UM 2012.pdf · 2019. 2. 11. · Avgust, 2012 A.) OBVEZNI PREDMET / OBLIGATORY SUBJECT MEDICINSKA FAKULTETA UČNI NAČRT PREDMETA / COURSE SYLLABUS Predmet: Biomedicinska Informatika

Avgust, 2012

UČNI NAČRTI OBVEZNIH, TEMELJNIH IN IZBIRNIH PREDMETOV DOKTORSKEGA PROGRAMA

BIOMEDICINSKA TEHNOLOGIJA

DESCRIPTION OF OBLIGATORY, BASIC AND OPTIONAL SUBJECTS

IN THE POSTGRADUATE STUDY PROGRAM »BIOMEDICAL TECHNOLOGY«

April , 2012

Avgust, 2012

A.) OBVEZNI PREDMET / OBLIGATORY SUBJECT

MEDICINSKA FAKULTETA

UČNI NAČRT PREDMETA / COURSE SYLLABUS

Predmet: Biomedicinska Informatika

Course title: Biomedical Informatics

Študijski program in stopnja Study programme and level

Študijska smer Study field

Letnik Academic year

Semester Semester

BIOMEDICINSKA TEHNOLOGIJA 1 1,2

BIOMEDICAL TECHNOLOGY

Vrsta predmeta / Course type

Univerzitetna koda predmeta / University course code: 1001

Predavanja Lectures

Seminar Seminar

Sem. vaje Tutorial

Lab. vaje Laboratory

work

Teren. vaje Field work

Samost. delo Individ. work

ECTS

20 40 - 15 - 225 10

Nosilec predmeta / Lecturer: Izred. prof. dr. Dejan Dinevski Doc. dr. Miljenko Križmarič

Jeziki / Languages:

Predavanja / Lectures:

Slovensko/Slovene

Vaje / Tutorial: Slovensko/Slovene

Pogoji za vključitev v delo oz. za opravljanje študijskih obveznosti:

Prerequisits:

Kandidat mora imeti pred vpisom ustrezno znanje iz naravoslovnih ved z ustreznega področja na nivoju univerzitetnega študija.

Prior to entering, the candidate for postgraduate program must have an appropriate knowledge and understanding of bioscience (biology, chemistry, physics, mathematics) on the university level.

Vsebina:

Content (Syllabus outline):

- Računalništvo in informacijske tehnologije - Medicinska informatika - Podatkovne zbirke: vrste in namen,

podatkovno modeliranje, podatkovno rudarjenje relacijske zbirke, bibliografske zbirke

- Informacijska omrežja: topologije, gradniki, internetne storitve, intranet

- Uporaba slik in grafike v medicini - Odločitveni sistemi v medicini - Inteligentni sistemi v medicini - Bioinformatika - Napredno iskanje strokovnih in bibliografskih

informacij s področja medicine - biomedicinska tehnologija v kliničnih procesih

- Computer science and information technology - Medical informatics - Databases: types and purpose, data modeling,

data mining, relational databases, bibliographic databases

- Information networks, topology, internet services, intranet

- Pictures and graphics in medicine - Decision support systems in medicine - Intelligent systems in medicine - Bioinformatics - Advanced search methods of medical and

bibliographic data - biomedical technology in clinical settings - simulators and simulations in medicine

Avgust, 2012

- simulatorji in simulacije v medicini - Statistične in hevristične metode analize

podatkov - Osnove telemedicinske tehnologije,

telezdravstvo, telenega, telenadzor, telekonzultacije

- Pregled telemedicinske prakse (teledermatologija, telekirurgija, telepatologija, telekardiologija…)

- Statistical and heuristics methods for data analysis

- Basics of telemedicine technology, telehealth, telecare, telemonitoring, teleconsultations

- Overview of telemedicine practice (teledermatology, telesurgery, telepathology, telecardiology…)

Temeljni literatura in viri / Readings:

1. Edward H. Shortliffe, James J. Cimino: Biomedical Informatics, Springer USA, 2006 2. J.H. van Bemmel, M.A. Musen (Editors). The Handbook of Medical Informatics. Springer-Verlag,

New York, 1998 3. Bashshur RL, Shannon GW, History of Telemedicine –Evolution, Context and Transformation, Mary

Ann Liebert publishers, New York, 2009. 4. Kyle RR, Murray BW. Clinical simulation: operations, engineering, and management. Amsterdam,

Academic Press, 2008 5. Enderle J, Blanchard SM, Bronzino JD. Introduction to Biomedical Engineering. Elsevier Science

and Technology, 2005.

