Sibbald Symposium: Critical Care Capacity. Critical Care Canada Forum. Toronto, Ontario, Canada. Presenter(s): Fowler RA, Scales DC, (moderators).

5. 2012 Jul 6 Invited Speaker. Comunicación Enfermera-Médico en la UCI. Foro Internacional de Medicina Crítica Ventilación Mecánica, Sepsis y Tópicos Selectos Tecnológico de Monterrey Campus Ciudad de México. Mexico City, Mexico. Presenter(s): Fowler RA.

6. 2012 Jul 6 Invited Speaker. Cuidados del Paciente y la Población Durante Pandemias o Epidemias y Enfermedad Crítica. Foro Internacional de Medicina Crítica Ventilación Mecánica, Sepsis y Tópicos Selectos Tecnológico de Monterrey Campus Ciudad de México. Mexico City, Mexico. Presenter(s): Fowler RA.

7. 2012 Jun 19 Invited Speaker. Access to Trauma Care in Canada. University of Toronto Critical Care Residents’ Day. Toronto, Ontario, Canada. Presenter(s):

Hill A, Pinto R, Nathens A, Fowler RA (supervisor).

8. 2012 Jul 5 Invited Speaker. Enfermos. Foro Internacional de Medicina Crítica Ventilación Mecánica, Sepsis y Tópicos Selectos Tecnológico de Monterrey Campus Ciudad de México. Mexico City, Mexico. Presenter(s): Fowler RA.

9. 2012 Jun 5 Invited Speaker. US-Canada Comparison of Intensity of Care at the End

of Life. Commonwealth Fund Harkness International Fellow. New York, United States. Presenter(s): Fowler RA.

10. 2012 May 31 Invited Speaker. RN-MD Communication in the ICU. Critical Care

Education Day 2012. Sunnybrook Health Sciences Centre. Toronto, Ontario, Canada. Presenter(s): Fowler RA.

11. 2012 May 22 Invited Speaker. US-Canada Comparison of Intensity of Care at the End of Life. Dartmouth University NIH /NIA Research Group Meeting. Wentworth-by-the-Sea, New Hampshire, United States. Presenter(s): Fowler RA.

2012 May 16 Invited Speaker. Characterizing In-Patient Research Involvement at U of T Teaching Hospitals. Sunnybrook Health Sciences Centre, Department of Medicine Research Day. Toronto, Ontario, Canada. Presenter(s): Guo R, Fowler RA (supervisor).

12. 2012 May 9 Invited Speaker. Canadian Health Care System. Commonwealth Fund Canadian Policy Briefing. Montreal, Quebec, Canada. Presenter(s): Fowler RA.

13. 2012 May 3 Invited Speaker. Fowler RA. End of Life Care Agenda. Ontario Medical Association Annual Council. Toronto, Canada.

14. 2012 Jan 12 Invited Speaker. E-PROTECT - economic evaluation of the PROTECT trial. Canadian Critical Care Trials Group. Toronto, Ontario, Canada. Presenter(s): Fowler RA.

Research Funding: 1. 2012 – 2017 Co-Investigator. Technology evaluation in the elserly network (TECH

VALUE NET). Networks of Centres of Excellence (NCE). Cash /in-kind contributions $21,409,646 from other partners. Collaborators: Scientific Director: Heyland DK; Co-Investigators: 44 Network Investigators across Canada. 23,888,157 CAD. [Grants]

2. 2012 – 2014 Co-Investigator. Evaluation of a novel cardiopulmonary resuscitation (CPR) video decision aid to promote shared decision-making. Heart and Stroke Foundation of Canada (HSFC). PI: Kryworuchko, Jennifer. 65,376 CAD. [Grants]

3. 2012 – 2014 Co-Investigator. Pilot KT intervention to address gender differences in access to post arrest care. Canadian Institutes of Health Research (CIHR). PI: Rac, Valeria. Collaborators: Slutsky A, Abramson B, Dorian P, Bierman A, Parsons J, Scales DC, Fowler R, Gray S, Dainty K, Zwarenstein M, Kiss A. 218,994 CAD. [Grants]

4. 2012 – 2014 Primary Investigator. Regional and temporal variations in incidence, prevalence and outcomes of critical illness among pregnant and post-partum women and newborns in Canada. Canadian Institutes of Health Research (CIHR). Collaborators: Damon Scales, Stephen Lapinsky, Joel Ray, Ruxandra Pinto, Kazu Aoyama. 41,325 CAD. [Grants]

5. 2012 – 2014 Co-Investigator. DECIsion-making about goals of care for hospitalized meDical PatiEnts: a multicentre, mixed-methods study. The DECIDE Study. Canadian Institutes of Health Research (CIHR). Collaborators: Daren Heyland, John You, Martin Albert, Kevin Brazil, Andrew Day, James Downar, Roy Ilan, Dev Jayaraman, Jennifer Kryworuchko, Francois Lamontagne, Irene Ma, Anita Palepu, John Shik, Patricia Strachan. 157,908 CAD. [Grants]

6. 2012 – 2014 Principal Investigator. Optimizing duration of antibiotic therapy for

bloodstream infections. Physicians Services Incorporated Foundation (The) (PSI). 167,000. [Grants]

7. 2011 – 2014 Co-Investigator. Understanding Long-Term Mechanical Ventilation in

Canada: A Programmatic Approach. Canadian Institutes of Health Research (CIHR). Collaborators: AMIN, Reshma; MAWDSLEY, Cathy; FAN, Eddy; FOWLER, Robert A; FRASER, Ian M; GOLDSTEIN, Roger S; KATZ, Sherri L; KING, Judith A; LEASA, David J; MCKIM, Douglas; NONOYAMA, Mika L; ROAD, Jeremy D; RUBENFELD, Gordon. 349,863 CAD. [Grants]

8. 2011 – 2013 Principal Investigator. Comparison of End-of-Life Care in Canada and the United States. The Commonwealth Fund. 20,000 CAD. [Grants] 9. 2011 – 2013 Co-Investigator. Council of Academic Hospitals of Ontario (CAHO)

Implementation of Antimicrobial Stewardship Programs (ASP) in Intensive Care Units in Ontario Academic Hospitals. PI: Morris, Andrew. Collaborators: Bell C, Fowler R, Burry L, Daneman N, Dresser L, Elligsen M, Herridge M, Mehta S, Muller M. 768,000 CAD. [Grants]

10. 2011 – 2013 Principal Investigator. A National Comparison of Intensity of End-of-

Life Care in Canada: Defining Changing Patterns, Risk Factors and Targets for Intervention. Canadian Institutes of Health Research. 99,208 CAD. [Grants]

11. 2011 – 2012 Co-Investigator. Planning meeting for the PREEDICCT study. Canadian

Institutes of Health Research. PI: Christian, Michael. Collaborators: Fisman D, Fowler R, Marshall J, Zygun D. 23,842 CAD. [Grants]

Jan Friedrich (St. Michael’s Hospital) Peer Reviewed Publications: 1. Wald R, Friedrich JO, Bagshaw SM, Burns KEA, Garg AX, Hladunewich MA, House AA, Lapinsky S,

Klein D, Pannu NI, Pope K, Richardson RM, Thorpe KE, Adhikari NKJ. Optimal mode of clearance in critically ill patients with acute kidney injury (OMAKI) – a pilot randomized controlled trial of hemofiltration vs hemodialysis: a Canadian Critical Care Trials Group project. Crit Care. Crit Care 2012 Oct 24: 16(5): R205.

2. Odutayo A, Adhikari NKJ, Barton J, Burns KEA, Friedrich JO, Klein D, Lapinsky S, Litwin S, Meret A, Moineddin R, Richardson B, Richardson R, Zaltzman A, Hladunewich M, Wald R. Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort study. Can J Anaesth. Can J Anaesth 2012 Oct; 59(10):934-42

3. Friedrich JO, Wald R, Bagshaw SM, Burns KE, Adhikari NKJ. Hemofiltration compared to hemodialysis for acute kidney injury: systematic review and meta-analysis. Crit Care. Crit Care 2012 Aug 6; 16(4): R146.

4. Friedrich JO, Adhikari NKJ, Beyene J. Ratio of geometric means to analyze cotinuous outcomes in meta-analysis: Comparison to mean differences and ratio of arithmetic means using empiric data and simulation. Stat Med. Stat Med 2012 July 30; 31(17):1857-86.

5. Barrett KA, Ferguson ND, Athaide V, Cook DJ, Friedrich JO, McDonald E, Pinto R, Smith OM, Stevenson J, Scales DC. Surrogate decision makers’ attitudes towards research decision making for critically ill patients. Inten Care Med. Inten Care Med 2012 Oct; 38(10):1616-23.

6. Clark E, Wald R, Levin A, Brouchard J, Adhikari NK, Hladunewich M, Richardson RM, James MT, Walsh MW, House AA, Moist L, Stollery DE, Burns KE, Friedrich JO, Barton J, Lafrance JP, Pannu N, Bagshaw SM; for the Canadian Acute Kidney Injury (CANAKI) Investigators. Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multi-centre observational study. Can J Anaesth. Can J Anaesth 2012 Sep; 59(9): 861-70.

7. Chant C, Mustard M, Thorpe KE, Friedrich JO. Nurse vs. nomogram-directed glucose control in a cardiovascular intensive care unit. A randomized controlled cross-over trial. Am J Crit Care. Am J Crit Care 2012; 21 (4): epub ahead of print.

8. Wald R, Quinn RR, Adhikari NK, Burns KE, Friedrich JO, Garg AX, Harel Z, Hladunewich MA, Luo J, Mamdani M, Perl J, Ray JG; for the University of Toronto Acute Kidney Injury Research Group. Risk of chronic dialysis and death following acute kidney injury. Am J Med. Am J Med 2012 Jun; 125(6): 585-93.

9. Bagshaw SM, Wald R, Barton J, Burns KEA, Friedrich JO, House AA, James MT, Levin A, Moist L, Pannu N, Stollery DE, Walsh MW. Clinical factors associated with initiation of renal replacement therapy in critically ill patients with acute kidney injury—A prospective multicenter observational study. J Crit Care. J Crit Care 2012 Jun; 27(3): 268-75.

Presentations/Lectures: 1. Acute Renal Failure and Renal Replacement Therapy in ICU. Canadian Critical Care Review.

Toronto, Ontario. May 28, 2012 2. Continuous Renal Replacement Therapy – Modalities and mechanisms, Critical Care Medicine.

University of Toronto, Ontario. February 28, 2012

John Granton (Toronto General Hospital, University Health Network) Peer Reviewed Publications:

1. Fan E, Checkley W, Stewart TE, Muscedere J, Lesur O, Granton JT, Freitag AP, Jacka M, Ferguson

ND, Meade MO. Complications from recruitment maneuvers in patients with acute lung injury: secondary analysis from the lung open ventilation study. Respir Care. 2012 Nov;57(11):1842-9. Coauthor or Collaborator.

2. Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hebert P, Sabri E, Meade M, Canadian Critical Care Trials G. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA. 2012 Nov 21;308(19):1985-92. Coauthor or Collaborator.

3. Lalu MM, McIntyre L, Pugliese C, Fergusson D, Winston BW, Marshall JC, Granton J, Stewart DJ, Canadian Critical Care Trials G. Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials. PLoS One. 2012;7(10):e47559. Coauthor or Collaborator.

4. Wang VN, Ahmed M, Ciofani A, Sasson Z, Granton JT, Mak S. The effect of endogenous estrogen on Doppler-estimated right ventricular systolic pressure during exercise. Canadian journal of physiology and pharmacology. 2012 Oct;90(10):1364-71. Coauthor or Collaborator.

5. Downar J, Knickle K, Granton J, Hawryluck L. Using standardized family members to teach communication skills and ethical principles to critical care trainees. Crit Care Med. 2012 Jun;40(6):1814-9. Coauthor or Collaborator.

6. de Perrot M, Granton JT, McRae K, Pierre AF, Singer LG, Waddell TK, Keshavjee S. Outcome of patients with pulmonary arterial hypertension referred for lung transplantation: A 14-year single-center experience. J Thorac Cardiovasc Surg. 2012 Apr;143(4):910-8. Co-Principal Author.

7. Mura M, Anraku M, Yun Z, McRae K, Liu M, Waddell TK, Singer LG, Granton JT, Keshavjee S, de Perrot M. Gene expression profiling in the lungs of patients with pulmonary hypertension associated with pulmonary fibrosis. Chest. 2012 Mar;141(3):661-73 (Trainee publication, Dr. Mura is a fellow in the pulmonary hypertension program). Coauthor or Collaborator.

8. Mak S, Witte KK, Al-Hesayen A, Granton JJ, Parker JD. Cardiac sympathetic activation in patients with pulmonary arterial hypertension. Am J physiol regul integr comp physiol. 2012 May 15;302(10):R1153-7. Coauthor or Collaborator.

9. Johnson SR, Brode SK, Mielniczuk LM, Granton JT. Dual therapy in IPAH and SSc-PAH. A qualitative systematic review. Respir Med. 2012 May;106(5):730-9 (Trainee publication, Johnson PhD candidate. Brode, Respirology Resident). Senior Responsible Author.

10. Gerard LM, Xing K, Sherifi I, Granton J, Barth D, Abdelhaleem M, Bergeron C, Weitzman S, Cserti-Gazdewich C. Adult hemophagocytic lymphohistiocytosis with severe pulmonary hypertension and a novel perforin gene mutation. Int J Hematol. 2012 Apr;95(4):445-50 (Trainee publication, Resident). Coauthor or Collaborator.

11. Johnson SR, Granton JT, Tomlinson GA, Grosbein HA, Hawker GA, Lee P, Seary ME, Feldman BM. Effect of warfarin on survival in scleroderma-associated pulmonary arterial hypertension (SSC_PAY) and idiopathic PAH. A Bayesian approach to evaluating treatment for uncommon disease. J Rheumatology. 2012 Feb;39(2):276-85. (Trainee publication, Post doctoral paper). Coauthor or Collaborator.

12. Yeung MS, Lapinsky SE, Granton JT, Doran DM, Cafazzo JA. Barriers and opportunities in general internal medicine units. J Clin Nurs. 2012 Apr;21(7-8):975-82 (Trainee publication, Engineering Masters Thesis Yeung, Melanie). Coauthor or Collaborator.

Review Articles, Letters & Editorials:

1. Granton, John. The right ventricle in pulmonary hypertension: when good neighbors go bad. Am J Respir Crit Care Med. 2012, 186(2):121-3. Principal Author.

Abstracts:

1. S Mehta, L Burry, D Cook, M Steinberg, D Fergusson, P Hebert, M Herridge, J Granton, N Ferguson, J Devlin, M Tanios, R Fowler, P Dodek, K Burns, M Jacka, K Olafson, S Reynolds, S Keenan, Y Skrobik, J Kutsogiannis, K Antoni, M Meade, for the SLEAP Investigators and Canadian Critical Care Trials Group. SLEAP:. A multicenter randomized trial of daily awakening in critically ill patients being managed with a sedation protocol. Am J Respir Crit Care Med. 2012;185: A3882. Coauthor or Collaborator.

Presentations/Lectures: 1. 2012 Dec 12 Speaker. Withdrawal of life support. Canadian Broadcasting Corporation -

Metro Morning. Toronto, Canada.

2. 2012 Dec 7 Distinguished Speaker. Management of advanced pulmonary hypertension and right heart failure. British Thoracic Society. London, London, City of, United Kingdom.

3.2012 Nov 26 Invited Speaker. Pulmonary hypertension. Division of Cardiology, Universtiy of Western Ontario. London, Ontario, Canada. cardiology grand rounds.

4. 2012 Nov 26 Invited Speaker. Resident case presentation. Division of Cardiology,

University of Western Ontario. London, Ontario, Canada. Presented and reviewed interesting cases with the Cardiology Fellows and residents.

5. 2012 Oct 30 Invited Speaker. Decision making at the end of life - a clinician’s perspective. Canadian Critical Care Forum. Toronto, Ontario, Canada.

6.2012 Sep 28 Invited Speaker. Lung Transplant for Pulmonary Hypertension. Who, what,

when. University of Toronto. Toronto, Ontario, Canada. Part of the U of T update in Pulmonary Hypertension.

7. 2012 Jun 8 Invited Speaker. The heart and the lung. Toronto International Heart Summit. Toronto, Ontario, Canada.

8. 2012 May 26 Invited Speaker. Canadian Perioperative Anaesthesia Meeting. McMaster University. Hamilton, Ontario, Canada. Perioperative management of the patient with pulmonary hypertension.

9.2012 May 23 Invited Speaker. Exercise Interpretation Part II. congenital cardiac program.

Ontario, Canada. 10. 2012 May Invited Lecturer. Comprehensive care of the patient with pulmonary

hypertension - a model of interprofessional care. 11th International Pulmonary Hypertension Forum. Dublin, Ireland.

11. 2012 Apr Invited Lecturer. Pulmonary hypertension secondary to heart failure with

preserved ejection fraction. Canadian Respiratory Conference, Canadian

Thoracic Society. Vancouver, British Columbia, Canada.

12. 2012 Mar 11 Invited Speaker. End of Life Care. CBC Radio - CBC Sunday Edition. Canada. http://www.cbc.ca/thesundayedition/shows/2012/03/11/barney-frank---end-of-life-care---katie-malloch/.

13.2012 Feb Invited Speaker. Heart Lung Interactions. Oakville ICU physicians. Ontario,

Canada. Local CME event. (Continuing Education). 14. 2012 Jan 20 Invited Speaker. City Wide Respirology Rounds. Toronto, Ontario, Canada.

Presenter(s): Granton and Moric. Pulmonary hypertension - understanding hemodynamics and left heart failure. (Continuing Education).

Research Funding: 1. 2012 Sep - 2015 Aug Principal Applicant. RePo1. Randomized, controlled trial of sildenafil in

patients with portal pulmonary hypertension. Canadian Institutes of Health Research (CIHR). PI: Granton, John. Collaborators: Mehta S, Provencher S, Swiston J, Langleben D, Renner E, Tomlinson G, Johnson S, Lien D, Bishouty Z. 188,289 CAD. [Grants] Multicenter RCT of sildenafil vs placebo in patients with portal-pulmonary hypertension.

2. 2012 Mar - 2016 Feb Co-Investigator. Measuring Exercise Tolerance for Surgery (METS).

Canadian Institutes of Health Research (CIHR). Cardiovascular. PI: Wijesundera, Duminda. 987,066 CAD. [Grants] Randomized trial to evaluate the utility of standardized exercise testing in prognosticating outcomes in high risk surgical patients.

3. 2012 Mar - 2014 Feb Co-Investigator. Cellular Immunotherapy for Septic Shock (CISS): A Phase I trial. Canadian Institutes of Health Research (CIHR). Circulatory Physiology. PI: McIntyre, Lauralyn. Collaborators: Duncan Stewart, Keith Walley, John Marshall, Brent Winston, M Lau, S Mei, D Courtman, Dean Ferguson. 366,812 CAD. [Grants] Safety and proof of concept study. Evaluation of Progenitor cells in patients with Septic Shock.

4. 2012 Jan - 2014 Dec Co-Principal Investigator. Development of a Smoking Cessation Collaborative. U of T Department of Medicine. PI: Granton, John. Collaborators: Peter Selby. 71,750 CAD. [Grants] To help develop a smoking cessation collaborative across the TASN hospitals.

5. 2011 Nov - 2012 Oct Co-Principal Investigator. Osteopontin in Idiopathic Pulmonary Arterial Hypertension, A Biomarker and Therapeutic Target. Enteligence Award Program. 100,000 USD. [Research Fellowships]

6.2011 Apr – 2014 Mar Co-Investigator. Screening for dysphagia in patients following prolonged

intubation. Canadian Institutes of Health Research (CIHR). PI: Martino, Rosemary. Collaborators: Martino, Rosemary, Terry Yeo. Stacy Skortez (PhD Candidate). 212,077 CAD. [Grants]

Sara Gray (St. Michael’s Hospital) Peer Reviewed Publications: 1. Rose L, Gray S, Burns K, Atzema C, Kiss A, Worster A, Scales DC, Rubenfeld G, Lee J. Emergency

Department Length of Stay for Patients Requiring Mechanical Ventilation: A Prospective Observational Study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2012 Apr 11;20:30.

2. Djogovic D, Green R, Keyes R, Gray S, Stenstrom R, Sweet D, et al. Canadian Association of Emergency Physicians sepsis treatment checklist: optimizing sepsis care in Canadian emergency departments. Canadian Journal of Emergency Medicine. 2012 Jan;14(1):36-9.

Presentations/Lectures: 1. Critical Care Track. Canadian Association of Emergency Physicians. Niagara Falls, Ontario, Canada.

CAEP Conference. June 5, 2012.

2. Difficult cases in ventilation. Canadian Association of Emergency Physicians. Niagara Falls, Ontario, Canada. CAEP Conference. June 5, 2012

3. I have intubated, now what? MacMaster University, Hamilton. November 2, 2012.

4. Five things you need to know about sepsis. North York General Hospital Emergency Medicine Update. Toronto, Ontario. May 12, 2012

5. Critical Care Cases: How the experts think. North York General Hospital Emergency Medicine update. Toronto, Ontario. Presenter(s): Gray SH, Howes D, Betzner M. May 10, 2012

Research Funding: 1. Pilot KT intervention to address gender differences in access to post arrest care. Canadian Institutes

of Health Research (CIHR). Circulatory & Respiratory Health. Role: Co-Investigator. Total amount: 218,000 CAD.

Anne-Marie Guerguerian (Hospital for Sick Children) Peer Reviewed Publications: 1. Fan E, Guerguerian AM. Extracorporeal life support basics for acute respiratory failure: now and

moving forward. Critical Care Rounds. Vol 8, 6; 2012. Senior Responsible Author.

2. Kim DJ, Czosnyka Z, Kasprowicz M, Smieleweski P, Baledent O, Guerguerian AM, Pickard J, Czosnyka M. Continuous monitoring of Monro-Kellie doctrine: Is it possible? J Neurotrauma. May 1, 2012. 29(7): 1354-1363. November 4, 2011 Epub ahead of print (Trainee publication, Post doctoral research fellow). Coauthor or Collaborator.

3. Moghimi S. Kushki A, Guerguerian AM, Chau T. Characterizing emotional response to music in the prefrontal cortex using near infrared spectroscopy. Neuroscience Letters. 2012 Sep 6;525(1):7-11. Coauthor or Collaborator.

4. Moghimi S, Kushki A, Power S, Guerguerian AM, Chau T. Automatic detection of a pre-frontal cortical response to emotionally-rated music using multi-channel near-infrared spectroscopy. Journal of Neural Engineering. 9(2):026022. Epub 2012 Mar 15. Submission ID: JNE/400878/PAP. Coauthor or Collaborator.

In Press: 1. Jarayam N., Spertus JA., Tang F., Berg R.A., Nadkarni V., Raymond T., Guerguerian AM., Chan

PS. Hospital variation in survival after pediatric in-hospital cardiac arrest. Circulation. under internal peer review. Coauthor or Collaborator.

2. Guerguerian AM, Ogino M, Dalton H, Shekerdemian LS. How to set up an ECLS Program. Pediatric Critical Care Medicine. In Press. Principal Author.


1. Honjo O, Merklinger S, Poe J, Guerguerian AM, Taylor K, Zhang H, Van Arsdell GS. Establishment of mechanically- assisted primary bidirectional cavopulmonary shunt in neonates and infants: an acute human pilot study. Circulation. 2012;126:A19213. This paper was presented at the 2012 American Heart Association Scientific Sessions, Los Angeles, California, November 3-7. Coauthor or Collaborator.

Abstracts:

1. 2012 Nov Co-author. Parent-and Teacher-Rated Attention in the First Year following in the First Year following Pediatric raumatic Brain Injury (TBI). The Hospital for Sick

Children’s Research Institute Retreat. Toronto, Ontario, Canada. Presenter(s): Wilkinson A, Simic N, Nenadovic V, Hussain S, Van Huyse J, Guerguerian AM, Raybaud C, Hahn C, Dennis M, Choong K, Fraser D, Campbell C, Doherty D, Dhanani S, Lacroix J, Schachar R, Hutchison J. Poster presentation.

2. 2012 Nov Co-author. Executive Functioning in the First Year Following Pediatric

Traumatic Brain Injury. The Hospital for Sick Children’s Research Institute Retreat. Toronto, Ontario, Canada. Presenter(s): Simic N, Wilkinson A, Nenadovic V, Hussain S, Van Huyse J, Guerguerian AM, Raybaud C, Hahn C, Denniw M, Choong K, Fraser D, Campbell C, Doherty D, Dhanani S, Lacroix J, Schachar R, Hutchison J. Poster presentation.

Presentations/Lectures: 1. 2012 June Invited Speaker. Major Quality of Care Initiatives 2011/12-Updates: ECMO

2011/12-Updates: ECMO Improvements. SickKids. Labatt Family Heart Centre 9th Annual Retreat. Toronto, Ontario, Canada. Presenter(s): Guerguerian AM. Metropolitan Hotel, June 14, 2012.

2. 2012 Dec Invited Speaker. PCICS/ELSO Joint Consensus statement - Setting Up an ECLS

Program. The Pediatric Cardiac Intensive Care Society 9th International Conference. Miami, Florida, United States. Loews Miami Beach Hotel, Miami, Florida, December 9-12, 2012.

3. 2012 Nov Invited Speaker. Traumatic/Acquired Brain Injury. Research Institute, Hospital for Sick Children. Toronto, Ontario, Canada. Presenter(s): . The Hospital for Sick Children’s Research Institute’s Annual Scientifc Retreat, Metro Toronto Convention Centre.

4. 2012 Oct Poster Presentation. The Development of an ICU Mobiliser for Paediatric Extra-Corporeal Support. Critical Care Canada Forum. Toronto, Ontario, Canada. Presenter(s): Lati J, Davidson L, Poe J, Gauthier D, Shaw K, St George-Hyslop C, Guerguerian AM. Sheraton Centre Hotel & Conference Centre - October 28-31, 2012.

5. 2012 Oct Poster Presentation. An Interprofessional Approach to Early Mobilization for Paediatric Extra-Corporeal Support. Critical Care Canada Forum. Toronto, Ontario, Canada. Presenter(s): Lati J, Davidson L, Macartney J, Niles E, Granger C, St-George-Hyslop C, Liske L, Hamilton L, Kahan I, O’Connell A, Dos Santos S, Hassall A, DeLorenzo S, Cartelle C, hiller S, Petro S, Foreman C, Rodriguez S, Gauthier D, Guerguerian AM. Sheraton Centre Hotel & Conference Centre - October 28-31, 2012.

6. 2012 Oct Facilitator. Session: Cardiology II. Critical Care Canada Forum. Toronto, Ontario, Canada. Sheraton Centre Hotel & Conference Centre - October 28-31, 2012.

7. 2012 Oct Invited Speaker. Caring for the Brain-Injured Patient II- Traumatic Brain Injury Trials - What’s Next? Critical Care Canada Forum. Toronto, Ontario, Canada. Sheraton Centre Hotel & Conference Centre - October 28-31, 2012.

8. 2012 Oct Invited Speaker. Cardiology II- Pediatric Resuscitation - What’s Next? Critical Care

Canada Forum. Toronto, Ontario, Canada. Sheraton Centre Hotel & Conference Centre - October 28-31, 2012.

9. 2012 Oct Invited Speaker. Extracorporeal Life Support (ECLS)/Advanced Technologies (AT) in the Cardiac Critical Care Unit (CCCU). Cardiac CCU Retreat. Toronto, Ontario, Canada.

Research Funding: 1. 2012 Jul - 2015 Jun Co-Principal Investigator. A Randomized Controlled Trial of Hybrid and

Norwood Surgical Strategies for Single Ventricle Congenital Heart Disease. Heart and Stroke Foundation of Canada (HSFC). PI: Caldarone, Christopher; Guerguerian, Anne-Marie. Collaborators: Van Arsdell G, Schwartz S., McCrindle B., Chaturvedi R., Laughlin S., Dennis M. 228,234 CAD. [Grants]

2. 2010 Jul - 2015 Jun Site Investigator. A randomized controlled trial of Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA). National Heart, Lung, and Blood Institute (NHLBI) (USA). PI: Moler, Frank; Dean, Mike. Collaborators: Schwartz, Steven M; Guerguerian, Anne-Marie - THAPCA site investigators. 21,000,000 USD. [Grants]

David Hall (St. Michael’s Hospital) Publications: 1. Balter M, Hall D, (editors). Essential of Clinical Examination Handbook. University of Toronto. Co-

editor. 2012 Presentations/Lectures: 1. Primary Ciliary Dyskinesia-The Beat Goes On. Canadian Cardiovascular Congress. Toronto, Ontario.

October 30, 2012.

2. Exome sequencing in Primary Ciliary Dyskinesia. Hospital for Sick Children Division of Clinical and Metabolic Genetics. Toronto. Hospital for Sick Children Division of Clinical and Metabolic Genetics 1st annual Research Day. March 2, 2012. (Trainee Presentation)

3. Lung Mechanics . Adult Critical Care Medicine Lecture Series, Critical Care Medicine, St. Michael’s Hospital. August 14, 2012

4. Ventilator Waveform Analysis. Adult Critical Care Medicine Lecture Series, Critical Care Medicine, St. Michael’s Hospital. August 7, 2012

Research Funding: 1. Exome Sequencing in Primary Ciliary Dyskinesia. University of Toronto McLaughlin Centre. MC-

2012-08. Role: Principal investigator. Total amount: $30,000. May 2012 – April 2013 2. Rare Genetic Disorders of the Airways: Cross-sectional Comparison of Clinical Features, and

Development of Novel Screening and Genetic Tests. NIH. Rare Diseases Clinical Research Network. Role: Principal applicant. Total amount: $29,808. August 2012 – July 2013

Laura Hawryluck (Toronto General Hospital, University Health Network) Peer Reviewed Publications: 1. Downar J, Knickle K, Granton JT, Hawryluck L Using standardized family members to teach

communication skills and ethical principles to critical care trainees, Critical care Med 2012 Jun 40(6) 1814-9

Abstracts: 1. Luke Devine, Hawryluck L. Is it time to stop the code? : A multidisplinary team based scenario using

high fidelity simulation and standardized paticipants. International Meeting on Simulation in HealthCare San Diego Jan 2012.

2. Daley I, Doyle A, Hawryluck L., The Challenges of off-service Patients: exploring patterns of utilization of Critical Care Response Teams (CCRT), CACCN Dynamics Vancouver BC Sept 2012—abstract and poster presentation

3. Daley I, Doyle A, Hawryluck L., The Challenges of off-service Patients: exploring patterns of utilization of Critical Care Response Teams (CCRT), Dynamics Toronto May 2012—abstract and oral presentation

4. Robitaille T, Daley I, Morris D, Lazar N, Hawryluck L, Continuity of care in chronic critical illness,

Dynamics Toronto May 2012 –Abstract and oral presentation

5. Robitaille T, Daley I, Morris D, Lazar N, Hawryluck L, Continuity of care in chronic critical illness, CACCN Dynamics Vancouver BC Sept 2012—Abstract and oral presentation

6. Daley I, Doyle A, Hawryluck L, Challenges of off service patient, outcomes and role of CCRT, ESCIM abstract and poster presentation Lisbon Portugal Oct 2012

Presentations/Lectures: 1. Improving communication and decision-making – workshop with CVICU, University Health Network

Jan. 2012 2. End of Life decision-making and advance care planning panel discussion with M. Handelman and J.

Himel Feb 2012

3. CCRT Continuing Education: Airway Management with simulation workshop March 2012

4. Patient Advocacy and social media: new ethical frontiers, Evolutions, Canadian Association of Critical Care Nurses Toronto Chapter, April 30th, 2012

5. Acute Resuscitation and sudden Death, CCRT update, University Health Network, July 30, 2012

6. Update in medical legal issues: implications of the Rasouli case to date, Hotel Dieu Hospital Critical

care Grand Rounds, August 2012

7. The End of Life as we know it, webcast, MedicoLegal Society of Toronto March 23, 2012 8. End of life issues, OHA Conference for the Elderly May 2012

9. Hawry;uck L, Soins de fin de vie et allocations de resources, French Black African Conference in

Anesthesia and Critical care (SRANF), Nov 21-24th Grand Bassam Ivory Coast Africa

10. Hawryluck L and Pr F. Patry, Soins palliatives en Reanimation, Centre des Grands Brules, Abidjan

Ivory Coast Africa Nov 2012

11. Hawryluck L, Bouali R, Oxygene a Grand Debit et ventilation non-invasive, Centre des Grands Brules, Abidjan Ivory Coast Nov 2012

12. Hawryluck L, Defits ethiques en reamination, Centre des Grands Brules, Abidjan Ivory Coast Nov 2012

Research Funding: 1. Ethics and Values in Health Policy: improving care transitions for Ontario patients across the

continuum of care, PHSI $ 336 947.00, CO-investigator 2011- 2014

2. Development of a standard ethical framework to shape health policy development in Ontario with MHLTC Health Policy division, CIHR Co-PI, $12 500 2010-present

3. Cardiopulmonary Resuscitation in Transplant recipients, co-PI 2011- 2012 unfunded

4. Educational needs assessment for Critical Care in Nepal co-PI, 2011-present unfunded 5. Continuity of Care Rounds: an innovative approach to improving quality of care of longer stay MSICU

patients co-PI, 2011-present unfunded

6. Off service patients: can CCRT meet their care needs, co-PI 2011-present unfunded

7. Resuscitation Outcomes Consortium Amiodarone, Lidocaine or Neither for out of hospital cardiac arrest due to VF or VT. Co- Investigator REB 11-0503B 2011-May 2013

8. Resuscitation Outcomes Consortium Trial of Continuous compressions vs standard CPR in out of hospital arrests. Co-Investigator REB 11-0208B 2011 May-2013

9. Hemodynamics post lung transplant in patients with pulmonary hypertension, Co-PI, 2010- present unfunded

Christopher Hayes (St. Michael’s Hopsital) Peer Reviewed Publications: 1. Hayes CW. The Surgical Safety Checklist: Improved Patient Safety through Improved Teamwork.

Healthcare Quarterly. 15 (Special Issue) 2012: 57-62.


1. Improving Safety and Quality: The role of champions. Health PEI. Charlottetown, Prince Edward Island, Canada. November 6, 2012

2. Canada’s Virtual Forum on Patient Safety and Quality Improvement. Canadian Patient Safety Institute. Edmonton, Alberta, Canada. November 1, 2012.

3. Preventing HAIs…Improving patient safety, Johnson and Johnson Healthcare Acquired Infections

Symposium. Toronto, Ontario. September 24, 2012. 4. When is an Incident a “Critical Incident”? Ontario Hospital Association. Toronto, Ontario. June 4,

2012. 5. Applying the Canadian Incident Analysis Framework. Canadian Society of Physician Executives,

Canadian Medical Association. Ottawa, Ontario. April 12, 2012.

6. Building Capacity in Patient Safety Training: Residency and Beyond. National Guard Health Affairs. Riyadh, Saudi Arabia. April 23, 2012.

7. Safe Surgery Saves Lives: A National Initiative to Improve Surgical Safety in Canada. National Guard Health Affairs. Riyadh, Saudi Arabia. April 22, 2012.

8. Clinical Pathological Conference - Patient Safety. Medical Gran Rounds, St. Michael’s Hospital, Toronto, Ontario. January 25, 2012.

Research Funding: 1. SEARCHED: Sepsis Early Antibiotics and Resuscitation to Control Infected Patients in the

Emergency Department. AHSC Alternate Funding Plan Innovation Fund - MOHLTC. Role: Principal investigator. Total amount: 82,455. October 2012 - 2013

Margaret Herridge (Toronto General Hospital, University Health Network) Peer Reviewed Publications: 1. Batt J, Dos Santos CC, Cameron JI, Herridge MS. Intensive-Care Unit Acquired Weakness

(ICUAW): Clinical Phenotypes and Molecular Mechanisms. Am J Respir Crit Care Med. 2012 Nov 29: epub ahead of print. In Press. Senior Responsible Author.

2. Ferguson ND, Scales DC, Pinto R, Wilcox ME, Cook DJ, Guyatt GH, Schünemann HJ, Marshall JC,

Herridge MS, Meade MO; for the Canadian Critical Care Trials Group. Integrating Mortality and Morbidity Outcomes: Using Quality-Adjusted Life Years in Critical Care Trials. AM J Resp Crit Care Med. 2012 Nov 30. [Epub ahead of print]. Coauthor or Collaborator.

3. Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J,

Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hébert P, Sabri E, Meade M; SLEAP Investigators; Canadian Critical Care Trials Group. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA. 2012 Nov 21;308(19):1985-92. Coauthor or Collaborator.

4. Wilcox E, Rivera P, Sasson C, Ware L, Wunsch L, Herridge MS. Clinical Year in Review II : Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS), Critical Care Update 2012 and Lung Cancer. Am J Respir Crit Care Med. 2012 In Press. In Press. Senior Responsible Author.

5. Bienvenu OJ, Colantuoni, Mendez-Tellez PA, DInglas VD, Shanholtz C, Husain N, Dennison CR, Herridge MS, Pronovost PJ, Needham DM. Depressive Symptoms and Impaired Physical Function after Acute Lung Injury: A 2-Year Longitudinal Study. Am J Respir Crit Care Med 2012; 185: 517-524. Coauthor or Collaborator.

In Press: 1. Choong K, Koo K, Cook D, Thabane L, Chu, R, Clark H, Herridge MS, Meade M. Early Mobilization

in Critically Ill Children: A Survey of Canadian Practice. Crit Care Med. 2012 In Press. In Press. Coauthor or Collaborator.

2. Herridge MS. Surviving ARDS: Is There a Role for ALI/ARDS Specific Rehabilitation? Sem Respir

Crit Care Med. 2012 In Press. In Press. Principal Author. 3. Wilcox E, Tansey C, Matte A, Tomlinson G, Herridge MS. Five-year radiological outcomes in

Survivors of ARDS. CHEST. In Press (Trainee publication). Senior Responsible Author. 4. N. Zytaruk, M. Meade, S. Mehta, R. Hall, J. Granton, N.D. Ferguson, A. Freitag, J. Muscedere, R.

Fowler, Y. Skrobik, M. Jacka, J. Marshall, F. Lauzier, F. Lamontagne, A. Turgeon, N. Vlahakis, J.R. Klinger, P. Devereaux, M. Ostermann, O. Berwanger, K. Khwaja, L. Burry, J. Freidrich, K.E.A. Burns, M. Herridge, D.J. Cooper, A. Bersten, D. Heels-Ansdell, D. Cook for the PROTECT Investigators, the CCCTG and the ANZICS-CTG. Risk Factors For Pulmonary Embolism In Medical-Surgical ICU Patients. Am J Resp Crit Care Med 2011 p.A2359. In Press. Coauthor or Collaborator.

5. S Mehta, L Burry, D Cook, M Steinberg, D Fergusson, P Hebert, M Herridge, J Granton, N Ferguson,

J Devlin, M Tanios, R Fowler, P Dodek, K Burns, M Jacka, K Olafson, S Reynolds, S Keenan, Y Skrobik, J Kutsogiannis, K Antoni, M Meade, for the SLEAP Investigators and Canadian Critical Care Trials Group. SLEAP: A multicenter randomized trial of daily awakening in critically ill patients being managed with a sedation protocol. Am J Respir Crit Care Med 2012;185: A3882. In Press. Coauthor or Collaborator.

6. L. Pearmain, A. Steel, N. Lazar, A. Pierre, L. Hawryluck, E. Fan, L.M.Chu, L. Chan, A.L. Matte, J.I.Cameron, M.S. Herridge. Venoarterial Extracorporeal Membrane Oxygenation (ECMO) For Hemodynamic Collapse from Toxic Shock Syndrome and H3N2 Influenza. Proc Am Thorac Soc. In Press. Senior Responsible Author.

7. Herridge MS. Lung Injured Patients Do Not Need a Specialized Rehabilitation Program: ICUAW as a

Case Study. Sem Resp Crit Care Med. In Press. In Press. Principal Author.

8. Haas B and Herridge MS. Intensive Care Unit Acquired Weakness. Textbook of Trauma and Critical Care. In Press (Trainee publication). Senior Responsible Author.

9. Herridge MS. Models of Rehabilitative Care after Critical Illness. IN The Legacy of Critical Illness: A

text book of Post ICU Medicine. In Press. Co-Principal Author. 10. Herridge MS. Linking ICU practice to long-term outcome: Fostering a longitudinal vision for ICU-

acquired morbidity. Am J Respir Crit Care Med 2012 In Press. In Press. Principal Author. Submitted Publications: 1. Mobilization of Critically Ill Adults: Survey of Knowledge, Perpectives and Practices of Canadian

Physicians and Physiotherapsits. Koo K, Chhong K, Cook D, Herridge MS, Newman A, Lo V, Priestap F, Campbell E, Burns K, Lamontagne F, Meade M.

2. Batt J, Dos Santos C, Cameron JI, Herridge MS. Intensive Care Acquired Weakness: Clinical

Phenotypes, Spectrum of Disability and Pathophysiology. Am J Resp Crit Care Med. under revision. Senior Responsible Author.

3. Fan E, Brower R, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, Hopkins RO, Hough CL, Kress JP, Latronico N, Moss M, Needham D, Rich M, Stevens R, Winkelman C, Zochodne D, Ali N. AN OFFICIAL ATS CLINICAL PRACTICE GUIDELINE: THE DIAGNOSIS OF INTENSIVE CARE UNIT ACQUIRED WEAKNESS. Am J Resp Crit Care Med. Coauthor or Collaborator.

4. Pearmain L, Herridge MS. Patient and Caregiver Outcomes after Acute Respiratory Distress

Syndrome. Minerva Anesthesiologica (Trainee publication, Critical care clinical fellow). Senior Responsible Author.

Book Chapters: 1. Kress JP and Herridge MS. Medical and Economic Implications of Physical Disability of Survivorship.

Sem Resp Crit Care Med. 2012 In Press. In Press. Co-Principal Author. Review Articles, Letters, and Editorials: 1. Herridge MS. The Robust and Homogeneous Phenotype of Severe Lung Injury. CHEST 2012 In

Press. In Press.Principal Author. 2. Kress JP and Herridge MS. Medical and Economic Implications of Physical Disability of Survivorship.

Sem Resp Crit Care Med. 2012 In Press. In Press. Co-Principal Author. Abstracts: 1. S Mehta, L Burry, D Cook, M Steinberg, D Fergusson, P Hebert, M Herridge, J Granton, N Ferguson,

J Devlin, M Tanios, R Fowler, P Dodek, K Burns, M Jacka, K Olafson, S Reynolds, S Keenan, Y Skrobik, J Kutsogiannis, K Antoni, M Meade, for the SLEAP Investigators and Canadian Critical Care Trials Group. SLEAP: A multicenter randomized trial of daily awakening in critically ill patients being

managed with a sedation protocol. Am J Respir Crit Care Med 2012;185: A3882. In Press. Coauthor or Collaborator.

2. Raggi M, Cameron JI, Singer S, Herridge MS. Long-term Outcomes in Lung Transplant (LTX) Patients Requiring Prolonged Mechanical Ventilation. Am J Respir Crit Care Med 2012; 185: A2298. Senior Responsible Author.

3. Raggi M, Herridge MS, Brooks D, Singer L, Cameron JI. Outcomes in Family Caregivers of Lung Transplant (LTX) Patients Requiring Prolonged Mechanical Ventilation. Am J Respir Crit Care Med 2012; 185: A2294. Senior Responsible Author.

4. Mathur S, Topalovic N, Sala J, Chow G, Gage WH, Cameron J, Herridge MS. Decrements in muscle strength and muscle power following critical illness. Submitted to the Combined Sections Meeting, American Physical Therapy Association, May 2012. In Press. Senior Responsible Author.

Presentations/Lectures: 1. 2012 Nov Invited Speaker. Ubiquitination in ICU Acquired Weakness: Clinical Phenotypes and

Molecular Mechanisms. National Heart, Lung and Blood Institute/ National Institute of Health. Bethesda, United States.

2. 2012 Nov Visiting Professor. Long-term Outcomes after ARDS. British Thoracic Society. London,

United Kingdom. 3. 2012 Oct Invited Speaker. ICU as One Step in the Continuum of Treatment. European Society of

Intensive Care Medicine. Lisbon, Spain. 4. 2012 Oct Invited Speaker. Burnout Syndrome in the ICU. European Society of Intensive Care

Medicine. Lisbon, Spain. 5. 2012 Oct Invited Speaker. How to be an Effective Mentor. European Society of Intensive Care

Medicine. Lisbon, Spain. 6. 2012 Oct Invited Speaker. Rehabilitation after Critical Illness. European Society of Intensive Care

Medicine. Lisbon, Spain.

7. 2012 Sept Distinguished Speaker. Long-term Outcomes after ARDS and Rehabilitation Strategies. Swedish Society of Anesthesia and Intensive Care Medicine. Sweden.

8. 2012 Sept Distinguished Speaker. Outcomes after Critical Illness and Where we go from here.

Swedish Society of Anesthesia and Intensive Care Medicine. Sweden. 9. 2012 May Invited Speaker. Outcomes after ARDS and a discussion of the ACOS study. American

Journal of Respiratory and Critical Care Medicine. United States. Podcast conducted and then aired through the Journal website.

10. 2012 May Chair. Clinical Year in Review-1. American Thoracic Society. San Francisco, California,

United States.

11. 2012 May Chair. Clinical Year in Review-2. American Thoracic Society. San Francisco, California, United States.



14. 2012 May Invited Speaker. Ubiquitination in ICU Acquired Weakness. American Thoracic Society. San Francisco, California, United States.

15. 2012 May Presenter. Towards RECOVER: Long-term patient outcomes after Prolonged Mechanical

Ventilation. American Thoracic Society. San Francisco, California, United States. 16. 2012 Apr Distinguished Speaker. Outcomes after Critical Illness and Rehabilitation. Physical

Therapy and Allied Health Professionals. Toronto, Ontario, Canada. Research Funding: 1. 2013 Jan - 2015 Jan Co-Principal Investigator. Towards RECOVER: Interdisciplinary and

molecular characterization of functional disability after critical illness and development of a familycentred rehabilitation program. Alternate Funding Plan -University Health Network/MSH. PI: Herridge and Cameron. Collaborators: towards RECOVER investigators. 198,000 CAD. [Grants].

2. 2012 Jul - 2013 Jul Co-Investigator. One-Day Point Prevalence for ICU early Mobility.

Academic Health Science Centre AFP Innovation Fund. AFP Innovation Fund. PI: Karen Koo. 102,103 CAD. [Clinical Trials] Point prevalence study.

3. 2012 Jul - 2013 Jul Co-Investigator. One-day point prevalence of ICU early mobility across

Canada. Physician Services Incorporated Health Research Grant. 58,234 CAD. [Grants].

4. 2011 Jul - 2013 Jun Co-Investigator. Muscle Outcomes after Critical Illness. Physicians

Services Incorporated Foundation (The) (PSI). PI: Batt, Jane. 80,000 CAD. [Grants].

5. 2011 Jul - 2012 Jun Co-Investigator. The Effects of Electrical Muscle Stimulation (EMS) on Muscle Atrophy and Functional Outcomes in Critically Ill Patients: A Pilot Randomized Controlled Trial. Canadian Respiratory Health Professionals. PI: Lo, Vincent and Mathur, Sunita. 24,931 CAD. [Grants].

6. 2011 Jul - 2012 Jun Co-Investigator. The Canadian Pandemic Research Preparedness Strategy. Public Health Agency of Canada. PI: Karen Burns, Rob Fowler and John Marshall. 250,000 CAD. [Grants].

7. 2010 Sep - 2012 Aug Co-Investigator. Muscle outcomes after critical illness. Physicians Services Inc. PI: Jane Batt. 169,634 CAD. [Grants].

8. 2009 Sep - 2013 Aug Principal Investigator. Towards RECOVER: Long-term Clinical Outcomes and Needs Assessment in ICU Survivors of Prolonged Mechanical Ventilation and their Caregivers. Canadian Institutes of Health Research (CIHR). 654,368 CAD. [Grants].

Patricia Houston (St. Michael’s Hospital) Peer Reviewed Publications: 1. Spadafora, S, Houston PL, Levine, M. A National Curriculum in Anesthesia: Rationale, Development,

Implementation, and Implications. Can J Anesth. Jul;59(7):636-41. 2012. Co-author.

Presentations/Lectures: 1. Panelist. Sustainability of Healthcare - how do we move forward. Australian Society of

Anesthesiologists. Australia. 2012.

2. Physician Leadership - Anesthesia at a Crossroads. BCAS. Canada. December 2012. 3. Professionalism in Canadian Anesthesiology. BCAS Annual Meeting. Vancouver, British Columbia,

Canada. December 2012.

4. Re-Design of a Pre-Admission Facility: Interactive Quality Improvement Workshop. Canadian Anesthesia Society Meeting. June 2012.

Tilman Humpl (Hospital for Sick Children) Peer Reviewed Publications: 1. Apitz C, Honjo O, Humpl T, Li J, Assad RS, Cho MY, Hong J, Freidberg MK, Redington AN.

Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload. J Thorac Cardiovasc Surg. 2012 Dec;144(6):1494-501 CA

2. Bastero-Minon P, Russell JL, Humpl T. Frequency, characteristics, and outcomes of pediatric

patients readmitted to the cardiac critical care unit. Intensive Care Med. 2012 Aug;38(8):1352-7 SRA 3. Fraser C, Jaquiss R, Rosenthal D, Humpl T, Canter C, Blackstone E, Naftel D, Ichord R, Bomgaars

L, Tweddell J, Massicotte P, Turrentine M, Cohen G, DeVaney E, Pearce FB, Carberry K, Kroslowitz R, Almond C; on behalf of the Berlin Heart Study Investigators: Prospective trial of a pediatric ventricular assist device. N Engl J Med. 2012 Aug;367(6):532-4 CA

4. Berger RMF, Beghetti M, Humpl T, Raskob GE, Ivy DD, Jing ZC, Bonnet D, Schulze-Neick I, Barst

RJ. Clinical features of Pediatric pulmonary hypertensive vascular disease: The global registry tracking outcomes and practice in pediatric pulmonary hypertension (TOPP). Lancet. 2012 Feb;379(9815):537-46 CA

5. Apitz C, Honjo O, Friedberg MK, Assad RS, Van Arsdell G, Humpl T, Redington AN. Beneficial

effects of vasopressors on right ventricular function in experimental acute right ventricular failure in a rabbit model. Thorac Cardiovasc Surg. 2012 Feb;60(1):17-23 CA

Non-Peer Reviewed: 1. Granton J, (Chair), Panel: Ibrahim R, Humpl T, Swiston J, Kiess M. Colloquium: Advances in

Pulmonary Arterial Hypertension Diagnosis and Mangement. Medical Post Supplement. 2012 CA Presentations/Lectures: 1. Pediatric Ventricular Assist Device. Heart Transplant Symposium, Cambridge, Ontario, Canada.

October 2012

2. Wong J, Belik J, Humpl T, Reyes J, Narang I. Sleep disordered breathing in children with trisomy 21 and pulmonary hypertension. ERS Annual Congress, Vienna, Austria. September 2012 CA

3. Immediate Postoperative Care (Session III: Patient Care after Implantation). Mechanical Cardiac Support in Pediatric Heart Disease State of the Art 2012. St. Louis, Missouri, USA. September 2012

4. Beghetti M, Schulze Neick I, Barst RJ, Kronmal RA, Berger RMF, Humpl T, for the TOPP Registry Investigators. Can the clinical classification of congenital heart disease associated pulmonary arterial hypertension be used in pediatrics? Analysis of the TOPP registry. ESC Congress, Munich, Germany. August 2012 SRA.

5. Humpl T, Barst RJ, Kronmal R, Berger RMF, Moore D, Fasnacht Boillat, MS, Zuk M, Beghetti M, Schulze-Neick I. Contemporary therapy in pediatric pulmonary hypertension (PH) – results from the global registry tracking outcomes and practice in pediatric pulmonary hypertension (TOPP). ESC Congress, Munich, Germany. August 2012 PA

6. Humpl T, Barst RJ, Barst R, Kronmal RA, Berger RMF, Moore DJ, Fasnacht Boillat MS, Schulze-Neick I, Beghetti M. Treatment patterns in pediatric pulmonary hypertension (PH) – Results from the first pediatric global registry: Tracking Outcomes and Practices in Pediatric Pulmonary Hypertension (TOPP). 2012 Pulmonary Hypertension Association, Orlando, Florida, USA. June 2012 PA

7. Schulze-Neick I, Humpl T, Berger RMF, Kronmal RA, Weintraub R, Saji B, Yung D. Barst RJ, Beghetti M. Hemodynamic characteristics at diagnosis in children with pulmonary hypertension: Insights from the global TOPP (Tracking Outcomes and Practices in Pediatric Pulmonary Hypertension) Registry. 2012 Pulmonary Hypertension Association, Orlando, Florida, USA. June 2012 CA

8. Beghetti M, Schulze Neick I, Barst RJ, Kronmal RA, Berger RMF, Humpl T, for the TOPP Registry Investigators. Can the clinical classification of congenital heart disease associated pulmonary arterial hypertension be used in pediatrics? Analysis of the TOPP registry. 46th Annual Meeting of the Association for European Paediatric and Congenital Cardiology, Istanbul, Turkey. May 2012 SRA

9. Humpl T, Barst RJ, Barst R, Kronmal RA, Berger RMF, Moore DJ, Fasnacht Boillat MS, Schulze-

Neick I, Beghetti M. Treatment patterns in pediatric pulmonary hypertension (PH) – Results from the first pediatric global registry: Tracking Outcomes and Practices in Pediatric Pulmonary Hypertension (TOPP). 46th Annual Meeting of the Association for European Paediatric and Congenital Cardiology, Istanbul, Turkey. May 2012 PA

10. Pulmonalarterielle Hypertonie im Kindesalter (Pulmonary Arterial Hypertension in Pediatrics). Grand Rounds Kardiologie, Inselspital Bern, Switzerland. May 2012

11. Humpl T, Barst RJ, Barst R, Kronmal RA, Berger RMF, Moore DJ, Fasnacht Boillat MS, Schulze-Neick I, Beghetti M. Treatment patterns in pediatric pulmonary hypertension (PH) – Results from the first pediatric global registry: Tracking Outcomes and Practices in Pediatric Pulmonary Hypertension (TOPP). Pediatric Academic Societies Annual Meeting, Boston, Massachusetts, USA. April 2012 PA

12. Schulze-Neick I, Humpl T, Berger RMF, Kronmal RA, Weintraub R, Saji B, Yung D. Barst RJ, Beghetti M. Hemodynamic characteristics at diagnosis in children with pulmonary hypertension: Insights from the global TOPP (Tracking Outcomes and Practices in Pediatric Pulmonary Hypertension) Registry. Pediatric Academic Societies Annual Meeting, Boston, Massachusetts, USA. April 2012 PA

13. Peri operative pulmonary hypertension management. 30th Congress of the Brazilian Society for Cardiovascular Surgery. Brazil. April 2012

14. Hemodynamic support: From vasoactive drugs to Berlin Heart – What is the limit? 30th Congress of the Brazilian Society for Cardiovascular Surgery. Brazil. April 2012

15. The pediatric cardiovascular surgery postoperative care unit in the XXI Century. 30th Congress of the Brazilian Society for Cardiovascular Surgery. Brazil. April 2012

16. Jacques F, Honjo O, Moga M-A, Grasso F, Baba K, Hickey E, Humpl T, Schwartz S, Caldarone CA, Redington AN, Van Arsdell G. Improving survival by targeting errors. ACC, Chicago, Illinois, USA. March 2012 PA

17. Floh A, Bastero-Minon P, Humpl T. Active circulation volume as a volumetric marker for routine bedside use with pediatric ICU patients. SCCM, Houston, Texas, USA. February 2012 SRA

Jamie Hutchison (Hospital for Sick Children) Peer Reviewed Publications: 1. Zolkipli Z, Sherlock M, Biggar WD, Taylor G, Hutchison JS (CA), Peliowski A, Alman BA, Ling SC,

Tein I. Abnormal fatty acid metabolism in spinal muscular atrophy may predispose to perioperative risks. European Journal of Paediatric Neurology. 2012 Sep;16(5):549-53.

Presentations/Lectures: 1. Visiting Professor. Brain hypothermia treatment for children. National Centre for Child Health and

Development. Japan. Presenter(s): Hutchison, James.

2. Visiting Professor. Neuroprotection in brain injury. Tokyo Metropolotan Children’s Medical Centre. Japan. Presenter(s): Hutchison, James.

3. Invited Speaker. Controversies in the Pediatric Neuro ICU: Sodium Management in the Head-Injured

Child: Do you need to run them high? Society for Critical Care Medicine. Houston, Texas, United States. Presenter(s): Hutchison, James.

4. Invited Speaker. Brain hypothermia treatment for children. Japenese Society of Intensive Care

Medicine. Japan. Presenter(s): Hutchison, James.

5. Invited Speaker. Research Challenges. Japenese Society of Intensive Care Medicine. Japan. Presenter(s): Hutchison, James.

6. Participant. Panel discussion on education in pediatric neurocritical care. Japenese Society of

Intensive Care Medicine. Japan. Presenter(s): Hutchison, James Research Funding: 1. 2010-2012 Principal Applicant. Biomakers and Quality of Life in Children with Traumatic Brain

Injury. Ontario Neurotrauma Foundation / Victoria Neurotrauma Foundation. PI: Hutchison, Jamie. Collaborators: Vicki Anderson, Anne-Marie Guerguerian, Miriam Beauchamp, Martin Post. 505,527

2. 2010-2012 Collaborator. The Pediatric Traumatic Brain Injury Computerized Tomography Scan

Tool. Ontario Neurotrauma Foundation. PI: Guerguerian, Anne-Marie. Collaborators: Jamie Hutchison, A. Kulkarni, S. Laughlin. 98,000

3. 2009-2015 Co-applicant. Therapeutic Hypothermia in Pediatric Cardiac Arrest. National Institutes of

Health. Collaborators: Frank Moler, Jamie Hutchison. 3,600,000. [Grants]

4. 2009-2012 Collaborator. Continuous EEG monitoring in the Paediatric Intensive Care Unit.

Canadian Institutes of Health Research. Collaborators: Cecil Hahn, Jamie Hutchison, Chris Parshuram. 431,695. [Grants] SickKids New Investigator Grant.

5. 2007-2012 Co-applicant. Centre for Study of Complex Childhood Disease. Canadian Foundation for

Innovation. Collaborators: Martin Post, Jamie Hutchison. 20,400,000. [Grants]

Brian Kavanagh (Hospital for Sick Children) Peer Reviewed Publications: 1. N Ngiam, BP Kavanagh. Ventilator induced lung injury: the role of gene activation. SRA

Current Opinion in Critical Care 18:16-22, 2012.

2. D Engelberts, A Malhotra, JP Butler, GP Topulos, SH Loring, BP Kavanagh. SRA Relative Effects of Negative vs. Positive pressure ventilation depend on applied conditions. Intensive Care Medicine 38:879-85, 2012.

3. G Peng, J Ivanovska, C Kantores, T Van Vliet, D Engelberts, BP Kavanagh, M Enomoto, J Belik, A

Jain, P McNamara, R Jankov. Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats. C American Journal of Physiology-Heart and Circulation Physiology 302:H2599-611, 2012.