Cilji in kompetence: Objectives and competences:

Študent bo spoznal biomedicinsko in informacijsko tehnologijo ter aplikacije na področju medicine. Na podlagi osnov se bo poglobil v nekatera specialnima področja odločitvenih in inteligentnih sistemov ter bioinformatike. Specialna področja bodo študentje usvojili predvsem s raziskovalnimi seminarskimi nalogami. To znanje bo študent lahko uporabljal pri raziskovalnem in praktičnem reševanju medicinskih problemov

Students will learn about biomedical and information technology/application in medicine. Special attention will be focused to decision support and intelligent systems and also bioinformatics. Advanced subjects will be studied through research assignments. The gained knowledge will be used by research and practical problem solving.

Predvideni študijski rezultati:

Intended learning outcomes:

Znanje in razumevanje bioinformacijskih tehnologij s katerimi bo študent sposoben bolj učinkovito reševati raznovrstne medicinske probleme. Prenesljive/ključne spretnosti in drugi atributi: - programiranje in delo z računalnikom - poznavanje računalniško podprte

biomedicinske tehnologije - poznavanje simulatorjev in simulacij v

medicini - sposobnost napredne analize in razumevanja

podatkov.

Knowledge and Understanding of bioinformatics technologies in more efficient solving of various medical problems Transferable/Key Skills and other attributes: - programming and computer skills - knowledge about computer supported

biomedical technology - knowledge about medical simulators and

simulations - the ability to perform complex data analysis

Metode poučevanja in učenja:

Learning and teaching methods:

Predavanja

Seminar

Vaje, e-izobraževanje

Lectures,

Seminar

Excercises, e-learning

Načini ocenjevanja:

Delež (v %) / Weight (in %)

Assessment:

seminarska naloga pisni izpit ustni zagovor

30% 50% 20%

Seminar work Written exam Oral exam

Avgust, 2012

B.) TEMELJNI PREDMETI / BASIC SUBJECTS

Univerza v Mariboru University of Maribor

Medicinska fakulteta Faculty of Medicine

OPIS PREDMETA / SUBJECT SPECIFICATION

Predmet: BIOFIZIKA

Subject Title: BIOPHYSICS

Študijski program Study programme


Letnik Year

Semester Semester

BIOMEDICINSKA TEHNOLOGIJA BIOMEDICAL TECHNOLOGY

1 1,2

Univerzitetna koda predmeta / University subject code: 1002

Predavanja

Lectures Seminar Seminar

Sem. vaje Tutorial

Lab. vaje Lab. work



ECTS

20 40 15 225 10

Nosilec predmeta / Lecturer: Red. prof. dr. Milan BRUMEN

Jeziki / Languages:

Predavanja / Lecture: slovenščina, angleščina / Slovenian, English

Vaje / Tutorial:


Prerequisites:



Vsebina: Contents (Syllabus outline):

Kemijske vezi in medmolekularne interakcije ter struktura bioloških makromolekul in supramolekularnih kompleksov. Vezava ligandov in alosterični pojavi. Voda, njena struktura in pomen za biološke sisteme. Biofizika celične membrane in celice: osmozne lastnosti in kislinsko-bazno ravnotežje, metabolizem celice, mehanske lastnosti celične membrane, transport preko celične membrane, električna vzdražljivost celice in prenos električnega impulza. Biofizika celičnega skeleta in molekularnih strojev subceličnih dimenzij (delovanje mišice). Izbrani fiziološki sistemi: kri in krvni obtok, čutila, okostje in mišice, živčevje. Regulacija bioloških sistemov (sistemska analiza, regulacija metaboličnih sistemov - kontrolna teorija). Biološki dinamični sistemi (celična signalizacija, razvoj populacije). Samoorganizacija bioloških sistemov. Teorije in modeli evolucije. Interakcija neionizirajočega elektromagnetnega sevanja s humanim tkivom. Interakcija ionizirajočega sevanja s humanim tkivom. Pregled eksperimentalnih biofizikalnih metod. Pregled osnovnih konceptov statistične termodinamike s poudarkom na obravnavi bioloških