4. M Chierichetti, D Engelberts, A El-Khuffash, P Babyn, M Post, BP Kavanagh. Continuous negative

abdominal distension augments recruitment of atelectatic lung. SRA Critical Care Medicine 40:1864-72, 2012.

5. MR Tonelli, JR Curtis, KK Guntupalli, GD Rubenfeld, AC Arroliga, L Brochard, IS Douglas, DD

Gutterman, JR Hall, BP Kavanagh, J Mancebo, CJ Misak, SQ Simpson, AS Slutsky, AF Suffredini, BT Thompson, LB Ware, AP Wheeler, MM Levy; ACCP/ATS/SCCM Working Group. An official multi-society statement: the role of clinical research results in the practice of critical care medicine. American Journal of Respiratory and Critical Care Medicine 185:1117-24, 2012

6. EC Goligher, ND Ferguson, BP Kavanagh. Ventilator-induced diaphragm dysfunction: From mice

(hopefully) to men (Editorial). SRA Anesthesiology 117:463-64, 2012

7. Kavanagh BP. Glucose in the ICU – Evidence, guidelines and outcomes (Editorial). SRA New England Journal of Medicine 367:1259-60, 2012.

Submitted Publications: 1. N de Prost, EL Costa, T Wellman, G Musch, MR Tucci, T Winkler, RS Harris, K Takahashi, JG

Venegas, BP Kavanagh, MF Vidal Melo. Effects of ventilation strategy on distribution of lung inflammatory cell activity. C Critical Care Medicine (submitted)

2. M Cereda, Y Xin, K Emami, J Huang, J Rajaci, H Profka, B Han, P Mongkolwisetwara, S Kadlecek,

NN Kuzma, S Pickup, BP Kavanagh, CS Deutschman, RR Rizi. PEEP increments during anesthesia in normal lung result in hysteresis and greater numbers of smaller aerated airspaces. C Anesthesiology (submitted)


1. Critical Care Canada Forum, Toronto, Canada, OCTOBER 2012 • Plenary RCT: The CHEST Trial (Co-Moderator) • Do circulating mediators cause VILI? • Plenary address: Evidence-Based Guidelines for Sedation in 2012: Are We There? (Co-

Moderator)

2. ANZICS/ACCCN Intensive Care Annual Scientific Meeting, Adelaide, Australia, OCTOBER 2012 • Acute lung injury (paediatric plenary) • Lessons learned from trials of PEEP

• Was Nice-Sugar really Necessary?

3. European Society of Intensive Care Medicine 25th Annual Congress, Lisbon, Portugal, OCTOBER 2012

• Targeting normal values in critical illness – what is the rationale? • Molecular Mechanisms in Sepsis (Chair) • Open lung strategies during shock: balancing competing priorities • Pediatric respiratory insufficiency

4. American Society of Anesthesiologists (ASA) Annual Meeting, Washington, USA, OCTOBER 2012

• We Give Too Much Fluid for High Risk Surgery (Co-Chair)

5. 4th Congress of the European Academy of Paediatric Societies (EAPS), Istanbul, Turkey, OCTOBER 2012

• Respiratory Failure (Chair) • Pro-Con debate: RCTs in ICU setting: sense or no sense (CON) • Control of Breathing (Chair)

6. Paediatric Intensive Care Society (PICS) Annual Conference, Dublin, Ireland, SEPTEMBER 2012

• Getting stuck with guidelines – Lessons from Glucose in ICU (plenary lecture)

7. American Thoracic Society Annual Meeting, San Francisco, USA, MAY 2012 • Mechanical ventilation, ventilator-induced lung injury (Postgraduate Course)

8. Stollery Children’s Hospital, Division of Pediatric Critical Care, Edmonton, Canada, MAY 2012 • The folly of normalizing parameters in ICU (Invited Professor – Critical Care Rounds)

9. University of Pennsylvania, Dept of Anesthesiology and Critical Care, Philadelphia, USA, MAY

2012 • How mechanical ventilation injures lungs (Invited Professor – Dept of Anesthesiology Research in

Progress Seminar)

10. College of Physicians & Surgeons of Columbia University, Dept of Anesthesiology, New York, USA, MAY 2012

• How does mechanical ventilation cause lung injury? (Invited Professor – Dept of Anesthesiology Research Seminar)

11. 9th Annual Critical Care Symposium, Manchester, UK, APRIL 2012

• Mechanisms of ventilator induced lung injury • Lessons from controlling glucose in ICU • ICU research (workshop) • Sepsis (co-chair)

12. Pediatric Intensive Care Congress, Sao Paulo, Brazil, APRIL 2012

• Adequacy of oxygenation in mechanical ventilation • Ventilation induced lung injury • New modes of pediatric mechanical ventilation

13. North of England Intensive Care Society (NEICS) Spring Meeting, Wynyard Hall, Darlington, UK,

MARCH 2012 • Glucose control • Carbon dioxide: how much is too much?

14. 32nd International Symposium of Intensive Care and Emergency Medicine, Brussels, Belgium,

MARCH 2012

• Controlled negative pressure ventilation • The role of PCO2 and atelectasis • ARDS – New Therapeutic Options: Gene activation • Special Populations: The pediatric patient • VILI: What are the mechanisms? • Should We Regionalize Critical Care? (moderator)

15. 10th European Postgraduate Course in Neonatal and Pediatric Intensive Care, Berne, Switzerland,

MARCH 2012 • Choosing patient tailored hemodynamic monitoring, targets and therapies in the child suffering

from acute lung injury • Old and new insights in ventilator associated lung injury • Therapeutic strategies (ventilatory/nonventilatory) in pediatric ALI/ARDS • Update on insulin therapy in the critically ill and additional cons • Respiratory System session (co-chair)

16. Quebec Society of Intensivists 10th Annual Congress, Quebec City, Canada, FEBRUARY 2012

• Allen Spanier Lecture: Striving for normal – a wise approach in critical care?

17. Society of Critical Care Medicine 41st Annual Congress, Houston, USA, FEBRUARY 2012 • What’s new in physiologic and molecular mechanisms of acute pulmonary hypertension and right

heart failure Research Funding: 1. Therapeutic Potential of Hepoxilin Analogues (Operating Grant) Canadian Institutes of Health

Research (CIHR) Co-Principal applicant PI: M Post 2008-2013 620,000

2. Ventilator-Induced Lung Injury: Linking gene activation, physiology and outcome (Operating

Grant)Canadian Institutes of Health Research (CIHR) Principal Applicant Co-applicant M Post 2008-2013 643,000

3. Preclinical Assessment of Therapeutic Hypercapnia (Operating Grant) Canadian Institutes of Health

Research (CIHR) Sole Applicant (Renewal) 2009-2014 563,000

David Klein (St. Michael’s Hospital) Peer Reviewed Publications: 1. Romaschin AD, Klein DJ, Marshall JC. Bench-to-bedside review: Clinical experience with the

endotoxin activity assay. Critical Care. 2012 Dec 3;16(6):248.

2. Wald R, Friedrich JO, Bagshaw S, Burns K, Garg AX, Hladunewich MA, House AA, Lapinsky S, Klein D, Pannu NI, Pope K, Richardson RM, Thorpe K, Adhikari NKJ. Optima mode of clearance in critically ill patients with acute kidney injury (OMAKI): a pilot randomized controlled trial of hemofiltration versus hemodialysis: A Canadian Critical Care Trials Group Project. Critical Care. 2012 Oct 24;16(5):R205.

3. Parsons JA, Zdanowicz Y, Brezden-Masley C, Sheppard AJ, Grenville A, Kauffman C, Jiang D, Baxter NN, Bryant H, Klein D. Canadians’ Attitudes and Awareness Towards Colorectal Cancer Screen-ing: Results of a National Survey. The Open Colorectal Cancer Journal. 2012 Oct;5(10):38-46.

4. Odutayo A, Adhikari N, Barton J, Burns K, Friedrich JO, Klein DJ, Lapinsky S, Litwin S, Meret A, Moineddin R, Richardson B, Richardson R, Zaltzman A, Hladunewich M, Wald R. The Epidemiology of Acute Kidney Injury in Canadian Critical Care Units: A Prospective Cohort Study. Canadian Journal of Anesthesia. 2012 Oct;59(10):934-942.

5. Yaguchi A, Yuzawa J, Klein DJ, Takeda M and Harada T. Combining intermediate levels of the endotoxin activity assay (EAA) with other biomarkers in the assessment of patients with sepsis: results of an observational study. Critical Care. 2012 May 18;16(3):R88.

Presentations/Lectures: 1. Politics, Policy and Practice in Ontario Healthcare. St. Michael’s Hospital Critical Care Grand Rounds.

Toronto, Ontario. June 2012. 2. The EUPHRATES Trial - A Theragnostics Approach to Sepsis. Spectral Diagnostics. New York, New

York, United States. May 2012. Research Funding: 1. Effect of Liraglutide in Obese Subjects with Moderate or Severe Obstructive Sleep Apnea. Novo

Nordisk Canada Inc (Mississauga, ON). Role: Site Investigator. May 2012.

Afrothite Kotsakis (Hospital for Sick Children) In Press: 1. Neal R, Williamson G, Parshuram C, Mohseni-Bod H, Kotsakis A. Does a designated paediatric

CCRT reduce readmission rates to paediatric critical care?. In Preparation.

Presentations/Lectures: 1. 2012 Nov Mentor. Factors Associated with Readmission Within 48 Hours to a Cardiac Critical Care Unit. American Association (AHA). Los Angeles, California, United States. Presenter(s): Williamson G, Neal R, Mohseni-Bod H, Parshuram C, Kotsakis A. 2. 2012 June Invited Speaker. Simulating ECMO Resuscitation. University of Toronto, Interdepartmental Division of Critical Care Medicine, Critical Care Medicine Residents’ Day. Toronto, Ontario, Canada. Presenter(s): Kotsakis A 3. 2012 May Lecturer. ECPR Simulation Based Team Training. St Michaels Hospital - Li Ka Shing knowledge Institute. Toronto, Ontario, Canada. Presenter(s): Kotsakis A. Research Funding: 1. 2010 Dec – 2014 Dec Investigator. Can adherence to PALS guidelines be improved by team

training of pediatric resuscitation team members? Heart and Stroke Foundation of Canada (HSFC) and the Canadian Institutes of Health Research Institute of Circulatory and Respiratory Health (CIHR-ICRH). PI: Gilfoyle, Elaine. Collaborators: Duff, J., Kotsakis, A., Gottesman, R., Writer, H. 474,038 CAD. [Grants] The goal of this initiative is to fund research in monitoring and optimizing the technical aspects of CPR, which will ultimately result in enhanced quality CPR and improved outcomes in both adult and paediatric populations.

2. 2010 Oct – 2014 Sep Site Investigator. Evaluating Processes of Care & the Outcomes of

Children in Hospital (EPOCH): A Cluster Randomized Trail of the Bedside Early Warning System. Canadian Institutes of Health (CIHR). PI: Parshuram, C. 3,266,764 CAD. [Grants]

John Laffey (St. Michael’s Hospital) Peer Reviewed Publications: 1. Hayes M, Curley G, Laffey JG. Stem cell therapies for ALI/ARDS – hope or hype? Critical Care 2012

Dec; 16: 205. 2. Contreras M, Ansari B, Curley G, Higgins BD, Hassett P, O'Toole D, Laffey JG. Hypercapnic acidosis

attenuates ventilation-induced lung injury by a nuclear factor-κB-dependent mechanism. Crit Care Med. 2012 Sep;40(9):2622-30. doi: 10.1097/CCM.0b013e318258f8b4

3. McAuley DF, Laffey JG, O'Kane CM, Cross M, Perkins GD, Murphy L, McNally C, Crealey

G, Stevenson M; HARP-2 investigators; Irish Critical Care Trials Group. Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial. Trials. 2012 Sep 17;13:170. doi: 10.1186/1745-6215-13-170

4. Alexiev V, Salim A, Kevin LG, Laffey JG. An observational study of the Baska® mask: a novel supraglottic airway. Anaesthesia. 2012 Jun;67(6):640-5. doi: 10.1111/j.1365-2044.2012.07140.

5. Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O'Brien T, O'Toole D, Laffey JG.

Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax. 2012 Jun;67(6):496-501. doi: 10.1136/thoraxjnl-2011-201059. Epub 2011 Nov 21.

6. Bradley D, McNeil B, Laffey JG, Rowan NJ. Studies on the pathogenesis and survival of different

culture forms of Listeria monocytogens to pulsed UV-light irradiation after exposure to mild-food processing stresses. Food Microbiology 2012 Jun;30(2):330-9. Epub 2012 Jan 3

7. Oliver KM, Lenihan CR, Bruning U, Cheong A, Laffey JG, McLoughlin P, Taylor CT, Cummins EP. Hypercapnia induces cleavage and nuclear localization of REL B giving insight into CO2 sensing and signalling. J Biol Chem. 2012 April 20;287(17):14004-11. doi: 10.1074/jbc.M112.347971. Epub 2012 Mar 6.

8. Ansari B, Laffey JG. Ischemia-reperfusion-induced lung injury: could hypercapnia have a therapeutic

role? Crit Care Med. 2012 Feb;40(2):688-90. 9. Hayes M, Curley G, Laffey JG. Mesenchymal stem cells - a promising therapy for Acute Respiratory

Distress Syndrome. F1000 Med Rep. 2012;4:2. doi: 10.3410/M4-2. Epub 2012 Jan 3. Presentations/Lectures: 1. Hypercapnia in ARDS – balancing risks and benefits, presented at NVIC (Nederlandse

Intensivistendagen) 2012 Intensive Care Society annual Scientific conference. Ede, Netherlands. February 10, 2012.

2. Effects of hypercapnia in injury, inflammation and repair, presented at Scottish Intensive Care Society

annual scientific conference. St. Andrews, Scotland. January 20, 2012. 3. Gene and stem cell therapies for ARDS – hope or hype, presented at Scottish Intensive Care Society

annual scientific conference. St. Andrews, Scotland. January 20, 2012.

Research Funding: 1. Determination of the therapeutic potential of human mesenchymal stem cells for sepsis induced

ALI/ARDS. Translational Research Award. Health Research Board, Ireland. Role: Principal applicant. Total amount: 944,078.77 Euro. October 2012 – September 2016.

2. Investigation of therapeutic potential of mesenchymal stem cells to aid repair following acute lung

injury. Health Research Board, Ireland. Role: Principal applicant. Total amount: 300,000 Euro. April 2012 – March 2015.

Stephen Lapinsky (Mount Sinai Hospital) Peer Reviewed Publications: 1. Katsios CM, Burry L, Nelson S, Jivraj T, Lapinsky SE, Wax RS, Christian M, Mehta S, Bell CM,

Morris AM . An antimicrobial stewardship program improves antimicrobial treatment by culture site and the quality of antimicrobial prescribing in critically ill patients Critical Care 2012, 16:R216

2. Wald R, Friedrich JO, Bagshaw SM, Burns KE, Garg AX, Hladunewich MA, House AA, Lapinsky S, Klein D, Pannu NI, Pope K, Richardson RM, Thorpe K, Adhikari NK. Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI) - a pilot randomized controlled trial of hemofiltration versus hemodialysis: a Canadian Critical Care Trials Group project. Critical Care 2012, 16:R205

3. Rimmer E, Kumar A, Doucette S, Marshall J, Dial S, Gurka D, Dellinger P, Sharma S, Penner C, Kramer A, Wood K, Ronald J, Kumar A, Turgeon AF, Houston DS, Zarychanski R; Cooperative Antimicrobial Therapy of Septic Shock Database Research Group. Activated protein C and septic shock: A propensity-matched cohort study. Crit Care Med. 2012;40:2974-81

4. Odutayo A, Adhikari NK, Barton J, Burns KE, Friedrich JO, Klein D, Lapinsky S, Litwin S, Meret A, Moineddin R, Richardson B, Richardson R, Zaltzman A, Hladunewich M, Wald R. Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort study. Can J Anaesth. 2012;59:934-42

5. Arabi YM, Dara SI, Memish Z, Al-Abdulkareem A, Tamim HM, Al-Shirawi N, Parrillo JE, Dodek P, Lapinsky S, Feinstein D, Wood G, Dial S, Zanotti S, Kumar A; Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Antimicrobial therapeutic determinants of outcomes in cirrhotic patients with septic shock. Hepatology. 2012;56:2305-15.

6. Lapinsky SE. Pregnancy joins the hit list*. Crit Care Med. 2012;40:1679-80

7. Summa-Sorgini C, Fernandes V, Lubchansky S, Mehta S, Hallett D, Bailie T, Lapinsky SE, Burry L. Errors Associated with IV Infusions in Critical Care. Can J Hosp Pharm. 2012;65:19-26.

8. Mehta S, Lapinsky SE. A Peek at PEEP in Patients With AIDS. Respir Care. 2012;57:321-2.

9. Yeung MS, Lapinsky SE, Granton JT, Doran DM, Cafazzo JA. Examining nursing vital signs documentation workflow: barriers and opportunities in general internal medicine units. J Clin Nurs. 2012; 21(7-8):975-82.

Book Chapters: 1. Lapinsky SE. Care of the critically ill pregnant patient. In: Parsons & Wiener-Kronish (eds), Critical

Care Secrets 5th Ed, Elsevier, 2012.

2. Lapinsky SE. Pregnancy. In: Clinical Respiratory Medicine (4th Edition), Spiro, Augusti & Silvestri (Eds), Elsevier, Philadelphia, 2012

In Press: 1. Lapinsky SE. Cardiopulmonary complications in pregnancy. International Journal of Intensive Care.

(Principal Author) (In press)

2. Fan E, Golan E, Lapinsky SE. Recruitment maneuvers in acute lung injury and acute respiratory distress syndrome. International Respiratory Care Clinics and Technology. (In press) (Senior Responsible Author) (Trainee publication).

3. Lapinsky SE, Tram C, Mehta S, Maxwell CV. Restrictive lung disease in pregnancy. Chest (in press)

4. Lapinsky SE, Nelson-Piercy C. The lungs in obstetric and gynaecologic disease. In: Murray and Nadel, Textbook of Respiratory Medicine. 6th Ed, Elsevier, Philadelphia (in press)

5. Lapinsky SE. Computers in Intensive Care. In: Rubenfeld G, Scales D (eds). The Organization of Critical Care: An Evidence-Based Approach to Improving Quality. Springer, (in press)

6. Lapinsky SE. Tetanus. In: Papadakos P, Gestring M (eds). Encyclopedia of Trauma Care. Springer, (in press)

7. Lapinsky SE. Auto-PEEP. In: Papadakos P, Gestring M (eds). Encyclopedia of Trauma Care. Springer, (in press)

8. Lapinsky SE. Pregnancy. In: Papadakos P, Gestring M (eds). Encyclopedia of Trauma Care. Springer, (in press)

9. Lapinsky SE. Information technology in Critical Care. In: Romano E (Ed), Il Malato Critico, UTET Scienze Mediche. (in press)

10. Lapinsky SE. Pulmonary manifestations of systemic conditions: Pregnancy, In: Albert, Silvestri and Agusti (eds), Clinical Respiratory Medicine, 4th Ed, Elsevier, (in press)

Submitted Publications: 1. Lapinsky SE. Sepsis due to nonobstetric causes in the pregnant patient. In: Terapia Intensiva, 5th

Ed, Sociedad Argentina De Terapia Intensiva, submitted

2. Lapinsky SE. Obstetrical infections. Critical Care Clinics, submitted

Abstracts: 1. Tram C, Lapinsky S, Maxwell C. Restrictive lung disease in pregnancy. Chest 2012;

142(abstracts):382A

2. Dresser, Linda; Jivraj, Tanaz; Steinberg, Marilyn; Duplisea, Kevin; Nelson, Sandra; Poutanen, Susan; Singh, Jeff; Lazar, Neil; Lapinsky, Stephen; Morris, Andrew. Impact of antimicrobial stewardship program prospective audit and feedback program on fungemia in the Intensive Care Unit. Critical Care Canada Forum, Toronto, 2012

3. Duplisea, Kevin; Jivraj, Tanaz; Poutanen, Susan; Nelson, Sandra; Dresser, Linda; Steinberg, Marilyn; Lapinsky, Stephen; Lazar, Neil; Singh, Jeff; Bell, Chaim; Morris, Andrew. Effect of prospective audit and feedback as part of an ICU antimicrobial stewardship program on antimicrobial susceptibility to Pseudomonas aeruginosa. Critical Care Canada Forum, Toronto, 2012

4. Mohiuddin, Qasim; Nelson, Sandra; Steinberg, Marilyn; Jivraj, Tanaz; Harris, Cynthia; Burry, Lisa; Varga, Lynn; Lapinsky, Stephen; Bell, Chaim; Morris, Andrew. A point prevalence study to evaluate clinical compliance with a ventilator associated pneumonia algorithm in the Intensive Care Unit. Critical Care Canada Forum, Toronto, 2012

5. K. Aoyama, R.A. Fowler, S.E. Lapinsky, D.C. Scales, R. Pinto. Incidence, characteristics and outcomes of pregnancy related critical illness over time in Canada. Critical Care Canada Forum, Toronto, 2012

6. Aoyama, Kazuyoshi; Lapinsky, Stephen; Fowler, Robert. Incidence of peripartum cardiomyopathy in Canada. Critical Care Canada Forum, Toronto, 2012

7. K. Aoyama, R.A. Fowler, S.E. Lapinsky, D.C. Scales, R. Pinto. Incidence, characteristics and outcomes of pregnancy related critical illness over time in Canada. European Society for Intensive Care Medicine, Lisbon, 2012

Reviews, Letters & Editorials: 1. Lapinsky SE.Tracheal intubation in the critically ill: just say no to drugs. Br J Anaesth. 2012

Aug;109(2):287.

Presentations/Lectures: 1. 2012 July International Society of Obstetric Medicine, Oxford, England.

“Restrictive lung disease in pregnancy”

2. 2012 July The Basics of Respirology, Introductory Course for First Year Respirology Residents in Ontario. Toronto. “Non-invasive ventilation”.

3. 2012 May 7th International Conference on Rapid Response Systems, Sydney, Australia “Evaluation of an electronic vitals signs capture and alert system”

4. 2012 May Canadian Critical Care Review Course. Toronto, Canada. “Obstetrics and Critical Care.

5. 2012 Feb Respirology Grand Rounds, Toronto (and Teleconferenced provincially) “Mechanical ventilation update”

6. 2012 Jan Ontario Thoracic Society, Better Breathing Conference, Toronto

“iRespirology – technology aids for practice and decision making” “There’s an app for that”

Research Funding: 1. 2012 Feb - 2012 Aug Co-Investigator. Acute Lung Injury in the ICU: Scope of the Problem and

Focus on Prevention. Physician Services Incorporated. Health Research Grant. PI: Galvin, Imelda. Collaborators: Niall Ferguson, Jeffrey Singh, Stephen Lapinsky, Andrew Steel. 39,500 CAD. [Grants]

2. 2011 Jul - 2013 Jun Co-Investigator. Standard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI). Canadian Institutes of Health Research (CIHR). PI: Wald, Ron. 227,720 CAD. [Clinical Trials].

3. 2010 - 2012 Collaborative H1N1 influenza adjuvant treatment (CHAT) pilot trial. PSI,

CIHR; PI: Dr. J. Marshall

4. 2008 - 2013 Natural Sciences and Engineering Research Council of Canada (NSERC). NSERC Strategic Network: Healthcare support through information technology enhancements. PI: Dr. D. Plant. Collaborator. $5,000,000. [Grants].

Peter C. Laussen (Hospital for Sick Children) Publications: 1. Tweddell JS, Sleeper LA, McCrindle BW, Williams IA, Mahony L, Pizarro C, Ravishankar C, Cnota J,

Frommelt PC, Pemberton V, Bradley S, Li JS, Puchalski M, Laussen PC, Jacobs JP, Pike N, Kirshbom P, Hirsch JC, Ohye RG; for the Pediatric Heart Network Investigators. Intermediate-Term Mortality and Cardiac Transplantation in Infants with Single-Ventricle Lesions: Risk Factors and Their Interaction with Shunt Type J Thoracic Cardiovasc Surg 2012 Jul;144(1):152-159.

2. Newburger JW, Sleeper LA, Bellinger DC, Goldberg CS, Tabbutt S, Lu M, Mussatto KA, Williams IA, Gustafson KE, Mital S, Pike N, Sood E, Mahle WT, Cooper DS, Dunbar- Masterson C, Krawczeski CD, Lewis A, Menon SC, Pemberton VL, Ravishankar C, Atz TW, Ohye RG, Gaynor JW; Pediatric Heart Network Investigators. Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation. 2012 May 1;125(17):2081-91.

3. Mehta NM, Costello JM, Bechard L, Johnson VM, Zurakowski D, McGowan FX, Laussen PC,. Duggan C. Resting energy expenditure following Fontan surgery in children with single ventricle heart defect. J Parenter and Enteral Nutr 2012;36(6):685-92.

4. Tabbutt S, Ghanayem N, Cooper DS, Frank DU, Lu M, Frommelt P, Lai WW, Goldberg CS, Graham EM, Krawczeski CD, Mahony L, Ravishankar C, Sleeper LA, Kirsh JA, Lewis A, Lodge A, Ohye R, Pizarro C, Simsic J, Spurrier E, Stylianou M, Laussen PC for the Pediatric Heart Network Investigators. Risk Factors For Hospital Mortality And Morbidity Following The Norwood Procedure: Results From The Multicenter Single Ventricle Reconstruction Trial. J Thoracic Cardiovas Surg 2012;144(4):882-95.

5. Ohye RG, Schonbeck JV, Eghtesady P, Laussen PC, Pizarro C, Shrader P, Frank D, Graham EM, Hill K, Jacobs JP, Kanter RK, Kirsh JA, Lambert L, Lewis AB, Ravishankar C, Tweddell JS, Williams IA, Pearson GA for the Pediatric Heart Network Investigators. Cause, Timing and Location of Death in the Single Ventricle Reconstruction Trial. J Thoracic Cardiovasc Surg 2012;144(4):907-14

6. Agus MSD, Steil GM, Wypij D, Costello JM, Laussen PC, Langer M, Alexander JL Scoppettuolo LA, Pigula FA, Charpie JR, Ohye RG, Gaies MG, for the SPECS Study Investigators. Tight Glycemic Control versus Standard Care after Pediatric Cardiac Surgery. New Engl J Med 2012 Sept 27th 367;367(13):1209-19.

7. Pasquali SK, Ohye RG, Lu M, Kaltman J, Caldarone CA, Pizarro C, Dunbar-Masterson C, Gaynor JW, Jacobs JP, Kaza AK, Newburger J, Rhodes JF, Scheurer M, Silver E, Sleeper LA, Tabbutt S, Tweddell J, Uzark K, Wells W, Mahle WT, Pearson GD; Pediatric Heart Network Investigators. Variation in perioperative care across centers for infants undergoing the Norwood procedure. J Thorac Cardiovasc Surg. 2012 Oct;144(4):915-21.

8. Giglia TM, DiNardo J, Ghanayem NS, Ichord R, Niebler RA, Odegard KO, Massicotte P, Yates AR, Laussen PC, Tweddell JS. Bleeding and thrombotic emergencies in the CICU: unchecked balances. Wor J for Ped and Cong Heart Surg 2012.

In Press: 1. Laussen PC, Allan C, LaRovere J. Risky Business: Human factors in Critical Care. World J Ped

Congen Heart Surg.

2. Rajagopal SK, Carmona F, Perez-Rossello JM, Gordon CM, Pigula FA, Laussen PC. Fractures related to metabolic bone disease in critically ill children with congenital heart disease. Crit Care Med


1. 2012 Debate: “Con: Palliative care should be instituted for every patient with HLHS at the time of diagnosis”. Pediatric Cardiac Intensive Care Society, 9th International Conference. Miami. Dec 9th 2012

2. 2012 “The Future of monitoring data management: Real-time risk management and

data interrogation” The Pediatric Cardiac Intensive Care Society, 9th Internation Conference. Miami. Dec 9th 2012

3. 2012 “Predicting Adverse Events Through Monitoring”. Critical Care Canada Forum

2012, Toronto, Ontario, October 31st.

4. 2012 “Safety and Quality: Lessons from NASCAR and NASA”. American Academy of Orthopaedic Surgeons,Fall meeting, Philadelphia PA October 19th

5. 2012 “Meaningful visualization and analysis of real time monitoring” Risky Business:

Pediatric Day. Great Ormand Street Hospital for Children, London. May 25th 6. 2012 “Risky Business”. Pedaitric Orthopedic Society of North America annual

meeting. Denver May 19th

7. 2012 “Congenital Heart Disease in Newborns: Beyond Survival” HMS Continuing

Education: Issues in Neonatology 2012. Boston, Massachusetts, March 1st

8. 2012 “Using real time data to catch critical care issues before they happen: T3” First

Annual Innovation day, Boston Children’s Hospital. February 14th

9. 2012 “Predictive rather than prescriptive decisions in critical care” Congenital Cardiology

Group summit. Laguna Niguel, California. February 4th. Research Funding: 1. Boston Children’s Hospital Feb 2012 – June 2013 Provider-Payor Quality Initiative (PPQI) Project title: “Tracking, Trajectory & Trigger tool (T3)” Role: Principal Investigator (30% effort) Funding amount: $1,475,000 2. NIH-SBIR 1R43HL117340-01

July 2012 – July 2014 Title of Project: Risk Assessment Using Non-Invasive Measurements in Post-Operative Pediatric Patients Role: Boston Children’s Hospital PI Co Sponsor: Sterling Point Research LLC; $498,191 for 2 years

3. NIH 1RO1 HL088448-01 2007-2012

Title of Project: TECS: Trial Euglycemia in Cardiac Surgery Role: Primary co-investigator (15% effort) Principal Investigator: Dr Michael Agus

Bernard Lawless (St. Michael’s Hospital) Presentations/Lectures: 1. A Physician Perspective on Physician Engagement and Leadership. CIHR, CFHI, and the

Saskatchewan Ministry of Health. Saskatchewan, Canada. December 6, 2012.