Chemical bonding, intermolecular interactions and structure of biological macromolecules and supramolecular systems. Binding of ligands and allosteric phenomena. Structure of water and its meaning for biological systems. Cell and cell membrane biophysics: osmotic properties, acid-base equilibrium, metabolism, mechanical properties of a cell membrane, membrane transport, electrical excitability and propagation of electric pulse. Biophysics of cytoskeleton and molecular motors. Selected physiological systems: blood and cardiovascular system; senses, skeletal-muscular system, nervous system. Regulation of biological systems (system analysis, control theory of metabolic systems). Biological dynamic systems (cell signalling, evolution of population). Self-organisation of biological systems. Theory and models of evolution. Interaction of non-ionising electromagnetic radiation with human tissue. Interaction with ionising radiation with human tissue. Overview of experimental methods in biophysics. Overview of basic concepts in statistical thermodynamics applied to biological systems.

Avgust, 2012

sistemov.

Temeljni študijski viri / Textbooks:

- P.R. Bergethon: The physical basis of biochemistry, Springer 1998 - S. Bromberg, K.A. Dill: Molecular Driving Forces: Statistical thermodynamics in chemistry and biology, Garland Publishing 2002 - B.H. Brown, R.H. Smallwood, D.C. Barber, P.V. Lawford, D.R. Hose: Medical physics and biomedical engineering, Institute of Physics Publishing 2001 - R. Cotterill: Biophysics: An Introduction, John Wiley & Sons 2003 - H. Flyvbjerg, J. Hertz, M:H.Jensen, O.G. Mouritsen,K. Sneppen: Physics of biological systems: From molecules to species, Springer 1997 - R. Glaser: Biophysics, Springer 1999 - D.T. Haynie: Biologocal thermodynamics, Cambridge University Press 2001 - D.J. Schneck, J:D. Bronzino: Biomechanics: Principles and Applications, CRC Press 2003 - J.A. Tuszynski, M. Kurzynski: Introduction to molecular biophysics, CRC Press 2003

Cilji: Objectives:

Cilj predmeta je obravnavati strukturo in funkcijo bioloških sistemov oziroma njihovih gradnikov na molekularni in makromolekularni ravni, na stopnji supramolekularne organiziranosti, na ravni celice in interakcije med njimi ter na ravni organov človeškega telesa. Pristop temelji na matematični formulaciji konceptov v biofiziki. Obravnavani primeri so izbrani iz humane biologije in zato posebej zanimivi za medicino.

The main objective of the course is to discuss the structure and function of biological systems on different levels of biological complexity from a molecular, macromolecular and supramolecular level to a cellular level and tissue as well as to organs of the human body. The course is based on mathematical formulation of biophysical concepts. In particular, systems presented are selected from human biology and, therefore, they are applicable to medicine.



Znanje in razumevanje: Osvojeno pregledno interdisciplinarno znanje o strukturnih lastnosti in delovanju bioloških sistemov na različnih ravneh organiziranosti od molekule do organizma.

Knowledge and Understanding: Broad interdisciplinary knowledge of structure and function of different biological systems considered at different levels of complexity from molecules to human organs.

Prenesljive/ključne spretnosti in drugi atributi: Sposobnost vključitve v poglobljeno raziskovalno delo z namenom nadaljevanja doktorskega študija in izdelave doktorata na različnih problemih biomedicine.

Transferable/Key Skills and other attributes: Ability of a student to be involved deeply in research in order to continue his/her doctoral studies leading to PhD thesis on various problems from biomedicine.



predavanja seminarji

lectures seminars



Assessment:

Način (pisni izpit, ustno izpraševanje, naloge, projekt) Ustno izpraševanje Seminarska naloga

Type (examination, oral, coursework, project): Oral examination Coursework

Materialni pogoji za izvedbo predmeta : Material conditions for subject realization

Predavanja in seminarji bodo potekala v prostorih Medicinske fakultete Univerze v Mariboru. Multimedijska oprema predavalnice; dostop na internet.

Lectures and seminars will be held in lecture rooms of Medical Faculty, University of Maribor. Multimedia equipment, access to internet.

Obveznosti študentov: Students’ commitments:

(pisni, ustni izpit, naloge, projekti) (written, oral examination, coursework, projects):

Seminarska naloga, ustni izpit Coursework, oral examination

Avgust, 2012




Predmet: BIOKEMIJA

Subject Title: BIOCHEMISTRY



Letnik Year

Semester Semester


1 1/2


Predavanja


Sem. vaje Tutorial

Lab. vaje Lab. work



ECTS

20 40 15 225 10

Nosilec predmeta / Lecturer: Prof. dr. Avrelija CENČIČ Prof. dr. Gert M. KOSTNER Prof. dr. Črtomir STROPNIK

Jeziki / Languages:

Predavanja / Lecture: slovenščina, angleščina / slovenian, english

Vaje / Tutorial: slovenščina, angleščina, francoščina/ slovenian, english, french


Prerequisites:




Biomolekule.

Metode izolacije in kvantitativnega ter kvalitatitvnega določanja strukture in funkcije beljakovin: elektroforeza, kromatografske metode, pI, spektrofotometrija, FTIR, MALDI-MS, proteomika in metabolomika, biološki modeli.

Imunocito(histo)kemiske metode: temeljni principi in aplikacije.

Napake v strukturi beljakovin in z njimi povezane bolezni.

Encimi: Regulacija in klinična aplikacija: plazemski intracelularni encimi, merjenje encimske aktivnosti, serumski markerji pri poškodbah tkiva, encimi kot analitični in terapevtski reagenti.

Heteropolisaharidi: glikoproteini in glikolipidi, proteoglikani in peptidoglikani, oligosaharidi in občutljivost gostitelja.

Metode določanja ogljikovih hidratov.

Lektini.

Transdukcija.

Biomolecules.

Methods of isolation and determination of proteins: electrophoresis, chromatography, pI, spectrophotometry, FTIR, MALDI-MS, proteomics and metabolomics, biological models.

Imunocyto(histo)chemistry: principles and applications.

Protein folding and associated diseases.

Enzymes: Regulation and clinical applications: intracellular enzymes from plasma, measurements of enzyme activity, serum markers in the diagnosis of tissue damage, enzymes as analytical reagents and therapeutic agents.

Heteropolysaccharides: glycoproteins and glycolipids, proteglycans and peptidoglycans.

Analytical methods in glycobiochemistry.

Lectins.

Transduction.

Gastrointestinal digestion and absorption, gastrointestinal hormones, thermic effect

Avgust, 2012

Gastrointestinalna digestija in absorbcija, gastrointestinalni hormoni, termični učinek hrane.

Izbrane vsebine iz metabolizma ogljkovih hidratov.

Lipidi: fosfolipidi in glikosfingolipidi v klinični medicini, holesterol in žolčne kisline, plazemski lipoproteini in z njimi povezane napake v organizmu.

Metabolna homeostaza: metabolična vloga organov, homeostaza ogljkovih hidratov, homeostaza lipidov.

Homeostaza beljakovin.

Nepravilnosti v metabolni homeostazi.

Endokrini metabolizem- primeri organskih sistemov.

Molekularna imunologija: molekule in kemijski procesi v imunskem sistemu, protitelesa, interferoni in citokini.

Biokemija raka.

Metode pridobivanja protiteles in njihova analitska vrednost.

Cepiva.

Biokemija hemostaze: interakcije med metabolizmom lipidov in hemostazo.

Izbrane vsebine iz metabolizma vitaminov in njihovih nadomestkov.

Keto-nukleozidi.

Toksini in droge, doping. Principi in aplikacije.

of food.

Selected topics in crbohydrate metabolism.

Lipids: phospholipids and glycolipids in clinical medicine, cholesterol and bile acids, plasma lipoprotein associated disorders.