2. Quality Improvement Tools to Accelerate Excellence in Critical Care. Onatario Hospital Association / Critical Care Services Ontario. Toronto, Ontario, Canada. November 21, 2012

3. The Quality of Knowledge Translation Studies in Critical Care. American Thoracic Society. San Francisco, California, United States. May 21, 2012

4. Knowledge Translation Interventions for Critically Ill patients: A systematic review. American Thoracic Society. San Francisco, California, United States. May 20, 2012

5. Evaluation of Critical Care Response Teams: An End-user Perspective. American Thoracic Society. San Francisco, California, United States. May 20, 2012.

6. Physician Leadership and Change Implementation. Health Quality Ontario / Ontario Renal Network. Toronto, Ontario, Canada. May 2, 2012.

Research Funding:

1. The CCKTN seeks to address the gap between research and application of best practices with strategies to implement new research at the bedside. The goal is to increase the adoption of research evidence in order to improve the outcomes of patients and reduce costs of treating critically ill patients. Canadian Critical Care Knowledge Translation Network. CIHR. Role: Co-investigator. Total amount $599,611. October 2012 – September 2015.

2. Physician leadership and engagement for health system improvement and accountability. Canadian Institutes of Health Research (CIHR). Expedited Knowledge Synthesis. Role: Co-investigator. Total amount: 83,463. April – October 2012.

Neil Lazar (Toronto General Hospital, University Health Network) Presentations/Lectures: 1. 2012 Mar 18 Invited Speaker. Mechanisms of Hypoxemia. An approach to management.

Section of Anaesthesia & Critical Care, University of West Indies. Kingston, Mona, Jamaica. New Advances & Controversies in Critical Care Medicine. (Continuing Education).

2. 2012 Mar 17 Invited Speaker. Futility of Care/Withdrawal of life support. Section of Anaesthesia & Critical Care, University of West Indies. Kingston, Mona, Jamaica. New Advances & Controversies in Critical Care Medicine. (Continuing Education).

Warren Lee (St. Michael’s Hospital) Peer Reviewed Publications: 1. Armstrong SM, Wang C, Tigdi J, Si X, Dumpit C, Charles S, Gamage A, Moraes TJ, Lee WL.

Influenza infects lung microvascular endothelium leading to microvascular leak: role of apoptosis and claudin-5. Plos One 2012; 7(10):e47323. 2012.

2. Armstrong SM, Khajoee V, Wang C, Wang T, Tigdi J, Yun J, Kuebler WM, Gillrie M, Davis SP, Ho M,

Lee WL. Co-regulation of Transcellular and Paracellular Leak Across Microvascular Endothelium By Dynamin and Rac. The American Journal of Pathology 2012;180:1308-1323.

3. Petruzziello T, Yuen D, Page A, Matouk C, Wong D, Tsui A, Turgeon P, Fish J, Ho JJD, Steer B, Khajoee V, Tigdi J, Lee WL, Motto D, Advani A, Gilbert R, Karumanchi SA, Tarr P, Liles C, Brunton J, Marsden P. The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated haemolytic uremic syndrome in humans and mice. The Journal of Clinical Investigation 2012;122(2):759-776.

4. Goldenberg NM, Steinberg BE, Lee WL. Do viral infections mimic bacterial sepsis? A review of

methods and mechanisms. Antiviral Research 2012;93:2-15. Presentations/Lectures: 1. Vascular leak in sepsis and viral infections. Antiviral Congress, Cambridge (MA). November 2012. 2. The lung endothelium as a therapeutic target during severe influenza. Critical Care Forum. Toronto,

Ontario. November 2012. 3. Co-regulation of transcytosis and paracellular leak across microvascular endothelium by dynamin and

RAC.Experimental Biology 2012 (International Conference), San Diego, United States. April 2012.

Research Funding: 1. Co-applicant. Endothelial and transendothelial events underlying immune cell infiltration of metabolic

tissues in pre-diabetes. Canadian Diabetes Association. Role: Co-applicant. Total amount: 275,000. July 2012 – June 2015.

John Marshall (St. Michael’s Hospital) Peer Reviewed Publications: 1. McIntyre LA, Fergusson DA, Cook DJ, Rowe BH, Bagshaw SM, Easton D, Emond M, Finfer S, Fox-

Robichaud A, Gaudert C, Green R, Hebert P, Marshall J, Rankin N, Stiell I, Tinmouth A, Pagliarello J, Turgeon AF, Worster A, Zarychanski R for the Canadian Critical Care Trials Group: Fluid resuscitation with 5% albumin versus normal saline in early septic shock: A pilot randomized controlled trial. J.Crit.Care 2012; 27(3):317.e1-6.

2. Casserly B, Gerlach, H, Philips G, Marshall JC, Levy M: Evaluating the use of recombinant human Activated Protein C (rhAPC) in adult severe sepsis: Results of the Surviving Sepsis Campaign (SSC). Crit. Care Med. 2012; 40(5):1417-1426.

3. McIntyre L, Fergusson DA, Rowe B, Cook DJ, Arabi Y, Bagshaw SM, Emond M, Finfer S, Fox-

Robichaud A, Gray A, Green R, Hebert P, Lang E, Marshall J, Stiell I, Tinmouth A, Pagliarello J, Turgeon A, Walsh T, Worster A, Zarychanski R; for the Canadian Critical Care Trials Group: The PRECISE RCT: Evolution of an early septic shock fluid resuscitation trial. Transfus. Med. Rev. 2012 26(4):333-341.

4. Ranieri VM, Thompson BT, Barie PS, Dhainaut J-F, Douglas IS, Finfer S, Gårdlund B, Marshall JC,

Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL: Efficacy and safety of drotrecogin-alpha activated in adult patients with septic shock. N. Engl. J Med. 2012; 366(22):2055-2064.

5. Bayer O, Reinhart K, Kohl M, Kabisch B, Marshall J, Sakr Y, Bauer M, Hartog C, Schwartzkopf D,

Riedemann N: Effects of fluid resuscitation with synthetic colloids or crystalloids alone on shock reversal, fluid balance and patient outcomes in patients with severe sepsis - a prospective sequential analysis. Crit. Care Med. 2012; 40(9):2543-2551.

6. Rimmer E, Kumar A, Doucette S, Marshall J, Dial S, Gurka D, Dellinger P, Sharma S, Penner C,

Kramer A, Wood K, Ronald J, Kumar A, Turgeon AF, Houston DS, Zarychanski R; The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group: Activated protein C and septic shock: A propensity-matched cohort study. Crit. Care Med. 2012; 40(11):2974-2981.

7. Marshall JC: Location, location, location: Unravelling the nuances of innate immune regulation.

Crit. Care Med. 2012; 40(11):3093-3094. 8. Marshall JC: Biomarkers in critical illness: Good answers, but what’s the question? J. Crit. Care

2012; 27(5):519-521.

9. Casserly B, Gerlach H, Phillips GS, Lemeshow S, Marshall JC, Osborn TM, Levy MM: Low dose steroids in adult septic shock: Results of the Surviving Sepsis Campaign. Intensive Care Med 2012 Oct 12 [Epub ahead of print].

10. Lalu MM, McIntyre L, Pugliese C, Fergusson D, Winston BW, Marshall JC, Granton J, Stewart DJ,

for the Canadian Critical Care Trials Group: Safety of cell therapy with mesenchymal stromal cells (SafeCell): A systematic review and meta-analysis of clinical trials. PLOS One 2012; 7(10):e47559.

11. Marshall JC: New translational research provides insights into liver dysfunction in sepsis. PLOS

Medicine 2012 Nov;9(11):e1001341. 12. Romaschin AD, Klein DJ, Marshall JC: Clinical experience with the Endotoxin Activity Assay (EAA).

Crit. Care 2012; 16:248.

13. Marshall JC, Herridge MS, Meade MO, for the Canadian Critical Care Trials Group: Integrating

mortality and morbidity outcomes: Using Quality-Adjusted Life Years (QALYs) in critical care trials. Am. J. Respir. Crit. Care Med. 2012 Nov 30 [Epub ahead of print]

14. Reinhart K, Kissoon N, Daniels R, Marshall J, Dellinger RP, Jimenez EJ, on behalf of the World

Sepsis Day Steering Committee: What we learned from the first World Sepsis Day. J. Crit. Care 2012;27(6):735-736.


1. CIHR/ICRH Advisory Board Meeting, Kananaskis, Alberta, January 11, 12 2012. The Canadian Critical Care Trials Group.

2. 2012 Emergency Preparedness and Response Forum, Public Health Agency of Canada, Edmonton, Alberta January 18, 2012: Facilitating pandemic research in the sickest patients: Emerging global strategies

3. 32nd International Symposium of Intensive Care and Emergency Medicine, Brussels, Belgium, March

20-23, 2012. 1. Goal-directed deresuscitation. 2. After PROWESS-Shock: Implications for future studies. 3. Talactoferrin as a treatment for sepsis.

4. 9th Annual Critical Care Symposium, Manchester, UK April 26-27, 2012. 1. Source control in sepsis. 2. Industry-led trials are obsolete in the 21st century PRO. 3. Resuscitation and deresuscitation. 4. PIRO in 2012 – Where do we stand? 5. Management of severe pancreatitis.

5. 10o Simposio Internacional Emergencias Médicas y Patiente Crítico, Santiago, Chile May 10-12, 2012. 1. TNF as a target in sepsis. 2. Damage control for the intensivist. 3. Source control in complex infections. 4. Resuscitation and deresuscitation.

6. 10th Greek Armed Forces Medical Corps Critical Care and Emergency Medicine Conference, Athens, Greece, May 25,26, 2012. 1. Critical illness is an iatrogenic disorder. 2. Empiric antibiotics in the critically ill: Results of the AATICC trial.

7. 2nd Paris International Conference on Intensive Care, Société de Réanimation del la Langue Française, Paris France, June 7,8, 2012. 1. Source control and Selective Decontamination of the Digestive Tract. 2. Activated protein C in septic shock: Results of the PROWESS-Shock study. 3. Intravenous immunoglobulins in sepsis.

8. WHO Consultation: Towards effective treatment of severe acute respiratory illnesses, Annecy France, July 5,6, 2012. Critical care for severe acute respiratory illness.

9. 11th International Congress on Complexity in Acute Illness, Ottawa, Canada, September 6 – 9, 2012:

What is a disease in the critically ill? Towards a staging system for severe acute illness.

10. Seminar on the Treatment of Severe Infections, Winnipeg, Manitoba, September 18, 2012: Acute therapy and de-escalation in abdominal sepsis

11. 1er Simposio Internacional de Medicina Criticá “Dr. José Besso”, Caracas Venezuela, September 20, 21, 2012. 1. Management of severe intra-abdominal sepsis. 2. MODS: New horizons. 3. The marvelous world of biomarkers. 4. Sepsis trials: What do we need to know?

12. 16th International Meeting, Peruvian Society of Intensive Medicine, Cusco, Peru, September 26-28, 2012: 1. Biomarkers in shock. 2. Damage control in the ICU. 3. What can we do to improve the management of sepsis? 4. Resuscitation and deresuscitation.

13. XXXIX Reunión Annual Nacional Associación Mexicana de Medicina Crítica y Terapia Intensiva, León, Guanajuato, Mexico, October 24 – 27, 2012. 1. Principles of source control in the

management of infection for the intensivist. 2. Critical illness is an iatrogenic disorder. 3. Management of severe acute pancreatitis.

14. American Heart Association Resuscitation Science Symposium, Los Angeles, CA, November 4, 2012: InFACT: A global research initiative.

15. International Sepsis Forum Sepsis 2012, Paris France, November 7-9, 2012: Establishing efficacy in

clinical trials.

16. 9th Turkish Congress of Intensive Care Medicine/1st Euro-Asian Critical Care Meeting, Ankara, Turkey, November 28-30, 2012. Guidelines, the Global Sepsis Alliance, and InFACT

Research Funding: 1. Cellular Immunotherapy for Septic Shock (CISS): A phase 1 trial. Canadian Institutes of Health

Research. Role: Co-investigator. Total amount: $366,811 (2012-2014) 2. Cellular and molecular mechanisms of prolonged neutrophil-mediated inflammation in trauma and

sepsis: The role of PBEF/Nampt/visfatin. Physicians’ Services Incorporated Foundation. Role: Principle Investigator. Total amount: $169,500 2012-2014

David Mazer (St. Michael’s Hospital) Peer Reviewed Publications: 1. Bokesch PM, Szabo G, Wojdyga R, Grocott HP, Smith PK, Mazer CD, Vetticaden S, Wheeler A,

Levy JH. Phase 2 Prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass. (CONSERV-2 Trial). J Thorac Cardiovas Surg. 2012;143(5):1022-9.

2. Shehata N, Burns LA, Nathan H, Hebert P, Hare GMT, Fergusson D, Mazer CD. A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery. Transfusion 2012;52(1):91-9.

3. Nalla BP, Freedman J, Hare GMT, Mazer CD. Update on blood conservation for cardiac surgery. J

Cardiothorac Vasc Anesth 2012;26(1):117-33.

4. Lecker I, Orser BA, Mazer CD. "Seizing" the opportunity to understand antifibrinolytic drugs. Can J Anesth 2012;59(1):1-5.

5. Lecker I, Orser BA, Mazer CD. "Seizing" the opportunity to understand antifibrinolytic drugs. Can J

Anesth 2012;59(1):1-5. 6. Tousignant C, Kim H, Papa F, Mazer CD. Evaluation of TAPSE as a measure of right ventricular

output. Can J Anesth 2012;59(4):376-83.

7. Denault AY, Tardif JC, Mazer CD, Lambert J; for the BART Investigators. Difficult and complex separation from cardiopulmonary bypass in high-risk cardiac surgical patients: A multicenter study. J Cardiothorac Vasc Anesth 2012;26(4):608-16.

8. Hutton B, Joseph L, Fergusson D, Mazer CD, Shapiro S, Tinmouth A. Risks of harms using

antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomized and observational studies. Br Med J 2012;345:e5798.

9. Fortis S, Spieth PM, Lu WY, Parotto M, Haitsma JJ, Slutsky AS, Zhong N, Mazer CD, Zhang H.

Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury. Int Care Med 2012;38(9):1548-55.

10. Ferraris VA, Saha SP, Oestreich JH, Song HK, Rosengart T, Reece TB, Mazer CD, Bridges CR,

Despotis GJ, Jointer K, Clough ER. 2012 Update to The Society of Thoracic Surgeons Guideline on Use of Antiplatelet Drugs in Patients Having Cardiac and Noncardiac Operations. Ann Thorac Surg 2012;94(5):1761-81.

11. Shehata N, Forster A, Li L, Rothwell DM, Mazer CD, Naglie G, Fowler R, Tu JV, Rubens FD,

Hawkens S, Wilson K. Does anemia impact hospital readmissions after coronary artery bypass surgery? Transfusion 2012 Dec 11. [Epub ahead of print] PMID: 23228115.

12. Kim N, Voicu L, Hare GM, Cheema-Dhadli S, Chong CK, Chan SK, Bichet DG, Halperin ML, Mazer

CD. Response of the renal inner medulla to hypoxia: possible defense mechanisms. Nephron Physiol 2012;121(1-2):1-7.

13. Lecker I, Wang DS, Romaschin AD, Peterson M, Mazer CD, Orser BA. Tranexamic acid

concentrations associated with human seizures inhibit glycine receptors. J Clin Invest 2012;122(12):4654-66.

14. Kim N, Cheema-Dhadli S, Hare GMT, Chong CK, Halperin ML , Mazer CD. Non-natriuretic Doses of Furosemide: Potential Use for Decreasing the Workload of the Renal Outer Medulla with Minimal Magnesium Wasting in the Rat. Nephron Physiol. 2012;122:7-12.

Presentations/Lectures: 1. “New antiplatelet agents and their impact inperioperative medicine: What are we to expect in the

near future?” Presented at The European Anaesthesiology Congress meeting, Paris France June 2012.

2. “Update on best practices (Blood transfusion, HIT, and antifibrinolysis).” (Moderator) International Forum of Cardiovascular Anesthesia (IFCA), the 8th International Chinese Cardiovascular Anesthesia Forum (ICCAF), China Heart Congress 2012. Beijing, China August 10-12, 2012.

3. “Controversies about antifibrinolytic agents and new antithrombotic drugs in cardiac surgery.”

International Forum of Cardiovascular Anesthesia (IFCA), the 8th International Chinese Cardiovascular Anesthesia Forum (ICCAF), China Heart Congress 2012. Beijing, China August 10-12, 2012.

4. “How to balance efficacy vs bleeding risks in ACS patients destined for CABG?” Workshop

participant. Canadian Cardiovascular Society meeting. Toronto, ON Oct 31, 2012.

5. “Implementation of the new Nurse Practitioner (NP) authorities to optimize care and patient flow for cardiovascular surgical patients.” Canadian Cardiovascular Society meeting. Toronto, ON Oct 29, 2012.

6. “New antithrombotic agents in cardiac and non-cardiac patients.” New Zealand Anesthesia Annual

Scientific Meeting combined with the 13th International Congress of Cardiothoracic and Vascular Anesthesia. Auckland, New Zealand, November 12-14, 2012.

Research Funding: 1. REPLACE (Randomized evaluation of fibrinogen versus placebo in complex cardiovascular

surgery): a prospective, multinational, multicenter, randomized, double-blind, placebo-controlled, phase III study for the use of Fibrinogen Concentrate (Human) (FCH) in complex cardiovascular surgery. Role: Site Investigator. CSL Behring 2012

2. A Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt (RE-ALIGN study) Role: Co-Investigator Boehringer-Ingelheim Canada Ltd 2012-2013

Sangeeta Mehta (Mount Sinai Hospital) Peer Reviewed Publications: 1. Mehta S, Quittnat Pelletier F, Brown M, Ethier C, Wells D, Burry L, MacDonald R. Why substitute

decision makers provide or decline consent for ICU research studies: A questionnaire study. Intensive Care Medicine 2012; 38(1):47-54.

2. Little A, Ethier C, Ayas N, Thanachayanont T, Jiang D, Mehta S. A patient survey of sleep quality in the Intensive Care Unit. Minerva Anestesiologica 2012; 78(4):406-14.

3. Summa-Sorgini C, Fernandes V, Lubchansky S, Mehta S, Hallett D, Bailie T, Lapinsky S, Burry L. Errors associated with IV infusions in critical care. Can J Hosp Pharm 2012; 65(1):19–26.

4. Rose L, Smith O, Gelinas C, Haslam L, Dale C, Luk E, Burry L, McGillion M, Mehta S, Watt-Watson J. Critical care nurses’ pain assessment and management practices: a survey in Canada. American Journal of Critical Care 2012; 21(4):247-255.

5. McMullen SM, Meade M, Rose L, Burns K, Mehta S, Doyle R, Henzler D, for the Canadian Critical Care Trials Group (CCCTG). Partial ventilatory support modalities in acute respiratory failure: a systematic review. PLoS One 2012; 7(8):e40190. Epub 2012 Aug 16.

6. Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hebert P, Sabri E, Meade M, for the SLEAP Investigators and the Canadian Critical Care Trials Group. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: A randomized controlled trial. JAMA 2012; 308(19):1985-1992. doi:10.1001/jama.2012.13872.

7. Arabi Y, Haddad S, Al-Dawood A, Al-Dorzi H, Tamim HM, Jones G, McIntyre L, Mehta S, Solaiman O, Sadat M, Afesh L, Sami B. The impact of permissive underfeeding versus target enteral feeding on mortality and morbidity in adult critically ill patients: Study protocol for a multicenter randomized controlled trial. Trials 2012;13:191. doi: 10.1186/1745-6215-13-191.

8. Katsios CM, Burry L, Nelson S, Bell CM, Jivraj T, Lapinsky SE, Wax RS, Christian M, Mehta S, Morris AM. An antimicrobial stewardship program improves antimicrobial treatment by culture site and the quality of antimicrobial prescribing in critically ill patients. Critical Care 2012 Nov 5;16(6):R216

9. Smith OM, McDonald E, Zytaruk N, Foster D, Matte A, Clarke F, Meade L, Godfrey N, Vallance S, Galt P, Rajbhandari D, Rocha M, Mehta S, Ferguson N, Hall R, Fowler R, Burns K, Qushmaq I, Ostermann M, Heels-Ansdell D, Cook D, for the PROTECT Research Coordinators, PROTECT Investigators, Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Rates and determinants of informed consent: a case study of an international thromboprophylaxis trial. J Crit Care 2013;28(1):28-39. doi: 10.1016/j.jcrc.2012.08.005. Epub 2012 Oct 22.

Non Peer Reviewed Publications: 1. Ip T, Mehta S. The role of HFOV in the treatment of acute respiratory failure in adults. Current

Opinion in Critical Care 2012;18: 70-79.

2. Mehta S, Lapinsky SE. A peek at PEEP in patients with AIDS (Editorial). Respiratory Care 2012;57 (2): 321-322.

3. Mehta S. The intensive care unit continuum of care: Easing death. Crit Care Med 2012; 40(2); 700–701.

4. Chen R, Mehta S. Management of Sedation and Delirium in the ICU. In Surgery: Evidence-Based Practice. Cohn S.M., Brower S.T. Eds.; People's Medical Publishing House USA, Shelton CT, 2012; Ch 116. pp 917-925.

5. Mehta S. Early sedation of mechanically ventilated, critically ill patients – another wake-up call! (Editorial) Am J Respir Crit Care Medicine 2012; 186:699.

In Press: 1. Galvin S, Burry L, Mehta S. Rethinking sedation in the ICU. In Legacy of Critical Illness, Stevens RD,

Hart N, Herridge M, Ed.: Oxford University Press, Oxford, 2012. In press.

Abstracts: 1. N Zytaruk, M Meade, S Mehta, R Hall, J Granton, ND Ferguson, A Freitag, J Muscedere, R Fowler, Y

Skrobik, M Jacka, J Marshall, F Lauzier, F Lamontagne, A Turgeon, N Vlahakis, JR Klinger, P Devereaux, M Ostermann, O Berwanger, K Khwaja, L Burry, J Freidrich, KEA Burns, M Herridge, DJ Cooper, A Bersten, D Heels-Ansdell, D Cook; for the PROTECT Investigators, the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Risk Factors for Pulmonary Embolism In Medical-Surgical ICU Patients. Am J Resp Crit Care Med 2012;185: A2359.

2. C Katsios, M Donadini, M Meade, S Mehta, R Hall, L McIntyre, G Guyatt, P Dodek, J Muscedere, J Granton, J Friedrich, R Fowler, Y Skrobik, J Kutsiogiannis, M Albert, C Doig, M Cox, N Vlahakis, J Klinger, J Nates, A Bersten, D Heels-Ansdell, N Zytaruk, M Crowther, DJ Cook. Published Prediction Models Do Not Discriminate Among Critically Ill Patients in Clinically Suspected Pulmonary Embolism in ICU. Am J Resp Crit Care Med 2012;185: A2360.

3. JI Cameron, L Chan, AI Czerwonka, LM Chu, AL Matte, ND Ferguson, S Mehta, J Friedrich, N Adhikari, R Fowler, DJ Cook, JC Rudkowski, H Meggison, SE Abbey, JA Batt, C dos Santos, J Flannery, G Leung, J Marshall, A Moody, G Rubenfeld, DC Scales, T Sinuff, A Slutsky, F Lamontagne, M Levasseur, G Tomlinson, and MS Herridge. Long-Term Outcomes After Prolonged Mechanical Ventilation: Family Caregiver Outcomes From The Towards RECOVER Study. Am J Respir Crit Care Med 2012;185: A1090.

4. MS Herridge, LM Chu, AL Matte, L Chan, G Tomlinson, ND Ferguson, S Mehta, J Friedrich, N Adhikari, R Fowler, DJ Cook, JC Rudkowski, H Meggison, SE Abbey, J Batt, C dos Santos, J Flannery, G Leung, JC Marshall, AR Moody, G Rubenfeld, DC Scales, T Sinuff, A Slutsky, F Lamontagne, M Levasseur, J Cameron. Long-Term Patient Outcomes After Prolonged Mechanical Ventilation: The Towards RECOVER Study. Am J Respir Crit Care Med 2012;185: A2546.

5. S Mehta, L Burry, D Cook, M Steinberg, D Fergusson, P Hebert, M Herridge, J Granton, N Ferguson, J Devlin, M Tanios, R Fowler, P Dodek, K Burns, M Jacka, K Olafson, S Reynolds, S Keenan, Y Skrobik, J Kutsogiannis, K Antoni, M Meade, for the SLEAP Investigators and Canadian Critical Care Trials Group. SLEAP: A multicenter randomized trial of daily awakening in critically ill patients being managed with a sedation protocol. Am J Respir Crit Care Med 2012;185: A3882.

6. Herridge M, Chu LM, Matte AL, Chan L, Tomlinson G, Ferguson ND, Mehta S, Friedrich J, Adhikari N, Fowler R, Cook DJ, Rudkowski R, Meggison H, Abbey SE, Batt JA, dos Santos C, Flannery JF, Leung G, Marshall JC, Moody AR, Rubenfeld G, Scales DC, Sinuff T, Slutsky AS, Cameron J for the CCCTG. Long-Term Outcomes after Prolonged Mechanical Ventilation: Survivor and Family Caregiver Outcomes from the Towards RECOVER Study. Innovation Fund Meeting 2012.

7. OM Smith, C Dale, C Filice, J Filice, D Foster, C Jones, Y Lee, A Matte, E McDonald, K Porretta, M Steinberg, R Ward, K Wheeler, S Mehta, R Pinto, L Rose. Nurses Attitudes to the Conduct of ICU Research: A Multi-Centre Survey. ESICM Meeting, Lisbon, October 16, 2012. Intensive Care Medicine 2012; 38(1):S304.

8. S Mehta, J Devlin, Y Skrobik, M Meade, D Cook, D Fergusson, M Steinberg, J Granton, N Ferguson, M Tanios, P Dodek, R Fowler, K Burns, M Jacka, K Olafson, S Keenan, S Reynolds, J Kutsogiannis, R Mallick, L Burry, for the SLEAP Investigators and the Canadian Critical Care Trials Group. Delirium, sub-syndromal delirium, antipsychotic use, and associated clinical outcomes in critically ill mechanically ventilated patients enrolled in the SLEAP multicenter randomized trial. Intensive Care Medicine 2012; 38(1):S128.

9. L Rose, L Kenny, G Tait, S Mehta. Acceptable Ventilator Setting and Monitoring Parameter Ranges for Initiation of Controlled Mechanical Ventilation – A Clinician Survey. ESICM Meeting, Lisbon, October 16, 2012. Intensive Care Medicine 2012; 38(1):S266.

10. Digby GC, Parker CM, Keenan SP, Muscedere J, Sinuff T, Burns KE, Mehta S, Ronco JJ, Rose L, Ayas NT, Berthiaume LR, D’Arsigny CL, Stollery DE. Non-Invasive Ventilation Practice Patterns in Canadian Tertiary Care Centers: A Descriptive Analysis. Critical Care Canada Forum, Toronto, October, 2012.

11. Day A, Haj-Bakri S, Lubchansky S, and Mehta S. A Survey of Sleep, Anxiety, and Fatigue in Family Members of Intensive Care Unit Patients. Critical Care Canada Forum, Toronto, October 2012.

12. JI Cameron, L Chan, AI Czerwonka, LM Chu, AL Matte, ND Ferguson, S Mehta, J Friedrich, N Adhikari, R Fowler, DJ Cook, JC Rudkowski, H Meggison, SE Abbey, JA Batt, C dos Santos, J Flannery, G Leung, J Marshall, A Moody, G Rubenfeld, DC Scales, T Sinuff, A Slutsky, F Lamontagne, M Levasseur, G Tomlinson, and MS Herridge. Long-Term Outcomes After Prolonged Mechanical Ventilation: Family Caregiver Outcomes From The Towards RECOVER Study. Critical Care Canada Forum, Toronto, October 2012.

13. MS Herridge, LM Chu, AL Matte, L Chan, G Tomlinson, ND Ferguson, S Mehta, J Friedrich, N Adhikari, R Fowler, DJ Cook, JC Rudkowski, H Meggison, SE Abbey, J Batt, C dos Santos, J Flannery, G Leung, JC Marshall, AR Moody, G Rubenfeld, DC Scales, T Sinuff, A Slutsky, F Lamontagne, M Levasseur, J Cameron. Long-Term Patient Outcomes after Prolonged Mechanical Ventilation: The Towards RECOVER Study. Critical Care Canada Forum, Toronto, October 2012.

14. L Rose, R Maunder, J Hunter, A Day, M Steinberg, M Herridge, J Devlin, P Dodek, L Burry, S Mehta, for the Canadian Critical Care Trials Group. Sleep, cognitive and psychological morbidity following sedation protocol and daily sedative interruption vs sedation protocol alone in critically ill, mechanically ventilated adults (SLEAP-SCP). Crit Care Med 2012; 40 (12 Suppl.): Abstract 1104

Presentations/Lectures: 1. Sedation interruption vs sedation algorithm: Results of the SLEAP Trial. St Michael’s Hospital Critical

Care Rounds, Toronto. December 7, 2012.

2. Altered Pulmonary Physiology Seminar. Pulmonary Structure and Function Course, University of Toronto medical students, November 29, 2012.

3. A career in Science. Dragon Academy, Toronto, November 21, 2012.

4. Sedation Interruptions vs Protocolised Sedation? Results and implications of the SLEAP Trial – JAMA Audio interview, November 20, 2012. Posted on JAMA website. http://jama.jamanetwork.com/multimedia.aspx#AuthorInterviews

5. Daily sedation interruption – is it necessary? Critical Care Canada Forum, Toronto, October 31, 2012.

6. Delirium in mechanically ventilated adults – results from the SLEAP Trial. Critical Care Canada Forum, Toronto, October 31, 2012.