Metabolic homeostatis: organs, carbohydrate and lipid homeostasis.

Protein homeostasis.

Abnormalities in homeostasis.

Endocrine metabolism – organic systems.

Molecular immunology: molecules and chemical processes in immune system, antibodies, interferons and cytokines.

Biochemistry of cancer.

Production of antibodies and their applications.

Vaccines.

Biochemistry of hemostasis: interactions between lipid metabolism and hemostasis.

Selected topics from vitamin metabolism.

Keto-nucleosides.

Toxins, drugs, doping. Principles and applications


Modern experimental biochemistry/edited by Rodyner Boyer, 2002, ISBN: 0-8053-3111-5

Medical Biochemistry, Bhagavan, N.V. 2002, ISBN: 0-12-095440-0

Textbook of Biochemistry with clinical correlations, Devlin, T.M. (Ed.) 1993, ISBN: 0-471-51348-2

The essentials of glycobiology / edited by Ajit Varki ... et al.]., 1999, ISBN 0-87969-560-9

Reviews of Physiology Biochemistry and Pharmacology, 1994, ISBN: 3540575367 Reviews of Physiology, Biochemistry and Pharmacology/Special Issue on Signal Transduction III, 1994, ISBN: 3540575871

Molecualr and genetic interactions involving phytochemicals, Kreft, I. and Škrabanja, V. (Ed.) 2001, ISBN: 961-6379-02-X

Molecular interactions between microorganisms and cells, Hacker, J. and Heesemann, J. (Ed.)2002, ISBN: 0-471-17846-2

Mad Cow Disease and Related Spongiform EncephalopathiesSeries : Current Topics in Microbiology and Immunology , Vol. 284 Harris, D.A. (Ed.)2004, ISBN: 3-540-20107-6

Drug Discovery and Evaluation,Pharmacological Assays,Vogel, Hans G. (Ed.)2nd, completely revised, updated, and enlarged ed., 2002, ISBN: 3-540-42396-6

Cilji: Objectives:

Spoznati poglobljene vsebine iz strukture in funkcije biomolekul,

Povezati strukturo in funkcijo biomolekul v biokemičnih procesih človeškega telesa ter povezati napake v strukturi in funkciji s pojavom bolezenskih stanj.

Spoznati moderne metode eksperimentalne biokemije in njihovo uporabo.

To get familiar in depth with interactions between structure and function of biomolecules.

To achieve a synthesis of structure and function of biochemical processes in a human body, as well as correlate disorders in structure and function with the clinical medicine.

To get familiar with modern principles of

http://www.springeronline.com/sgw/cda/frontpage/0,11855,5-124-69-1191827-0,00.htmlhttp://www.springeronline.com/sgw/cda/frontpage/0,11855,5-124-69-1191827-0,00.html

Avgust, 2012

experimental biochemistry and its applications.



Znanje in razumevanje: Poglobljeno temeljno teoretično in praktično znanje na področju moderne eksperimentalne biokemije.

Knowledge and Understanding: In-depth knowledge of fundamental theoretical and practical principles of modern experimental biochemistry.

Prenesljive/ključne spretnosti in drugi atributi: teoretično in praktično znanje kot osnova za specializirane predmete (predmete izbirnih vsebin) ter za doktorsko disertacijo.

Transferable/Key Skills and other attributes: Theoretical and practical knowledge as well as skills in the use and interpretation of modern experimental methods as a basis of specialized subjects (chosen subjects) and for a doctoral thesis.



predavanja,

seminarji,

tutorials,

individualno delo z mentorjem

PBL

laboratorijske vaje

lectures

seminars

tutorials,

individual work with tutor

PBL

laboratory practical’s.



Assessment:

Način (pisni izpit, ustno izpraševanje, naloge, projekt) Pisni izpit: Ustni izpit: Seminarska naloga in opravljene laboratorijske vaje: .

Type (examination, oral, coursework, project): Written exam: Oral exam: Project work and accomplished laboratory practical’s: .


Dobro opremljen biokemijski laboratorij. Knjižnica in računalniška učilnica z dostopom od internetnih baz.