7. Poster Adjudicator. Critical Care Canada Forum, Toronto, October 29, 2012.

8. Sedation interruption vs sedation algorithm: Results of the SLEAP Trial. UHN-TGH Interdisciplinary Critical Care Rounds, Toronto. October 23, 2012.

9. Daily sedation holidays vs protocolized sedation: any difference? Hot Topics Session, ESICM Meeting, Lisbon, Portugal, October 17, 2012.

10. Results of the SLEAP Trial - Video interview, ESICM Congress, Lisbon, Portugal, October 17, 2012. Posted on ESICM website. http://www.esicm.org/news-article/sangeeta-mehta-sedation-study-interview

11. 14th Annual International Meeting of Respiratory Care Indonesia (Respina) 2012, Jakarta, Indonesia, October 2012. Invited as distinguished speaker – Declined.

12. Delirium, sub-syndromal delirium, antipsychotic use, and associated clinical outcomes in critically ill mechanically ventilated patients enrolled in the SLEAP multicenter randomized trial. Abstract Award Winning Session, ESICM Meeting, Lisbon, Portugal, October 16, 2012.

13. Sedation interruption vs sedation algorithm: Results of the SLEAP RCT. State of the Art Sedation, Agitation and Delirium in the ICU. Melbourne, Australia, May 23, 2012 (presented by teleconference).

14. SLEAP: A multicenter randomized trial of daily awakening in critically ill patients being managed with a sedation protocol. American Thoracic Society Meeting, Clinical trials in Critical Care, San Francisco, CA, May 23, 2012.

15. MSH/UHN Joint Department of Medicine Newsletter Spring 2012. Dr. Sangeeta Mehta featured in Member Spotlight as “a shining star in Critical Care and Respirology”.

16. Non-invasive ventilation in acute respiratory failure. Department of Medicine subspecialty noon rounds, Mount Sinai Hospital, May 11, 2012.

17. Sedation and Delirium in the ICU. Academic Medical Center Masterclass, Amsterdam, The Netherlands, January 26, 2012.

Research Funding: 1. SLEAP- Sleep, Cognition and Psychology (SLEAP-SCP): Psychological, cognitive and sleep

morbidity following the use of a sedation protocol vs a sedation protocol and daily sedative interruption in critically ill, mechanically ventilated adults. Co-principal Investigator, with Dr. Jonathan Hunter. Granting agency: CIHR Operating Grant Program Funding period: Oct 2010 – Sept 2012, Total funds $63,494

2. Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation: A systematic review. Senior Investigator, PI Dr. Lisa Burry Granting agency: Canadian Society of Hospital Pharmacists Research and Education Foundation Funding period: January 13, 2011 – January 2012. Total funds $3,500.

3. A prospective evaluation of the association between psychoactive medications and delirium in critically ill adults. Senior Investigator. PI Dr. Lisa Burry Granting agency: University of Toronto Rx & D Pilot Research Grant in Clinical Pharmacy Research for 2011 Funding period: May 3, 2011 – May 2012. Total funds $24,985.

4. Antimicrobial Stewardship Programs (ASP) in Intensive Care units in Ontario Academic Hospitals. Co-investigator, PI Dr. Andrew Morris Granting Agency: Council of Academic Hospitals of Ontario (CAHO). Funding period: December 2011 to November 2012. Total funds $768,000.

5. Phase 1 Study: The determination the maximum tolerable dosage of nebulized Sodium Nitroprusside in adult Acute Lung Injury Resident Project Supervisor for Dr. Terence Ip. Granting Agency Physicians’ Services Incorporated Foundation Resident Research Grant Competition Funding period: April 2012 to March 2013. Total funds: $20,000

6. One-day Point Prevalence of Acute Rehabilitation in Ontario Intensive Care Units: Rates of, Barriers

to and Facilitating Factors for Mobilization. Co-investigator, PI Dr Karen Koo. Granting Agency: AHSC AFP Innovation Fund – The Academic Medical Organization of Southwestern Ontario

7. One-day Point Prevalence of Acute Rehabilitation in Ontario Intensive Care Units: Rates of, Barriers to and Facilitating Factors for Mobilization. Co-investigator, PI Dr Karen Koo. Granting agency: Physicians’ Services Inc. Foundation Funding period: June 2012 to Dec 2013. Total funds: $58,000.

Briseida Mema (Hospital for Sick Children) Presentations/Lectures: 1. Pediatric Intensive Care Rounds, Hamad Medical Coporation, Doha, Qatar, 2012 Teaching technical skills. 2. 9th Annual Pediatric Emergency Medicine Conference, 2012 Procedure workshops: CVL and Thoracocentesis

3. Critical Care Medicine – Resident’s Day, University of Toronto, 2012 Efficient use of Stimulation tools for technical skills.

4. CCRT Education Day, Hospital for Sick Children, Toronto, 2012

Feedback: Through the looking glass - Co-presenter

5. Education Scholars Programe, Centre for Faculty Deveopment, 2012 Teaching Dossier: An educator’s tale – Co- presenter

Victoria McCredie (Sunnybrook Health Sciences Centre) Peer Reviewed Publications: 1. DowarJ, Barua R, Rodin D, Gudimella R, Lejnieks B, McCredie V, Hayes C, Steel A. Rapid

Response Teams, Do Not Resuscitate Orders, and Potential Opportunities to Improve End-of-Life Care: A Multicentre Retrospective Study. Journal of Critical Care 2012

Abstracts: 1. Sharma S, McCredie V, deMestral C, Hsiao M, Rutka J, Nathens A. Analysis of Trauma Team

Activation in Severe Head Injury: An Institutional Experience. Trauma Association of Canada, Toronto 2012

2. Zakrison T. McCredie VA. Nathens A. Recognition of Occult Shock in the Trauma Bay.Trauma Association of Canada, Toronto 2012

3. T. Zakrison, V. McCredie, E. Leung, G. Garcia, S. Rizoli, and A. Nathens Occult shock in trauma: What are Canadian traumatologists missing? Can J Surg. 2012 April; 55(2 Suppl): s2–s31.

4. Garavaglia M. McCredie VA. Hare G. Serum Lactate: A potential marker of tissue ischemia or metabolic dysfunction during prolonged craniotomy for brain tumour resection. Annual Shield’s Research Day, University of Toronto 2012

5. M. Garavaglia, V. McCredie, T. Mak, A. Rigamonti, M. Cusimano, A. Baker, C. Crescini, A. Romaschin, G. Hare.Serum Lactate: A Potential Marker of Tissue Ischemia or Metabolic Dysfunction During Craniotomy for Brain Tumor Resection40th Annual Meeting of the Society for Neuroscience in Anesthesiology and Critical Care, Washington, DC, October 12, 2012 Journal of Neurosurgical Anesthesiology. 24(4):440-507, October 2012.

6. Zakrison, T. McCredie VA. Baker, A. Making Handover Safer for our Trauma Patients – A Grassroots Approach to Quality.AAST, Hawaii 2012

7. Lo B, Fox-Robichaud A, McCredie V, Jaja B, Schweizer T, Meade M, Cook D, Macdonald L. Biochemical Prognostic Markers in Aneurysmal Subarachnoid Hemorrhage – a Systematic Review. Critical Care Canada Forum, Toronto 2012


1. Sharma S, McCredie V, deMestral C, Hsiao M, Rutka J, Nathens A. Analysis of Trauma Team Activation in Severe Head Injury: An Institutional Experience. Trauma Association of Canada, Toronto 2012

2. Transcranial Doppler: Overview and Hands-on. Canadian Anesthesiologists' Society Annual Meeting, Toronto, Canada

Research Funding: 1. 2011 – 2012 Prinicipal Investigator. Trauma and Neurosurgery Research Grant.University

of Toronto.Cerebral Tissue Oxygen Saturation During Blood Transfusion in Severe Traumatic Brain Injured Patients (COST TBI study). Collaborators: Baker A, Hare G, Rigamonti A. $2,000

2. 2011 – 2012 Investigator. St. Michael's Foundation Quality Innovation Fund.University of

Toronto.Making Handover Safer for our Trauma Patients – A Grassroots Approach to Quality. Principal Investigator: Zakrison, T. Collaborators: Nathens, A. Baker, A. $10,000

3. 2012 – 2013 Principal Investigator. Physicians Services Inc. Foundation. Cerebral Tissue Oxygen Saturation During Blood Transfusion in Severe Traumatic Brain Injured Patients (COST TBI study). Collaborators: Baker A, Hare G, Rigamonti A. $46,500

Avery Nathens (St. Michael’s Hospital) Peer Reviewed Publications:

1. Lenartowicz M, Parkovnick M, McFarlan A, Haas B, Straus SE, Nathens AB, Wong CL. An evaluation of a proactive geriatric trauma consultation service. Annals of Surgery. 2012 Dec;256(6):1098-101. Co-Principal Author.

2. Doumouras A, Gomez-Jaramillo D, Haas B, Boyes D, Nathens AB. Comparing methodologies for evaluating EMS ground transport access to time-critical emergency services: A case study using trauma center care. Acad Emerg Med. 2012 Nov;87(11):1616-21. Senior Responsible Author.

3. Calland JF, Nathens AB, Young JS, Neal ML, Goble S, Abelson J, Fildes JJ and Hemmila MR. The effect of dead-on-arrival and emergency department death classification on risk-adjusted performance in the American College of Surgeons Trauma Quality Improvement Program. J Trauma Acute Care Surg. 2012 Nov;73(5):1086-91. Co-Principal Author.

4. Ahmed N, Conn LG, Chiu M, Korabi B, Qureshi A, Nathens AB and Kitto S. Career satisfaction among general surgeons in Canada: a qualitative study of enablers and barriers to improve recruitment and retention in general surgery. Acad Med. 2012 Nov;87(11):1616-21. Coauthor or Collaborator.

5. Watkins TR, Nathens AB, Cooke CR, Psaty BM, Maier RV, Cuschieri J and Rubenfeld GD. Acute respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med. 2012 Aug;40(8):2295-303. Co-Principal Author

6. Doumouras AG, Haas B, Gomez D, de Mestral C, Boyes DM, Morrison LJ, Craig AM and Nathens AB. The Impact of Distance on Triage to Trauma Center Care in an Urban Trauma System. Prehosp Emerg Care. 2012 Jun 27. Senior Responsible Author.

7. Gomez D, Haas B, de Mestral C, Sharma S, Hsiao M, Zagorski B, Rubenfeld G, Ray J and Nathens AB. Gender-associated differences in access to trauma center care: A population-based analysis. Surgery. 2012 Jun 20. Senior Responsible Author.

8. Eskicioglu C, Gagliardi AR, Fenech DS, Forbes SS, McKenzie M, McLeod RS and Nathens AB. Surgical site infection prevention: a survey to identify the gap between evidence and practice in University of Toronto teaching hospitals. Can J Surg. 2012 Jun 1;55(3):036810-35710. doi: 10.1503/cjs.036810. Senior Responsible Author.

9. Ingraham AM, Haas B, Cohen ME, Ko CY and Nathens AB. Comparison of Hospital Performance in Trauma vs Emergency and Elective General Surgery: Implications for Acute Care Surgery Quality Improvement. Arch Surg. 2012 Mar 19. Senior Responsible Author.

10. Gomez-Jaramillo D, Haas B, de Mestral C, Sharma S, Hsiao M, Zagorski B, Rubenfeld G, Ray J, Nathens AB. Institutional and provider factors impeding access to trauma center care: an analysis of transfer practices in a regional trauma system. J Trauma Acute Care Surg. 2012 Nov;73(5):1288-93 (Trainee publication). Senior Responsible Author.

11. Haas B, Gomez D, Stukel T, Rubenfeld G, Nathens AB. The mortality benefit of direct trauma center transport in a regional trauma system: a population based analysis. J Trauma Acute Care Surg. 2012 Jun;72(6):1510-7. Senior Responsible Author.

12. Gomez D, Haas B, Al-Ali K, Monneuse O, Nathens AB, Ahmed N. Controversies in the management of splenic trauma. Injury. 2012; 43: 55–61. Coauthor or Collaborator.

13. Cuschieri J, Johnson JL, Sperry J, et al. Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg. 2012 May;255(5):993-999. Coauthor or Collaborator.

14. Stelfox HT, Straus SE, Nathens AB, Gruen RL, Hameed SM, Kirkpatrick A. Trauma Center Quality Improvement Programs in the United States, Canada and Australasia. Ann Surg. 2012 Jul;256(1):163-9. Coauthor or Collaborator.

15. Harvey A, Bandiera G, Nathens AB, Leblanc VR. The Impact of Stress on Resident Performance in Simulated Trauma Scenarios. J Trauma Acute Care Surg. 2012; 72(2): 497-503. Co-Principal Author.

16. Haas B, Xiong W, Brennan-Barnes M, Gomez D, Nathens AB. Overcoming barriers to population-based injury research: Development and validation of an ICD-10 to Injury Severity Score crosswalk. Can J Surg. 2012 Feb;55(1):21-6. Senior Responsible Author.

17. de Mestral C, Dueck A, Gomez D, Nathens AB. Blunt Abdominal Aortic Injury: Injury Patterns, Management and Mortality. Journal of Vascular Surgery. 2012 Jul 11. Senior Responsible Author.

Non-Peer Reviewed Publications: 1. Nathens AB, Cryer HG and Fildes J. The American College of Surgeons Trauma Quality

Improvement Program. Surg Clin North Am. 2012 Apr;92(2):441-54. Senior Responsible Author

Book Chapters: 1. Ingraham AM and Nathens AB. Postoperative Dehiscence. In: Clinical Scenarios in General

Surgery. Lippincott Williams & Wilkins, Philadelphia. 2012. Co-Principal Author.

In Press: 1. Moore L, Nathens AB, Stelfox T. Rates, patterns and determinents of unplanned readmission

following traumatic injury : a multicenter cohort study. Annals of Surgery. In Press. Coauthor or Collaborator.

2. Seok J, Shaw WH, Cuenca AH, et al. Genomic Responses in Mouse Models Poorly Mimic Human Inflammatory Diseases. PNAS. In Press. Coauthor or Collaborator.

3. Evans C, Bridge J, Tallon J, Nathens AB. A descriptive survey of systems of major trauma care in Canada. Canadian Journal of Emergency Medicine. In Press (Trainee publication). Senior Responsible Author.

4. de Mestral C, Dueck A, Sharma S, Haas B, Gomez D, Hsiao M, Hill A, Nathens AB. Evolution of the Incidence, Management and Mortality of Blunt Thoracic Aortic Injury in Canada: A Population-based Analysis. Journal of the American College of Surgeons. In Press (Trainee publication). Senior Responsible Author.

5. Sharma S, Rutka J, Nathens AB. Benchmarking trauma center performance: the limitations of mortality outcomes. J Trauma Acute Care Surg. In Press. Senior Responsible Author.

Submitted Publications: 1. Watkins TR, Cooke CR, Hudson LD, Caldwell HE, Rubenfeld GD, Nathens AB, Martin TR, Puget

Sound VA. Transfusion and lung injury: The role of red blood cell storage time. Critical Care Medicine. Coauthor or Collaborator.

Presentations/Lectures: 1. 2012 Jun Research supervisor. Unstable Chest Wall Injuries: A National Trauma Databank

Analysis of Flail Chest Injuries. Canadian Orthopedic Association. Ottawa, Ontario, Canada. Presenter(s): Deghan N, McKee M, Nathens AB. (Trainee Presentation).

2. 2012 Jun Lecturer. Biomedical Engineering Research Symposium. Li Ka Shing Knowledge

Institute & Ryerson University. Toronto, Ontario, Canada. Presenter(s): Avery B. Nathens. Pre-hospital care in Trauma.

3. 2012 May 4 Invited Speaker. Trauma Care Organization. Asia-Pacific Trauma Quality

Improvement Network. Kuala Lampur, Malaysia. 4. 2012 Apr Research supervisor. Access to trauma centre care for patients with major trauma.

Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Hill A, Fowler R, Nathens AB. (Trainee Presentation).

3. 2012 Apr Speaker. An evaluation of a proactive geriatric trauma consultation service. Trauma

Association of Canada. Toronto, Ontario, Canada. Presenter(s): McFarlan A, Haas B, Wong C, Zorzitto M, Strauss S, Lenartowicz M, Nathens AB.

4. 2012 Apr Research Supervisor. Predictin crumping during CT imaging using base deficit. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Pajak C, Nolan B, De Mestral C, McFarlan A, Zakirova R, Nathens AB. (Trainee Presentation). 5. 2012 Apr Predicting crumpting during CT imaging using base deficit. Trauma Association of

Canada. Toronto, Ontario, Canada. Presenter(s): Pajak C, Nolan B, DeMestral C, Mcfarlan A, Zakirova R, Bridge J, Nathens AB.

6. 2012 Apr Transition home using telehomecare technology to follow ABI patients and family

caregivers. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Canzian S, Nathens AB.

7. 2012 Apr Research supervisor. Analysis of trauma team activation in severe TBI: an institutional

experience. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Sharma S. Nathens AB. (Trainee Presentation).

8. 2012 Apr Research Supervisor. 97% of massive transfusion protocol (MTP) activations do not

include a complete hemorrhage panel. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Bowazeer M, Nathens AB.

9. 2012 Apr Caring about trauma care: public awareness, knowledge, and perceptions. Trauma

Association of Canada. Toronto, Ontario, Canada. Presenter(s): Bridge J, Nathens AB.

10. 2012 Apr Research Supervisor. Blunt splenic injury in patients with hereditary spherocytosis: a

population-based analysis. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Hsiao M, Nathens AB. (Trainee Presentation).

11. 2012 Apr Research Supervisor. Evaluating potential spatial access to trauma centre care by

severely injured patients. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Lawson F, Nathens AB, Schuurman N. (Trainee Presentation).

12. 2012 Apr Invited Speaker. Overcoming the Challenges of Geography: Improving Access to

Trauma Care. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Nathens AB.

13. 2012 Apr Telemedicine for trauma resuscitation: Developing a regional system to improve access

to expert trauma care in Ontario. Trauma Association of Canada. Toronto, Ontario, Canada. Presenter(s): Hicks C, Nathens AB.

14. 2012 Feb Invited Speaker. American College of Surgeons Trauma Quality Improvement Program. American Burn Association - Burn Quality Consensus Conference. District of Columbia, United States.

15.2012 Feb A contemporary analysis of mortality associated with gunshot wounds to the head.

Academic Surgical Congress (Society of University Surgeons). Las Vegas, Nevada, United States. Presenter(s): Sharma SV, Gomez D, DeMestral C, Hsiao M, Haas B, Rutka J, Nathens AB. (Trainee Presentation).

15. 2012 Feb Sex-Associated Differences in Access To Trauma Center Care: A Population-Based

Analysis. Academic Surgical Congress (Society of University Surgeons). Las Vegas, Nevada, United States. Presenter(s): Gomez Jaramillo D, Haas B, De Mestral C, Sharma S,Hsiao M,Zagorski B,Rubenfeld G, Ray J,Nathens AB. (Trainee Presentation).

15. 2012 Feb Population Based Analysis of Blunt Splenic Injuries in Children: Using Operative

Rate as a Quality of Care Indicator. Academic Surgical Congress (Society of University Surgeons). Las Vegas, Nevada, United States. Presenter(s): Hsiao M, Haas B, Gomez Jaramillo D, De Mestral C, Sharma S, Langer J, Nathens AB. (Trainee Presentation).

16. 2012 Jan Cholecystectomy on first admission for acute cholecystitis: every day counts.

Orlando, Florida, United States. Presenter(s): deMestral C, Zagorski B, Rotstein OD, Laupacis A, Haas B, Nathens AB. (Trainee Presentation).

Research Funding: 1. 2012 Oct – 2013 Oct Principal Investigator. The impact of tracheostomy timing on the

outcome of traumatic brain injury. Physician Services Incorporated Foundation. Resident Research Grant. 17,000 CAD. [Grants]

2. 2011 Jul – 2015 Jul Co-Investigator. Developing a Patient and Family-Centred

Approach for Measuring the Quality of Trauma Care. Canadian Institutes of Health Research (CIHR). PI: Stelfox, Tom. 628,692 CAD. [Grants] Co-investigator 2011-2014.

3. 2011 Apr – 2013 Apr Principal Investigator. Improving Patient Transition from Acute

Trauma Care Hospitalization: Identifying information and communication gaps during the discharge process. Ministry of Health and Long Term Care - Innovation Funding. MOHLTCl AHSC AFP Innovation Fund. Collaborators: Jennifer Bridge. 23,000 CAD. [Grants]

4. 2010 Jul – 2015 Jun Site Investigator. HL-10-006 Toronto Regional Coordinating Center;

Clinical Research Consortium to Improve Resuscitation Outcomes. National Institutes of Health (NIH) (USA). PI: Morrison LJ. Collaborators: Dorian P, Cheskes S, Slutsky A. 1,110,780 CAD. [Grants] NIH Department of Health and Human Resources/Heart & Stroke Foundation/Canadian Institute of Health Research.

3. 2010 Jul – 2015 Jun Principal Investigator. Trauma System Development in Canada:

Overcoming the Challenges of Geography Through an Evaluation of Structure and Process. Canadian Institutes of Health Research (CIHR). Collaborators: Cusimano M, Gagliardi A, Gomez D, Haas B, Hameed M, Lawless B, Morrison L, Peters P, Pong R, Rubenfeld G, Schurmann N, Snider C, Tallon J. 2,264,139 CAD. [Grants]

4. 2010 Jul – 2012 Jun Co-Principal Investigator. From Data to Daily Practice: An

Integrative Approach to Improving Trauma Centre Access in Rural Regions. Canadian Institutes of Health Research (CIHR). Fellowship. PI: Haas B. Collaborators: Gagliardi A. 110,000 CAD. [Grants]

5. 2010 Jul – 2012 Jun Principal Investigator. Towards Equity in Access to Trauma Care: A

Mixed-Methods Approach to Spatial Analyses of Existing Trauma Transfer Networks. Canadian Institutes of Health Research (CIHR). Collaborators: Gagliardi A, Gomez D, Haas B, Rubenfeld G, Gozdyra P. 199,844 CAD. [Grants]

Giuseppe Papia (Sunnybrook Health Sciences Centre) Submitted Publications: 1. Paul T Engels, Andrew N Beckett, Gordon D Rubenfeld, Hans Kreder, Joel A Finkelstein, Leondante

da Costa, Giuseppe Papia, Sandro B Rizoli, Homer C Tien. Physical Rehabilitation of the Critically ill trauma patient in the ICU. Critical Care Medicine. Coauthor or Collaborator.

2. Papia, G, Fan, J, Kapus A, Szaszi K, Marshall JC, Rotstein OD. Altered inhibitory kappa-B alpha

expression in alveolar macrophages following resuscitated hemorrhagic shock. Journal of Immunology. Principal Author.

Presentations/Lectures: 1. 2012 Jun 7 Invited Speaker. Peripheral Vascular Disease: New Procedures, Update 2012 for

Nurses and Technologists SHSC. Sunnybrook Health Sciences Centre. Toronto, Ontario, Canada. Presenter(s): Papia, Giuseppe.

2. 2012 May 30 Invited Speaker. Tibial Angioplasty and New Concepts in Limb Salvage. Canadian

Interventional Radiology Association Annual Meeting. Vancouver, British Columbia, Canada. Presenter(s): Papia, Giuseppe.

2. 2012 May 28 Presenter. Update on the Surgical Safety Checklist. QI Committee of the Board

Sunnybrook Health Sciences Centre. Toronto, Ontario, Canada. Presenter(s): Papia, Giuseppe.

3. 2012 May 18 Invited Speaker. Limb Salvage and New Approaches to Occlusive Disease. Sunnybrook Health Sciences Centre, Department of Surgery. Toronto, Ontario, Canada. Presenter(s): Papia, Giuseppe.

4. 2012 Apr 28 Invited Speaker. Successful Implimentation of the Surgical Safety Checklist:

Challenges and Successes. New Brunswick Operating Room Nurses Annual Meeting. Fredericton, New Brunswick, Canada. Presenter(s): Papia, Giuseppe.

Research Funding: 1. 2011 Nov – 2015 Dec Co-Investigator. Curcumin to Prevent Perioperative Complications After

Elective Abdominal Aortic Aneurysm Repair: a Randomized Controlled Trial. Canadian Institutes of Health Research (CIHR). Multi Center Study. PI: Tobe, Sheldon; Hladunewich, Michelle. Collaborators: Site Co-PI with Sheldon Tobe (Nephrology). 322,419 CAD. [Grants] The purpose of this study is to determine whether curcumin, a natural health product, can prevent acute kidney injury and other complications after elective AAA repair. If proven safe and effective, curcumin is an inexpensive intervention which can be readily applied to almost 50,000 AAA repairs performed worldwide each year. New knowledge about this intervention may also guide its use in other surgical and medical settings to prevent complications to the kidneys, heart and other organs..

Christopher Parshuram (Hospital for Sick Children) Peer Reviewed Publications: 1. Slater MB, Anand V, Uleryk EM, Parshuram CS. A systematic review of the RIFLE in children:

its application and association with the measures of mortality and morbidity. Kidney International. 2011, 81 (8) 791-8. Senior Responsible Author. Published in 2012.

Submitted Publications: 1. Taylor K, Mayell A, VanDenberg S, Blanchard N, Parshuram CS. Healthcare Videoconferencing

Prevalence in North America and British Hospitals. Paediatrics and Child Health. Senior Responsible Author.

2. Ebrahim S, Singh S, Parshuram CS. Satisfaction, invlovement and reflections: A survey of caregiver perceptions following PICU admission. Journal of Critical Care. Senior Responsible Author.

Presentations/Lectures: 1. 2012 Nov 28 Invited Speaker. Bedside Paediatric Early Warning System: the

collaborative collision of Science, Safety and Culture. Paediatric Grand Rounds, William Osler Hospital. Brampton, Ontario, Canada. Presenter(s): Parshuram, C.

2. 2012 Nov 4 Collaborator. 321 - Factors Associated with Readmission Within 48

Hours to Cardiac Critical Care. American Heart Association. Los Angeles, California, United States. Presenter(s): Grace Williamson.

3. 2012 Nov 1 Presenter. Evaluating the processes of care & the outcomes of children in

hospital (EPOCH): a cluster randomized trial of the Bedside Paediatric Early Warning System. Canadian Critical Care Trials Group. Toronto, Ontario, Canada. Presenter(s): Parshuram, C.

4. 2012 Oct 29 Moderator. Critcal Care Heamatology. Critical Care Canada Forum.

Toronto, Ontario, Canada. Presenter(s): Walsh, T. 5. 2012 Oct 29 Presenter. Enhancing Communication on Rounds. Critical Care Canada

Forum. Toronto, Ontario, Canada. Presenter(s): Parshuram, C. 6. 2012 Oct 29 Invited Speaker. Enhancing Communication on Rounds. Critical Care

Canada Forum. Toronto, Ontario, Canada. Presenter(s): Parshuram, C. 7. 2012 Jul Invited Speaker. A discussion on Evaluating Processes of Care & the

Outcomes of Children in Hospital: a cluster randomized trial of the Bedside PEWS. Bambino Gesu Hospital. Rome, Italy. Presenter(s): Parshuram, Christopher Sushil.

8. 2012 Jun Invited Professor. Children’s Hospital of Wisconsin. Milwaukee,

Wisconsin, United States. Presenter(s): Parshuram, Christopher Sushil. 9. 2012 Jun Visiting Professor. Stollery Children’s Hospital. Alberta, Canada.

Presenter(s): Parshuram, Christopher Sushil. 10. 2012 Jun Visiting Professor. EPOCH and the Bedside Paediatric Early Warning

System: and ongoing work. Paediatric Grand Rounds, Stollery Childrens Hospital. Edmonton, Alberta, Canada.

11. 2012 Apr Invited Presenter. EPOCH and the Bedside Paediatric Early Warning

System: an ongoing work. Paediatric Grand Rounds, St. Justines Hospital. Montreal, Quebec, Canada.

12. 2012 Apr Invited Speaker. Implementation and Outcomes. Paediatric Grand

Rounds, North York General Hospital. Toronto, Ontario, Canada. 13. 2012 Mar Presenter. The title remains the same (EPOCH). Acute Care Research

Rounds, Department of Critical Care Medicine, The Hospital for Sick Children. Toronto, Ontario, Canada.

14. 2012 Mar Invited Speaker. Paediatric pharmacotherapy: imprecise by design.

Paediatric Grand Rounds, CHUQ Hospital. Quebec City, Quebec, Canada. 15. 2012 Feb Visiting Professor. Combining Research & Quality the collaborative

development, validation & evaluation of an integrated communication tool to improve care in Hospital wards. Pediatric Grand Rounds, University of Texas, Southwestern Hospital. Dallas, Texas, United States. Presenter(s): Parshuram, Christopher Sushil.

16. 2012 Feb Visiting Professor. Development & Evaluation of the Bedside Paediatric

Early Warning System. Pediatric Grand Rounds, Maine Medical Center. Maine, United States. Presenter(s): Parshuram, Christopher Sushil.

17. 2012 Jan Invited Presenter. Effective implementation of the Bedside PEWS. Grand

Rounds, Starship Childrens Hospital. Auckland, New Zealand. Presenter(s): Parshuram, Christopher Sushil.

18. 2012 Jan Invited Presenter. Collaborative Development & Evaluation of the

Bedside Paediatric Early Warning System. Paediatric Grand Rounds, BC Children’s Hospital. British Columbia, Canada.

Research Funding: 1. 2010-14 Canadian Institutes of Health Research

The Bedside Paediatric Early Warning System: a cluster RCT of mortality and processes of care. $3,300,000

2. 2010-12 Ontario Neurotrauma Foundation (ONF).

The Pediatric TBI CT Scan Tool. PI: Guerguerian A. 100,000. [Grants]

Dominique Piquette (Sunnybrook Health Sciences Centre) Submitted Publications: 1. Piquette D, Tarshis J, Fowler R, Regehr G, Pinto R, LeBlanc, VR. Effects of clinical supervision on

patient care and resident learning during simulated ICU scenarios. Submitted to Critical Care Medicine, October 2012.

2. Piquette D, Mylopoulos M, LeBlanc VR. How does clinical supervision affects patient care, resident

participation, and resident learning: a qualitative study. Submitted to Critical Care Medicine, October 2012.

3. Piquette D, Tarshis J, Sinuff T, Fowler R, LeBlanc, V. Acute Stress During Resuscitation Episodes:

Impact on Resident Performance and Implications for Training. Submitted to Medical Teacher; September 2012.

Presentations/Lectures: 1. LeBlanc VR, Piquette D. Workshop session: Simulation as a research tool. Simulation Summit,

Ottawa, November 2012. 2. Piquette D, Tarshis J, Fowler R, Pinto R, Regehr G, LeBlanc VR. Effects Of The Level Of Clinical

Supervision On Resuscitation And Resident Learning During Simulated ICU Scenarios, ATS 2012, San Francisco, May 2012. (Poster presentation) [A1609]

3. Piquette D, Mylopoulos M, LeBlanc VR. Effect of the level of clinical supervision during ICU resuscitation scenarios on resident learning and patient care: a qualitative study. The 32nd International Symposium on Intensive Care and Emergency Medicine Team, Brussels, March 2012. (Poster presentation)

Andrea Rigamonti (St. Michael’s Hospital) Peer Reviewed Publications: 1. Desjardins P, Turgeon AF, Tremblay MH, Lauzier F, Zarychanski R, Boutin A, Moore L, McIntyre L,

English SW, Lacroix J, Rigamonti A, Fergusson DA. Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies. Critical Care,2012;. 16:R54

Research Funding: 1. Perioperative low-dose pregabalin for acute and chronic post-craniotomy pain: A two-centre

randomized controlled trial. Canadian Anesthesiologists’s Society. Role: Principal Investigator. Total amount: $30,000. 2012

2. Early Determination of Neurological Prognosis in ICU patients with Severe Traumatic Brain Injury: TBI-Prognosis Multicenter Prospective Study. Canadian Institutes of Health Research. Role: Site principal investigator. Total amount: $1,400,000. 2012

3. Observational Study of Cerebral Tissue Oxygen Saturation During Blood Transfusion in Severe Traumatic Brain Injured Patients. Physicians Services Incorporated Foundation. Role: Co-investigator. Total amount: $40,000. 2012

Sandro Rizoli (Sunnybrook Health Sciences Centre) Peer Reviewed Publications: 1. Jansen J, Inaba K, Resnick S, Fraga G, Starling S, Rizoli S, Boffard K, Demetriades D: Selective non

operative management of abdominal gunshot wounds: survey of practice. Injury 2012 Feb 14. [Epub ahead of print].

2. Bulger E; Guffey DM; Guyette F; Russell M; Brasel K; Kerby J; Minei J; Warden C; Rizoli S; Morrison L, Nichol G, Resuscitation Outcomes Consortium Investigators: Impact of Prehospital Mode of Transport after Severe Injury: A multicenter evaluation from the Resuscitation Outcomes Consortium. J Trauma Acute Care Surg. 2012 Mar; 72(3):567-575. Selected for CME activity - Physicians obtain CME credit after completing quiz.

3. Luz LD, Sankarankutty A, Passos E, Rizoli S, Fraga GP, Nascimento Jr B: Tranexamic acid for

traumatic hemorrhage. Rev Col Bras Cir. 2012; 39(1):77-80. 4. Fraga GP, Nascimento Jr B, Rizoli S: Evidence-based telemedicine: trauma & acute care surgery

(EBT-TACS). Rev Col Bras Cir. 2012; 39(1):3.

5. Callum J, Rizoli S: Plasma transfusion for patients with severe hemorrhage: what is the evidence? Transfusion 2012 May; 52 Suppl 1:30S-7S.

6. Hirano ES, Pereira BM, Bustorff-Silva JM, Rizoli S, Nascimento Jr B, Fraga GP: Not complicated acute appendicitis in adults: clinical or surgical treatment? Rev Col Bras Cir. 2012 Apr;39(2):159-164

7. Rizoli SB, Nascimento B: Just another fascinating property of hypertonic solutions or something clinically relevant this time? Crit Care Med. 2012 Aug;40(8):2519-20.

8. Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Shiu MY, Baker AJ, Li L, Shek PN, Hoyt DB, Bulger EM: Resuscitation of Traumatic Hemorrhagic Shock Patients With Hypertonic Saline - Without Dextran - Inhibits Neutrophil and Endothelial Cell Activation. Shock. 2012 Jul 6. [Epub ahead of print].

9. Sankarankutty A; Nascimento B; da Luz LT; Rizoli S: TEG® and ROTEM® in trauma: similar test but different results? World Journal Emergency Surgery 2012 7(Suppl 1):S3.

10. Mamtani R; Nascimento B; Rizoli S; Pinto R; LinY; Tien H: The utility of recombinant factor VIIa as a last resort in trauma. World J Emerg Surgery 2012 7 (Suppl 1):S7.

11. Carrasco CE; Godinho M; Barros MBA; Rizoli S; Fraga GP: Fatal motorcycle crashes: a serious public health problem in Brazil. World J Emerg Surgery 2012 7(Suppl 1):S5.

12. Fraga GP; Andrade VA; Schwingel R; Starling SV; Rizoli S: The scientific production in trauma of an emerging country. World J Emerg Surg 2012 7(Suppl 1): S13.

13. Schmidt BM; Rezende-NetoJB; Andrade MV; Winter PC; Carvalho Jr MG; Lisboa TA; Rizoli SB; Cunha-Melo JR: Permissive hypotension does not reduce regional organ perfusion compared to normotensive resuscitation: animal study with fluorescent microspheres. World Journal Emergency Surgery 2012 7(Suppl 1):S9.

14. Rizoli S; Leppäniemi A: The world of trauma working together. World Journal Emergency Surgery 2012 7(Suppl 1):S2

15. Godinho M, Garcia DD, Parreira JG, Fraga GP, Nascimento B, Rizoli S: Management of hemorrhage in patients with pelvic fracture and hemodynamically unstable. Rev Col Bras Cir. 2012 Jun 39(3):238-242.

16. Zago TM, Pereira BM, Calderan TRA, Hirano ES, Rizoli S, Fraga GP: Blunt hepatic trauma:

comparison between surgical and non operative treatment. Rev Col Bras Cir 2012; 39(4):307-313. 17. Rezende-Neto JB, Pastore Neto M, Hirano ES, Rizoli S, Nascimento Jr B, Fraga GP: Management of

retained hemothoraces after chest tube thoracostomy for trauma. Rev Col Bras Cir 2012; 39(4):344-349.

18. Bhella S, Gerard L, Lin Y, Rizoli S, Callum J: Obstetric and trauma database review at a single institution finds the optimal maternal age restriction for the transfusion of O- blood to women involved in trauma to be 45 years. Transfusion. 2012 Nov;52(11):2488-9.

19. Sankarankutty A; Da Luz LT; Campos T; Rizoli S; Fraga GP; Nascimento Jr. B: Uncomplicated Acute Cholecystitis: Early or Delayed Laparoscopic Cholecystectomy? Rev. Col. Bras. Cir. 2012; 39(5): 436-440.

20. Mastracci TM, Bhandari M, Mundi R, Rizoli SB, Nascimento BA, Schreiber M: Operative blood loss, blood transfusion and 30-day mortality in older patients after major noncardiac surgery. Evidence-Based Reviews in Surgery Group. Can J Surg. 2012 Dec;55(6):426-8.

21. Callum JL, Rizoli S: Assessment and management of massive bleeding: coagulation assessment, pharmacologic strategies, and transfusion management. Hematology. 2012;2012:522-8.

22. Sankarankutty A, da Luz LT, Campos T, Rizoli S, Fraga GP, Nascimento Jr B: Uncomplicated Acute

Cholecystitis: Early or Delayed Laparoscopic Cholecystectomy? Rev. Col. Bras. Cir. 2012; 39(5): 436-440.

23. Zakrison TL, Pereira BM, Marttos Jr AC, Fraga GP, Nascimento Jr B, Rizoli S:Venous thromboembolism prophylaxis in patients with traumatic brain injury. Rev Col Bras Cir. 2012 Dec; 39(6):553-557. SRI


1. Beth Israel Deaconess Medical Center – Harvard Medical School. Boston, USA. February 9, 2012. What's New in the Management of the Massive Bleeding Patients?

2. American Association for the Surgery of Trauma Grand Round. Teleconference. February 15, 2012. Coagulopathy and Massive Bleeding in Trauma. Lecturer

3. XIV Pre-Congress of the Brazilian Trauma Leagues. Campinas, Brazil. April 18, 2012. Management of the hypovolemic shock: permissive hypotension, transfusion 3:1 or 1:1:1?

4. XIV Pre-Congress of the Brazilian Trauma Leagues. Campinas, Brazil. April 17 to 19, 2012.

5. General Surgery Research Day of the University of Ottawa. Ottawa, Canada. April 25, 2012.

6. Grand Surgical Rounds – University of Ottawa. Ottawa, Canada. April 25, 2012. How to treat a bleeding patient in the 21st century.

7. New Jersey Association of Blood Bank Professionals Annual Spring Seminar and Meeting. New Brunswick, New Jersey, USA. May 15, 2012. Massive transfusion protocols in trauma.

8. Canadian Association of Emergency Physicians' (CAEP) 2012 Conference. Niagara Falls, Ontario,

Canada. June 3 2012. What's New in the Management of the Massively Bleeding Trauma Patient?

9. Board of Managers meeting of the American Association for the Surgery of Trauma, Kauai, Hawaii, Sept 11, 2012. Update on the Trauma Association of Canada. Lecturer

10. World Trauma Congress, Aug 23, 2012, Rio de Janeiro, Brazil. Pathophysiologic rationale and current view on the use of hypertonic saline resuscitation in TBI.

11. World Trauma Congress, Aug 24, 2012, Rio de Janeiro, Brazil. Mechanisms of trauma coagulopathy.

12. World Trauma Congress, Aug 24, 2012, Rio de Janeiro, Brazil. Clinical research: how to improve it in emerging countries?

13. Symposium on Economic Impact of Trauma and Wound Care in Latin America. World Trauma Congress, Aug 24, 2012, Rio de Janeiro, Brazil. Trauma management in Canada: access to trauma systems and novel technologies.

14. Session World Journal of Emergency Surgery. World Trauma Congress, August 24th 2012, Rio de Janeiro, Brazil. Moderator

15. World Trauma Congress, Aug 25, 2012, Rio de Janeiro, Brazil. Trauma Association of Canada.

16. 71st Annual Meeting American Association for the Surgery of Trauma, Kauai, Hawaii, Sept 12, 2012. “The principal components of acute traumatic coagulopathy.

17. Rizoli S, Bulger EM, Cuschieri J, Junger J, Rhind S: Prehospital hypertonic resuscitation is associated with hypo-coagulability, hyper-fibrinolysis and anti-inflammatory responses. 71st Annual Meeting of the American Association for the Surgery of Trauma, Kauai, Hawaii, September 12, 2012

18. Kirkpatrick A, Rizoli S, Ouellet JF, Sirois M, Tiruta C, Laupland K, Meade M, Trottier V, Ball C: Occult pneumothoraces in critical care (OPTICC): a prospective multi-centre randomized trial of pleural drainage for ventilated trauma patients with occult pneumothoraces. 71st Annual Meeting of the American Association for the Surgery of Trauma, Kauai, Hawaii, September 12, 2012

19. 4th Annual Southwest Trauma & Acute Care Symposium, Nov 1, 2012, Phoenix - Arizona, USA. Massive bleeding in trauma: evidence-based management is possible.

20. 4th Annual Southwest Trauma & Acute Care Symposium, Nov 1, 2012, Phoenix, AZ, USA. Diagnosing coagulopathy in trauma: the role of TEG and ROTEM made simple.

21. XXV Congress of the Panamerican Trauma Society, Nov 15, 2012, Medellin, Colombia. North versus South.

22. XXV Congress of the Panamerican Trauma Society, Nov 15, 2012, Medellin, Colombia. Does TEG/ROTEM really help in the management of bleeding? Lecturer

23. General Paper Competition. XXV Congress of the Panamerican Trauma Society, Nov 15th , 2012, Medellin, Colombia. Judge

24. American College of Surgeons Resident Paper Competition at the XXV Congress of the Panamerican Trauma Society, Nov 16th , 2012, Medellin, Colombia. Judge

25. Session Challenging Topics in Trauma. XXV Congress of the Panamerican Trauma Society, November 16th 2012, Medellin, Colombia. Moderator

26. Zakrison TL; Namias N; Rizoli S; Ortiz P: Canadian traumatologists and recognition of occult shock – results of a national survey. XXV Congress of the Panamerican Trauma Society, Medellin, Colombia, November 15th , 2012.

27. Zakrison T, Leung E, Kitto S, McFarlan A, Rosenbloom B, Jovicic A: Standardizing handover of critically injured trauma patients – more than just a checklist. 71st Annual Meeting American Association for the Surgery of Trauma, Kauai, Hawaii, Sept 12, 2012

28. Zakrison TL; Namias N; Puyana JC; Rizoli S; Ortiz P: Global trauma surgeons working in low and middle income countries. How accessible is ATLS? 25th Congress of the Panamerican Trauma Society, Medellin, Colombia, November 14-17, 2012

Research Funding: 1. Coagulopathy in trauma: a comparative study. Defense Research and Development Canada. Role:

Principal investigator. 2012

2. Age of blood evaluation trial in the resuscitation of critically ill patients (ABLE). CIHR. Role: Site investigator. 2012

3. Implementation of a remote thromboelastometry-guided transfusion algorithm to improve transfusion decisions in trauma. Alternative Funding Plan Innovation Fund. Role: Principal investigator. March 2012

Gordon Rubenfeld (Sunnybrook Health Sciences Centre) Peer Reviewed Publications: 1. Ferguson ND , Fan E, Camporota L, Antonelli M, Anzueto A , Beale R , Brochard L, Brower R ,

Esteban A, Gattinoni L, Rhodes A , Slutsky AS, Vincent JL , Rubenfeld GD, Thompson BT, Ranieri, VM. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Medicine. 2012 Oct.

2. Ferguson ND , Fan E, Camporota L, Antonelli M, Anzueto A , Beale R , Brochard L, Brower R ,

Esteban A, Gattinoni L, Rhodes A , Slutsky AS, Vincent JL , Rubenfeld GD, Thompson BT, Ranieri, VM. Erratum to: The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Medicine. 2012 Oct.

3. Gomez,David; Haas,Barbara; de Mestral,Charles; Sharma,Sunjay; Hsiao,Marvin; Zagorski,Brandon;

Rubenfeld,Gordon; Ray,Joel G.; Nathens,Avery B. Institutional and provider factors impeding access to trauma center care: An analysis of transfer practices in a regional trauma system. The Journal of Trauma and Acute Care Surgery. Nov 2012.

4. Tonelli, Mark R, Curtis J, Guntupalli Kalpalatha K, Rubenfeld Gordon D, Arroliga Alejandro C,

Brochard Laurent, Douglas Ivor S, Gutterman David D, Hall, Jesse R, Kavanagh Brian P, Mancebo Jordi, Misak Cheryl J, Simpson Steven Q, Slutsky Arthur S, Suffredini Anthony F, Thompson B, Ware Lorraine B, Wheeler Arthur P, Levy Mitchell M. An Official Multi-Society Statement: The Role of Clinical Research Results in the Practice of Critical Care Medicine. American Journal of Respiratory and Critical Care Medicine. 2012 May 15.

5. ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E,

Fan E, Camporota L, Slutsky AS: Acute Respiratory Distress Syndrome: The Berlin Definition. JAMA 2012: 307(23): pp 2526-33.

6. Haas B, Gomez D, Stukel T, Rubenfeld G, Nathens AB. The mortality benefit of direct trauma center transport in a regional trauma system: a population based analysis. J Trauma Acute Care Surg. 2012 Jun;72(6):1510-7.

7. Gomez D, Haas B, de Mestral C, Sharma S, Hsiao M, Zagorski B, Rubenfeld G, Ray J and Nathens AB. Gender-associated differences in access to trauma center care: A population-based analysis. Surgery. 2012 Jun 20.

8. Rubenfeld,Gordon D. Cost-Effective Critical Care: Cost Containment and Rationing. Seminars in Respiratory and Critical Care Medicine. August 2012.

9. Watkins TR, Nathens AB, Cooke CR, Psaty BM, Maier RV, Cuschieri J and Rubenfeld GD. Acute

respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med. 2012 Aug;40(8):2295-303.

10. Rubenfeld,Gordon D. Does the Hospital Make You Older Faster? American Journal of Respiratory and Critical Care Medicine. 2012 Apr 15.

11. Carson Shannon S, Kahn Jeremy M, Hough Catherine L, Seeley Eric J, White Douglas B, Douglas Ivor S, Cox Christopher E, Caldwell Ellen, Bangdiwala Shrikant I, Garrett,Joanne M, Rubenfeld,Gordon D. A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Critical Care Medicine. 2012 Apr 5.

12. Rose L, Gray S, Burns K, Atzema C, Kiss A, Worster A, Scales DC, Rubenfeld G, Lee J. Emergency

Department Length of Stay for Patients Requiring Mechanical Ventilation: A Prospective

Observational Study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2012 Apr 11;20:30.

Presentations/Lectures: 1. 2012 Dec 11 ARDS: will better definitions fix anything? The State of the Art Meeting 2012.

London, UK. 2. 2012 Dec 11 CMV: ignore, treat or prevent? The State of the Art Meeting 2012. London, UK. 3. 2012 Dec 10 Why we love evidence but hate evidence-based medicine. The State of the Art

Meeting 2012. London, UK. 4. 2012 Nov 29 What we have is a failure to communicate: end of life care in the ICU. 14th Annual

Roland H. Ingram Jr. Lecture at Emory University. Atlanta, Georgia, USA. 5. 2012 Oct 27 Surviving the Surviving Sepsis Guidelines: What to do with Weak Evidence you

Hate? 37th Anzics/ACCCN Intensive Care Annual Scientific Meeting. Adelaide, Australia

6. 2012 Oct 26 Current Therapies; PEEP, Sedation and Muscle Relaxant – How I Ventilate my

Patients. 37th Anzics/ACCCN Intensive Care Annual Scientific Meeting. Adelaide, Australia

7. 2012 Oct 25 The Global Burden of Critical Care Medicine. 37th Anzics/ACCCN Intensive Care

Annual Scientific Meeting. Adelaide, Australia 8. 2012 Oct 19 ARDS: The Berlin Definition. Michener Institute's Respiratory Therapy Clinical

Student Seminar Day. Toronto, Ontario, Canada 9. 2012 Oct 5 The ARDS Phenotype and its Relationship to Disease Outcome - Clinical

Phenotype. Pittsburgh International Lung Conference. Pittsburgh, Pennsylvania, USA.

10. 2012 Sept 21 What we have here is a failure to communicate.... Thomas Jefferson University,

Internal Medicine Grand Rounds. Philadelphia, Pennsylvania, USA. 11. 2012 Jun 22 ICU Organizational Model. Brazilian International Symposium of Intensive Care.

Brazil. 12. 2012 Jun 21 Epidemiology. Brazilian International Symposium of Intensive Care. Brazil. 13. 2012 Jun 21 Rescue Strategies in refractory hypoxia. Brazilian International Symposium of

Intensive Care. Brazil. 14. 2012 Jun 21 Critical Care Medicine base in evidence. Brazilian International Symposium of

Intensive Care. Brazil. 15. 2012Mar 22 Long term outcomes (session on early mobilization). International Symposium

Intensive Care Emergency Medicine. Belgium.

16. 2012 Mar 22 Should we be rationing? (session on regionalization). International Symposium Intensive Care Emergency Medicine. Belgium.

17. 2012 Mar 22 ARDS: Does the definition matter? International Symposium Intensive Care

Emergency Medicine. Belgium. 18. 2012 Mar 20 Can CMV be pathogenic? International Symposium Intensive Care Emergency

Medicine. Belgium 19. 2012 Mar 20 Are long term outcomes really poor? International Symposium Intensive Care

Emergency Medicine. Belgium Research Funding: 1. 2012 Oct – 2017 Sep Co-Investigator. Catecholamines as primary mediators of post-burn

hypermetabolism: A clinical prospective trial. Canadian Institutes of Health Research (CIHR). $851, 939 CAD. [Operating Grant]

2. 2010 Apr – 2015 Mar Principal Investigator. Trauma System Development in Canada:

Overcoming the challenges of geography through an evaluation of structure and process. Canadian Institutes of Health Research (CIHR). $400,000 CAD [Grant]

3. 2011 Apr – 2014 Mar Co-Investigator. Understanding Long-Term Mechanical Ventilation in

Canada: A Programmatic Approach. Canadian Institutes of Health Research (CIHR). $349,863 CAD. [Grant]

4. 2010 Oct – 2013 Sep Co-Investigator. Weaning and Variability Evaluation (WAVE)- a

multicenter evaluation of altered heart rate and respiratory rate variability to predict extubation failure. Canadian Institutes of Health Research (CIHR). $536,533 [Grant]

5. 2009 Oct – 2013 Sep Co-Investigator. The RECOVER Program: Phase I Towards RECOVER

- Outcomes and Needs Assessment in Survivors of Prolonged Mechanical Ventilation and Their Caregivers. Canadian Institutes of Health Research (CIHR). $704,367 [Operating Grant]

6. 2010 Jun – 2013 Aug Co-Investigator. A Randomized Phase II Trial of CMV Prevention in

Acute Lung Injury. National Institutes of Health (NIH) (USA) $1,240,314 CAD [Grant]

7. 2009 Mar – 2013 Apr Co-Investigator. Towards RECOVER - Evaluation of Clinical Outcomes,

Patient and Caregiver Needs and the Biology of Muscle and Nerve Injury in Critically Ill Survivorsof Prolonged Mechanical Ventilation. Canadian Institutes of Health Research (CIHR). $222,260 CAD [Grant]

8. 2011 Jan – 2012 Dec Co-Investigator. Catecholamines as Outcome Markers in Traumatic

Brain Injury Study (COMA in TBI Study). Physicians Services Incorporated Foundation (The) (PSI). $162,500 CAD [Grant]

9.2010 Dec – 2012 Nov Co-Investigator. The PACT Study: The impact of a post arrest consult

team on process and clinical outcomes in patients resuscitated from out-of-hospital cardiac arrest. Heart and Stroke Foundation of Canada (HSFC). $198,726 [Grant]

10. 2001 Jul – 2012 Jun Principal Investigator. Improving Ventilator Management and Preventing Injury to Patients with ARF. National Heart, Lung and Blood Institute (NHLBI) (USA). $4,036,688 CAD [Grant]

11.2010 May – 2012 Apr Co-Investigator. Transforming the care of patients with severe traumatic

brain injury in Toronto. Sunnybrook Health Sciences Centre. $99,060 CAD [Grant]

12.2010 Apr – 2012 Apr Co-Investigator. Outcomes of Critically Ill Patients Presenting to

Canadian Emergency Departments. Canadian Institutes of Health Research (CIHR). $118.957 CAD. [Grant]

13.2010 Apr – 2012 Mar Co-Investigator. Towards equity in access to trauma care: A mixed-

methods approach to spatial analyses of existing trauma transfer networks. Canadian Institutes of Health Research (CIHR). $199,844 CAD [Grant]

Damon Scales (Sunnybrook Health Sciences Centre) Peer Reviewed Publications: 1. Ganapathy A, Adhikari NK, Spiegelman J and Scales DC. Routine chest x-rays in intensive care

units: a systematic review and meta-analysis. Crit Care. 2012 Dec 12;16(2):R68 Role: Conceived idea, developed study design and analytical plan, contributed to analysis, supervised principal author, contributed to writing of manuscript. Senior Responsible Author.

2. Ferguson ND, Scales DC, Pinto R, Wilcox ME, Cook DJ, Guyatt GH, Schünemann HJ, Marshall JC, Herridge MS, Meade MO; for the Canadian Critical Care Trials Group. Integrating Mortality and Morbidity Outcomes: Using Quality-Adjusted Life Years in Critical Care Trials. Am J Respir Crit Care Med. 2012 Nov 30. [Epub ahead of print]. Co-Principal Author.

3. Golan E, Vasquez D, Ferguson ND, Adhikari NK, Scales DC. Prophylactic magnesium for improving neurological outcome after aneurysmal subarachnoid hemorrhage: systematic review and meta-analysis. J Crit Care. 2012 Nov 26 [Epub ahead of print] Role: Conceived idea, developed analytical plan and contributed to analysis, supervised residents, contributed to writing of manuscript. Senior Responsible Author.

4. Côte N, Turgeon AF, Lauzier F, Moore L, Scales DC, Bernard F, Zarychanski R, Burns KE, Meade MO, Zygun D, Simard JF, Boutin A, Brochu JG, Fergusson DA. Factors Associated with the Withdrawal of Life-Sustaining Therapies in Patients with Severe Traumatic Brain Injury: A Multicenter Cohort Study. Neurocrit Care. 2012 Oct 26 Role: Contributed to study idea, contributed to methods and analytical approach, contributed to writing of manuscript. Coauthor or Collaborator.

5. Barrett KA, Ferguson ND, Athaide V, Cook DJ, Friedrich JO, McDonald E, Pinto R, Smith OM, Stevenson J, Scales DC. Surrogate Decision Makers’ Attitudes Towards Research Decision Making for Critically Ill Patients. Intensive Care Med. 2012 Oct;38(10):1616-23. 2012 Jul 24 [Epub ahead of print]. Role: Conceived idea, developed analytical plan and contributed to analysis, supervised residents, contributed to writing of manuscript. Senior Responsible Author.

6. Hyzy B, Posa P, Scales DC. System level quality improvement initiatives: lessons from Keystone and other large scale projects. Semin Respir Crit Care Med. 2012 Aug;33(4):370-4 Role: Conceived of idea, wrote manuscript. Senior Responsible Author.

7. Ellis SM, Dainty KN, Munro G and Scales DC. Use of mechanical ventilation protocols in intensive care units: A survey of current practice. J Crit Care. 2012 Dec;27(6):556-63. 2012 Jul 2 [Epub ahead of print]. Role: Conceived idea, developed analytical plan and contributed to analysis, supervised principal author, contributed to writing of manuscript. Senior Responsible Author.

8. Shankar Hari M, Kruger PS, Di Gangi S, Scales DC, Perkins GD, McAuley DF and Terblanche M. Statin therapy in critical illness: an international survey of intensive care physicians’ opinions, attitudes and practice. BMC Clin Pharmacol. 2012 Jun 28;12(1):13. Role: Contributed to study idea, contributed to methods and analytical approach, contributed to writing of manuscript. Coauthor or Collaborator.

9. Gershengorn HB, Iwashyna TJ, Cooke CR, Scales DC, Kahn JM and Wunsch H. Variation in use of intensive care for adults with diabetic ketoacidosis. Crit Care Med. 2012 Jul;40(7):2009-15. Role: Contributed to study idea, contributed to methods and analytical approach, contributed to writing of manuscript. Coauthor or Collaborator.

10. Rose L, Gray S, Burns K, Atzema C, Kiss A, Worster A, Scales DC, Rubenfeld G and Lee J. Emergency department length of stay for patients requiring mechanical ventilation: a prospective observational study. Scand J Trauma Resusc Emerg Med. 2012 Apr 11;20(1):30. Role: Contributed to study idea, contributed to methods and analytical approach, contributed to writing of manuscript. Coauthor or Collaborator.

11. Garland A, Yogendran M, Olafson K, Scales DC, McGowan KL and Fransoo R. The Accuracy of Administrative Data for Identifying the Presence and Timing of Admission to Intensive Care Units in a Canadian Province. Med Care. 2012 Jan 19. Role: Contributed to study idea, developed study methods and analytical approach, contributed to analysis, contributed to manuscript. Coauthor or Collaborator.

12. Henry B and Scales DC. Ethical challenges in conducting research on dying patients and those at high risk of dying. Account Res. 2012 Jan;19(1):1-12. Role: Conceived article idea, developed methods, wrote manuscript. Senior Responsible Author

Review Articles, Letters, and Editorials: 1. Barrett KA and Scales DC. Considering the vulnerabilities of surrogate decision-makers when

obtaining consent for critical care research. Intensive Care Med. 2012 Jan;38(1):4-6. Epub 2011 Nov 26. Role: Conceived article idea, wrote manuscript. Senior Responsible Author.

In Press: 1. Doyle, J, Scales, DC. Tracheostomy in the ICU. Principles of critical Care. 4th edition. Editors Hall

JB, Schmidt GA, Wood LDH. McGraw-Hill, Chicago. Role: Wrote manuscript, supervised principle author. In Press. Senior Responsible Author.

Presentations/Lectures: 1. 2012 Dec 12 Invited Speaker. Improving post-resuscitation care for cardiac arrest survivors.

Trillium Health Sciences Centre and Credit Valley Hospital Cardiac Health Systems Rounds. Mississauga, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

2. 2012 Dec 7 Invited Lecturer. Methods in Epidemiological, Clinical and Operational Research (MECOR) Level 2 Course - Learning from our mistakes. American Thoracic Society. Cesme, Turkey. Presenter(s): Scales DC. (Continuing Education).

3. 2012 Dec 6 Invited Lecturer. Methods in Epidemiological, Clinical and Operational Research (MECOR) Level 2 Course - Survival analysis. American Thoracic Society. Cesme, Turkey. Presenter(s): Scales DC. (Continuing Education).

4. 2012 Dec 4 Invited Lecturer. Methods in Epidemiological, Clinical and Operational Research (MECOR) Level 2 Course - Sample size and power. American Thoracic Society. Cesme, Turkey. Presenter(s): Scales DC. (Continuing Education).

5. 2012 Dec 3 Invited Lecturer. Methods in Epidemiological, Clinical and Operational Research (MECOR) Level 2 Course - Overview of study designs. American Thoracic Society. Cesme, Turkey. Presenter(s): Scales DC. (Continuing Education).

6. 2012 Dec 3 Invited Lecturer. Methods in Epidemiological, Clinical and Operational Research (MECOR) Level 2 Course - Bias, confounding and chance. American Thoracic Society. Cesme, Turkey. Presenter(s): Scales DC. (Continuing Education).

7. 2012 Nov 30 Invited Speaker. Improving post-resuscitation care. Halton Healthcare - Grand Rounds. Milton, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

8. 2012 Nov 22 Invited Speaker. SPARC and beyond: Improving post-cardiac arrest care across a network of hospitals. The Hospital for Sick Children - Acute Care Research Rounds. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

9. 2012 Nov 21 Invited Speaker. Last Rights. Sunnybrook Health Sciences Centre - Department of Critical Care Grand Rounds. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

10. 2012 Nov 2 Invited Speaker. Randomization: Individuals, Groups, and Beyond. CCCTG Research Coordinators Annual Meeting. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

11. 2012 Nov 1 Invited Speaker. Post-arrest Respiratory Management. Ontario Respiratory Care Society Annual Conference. Markham, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

12. 2012 Oct 31 Moderator. Plenary symposium: Evidence-based guidelines for sedation 2012: Are we there? Critical Care Canada Forum 2012. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

13. 2012 Oct 31 Invited Speaker. Post-arrest care: Beyond Hypothermia. Critical Care Canada Forum 2012. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

14. 2012 Oct 29 Moderator. WJ Sibbald Critical Care Systems Symposium - Critical Care Capacity. Critical Care Canada Forum 2012. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

15. 2012 Oct 29 Moderator. Plenary RCT: The CHEST Trial. Critical Care Canada Forum 2012. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

16. 2012 Oct 28 Moderator. Back from the future 2032. Critical Care Canada Forum/CCCS Residents’ Day. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

17. 2012 Sep 26 Invited Speaker. Improving Outcomes for Survivors of Cardiac Arrest Across a Network of Hospitals. Sunnybrook Health Sciences Centre - Department of Critical Care Grand Rounds. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

18. 2012 Sep 10 Invited Speaker. Neuroprognostication after cardiac arrest and the PremaTOR study. Mackenzie Health, Department of Critical Care Medicine. Richmond Hill, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

19. 2012 Jun 28 Invited Speaker. Hypothermia after cardiac arrest and the ICE-PACS trial. Oakville-Trafalgar Memorial Hospital, Emergency Medicine Department. Oakville, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

20. 2012 Jun 20 Invited Speaker. Neuroprognostication after cardiac arrest and the PremaTOR study. Humber River Regional Hospital, Critical Care Department. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

21. 2012 Jun 12 Invited Speaker. Studying System-Level Interventions for Improving Quality of Care. Course lecture for HAD5306, Clinical Epidemiology Program. Department

of Health Policy, Management and Evaluation, University of Toronto. Toronto, Ontario, Canada. Presenter(s): Scales DC.

22. 2012 Jun 11 Invited Speaker. Studying multi-centered ICU quality improvement initiative. 6th Annual Critical Care Fellows Research Day. Montreal, Quebec, Canada. Presenter(s): Scales DC. (Continuing Education).

23. 2012 May 22 Facilitator. This can be done better: Quality, safety and process improvement in critical care. American Thoracic Society. San Francisco, California, United States. Presenter(s): Scales DC. (Continuing Education).

24 .2012 May 21 Invited Speaker. Preventing Complications of Critical Illness With A System-Level Interventions: How ICUs Can Work Together To Improve Quality. American Thoracic Society. San Francisco, California, United States. Presenter(s): Scales DC. (Continuing Education).

25. 2012 May 31 Facilitator. Clinical Trials in the Intensive Care Unit. American Thoracic Society. San Francisco, California, United States. Presenter(s): Scales DC. (Continuing Education).

26. 2012 May 20 Variation In Use Of Intensive Care For Adults With Diabetic Ketoacidosis. American Thoracic Society International Conference. San Francisco, California, United States.

27. 2012 May 20 The Quality of Knowledge Translation Studies In Critical Care. American Thoracic Society International Conference. San Francisco, California, United States.

28. 2012 May 20 Long-Term Outcomes After Prolonged Mechanical Ventilation: Family Caregiver Outcomes From The Towards RECOVER Study. American Thoracic Society International Conference. San Francisco, California, United States.

29. 2012 May 20 Knowledge Translation Interventions For Critically Ill Patients: A Systematic Review. American Thoracic Society International Conference. San Francisco, California, United States.

30. 2012 May 20 Long-Term Patient Outcomes After Prolonged Mechanical Ventilation: The Towards RECOVER Study. American Thoracic Society International Conference. San Francisco, California, United States.

31. 2012 May 4 Invited Speaker. Improving post-resuscitation care for cardiac arrest survivors. Trillium Health Centre - Emergency Medicine Grand Rounds. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

32. 2012 May 4 Invited Speaker. Improving neuroprognostication for survivors of cardiac arrest: the PremaTOR Study. St. Michael’s Hospital - Critical Care Research Rounds. Toronto, Ontario, Canada. Presenter(s): Scales DC. (Continuing Education).

33. 2012 May 3 Chair. Resuscitation in Motion Conference. St. Michael’s Hospital. Toronto, Ontario, Canada.

Research Funding: 1. 2012 Oct - 2016 Sep Co-Investigator. Early Determination of long-term Prognosis in critically ill

patients with Severe Traumatic Brain Injury (TBI-Prognosis multicenter prospective study). Canadian Institutes of Health Research (CIHR). Operating Grant. PI: Turgeon, A. Collaborators: Lauzier F, Bernard F, Lamontagne F, Scales DC, Burns K, Rigamonti A, McIntyre L, Pagliarello J,

Meade M. 1,053,131 CAD. [Grants]

2. 2012 Oct - 2014 Sep Co-Investigator. Pilot KT intervention to address gender differences in access to post arrest care. Canadian Institutes of Health Research (CIHR). Operating Grant. PI: Morrison, LJ. Collaborators: Abramson BL, Bierman AS, Dainty KN, Dorian P, Fowler RA, Gray SH, Kiss AJ, Parsons JA, Valeria R, Scales DC, Slutsky AS, Zwarenstein MF. 218,994 CAD. [Grants]

3. 2012 Jul - 2014 Jun Principal Investigator. Translating Evidence into Practice for Patients with Anoxic Brain Injury. Physicians Services Incorporated Foundation (The) (PSI). Fellowship in Translational Health Research. 300,000 CAD. [Grants]

4. 2012 Jun - 2015 May Co-Investigator. Canadian Critical Care Knowledge Translation Network. Canadian Institutes of Health Research (CIHR). Network Catalyst - Knowledge Translation. PI: Muscedere, J. Collaborators: Gibney N, Keenan SP, Lawless B, Legare M, Patrick W, Paunovic B, Shaw S, Trpkovski J, Chant C, Cook DJ, Dodek PM, Heyland DK, Lacroix J, Martin CM, Reynolds SC, Scales DC, Sinuff T, Turgeon AF. 599,611 CAD. [Grants]

5. 2012 Jun - 2013 May Co-Investigator. Therapeutic hypothermia: the impact of processes of care on outcomes after cardiac arrest. Physicians Services Incorporated Foundation (PSIF). PI: Lin, S. 20,000 CAD. [Grants]

6. 2012 – 2015 Co-Investigator. Integrating the willing bystander with emergency medical dispatch: A novel Smartphone application to recruit bystanders to provide CPR and use AEDs for victims of out-of-hospital cardiac arrest. Heart and Stroke Foundation of Canada (HSFC). PI: Brooks, Steven. 294,481 CAD. [Grants]

7. 2011 Oct - 2015 Sep Principal Investigator. Initiation of Cooling by EMS to Promote the

Adoption of in-hospital therapeutic hypothermia in Cardiac arrest Survivors -- ICE-PACS Randomized Controlled Trial. Canadian Institutes of Health Research (CIHR). Collaborators: Brooks SC, Cheskes S, Craig AM, Dainty KN, Darling S, Mamdani M, Morrison LJ, Perreira TA, Thorpe KE, Verbeek PR. 760,947 CAD. [Grants]

8. 2011 Oct - 2013 Sep Co-Investigator. A National Comparison of Intensity of End-of-Life Care in Canada: Defining Changing Patterns, Risk Factors and Targets for Intervention. Canadian Institutes of Health Research (CIHR). Operating Grant: Secondary Analysis of Databases. PI: Fowler, Robert A. Collaborators: Kozak JF, Rockwood K, Heyland DK, Rubenfeld G, Scales DC, Stukel TA, Wunsch H. 99,208 CAD. [Grants]

9. 2010 Dec - 2013 Mar Principal Investigator. Premature Termination of Resuscitation in Survivors of Cardiac Arrest (PremaTOR). Heart and Stroke Foundation of Canada & Canadian Institutes of Health Research. Resuscitation and Knowledge Transfer and Exchange 2010. Collaborators: Morrison L, Young GB, Brooks S, Golan E, Zwarenstein M. 197,000 CAD. [Grants]

10. 2010 Dec - 2012 Nov Co-Investigator. The impact of a Post Cardiac Arrest Consult Team (PACT)

on process and clinical outcomes in patients resuscitated from out-of-hospital cardiac arrest. Heart and Stroke Foundation of Canada (HSFC). PI: Brooks, Steven. Collaborators: Szadkowski LM, Morrison L, Scales DC,

Rubenfeld G, Jeffs LP, Madan M, Gray S, Friedrich J, Fam N, Dorian P, Dainty KN, Crystal E, Chapman M. 198,722 CAD. [Grants]

11. 2010 Dec - 2012 Nov Principal Investigator. Premature Termination of Resuscitation in Survivors

of Cardiac Arrest (PremaTOR). Heart and Stroke Foundation of Canada (HSFC). Collaborators: Brooks SC, Chapman MG, Zwarenstein MF, Morrison LJ, Golan E, Dale C, Young B. 193,120 CAD. [Grants]

12.2010 Oct – 2013 Sep Co-Investigator. Weaning and Variability Evaluation (WAVE) - a multicenter

evaluation of altered heart rate and respiratory rate variability to predict extubation failure. Canadian Institutes of Health Research (CIHR). Operating Grant. PI: Seely, Andrew. Collaborators: Ferguson ND, Fergusson DA, Hooper J, Lelouche F, Marshall JC, Maziak DE, McIntyre LL, Ramsay TO, Rubenfeld G, Scales DC, Wilkes P, Zarychanskl R. 563,533 CAD. [Grants]

13. 2010 Jul - 2012 Jul Co-Investigator. The impact of a post arrest consult team on process and

clinical outcomes in patients resuscitated from out-of-hospital cardiac arrest. Heart and Stroke Foundation of Canada. PI: Brooks S. Collaborators: Morrison L, Scales DC. 200,000 CAD. [Grants]

14. 2010 Feb - 2016 Feb Co-Investigator. From Bench to Bedside to Curbside. Clinical Research Consortium to improve Resuscitation Outcomes. National Institutes of Health, Heart and Stroke Foundation of Canada, CIHR. PI: Slutsky, Arthur. Collaborators: Black SE, Davis D, Dorian P, Hutchison JS, Lavery J, Morrison LJ, Redelmeier DA, Rotstein OD, Sibbald W, Young Investigator: Scales DC. 3,100,000 CAD. [Grants]

15. 2009 Dec - 2015 Nov Co-Investigator. Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Toronto Regional Coordinating Centre. Canadian Institutes of Health Research (CIHR). Resuscitation Outcomes Consortium. PI: Morrison, Laurie. Collaborators: Craig A, Baker A, Slutsky A, Nathens A, Scales DC, Redelmeier D, Hutchison J, Spence J, Morrison L, Feldman M, Rotstein OD, Dorian P, Verbeek R, MacDonald R, Rizoli S, Cheskes S, Brooks S. 1,002,000 CAD. [Grants]

16. 2009 Oct - 2015 Oct Co-Investigator. Toronto regional resuscitation research out of hospital network. Heart and Stroke Foundation of Canada (HSFC). Resuscitation Outcomes Consortium. PI: Morrison, Laurie. Collaborators: Craig A, Baker A, Slutsky A, Nathens A, Scales DC, Redelmeier D, Hutchison J, Spence J, Morrison L, Feldman M, Rotstein OD, Dorian P, Verbeek R, MacDonald R, Rizoli S, Cheskes S, Brooks S. 1,500,000 CAD. [Grants]

17.2009 Jul – 2014 Jun Principal Investigator. The Impact of an Aging Population on the Delivery of Critical Care Services in Canada. Canadian Institutes of Health Research (CIHR). 300,000 CAD. [Grants]

Steven Schwartz (Hospital for Sick Children) Peer Reviewed Publications:

1. Nayak PP, Sheth J, Cox PN, Davidson L, Forte V, Manlhiot C, McCrindle BW, Schwartz SM, Solomon M, Van Arsdell GS, Sivarajan VB. Predictive value of bronchoscopy after infant cardiac surgery: a prospective study. Intensive Care Med. 2012;38:1851-7. Coauthor or Collaborator.

2. Ghanayam NS, Allen KR, Tabbutt S, Atz AM, Clabby ML, Cooper DS, Eghtesady P, Frommelt PC, Gruber PJ, Hill KD, Kaltman JR, Laussen PC, Lewis AB, Lurito KL, Minich LL, Ohye RG, Schonbeck JV, Schwartz SM, Singh RK, Goldberg CS, for the Pediatric Heart Network Investigators. Interstage Mortality after the Norwood Procedure: Results of the Multi-center Single Ventricle Reconstruction Trial. J Thorac Cardiovasc Surg 2012;144:896-906. Coauthor or Collaborator.

3. Manlhiot C, Brandao LR, Kwok J, Kegel S, Menjak IB, Carew CL, Chan AK, Schwartz SM, Sivarajan VB, Caldarone CA, Van Arsdell GS, McCrindle BW. Thrombotic Complications and Thromboprophylaxis Across All Three Stages of Single Ventricle Heart Palliation. J Pediatr 2012;161:513-9. Coauthor or Collaborator.

4. Manlhiot C, McCrindle BW, Menjak IB, Yoon H, Holtby HM, Brandao LR, Chan AK, Schwartz SM, Sivarajan VB, Crawford-Lean L, Foreman C, Caldarone CA, Van Arsdell GS, Gruenwald CE. Longer blood storage is associated with suboptimal outcomes in high- risk pediatric cardiac surgery. Ann Thorac Surg. 2012;93:1563-9. Coauthor or Collaborator.

Abstracts:

1. Manlhiot C, Mital S, Gruenwald CE, Brandao LR, Manickaraj AK, Caldarone CA, Russell JL, Sivarajan VB, Schwartz SM, Holtby HM, McCrindle BW. Genetic polymorphisms associated with response to intraoperative heparin anticoagulation and thrombosis risk in pediatric patients undergoing cardiac surgery. Circulation. 2012;126:A18481. Coauthor or Collaborator.

2. Floh AA, Nakada M, La Rotta G, Manlhiot C, McCrindle BW, Van Arsdell GS, Schwartz SM. Feeding modifies the relationship between glucose metabolism, inflammation and outcomes after pediatric heart surgery. Circulation. 2012;126:A18800. Senior Responsible Author.

3. Friedberg MK, Schwartz SM, Zhang H, Manlhiot C, Chiu-Man C, Slorach C, Ilina MV, Seller N, McCrindle BW, Van Arsdell G, Stephenson EA. Sustained biventricular pacing may improve cardiac index, blood pressure and cerebral blood flow in infants with electrical dyssynchrony after surgery for congenital heart disease. Circulation. 2012;126:A16039. Coauthor or Collaborator.

4. Schwartz SM, Lu M, Ohye RG, Hill KD, Atz AM, Naim M, Williams I, Goldberg C, Lewis A, Pigula F, Pizarro C, Chai P, Burch P, Dunbar-Masterson C, Kaltman J, Kanter K, Sleeper LA, Schonbeck J, Ghanayem N, The Pediatric Heart Network Investigators. Risk factors for prolonged length of stay following stage II procedure in the Single Ventricle Reconstruction trial. Circulation. 2012;126:A16568. Primary Author/ Senior Responsible Author.


1. 2012 Dec Invited Talk. VADs and ECMO: What’s available and what would I pick when? ELSO/PCICS Joint Symposium: The Mechanical and Technical Aspects of Extracorporeal Support. Miami, Florida.

2. 2012 Dec Invited Talk. PCICS/ELSO Joint Consensus Statement: Medical Care of the Child on Mechanical Circulatory Support The. Pediatric Cardiac Intensive Care Society 9th International Conference. Miami, Florida.

3. 2012 Dec Invited Talk. Feeding and Nutrition and the Effects on Chronic Disease. The Pediatric Cardiac Intensive Care Society 9th International Conference. Miami, Florida.

4. 2012 Dec Invited Faculty. Moderator, opening plenary session: CICU in the 22nd Century. The Pediatric Cardiac Intensive Care Society 9th International Conference. Miami, Florida.

5. 2012 Dec Invited Faculty. Moderator: Worldwide Perspective of CICU. The Pediatric Cardiac Intensive Care Society 9th International Conference. Miami, Florida.

6. 2012 Nov Floh AA, Nakada M, La Rotta G, Manlhiot C, McCrindle BW, Van Arsdell GS, Schwartz SM. Feeding modifies the relationship between glucose metabolism, inflammation and outcomes after pediatric heart surgery. Presented at the American Heart Association Scientific Sessions 2012. Los Angeles, CA. Trainee Presentation.

7. 2012 Nov Schwartz SM, Lu M, Ohye RG, Hill KD, Atz AM, Naim M, Williams I, Goldberg C, Lewis A, Pigula F, Pizarro C, Chai P, Burch P, Dunbar-Masterson C, Kaltman J, Kanter K, Sleeper LA, Schonbeck J, Ghanayem N, The Pediatric Heart Network Investigators. Risk factors for prolonged length of stay following stage II procedure in the Single Ventricle Reconstruction trial. Presented at the American Heart Association Scientific Sessions 2012. Los Angeles, CA. Presenting Author.

8. 2012 Nov Manlhiot C, Mital S, Gruenwald CE, Brandao LR, Manickaraj AK, Caldarone CA, Russell JL, Sivarajan VB, Schwartz SM, Holtby HM, McCrindle BW. Genetic polymorphisms associated with response to intraoperative heparin anticoagulation and thrombosis risk in pediatric patients undergoing cardiac surgery. Presented at the American Heart Association Scientific Sessions 2012. Los Angeles, CA.

9. 2012 Nov Friedberg MK, Schwartz SM, Zhang H, Manlhiot C, Chiu-Man C, Slorach C, Ilina MV, Seller N, McCrindle BW, Van Arsdell G, Stephenson EA. Sustained biventricular pacing may improve cardiac index, blood pressure and cerebral blood flow in infants with electrical dyssynchrony after surgery for congenital heart disease. Presented at the American Heart Association Scientific Sessions 2012. Los Angeles, CA.

10. 2012 Sep Annual Visiting Professor in Paediatric Cardiology. How the Type of Norwood Performed Influences Post-op Care. Department of Pediatrics, Dalhousie University / IWK Health Centre. Halifax, Nova Scotia.

11. 2012 Sep Annual Visiting Professor in Paediatric Cardiology. Case Studies in the PICU:

CV Physiology in the PICU. Department of Pediatrics, Dalhousie University / IWK Health Centre. Halifax, Nova Scotia.

12. 2012 Sep Annual Visiting Professor in Paediatric Cardiology. Intensive Care

Management of Patients with a Duct-Dependent Circulation in the Current Era: Pre-op and Post-op Considerations. Department of Pediatrics, Dalhousie University / IWK Health Centre. Halifax, Nova Scotia.

13. 2012 Sep National Paediatric Cardiology Grand Rounds: Intensive Care Management of

Acute and Chronic Heart Failure in Children. Department of Pediatrics, Dalhousie University / IWK Health Centre. Halifax, Nova Scotia.

14. 2012 Jun Invited Talk. Inotropic Drugs are Hereby Charged with Providing False Hope and

Worsening Outcomes: Evidence for the Prosecution. Paediatric Heart Failure Summit/The 15th Annual Toronto Heart Summit. Toronto, Ontario.

15. 2012 May Invited Lecture. Hyperglycemia After Paediatric Heart Surgery: Is It A

Disease? Division of Neonatology Research Rounds. The Hospital for Sick Children. Toronto, Ontario

16. 2012 Mar Invited Talk. The Perioperative Child With Critical Fontan Circulation. 10th

European Postgraduate Course in Neonatal and Pediatric Intensive Care. Berne, Switzerland.

17. 2012 Mar Invited Talk. Chronic Compensated and Acute Decompensated Heart Failure.

10th European Postgraduate Course in Neonatal and Pediatric Intensive Care. Berne, Switzerland.

18. 2012 Mar Invited Talk. Choosing Patient Tailored Hemodynamic Monitoring, Targets and

Therapies After Cardiopulmonary Bypass for Congenital Heart Surgery. 10th European Postgraduate Course in Neonatal and Pediatric Intensive Care. Berne, Switzerland.

19. 2012 Mar Invited Talk. Cardiovascular Physiology Applied to Intensive Care. 10th

European Postgraduate Course in Neonatal and Pediatric Intensive Care. Berne, Switzerland.

Research Funding: 1. 2012-2015 Co-Investigator. (HSFC) – A Randomized Controlled Trial of Hybrid and

Norwood Surgical Strategies for Single Ventricle Congenital Heart Disease. (Principal Investigator: Christopher Caldarone, C, Co-Investigators: Glen Van Arsdell, Sandra Merklinger, Rajiv Chaturvedi, Helen Holtby, Suzanne Laughlin, Renee Sananes, Anne-Marie Guerguerian, Brian McCrindle, Edgar Jaeggi. - $228,234.

2. 2012-2014 Co-Investigator. (HSFC) - Can Sustained Post-Operative Biventricular Pacing

Improve Hemodynamics in Children with Electro-Mechanical Dyssynchrony After Surgical Repair of Congenital Heart Disease? NA 000177. PI: Mark Friedberg, Co-PI: Elizabeth Stephenson. Collaborator: Glen Van Arsdell. $172,481.

3. 2011-2013 Principal Investigator. (Labatt Family Heart Centre Innovation Fund) - Impact of

cardiopulmonary bypass and postoperative cardiac output on the development of postoperative acute kidney injury (AKI), as measured by a novel serum biomarker, neutrophil-gelatinase associated lipocalin (NGAL). Co-Investigators: Alejandro Floh, Joshua Blinder. - $24,000.

4. 2011-2014 Principal Investigator. (HSFO) - Glucose Homeostasis and Cardiac Output

After Paediatric Cardiac Surgery. Co-Investigators: Brian McCrindle, Seema Mital. NA 7834. $195,019.

5. 2011-2016 Co-Principal Investigator. Pediatric Heart Network - The Hospital for Sick

Children, Toronto. (NIH NHLBI) - Co-PI: Brian McCrindle, Seema Mital. Co-Investigators: Lee Benson, Leo Brandao, Christopher Caldarone, Anthony Chan, Colleen Gruenwald, Helen Holtby, Cedric Manlhiot, Luc Mertens, Jennifer Russell, V. Ben Sivarajan, Glen Van Arsdell. Contributor: Sananes, Renee. - $7,518,965 USD.

6. 2010- 2015 Co-Investigator. (CIHR) - Clinical Assessment of Thrombosis in

Children After Heart Surgery: The CATCH Study. Canadian Institutes of Health Research. PI: Brian McCrindle. Co-Investigators: Cedric Manlhiot1, Coleen Gruenwald, Leo Brandao, Anthony Chan,�Luc Mertens, Seema Mital, Helen Holtby, V. Ben Sivarajan, Glen Van Arsdell, Christopher Caldarone. - $1,514,330.

Christer Sinderby (St. Michael’s Hospital) Peer Reviewed Publications: 1. Doorduin J, Sinderby CA, Beck J, Stegeman DF, van Hees HW, van der Hoeven JG, Heunks LM.

The calcium sensitizer levosimendan improves human diaphragm function. Am J Respir Crit Care Med. 2012 Jan 1;185(1):90-5

1. Grasselli G, Beck J, Mirabella L, Pesenti A, Slutsky AS, and Sinderby C. Assessment of patient–

ventilator breath contribution during neurally adjusted ventilatory assist. Intensive Care Med. 2012 Jul;38(7):1224-32

2. Liu L, Liu H, Yang Y, Huang Y, Liu S, Beck J, Slutsky AS, Sinderby C, Qui H. Neuro-ventilatory efficiency and extubation readiness in critically ill patients. Crit Care. 2012 Jul 31;16(4):R143.

3. Brander L, Beck J, Sinderby C. Interpreting success or failure of neurally adjusted ventilatory

assist.Am J Respir Crit Care Med. 2012 Jun 1;185(11):1248 Book Chapters: 1. Sinderby C, Beck J.”Neurally Adjusted Ventilatory Assist”. Principles and Practice of Mechanical

Ventilation. Ed. Martin J Tobin, Third Ed. McGraw Hill 2012. Presentations/Lectures: 1. NAVA and patient-ventilator interaction, 28th annual Scientific Meeting for the College of

Anesthesiologists of Sri Lanka, Colombo, Sri Lanka. January 18, 20125 2. Non-invasive NAVA. 28th annual Scientific Meeting for the College of Anesthesiologists of Sri Lanka,

Colombo, Sri Lanka, Colombo, Sri Lanka. January 22, 2012.

3. VILI and VIDD. the 28th annual Scientific Meeting for the College of Anesthesiologists of Sri Lanka, Colombo, Sri Lanka, Colombo, Sri Lanka. January 22, 2012.

4. NAVA basics. 1st International conference on NAVA and neural monitoring of mechanical ventilation.

Houston, TX, USA. February 4 2012.

5. NAVA tutorial. 32nd International Symposium on Intensive Care and Emergency Medicine, Brussels,BE. March 21, 2012

6. Negative pressure ventilation. 32nd International Symposium on Intensive Care and Emergency

Medicine, Brussels,BE. March 20, 2012

7. NIV-NAVA. 32nd International Symposium on Intensive Care and Emergency Medicine, Brussels,BE. March 23, 2012.

8. PVBC. 32nd International Symposium on Intensive Care and Emergency Medicine, Brussels,BE.

March 23, 2012.

9. NAVA physiology of adding a respiratory muscle Meeting Point 2012, Radboud University Nijmegen medical Center, Nijmegen, The Netherlands. April 26, 2012.

10. Synchrony in premature babies Meeting Point 2012, Radboud University Nijmegen medical Center,

Nijmegen, The Netherlands. April 26, 2012.

Jeffrey Singh (Toronto Western Hospital, University Health Network) Peer Reviewed Publications: 1. Lee RSM, Bell CM, Singh JM, Hicks LK. Hepatitis B Screening Before Chemotherapy: A Survey of

Practitioners’ Knowledge, Beliefs, and Screening Practices. Journal of Oncology Practice. Lee, R. S. M., C. M. Bell, et al. (2012). “Hepatitis B Screening Before Chemotherapy: A Survey of Practitioners’ Knowledge, Beliefs, and Screening Practices.” Journal of Oncology Practice 8(6): 325-328. Coauthor or Collaborator.

2. Katharine Xing, Srinivas Murthy, W C Liles and Jeffrey M Singh. Clinical Utility of Biomarkers of Endothelial Activation in Sepsis - A Systematic Review. Critical Care. 2012 Jan 16;16(1):R7. (Trainee publication, Internal Medicine Resident). Senior Responsible Author.

In Press: 1. Singh JM, Mew E, Farias P, Albert R, Fan E. Challenges and Unintended Benefits of Implementing

a Screening Program for ICU Delirium. Principal Author.

2. Sadry S, Plener I, Mozessohn L, Lee JY, Shehata N, Singh JM. Management of Severe Dabigatran-Related Hemorrhage (Trainee publication, Internal Medicine Resident). Senior Responsible Author.

3. Singh JM, Farias P, Wheeler K, Mew E, Albert R, Fan E. Challenges in Assessing Delirium in the Neurointensive Care Unit. Principal Author

Presentations/Lectures: 1. 2012 Nov 15 Visiting Professor. Department of Emergency Medicine Grand Rounds:

Alphabet Soup: TBI, ICP, PEEP & ARDS. University of Ottawa Department of Emergency Medicine. Ottawa, Ontario, Canada.

2. 2012 Nov 15 Visiting Professor. Emergent Care of Neurological Emergencies: A Practical Review. University of Ottawa Department of Emergency Medicine. Ottawa, Ontario, Canada.

3. 2012 Nov 12 Panel Discussion Member. CAHO Antimicrobial Stewartship Program in Intensive Care Units (ICU) ARTIC Project. Antimicrobial Stewardship Program - Mount Sinai Hospital and University Health Network. Ontario, Canada.

4. 2012 Nov 9 Invited Speaker. Trauma - Time is Spine. Acute Spinal Care Triage and Management Symposium. Toronto, Ontario, Canada.

5. 2012 Oct 31 Facilitator. Targeting and Monitoring Sedation. Critical Care Canada Forum 2012.

6. 2012 Oct 31 Facilitator. Quality & Safety II - Practical Applications. Critical Care Canada Forum 2012.

7. 2012 Oct 31 Invited Speaker. Assessing Delirum in Pts with Acute Brain Injuries. Critical Care Canada Forum 2012.

8. 2012 Oct 31 Invited Speaker. Wake Up and Breathe: A Quality Improvement Project. Critical Care Canada Forum 2012. Toronto, Ontario, Canada.

9. 2012 Oct 30 Facilitator. Caring for the Brain-Injured Patient II. Critical Care Canada Forum 2012.

10. 2012 Oct 30 Invited Speaker. Management of Intracranial emergencies. Critical Care Canada Forum 2012. Toronto, Ontario, Canada.

11. 2012 Oct 23 Invited Speaker. What to Do When SpO2 is Low But Your Altitude Is High. Air Medical Transport Conference. Seattle, Washington, United States.

12 .2012 Oct 22 Invited Speaker. Transport Ventilation in Brain Injury : Why it Matters! Air Medical Transport Conference. Seattle, Washington, United States.

13.2012 Sep 19 Visiting Professor. Strategies for Improving Neurologic and Functional Outcomes of Mechanically-Ventilated Patients in the ICU : An Interactive Workshop. Foothills Medical Centre. Calgary, Alberta, Canada.

14. 2012 Sep 18 Visiting Professor. Strategies for Improving Neurologic and Functional Outcomes of Mechanically-Ventilated Patients in the ICU: An Interactive Workshop. Vancouver General Hospital. Vancouver, British Columbia, Canada.

15. 2012 Aug 21 Invited Lecturer. Critical Care Medicine Half-Day : Neurophysiology Review. Interdepartmental Division of Critical Care Medicine. Toronto, Ontario, Canada.

16. 12 Jun 12 Invited Panel Member. Leadership and Administrative Day for Clinical Fellows. University of Toronto Interdepartmental Division of Critical Care Medicine. Toronto, Ontario, Canada.

17. 2012 May 28 Invited Speaker. Transportation of the Critically-Ill Patient. Canadian Critical Care Review. Toronto, Ontario, Canada. Presenter(s): Jeffrey Singh.

18. 2012 May 21 Facilitator. Non-Pulmonary and Critical Care. American Thoracic Society. San Francisco, California, United States. (Continuing Education).

19. 2012 May 15 Invited Speaker. Update in Neurological Emergencies. Ornge Transport Medicine. Toronto, Ontario, Canada. Presenter(s): Jeffrey Singh. (Continuing Education).

20.2012 Apr 30 Invited Speaker. Evolutions in Critical Care. Canadian Association of Critical Care Nurses (Toronto Chapter). Ontario, Canada. Getting Patients Awake, Breathing and Delirium-Free: A Journey in Quality Improvement.

Research Funding: 1. 2012 Feb - 2012 Aug Co-Investigator. Acute Lung Injury in the ICU: Scope of the Problem and

Focus on Prevention. Physician Services Incorporated. Health Research Grant. PI: Galvin, Imelda. Collaborators: Niall Ferguson, Jeffrey Singh, Stephen Lapinsky, Andrew Steel. 39,500 CAD. [Grants]

2. 2011 May - 2012 May Co-Investigator. A Prospective Evaluation of the Association between

Psychoactive Medications and Delirium in Critically Ill Adults. Rx&D Pilot Research Grant. PI: Burry, Lisa. Collaborators: Louise Rose BN, MN, PhD Scott Kim, BSc David Williamson, MScPharm Marc Perreault, PharmD Dean Fergusson, PhD Marilyn Steinberg RN Hilary Rodrigues, BScPharm Virginia Fernandes, BSc, PharmD Orla Smith, RN, MN Jeffrey Singh, MD, FRCPC Sangeeta Mehta MD, FRCPC. 24,985 CAD. [Grants]

3. 2011 Jul – 2012 Jun Co-Principal Investigator. Delirium Screening and Prevention in the ICU: A Quality Improvement Project. Hospira Pharmaceuticals. PI: Singh, Jeffrey. Collaborators: Eddy Fan. 25,000. [Industrial Grants] A multifaceted quality improvement project involving training of all IP team member sin the screening, causes and prevention of delirium ink critically ill patients in the ICU.

4. 2012 Jul – 2012 Jul Principal Site Investigator. Toronto Traumatic Brain Injury Database.

Sunnybrook and Women’s College Health Sciences Centre. AFP innovation funds. PI: Chapman, Martin. Collaborators: Baker, Andrew; Singh, Jeffrey;Rigamonti, Andrea; Pham, Nicolas. [Clinical Trials] Creation of a TBI registry across Toronto teaching hospitals to assess current practice and adherence to best practices.

5. 2010 Sep – 2 012 Sep Co-Principal Investigator. Innovative approaches to mechanical ventilation

in spinal cord injured patients. Ontario Neurotrauma Foundation. Rapid Response - New Investigator. PI: Singh, Jeff. Collaborators: Spahija, Jadranka. 100,000 CAD. [Clinical Trials]

6.2010 Jan – 2012 Sep Principal Investigator. “Exploration of gender discrepancy in outcomes and

utilization of air medical transport”. Foundation for Air-medical Research and Education. Collaborators: McDonald, RD. 16,000 USD. [Grants] Principal Author / Senior Responsible Author.

Tasnim Sinuff (Sunnybrook Health Sciences Centre) Non-Peer Reviewed Publications: 1. Dale C, Angus JE, Sinuff T, Mykhalovskiy E. Mouth care for orally intubated patients: A critical

ethnographic review of the nursing literature. Intensive & Critical Care nursing: the official journal of the British Association of Critical Care Nurses. 2012 Oct 10. Coauthor or Collaborator.

Submitted Publications: 1. Sinuff T, Cahill N, Dhaliwal R, Wang M, Day AG, Heyland DK. The Value of ‘Audit and Feedback

Reports’ in Improving Nutritional Therapy in the Intensive Care Unit: A Multicenter Observational Study. JPEN (submitted). Principal Author.

Abstracts: 1. Duggal A, Perez d’Empaire P, Tremblay L, Sinuff T. Non Invasive Ventilation(NPPV/CPAP) in

Patients with Chest Trauma: A Systematic Review. 2012 Oct. Senior Responsible Author.

2. Matta R, Sinuff T, Heyland D, Cook D, Dodek P, Jiang X, Day A, Muscedere J, Canadian Critical Care Trials Group. Infecions in Mechanically Ventilated Patients in Canadian Intensive Care Units. 2012 Oct. Coauthor or Collaborator.

3. Duggal , Ganapathy A, Ratnapalan M, Tsang J, Sinuff T, Burns KE, Meade MO,Adhikari N. A Systematic Review of Pharmacotherapies for AcuteRespiratory Distress Syndrome ( ARDS). 2012 Oct. Coauthor or Collaborator.

4. Sinuff T, Muscedere J, Adhikari N, Stelfox T, Rubenfeld G, DOdek P, Pinto R, Heyland D, Cook D, Amaral A, Piquette D, Cahill N, Lawless B, Scales D, Garland A, for KRITICAL StudyGroup and the CCCTG. The Quality of KnowledgeTranslation Studies in Critical Care. 2012 May. Principal Author.

5. Cameron J, Chan L, Czerwonka A, CHu L, Matte A, Ferguson N, Friedrich J, Adhikari N, Fowler R, Cook D, Rudkowski J, Meggison H, Abbey. Long Term Outcomes After Prolonged Mechanical Ventilation: Family Caregiver Outcomes From the Towards RECOVER Study. 2012 May. Coauthor or Collaborator.

6. Herridge M, Chu L, Matte A, Chan L, Tomlinson G, Ferguson N, Mehta S, Friedrich J, Adhikari N, Fowler R, Cook D, Rudkowski J, Abbey S, Sinuff T, Cameron J, et al, In collaboration with the CCCTG. Long-Term Patient Outcomes After Prolonged Mechanical Ventilation: The Towards RECOVER Study. 2012 May. Coauthor or Collaborator.

7. Sinuff T, Garland A, Adhikari N, Stelfox T, Rubenfeld G, DodekP, Heyland D, Pinto R, Cook D, Amaral A, Piquette D, Cahill N, Lawless B, Scales D, Muscedere J, for KRITICAL Study Group and the CCCTG. Knowledge Translation Interventions For Critically Ill Patients: A Ststematic Review. 2012 May. Principal Author

Research Funding: 1. 2012 Jan – 2013 Jan Co-Investigator. One-day Point Prevalence of Acute Rehabilitation in

Canadian intensive Care Units: rates of, Barriers to and Facilitating Factors for Mobilization. AHSC AFP Innovation Fund. The Academic Medical Organization of Southwestern Ontario. PI: Koo,Karen. 102,183.9 CAD. [Grants]

2. 2011 Oct - 2012 Oct Co-Investigator. Clinical Practice Guidelines for Ventilator Associated Pneumonia. Canadian Institutes of Health Research (CIHR). Grant. PI: Muscedere, John. 99,079 CAD. [Grants]

3. 2011 Apr – 2014 Apr Co-Investigator. Advance Care Planning Evaluation in Hospitalized Elderly Patients: A multicenter, prospective study: The ACCEPT Study. Canadian Institutes of Health Research (CIHR). Operating Grant. PI: Heyland, Daren. 347,288 CAD. [Grants]

Venkatesan Ben Sivarajan (Hospital for Sick Children) Peer Reviewed Publications: 1. Manlhiot C, McCrindle BW, Menjak IB, Yoon H, Holtby HM, Brandao LR, Chan AK, Schwartz SM,

Sivarajan VB, Crawford-Lean L, Foreman C, Caldarone CA, Van Arsdell GS, Gruenwald CE. Longer blood storage is associated with supoptimal outcomes in high-risk pediatric cardiac surgery. Ann Thorac Surg 2012 May;93(5):1563-9. Epub 2011 Nov 30.

2. Manlhiot C, Brandao LR, Kwok J, Kegel S, Menjak IB, Carew CL, Chan AK, Schwartz SM,

Sivarajan VB, Caldarone CA, Van Arsdell GS, McCrindle BW. Thrombotic complications and thromboprophylaxis across all 3 stages of single ventricle heart palliation. J Pediatr. 2012 Sep;161(3):513-519.e3. doi: 10.1016/j.jpeds.2012.03.004. Epub 2012 Apr 17.

3. Nayak, P.P., Sheth, J., Cox, P.N., Davidson, L., Forte, V., Manlhiot, C., McCrindle, B.W.,

Schwartz, S.M., Solomon, M., Van Arsdell, G.S., Sivarajan, V.B.: Predictive value of bronchoscopy after infant cardiac surgery: a prospective study. Intensive Care Med. 2012 Nov;38(11):1851-7.

Abstracts:

1. Nov 2012 Genetic Polymorphisms Associated with Response to Intraoperative Heparin Anticoagulation and Thrombosis Risk in Pediatric Patients Undergoing Cardiac Surgery. Presented as an oral abstract at the AHA Scientific Sessions 2012, Los Angeles, CALIFORNIA, USA. Cedric Manlhiot, Seema Mital, Colleen E Gruenwald, Leonardo R Brandao, Ahok K Manickaraj, Christopher A Caldarone, Jennifer L Russell, VB Sivarajan, Steven M Schwartz, Helen M Holtby, Brian W McCrindle, The Hospital for Sick Children, Toronto, ON, Canada.

2. Nov 2012 Incidence, Risk Factors and Outcomes of Cardiac Arrest/Extracorporeal Life Support

Following Stage I Palliation. Presented as an oral abstract at the AHA Scientific Sessions 2012, Los Angeles, CALIFORNIA, USA. Eytan Kaplan, Osami Honjo, V Ben Sivarajan, The Hospital for Sick Children, Toronto, ON, Canada.

3. Nov 2012 Impact of Prenatal Diagnosis on Preoperative Neurological Morbidity in Neonates with

Transposition of the Great Arteries. Presented as an oral abstract at the AHA Scientific Sessions 2012, Los Angeles, CALIFORNIA USA. Masayuki Nakada, Osami Honjo, Roisin Osborne, Venkatesan Ben Sivarajan, The Hospital for Sick Children, Toronto, ON, Canada.

Presentations/Lectures: 1. Dec 2012 Special Session: Chronically Critically Ill Patient: When to Trach? Invited

Speaker: The Pediatric Cardiac Intensive Care Society Conference (PCICS), Miami Beach, Florida, USA

2. Nov 2012 Nakada M, Honjo O, Osborne R, Sivarajan VB. Impact of Prenatal Diagnosis on

Preoperative Neurological Morbidity in Neonates with Transposition of the Great Arteries. Abstract presented at the American Heart Association Scientific Sessions 2012. Los Angeles, CA

3. Nov 2012 Kaplan E, Honjo, O, Sivarajan VB. Incidence, Risk Factors and Outcomes of

Cardiac Arrest/Extracorporeal Life support Following Stage I Palliation. Abstract presented at the American Heart Association Scientific Sessions 2012. Los

Angeles, CA. 4. Nov 2012 Manlhiot C, Mital S, Gruenwald CE, Brandao LR, Manickaraj AK, Caldarone CA,

Russell JL, Sivarajan VB, Schwartz SM, Holtby HM, McCrindle BW. Genetic polymorphisms associated with response to intraoperative heparin anticoagulation and thrombosis risk in pediatric patients undergoing cardiac surgery. Abstract presented at the American Heart Association Scientific Sessions 2012. Los Angeles, CA.

5. Sep 18, 2012 Cardiopulmonary Interactions II, CCU Fellows Teaching. 6. Jul 10, 2012 Cardiopulmonary Interactions, CCU Fellows Teaching. 7. Jun 12, 2012 Complex Cardiac Kids – 4D Codes, Simulations. Code Blue Team Leaders

Training Course. 8. Apr 10, 2012 Morbid Anatomy Session #1 – Normal hearts, ASDs, VSDs. CCU Fellows

Teaching. 9. Mar 13, 2012 ECMO Lecture & Simulation. CCU Fellows Teaching. 10. Jan 24, 2012 Cardiopulmonary Interactions, Cardiology Fellows Teaching. Research Funding: 1. Jan 2009-12 Heart Centre Innovation Fund Amount: $6,300 Study: Energy Expenditure During Ventilation Weaning: A Randomized Controlled Trial Comparing Conventional Pressure Support CPAP versus Neurally Adjusted Ventilatory Adjustment (NAVA) Role: PI 2. Sept 2010-15 CIHR 2010 Operating Grants Amount: $1,514,330

Study: Clinical Assessment of Thrombosis in Children after Heart Surgery: The CATCH study

Role: COI 3. Sep 2011-16 NIH NHLBI Pediatric Heart Network Amount: $7,518,965

Study: Perform collaborative multi-institutional clinical studies aimed at improving the evidence base on which pediatric cardiology, and the team at SickKids has been a charter member since its inception 10 year ago.

Role: COI

Arthur Slutsky (St. Michael’s Hospital) Peer Reviewed Publications: 1. Chan MC, Spieth PM, Quinn K, Parotto M, Zhang H, Slutsky AS: Circadian rhythms: From basic

mechanisms to the intensive care unit. Critical Care Medicine 2012: 40 (1): pp 246-53. 2. Aslami H, Haitsma JJ, Hofstra JJ, Forquin S, Dos Santos C, Streutker C, Zhang H, Levi M, Slutsky

AS, Schultz MJ: Plasma-derived human antithrombin attenuates ventilator-induced coagulopathy but not inflammation in a Streptococcus pneumoniae pneumonia model in rats. Journal of Thrombosis and Haemostasis 2012: 10(3): pp 399-410.

3. Cabrera-Benitez NE, Parotto M, Post M, Han B, Spieth PM, Cheng WE, Valladares F, Villar J, Liu, M,

Sato M, Zhang H, Slutsky AS: Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition. Critical Care Medicine 2012: 40(2): pp 510-517.

4. Grasselli G, Beck J, Mirabella L, Pesenti A, Slutsky AS, Sinderby C: Assessment of patient-ventilator

breath contribution during neurally adjusted ventilatory assist. Intensive Care Medicine 2012: 38(7): pp 1224-32.

5. Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman

DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler Ap, Levy MM on behalf of the ACCP/ATS/SCCM Working Group: An Official Multi-Society Statement: The role of clinical research - Results in the practice of Critical Care Medicine. American Journal of Respiratory and Critical Care Medicine 2012: 185(10): pp 1117-1124.

6. ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E,

Fan E, Camporota L, Slutsky AS: Acute Respiratory Distress Syndrome: The Berlin Definition. JAMA 2012: 307(23): pp 2526-33.

7. Fortis S, Spieth PM, Lu WY, Parotto M, Haitsma JJ, Slutsky AS, Zhong N, Mazer CD, Zhang H:

Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury. Intensive Care Medicine 2012: 38: pp 1548-1555.

8. Smeding L, Leong-Poi H, Hu P, Shan Y, Haitsma JJ, Horvath E, Furmli S, Masoom H, Kuiper JW,

Slutsky AS, Parker TG, Plotz FB, Dos Santos CC: Salutary effect of resveratrol on sepsis-induced myocardial depression. Critical Care Medicine 2012: 40(6): pp 1896-1907.

9. Villar J, Zhang H, Blanco J, Slutsky AS. Year in Review 2011: Critical Care- respirology. Critical

Care 2012: 16(6):243. Book Chapters: 1. Brander L, Slutsky AS: Invasive Mechanical Ventilation. In: Clinical Respiratory Medicine, 4th

Edition (Spiro SG, Silvestri GA, Agusti A, eds). Elsevier Saunders, Philadelphia, PA 2012: pp 406-430.

Presentations/Lectures: 1. Society for Critical Care Medicine (SCCM) Annual Meeting, Houston, Texas, Feb 3, 2012 - Feb 6,

2012. (1) Co-chair, NAVA Symposium, (2) Ventilator-induced lung injury. 2. European Society of Intensive Care Medicine (ESICM), Brussels, Belgium, Mar 17, 2012 - Mar 22,

2012. 1) Organ Donation: Increasing the number of lungs for transplantation, 2) Moderator: Non-conventional modes of mechanical ventilation, 3) Issues in Mechanical Ventilation: Novel approaches

to minimize VILI. 3. 29th Conference on High Frequency Ventilation of Infants, Children and Adults, Snowbird, Utah, Mar

29, 2012 - Mar 30, 2012. 15th Robert de Lemos Memorial Lecture: History of mechanical ventilation. 4. Simposio Mostra Anestesia Rianimazione e Terapia Intesiva (SMART), Milan, Italy, May 9, 2012 -

May 11, 2012. (1) The new "Berlin" definition of ARDS, (2) Long term outcomes of survivors of ARDS.

5. Annual Conference of the East-West Alliances (EWA), Shantou University, China, May 26, 2012 -

May 27, 2012. Translational Medicine, Session Chair. Research Funding: 1. From Bench to Bedside to Curbside. Clinical Research Consortium to Improve Resuscitation

Outcomes. Morrison LJ, Slutsky AS, Dorian P: National Institutes of Health ($600,000) and funding partners: Heart and Stroke Foundation of Canada ($1,500,000) and CIHR (1,000,000) ($3,100,000 2010 - 2016)

2. Resuscitation Outcomes Consortium Core Training Grant: NIH (1,009,800), Heart & Stroke

Foundation of Canada (1,500,000), and Canadian Institutes of Health Research (1,000,000). Morrison LJ, Nathens A, Cheskes S, Slutsky AS, Dorian P: National Institutes of Health and funding partners ($35,098,000 2010 - 2016)

3. Mechanisms of ventilator-induced pulmonary fibrosis and its therapy. Slutsky AS: Canadian

Institutes of Health Research (CIHR) ($808,658 2010 - 2015)

Andrew Steel (Toronto General Hospital, University Health Network) Peer Reviewed Publications: 1. Russell T, Steel AC, Hawryluck L, Riazi S. Ecstacy-induced delayed rhabdomyolysis and neuroleptic

malignant syndrome in a patient with a positive malignant hyperthermia genetic test. Anaesthesia. 2012; 67(9):1021-4. (CPA)

2. Adeniji K, Steel AC. Pathophysiology of Acute Lung Injury. Anesthesiol Clin. 2012; 30(4):573-90. (CPA)

3. Beattie WS, Karkouti K, Tait G, Steel A, Yip P, McCluskey S, Farkouh M, Wijeysundera DN. Use of

clinically based troponin underestimates the cardiac injury in non-cardiac surgery: a single-centre cohort study in 51,701 consecutive patients.. Can J Anesth 2012; 59:1013–1022. (CPA)

Book Chapters: 1. Casas-Lopez C, Steel AC. Chapter: Haemodynamic Monitoring. In Encyclopedia of Trauma Care,

edited by Peter Papadakos and Mark Gestring. Springer 2012. (CPA) In Press: 1. Steel AC. Chapter: Intensive Care Management of the Heart, Heart-Lung, and Lung Transplant

Patient. In Oxford Textbook of Transplant Anaesthesia and Critical Care Medicine, edited by Biancofiore E, Dewolf A, Klinck JR, Niemann C, Pretto E, Watts A. 2012. In Press. (PA)

Presentations/Lectures: 1. Development of Acute Respiratory Distress Syndrome (ARDS) in the Intensive Care Unit. Critical

Care Canada Forum, Toronto, Canada. October 28, 2012. 2. Perioperative ventilation strategy. Ontario Medical Association, 57th Annual Ontario Anesthesiologists

Meeting, Toronto, Canada. September 28th -30th 2012. 3. Delirium and Critical Care Response Teams. Toronto General Hospital General Surgical Division

Symposium on Delirium, Toronto. June 26th 2012.

4. Predictors of Code Blue Arrest in Solid Organ Transplant Patients: A Retrospective Review, University of Toronto, Critical Care Medicine Residents’ Symposium Toronto, Canada. June 14, 2012.

5. Evaluation of an Electronic Vital Signs Capture and Alert System. 7th International Rapid Response Systems Meeting, Sydney, Australia. May 6, 2012.

6. Pathophysiology of Acute Lung Injury. Society of Cardiovascular Anesthesiologists Thoracic Anesthesia Symposium, Boston, US. April 27th -28th 2012

7. Update on Perioperative Shock. Toronto Anesthesia Symposium, Toronto, Canada. April 14th -15th

2012.

Thomas Stewart (Mount Sinai Hospital) Peer Reviewed Publications: 1. Fan E, Checkley W, Stewart TE, Muscedere J, Lesur O, Granton JT, Freitag AP, Jacka M, Ferguson

ND and Meade MO. Complications From Recruitment Maneuvers in Patients With Acute Lung Inquiry: Secondary Analysis From the Lung Open Ventilation Study. Respiratory Care November 2012 Vol 57 No 11. DOI: 10.4187/respcare.01684. Coauthor or Collaborator.

Abstracts: 1. Complications From Recruitment Maneuvers in Patients With Acute Lung Inquiry: Secondary Analysis

From the Lung Open Ventilation Study.

Claude Tousignant (St. Michael’s Hospital) Peer Reviewed Publications: 1. Hu R, Tousignant C, Chen R. Flow velocity patterns in the pulmonary artery and pulmonary

hypertension. Can J Anesth (online april 23rd, 2012).

2. Tousignant C, Kim H, Papa F, Mazer CD. Evaluation of TAPSE as a measure of right ventricular output. Can J Anesth 2012;59:376-383.

Reviews, Letters & Editorials: 1. Editorial: A. Stephane Lambert & Claude P. Tousignant. Anesthesia and Ultrasound: Riding the

waves. Can J Anesth. Dec 2012.

Lorraine Tremblay (Sunnybrook Health Sciences Centre) Submitted Publications: 1. Duggal A, Perez P, Golan E, Tremblay L, Sinuff T. The safety and efficacy of noninvasive ventilation

in patients with blunt chest trauma: a systematic review. Intensive Care Medicine. Coauthor or Collaborator.

2. Azoubel G, Callum J, Pinto R, Tremblay L, Tien H, Speers V, Rizoli S. Overtransfusion: An unrecognized complication of blood transfusion. Journal of Trauma. Coauthor or Collaborator.

3. Al Mahroos M, Capone Neto A, Hoffmann JP, Scarpelini S, Tremblay L, Nascimento B, Tien H, Rizoli S. Comparison of Thromboelastography (TEG) and INR in Diagnosing Coumadin-Induced Coagulopathy in Trauma. Injury. Coauthor or Collaborator.

4. Chaar M, Tremblay LN, Feliciano DV, Rozycki GS, Pettitt BJ. Revisiting the high rate of operative intervention and low mortality of penetrating trauma in children. Journal of Trauma. Co-Principal Author.

In Press: 1. Duggal A, Perez P, Tremblay L, Sinuff T. Non-invasive ventilation (NPPV/CPAP) in patients with

chest trauma: A systematic review. Intensive Care Medicine. In Press. Coauthor or Collaborator.

Presentations/Lectures: 1. 2012 Apr 19 Invited Speaker. C. Difficile Management. University of Toronto Annual

Surgical Update Course. Toronto, Canada. (Continuing Education). Research Funding: 1. 2011 Jul – 2013 Jun Principal Investigator. Implementation & Assessment of a Novel

Multidisciplinary e-Discharge Summary to Improve Efficiency, Satisfaction, and Safety of Transfer of Care for Complex Patients. AHSC AFP Innovation Fund 2010-2011. Collaborators: E. Etchells, P. Engels, K. Chan, L. Farquharson. 71,342 CAD. [Grants].

Natalie Wong (St. Michael’s Hospital) Presentations/Lectures: 1. The Benefits of a Simplified Method for CPR Training of Medical Professionals: A controlled

randomized study. European Society of Intensive Care Medicine. Lisbon, Portugal. Oct 16, 2012

2. Use of High-Fidelity Simulation Training to improve delivery of High Quality BLS by First Responders. European Society of Intensive Care Medicine. Lisbon, Portugal. October 15, 2012.

3. CRISP - PGY2 Core Internal Medicine. University of Toronto. Toronto, Ontario. May 11, 2012.

4. Resuscitation in Motion Conference. Toronto. May 3, 2012.

5. Continuing Medical Education Poster Presentation. St. Michael’s Hospital, Toronto, April 30,2012.

6. CPR Speaker Open Forum Expert Panel Discussion. Toronto. April 10, 2012.

7. CPC. Department of Medicine Medical Grand Rounds. Department of Medicine, St. Michael’s Hospital. Toronto. January 25, 2012.

Research Funding: 1. Quality Improvement Fund. SMH QIF. 21,000 CAD. [Grants]

Haibo Zhang (St. Michael’s Hospital) Peer Reviewed Publications: 1. Villar J, Zhang H, Blanco J, Slutsky AS. Year in Review 2011: Critical Care- respirology. Critical Care

2012: 16(6):243.

2. Antonelli M, Bonten M, Chastre J, Citerio G, Conti G, Curtis JR, De Backer D, Hedenstierna G, Joannidis M, Macrae D, Mancebo J, Maggiore SM, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H. Year in review in Intensive Care Medicine 2011: III. ARDS and ECMO, weaning, mechanical ventilation, noninvasive ventilation, pediatrics and miscellanea. Intensive Care Med. 2012 Apr;38(4):542-56.

3. Antonelli M, Bonten M, Chastre J, Citerio G, Conti G, Curtis JR, De Backer D, Hedenstierna G, Joannidis M, Macrae D, Mancebo J, Maggiore SM, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H. Year in review in Intensive Care Medicine 2011. II. Cardiovascular, infections, pneumonia and sepsis, critical care organization and outcome, education, ultrasonography, metabolism and coagulation. Intensive Care Med. 2012 Mar;38(3):345-58.

4. Antonelli M, Bonten M, Chastre J, Citerio G, Conti G, Curtis JR, De Backer D, Hedenstierna G, Joannidis M, Macrae D, Mancebo J, Maggiore SM, Mebazaa A, Preiser JC, Rocco P, Timsit JF, Wernerman J, Zhang H. Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals. Intensive Care Med. 2012 Feb;38(2):192-209.

5. Fortis S, Spieth PM, Lu WY, Parotto M, Haitsma JJ, Slutsky AS, Zhong N, Mazer CD, Zhang H. Effects of anesthetic regimes on imflammatory responses in a rat model of acute lung injury. Intensive Care Medicine 2012; 38: 1548-1555.

6. Chian CF, Chiang CH, Jung CY, Chuang CH, Liu SL, Zhang H, Ryu JH. Apocynin attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model. Shock 2012; 38(2):196-202.

7. Chiang CH, Chuang CH, Liu SL, Chian CF, Zhang H, Ryu JH. N-acetylcysteine attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Injury 2012; 43:1257-1263.

8. Winocur G, Henkelman M, Wojtowicz, Zhang H, Binns MA, Tannock IF. The effects of chemotherapy on cognitive function in a mouse model: a prospective study. Clinical Cancer Research 2012; 18(11):3112-3121.

9. McMullin G, Mackenzie R, Lau R, Khang J, Zhang H, Rajwans N, Liles WC, Pillai DR. Host immune response in returning travelers infected with malaria. Malar J 2012 3;11:148.

10. Aslami H, Haitsma JJ, Hofstra JJ, Florquin S, Dos Santos C, Streutker C, Zhang H, Levi M, Slutsky AS, Schultz MJ. Plasma-Derived Human Antithrombin Attenuates Ventilator-Induced Coagulopathy but not Inflammation in a Streptococcus pneumoniae Pneumonia Model in Rats. J Thromb Haemost. 2012; 10(3): 399-410.

Presentations/Lectures: 1. New frontiers in sepsis. Novel Therapies for resuscitation of emergency and critically ill patients. 16th

Annual Symposium of Taiwan Society of Intensive Care Medicine, International Convention Center, National University of Taiwan, Taipei, Taiwan, October 6-7, 2012

2. Intracellular LPS as a novel target in sepsis. 2nd Paris International Conference on Intensive Care - Sepsis, Paris, France, June 7-8, 2012

3. LPS Internalization as a novel mechanism in sepsis. European Congress of Immunology, Glasgow, Scotland, September 5-8, 2012

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University of Toronto Interdepartmental Division of ...Care+Digital+Assets/... · University of Toronto Interdepartmental Division of Critical Care ... Message from Arthur S. Slutsky,