Modern, equipped biochemical lab. Library and computer class-room with internet access.



Pisni in ustni izpit, seminarska naloga ter opravljene laboratorijske vaje

Written and oral exam, project work and accomplished laboratory practical’s.

Avgust, 2012




Predmet: MOLEKULARNA BIOLOGIJA

Subject Title: MOLECULAR BIOLOGY



Letnik Year

Semester Semester


1 1, 2


Predavanja


Sem. vaje Tutorial

Lab. vaje Lab work



ECTS

20 40 15 225 10

Nosilec predmeta / Lecturer: Prof. dr. Dimitrij KRAINC Prof. dr. Uroš POTOČNIK

Jeziki / Languages:

Predavanja / Lecture: Slovenski / Slovenian

Vaje / Tutorial: Slovenski / Slovenian


Prerequisites:



Vsebina:

Contents (Syllabus outline):

1. Uvod v molekularne metode v medicini 2. Genomika v klinični praksi 3. Molekularne metode odkrivanja novih

zdravil 4. Bioinformatika v molekularni medicini 5. Genska regulacija v bolezenskih procesih

1. Introduction to molecular medicine 2. Genomics in clinical practice 3. Molecular approaches to drug discovery 4. Bioinformatics in molecular medicine 5. Gene regulation in disease states


1. Molecular Cell Biology; Darnell, Lodish and Baltimore (Scientific American Books, W.H. Freeman and Company). 2. Human Molecular Genetics 2. 2nd ed. Strachan, Tom and Read, Andrew P.Oxford, UK: BIOS Scientific Publishers Ltd; 1999 (available fee of charge on Pubmed under Bookshelf: http://www.ncbi.nlm.nih.gov/entrez/query)

Cilji: Objectives:

Spoznati najnovejše molekularne metode, ki se uporabljajo v klinični medicini.

Introduce modern molecular approaches to clinical medicine.



Znanje in razumevanje: Genomike, proteomike in genske regulacije.

Knowledge and Understanding: Genomics, proteomics and gene regulation.

http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=hmg.TOC&depth=1http://www.bios.co.uk/book.asp?isbn=1859962025http://www.bios.co.uk/book.asp?isbn=1859962025

Avgust, 2012

Prenesljive/ključne spretnosti in drugi atributi: Uporabnost molekularnih metod v raziskavah bolezenskih stanj.

Transferable/Key Skills and other attributes: Practical skills in molecular investigations of disease states.



Predavanja, problemsko usmerjeno poučevanje i laboratorijske vaje

Lectures, problem-based learning, seminars and laboratory exercises



Assessment:

Način (pisni izpit, ustno izpraševanje, naloge, projekt) Pisno

Type (examination, oral, coursework, project): Written exam


Predavalnica, računalnik Lecture Hall, computer

Obveznosti študentov:

Students’ commitments:


Pisni izpit, projekt Written exam, projects

Opomba: Vse sestavine opisa predmeta do vključno z načini ocenjevanja za izvedbo

predmeta so obvezna sestavina učnega načrta predmeta kot ga določajo Merila za akreditacijo visokošolskih zavodov in študijskih programov (Ul. RS, št. 101/2004) v 7. členu. Obveznosti študentov ne sodijo k sestavinam opisa predmeta, so pa obvezni del sestavin študijskih programov in zato priporočljiv del obrazca opisa predmetov. Vse nadaljnje sestavine opisa v ležeči pisavi niso obvezne.

Avgust, 2012




Predmet: GENETIKA

Subject Title: GENETICS



Letnik Year

Semester Semester


Genetika Genetics

1 1, 2


Predavanja


Sem. vaje Tutorial

Lab. vaje Lab. work



ECTS

20 40 15 225 10

Nosilec predmeta / Lecturer: Prof. dr. Nadja KOKALJ VOKAČ Prof. dr. Maja RUPNIK Prof. dr. Peter DOVČ Prof. dr. Damjan GLAVAČ

Jeziki / Languages:

Predavanja / Lecture: Slovenščina / Slovene, Angleščina / English

Vaje / Tutorial:


Prerequisites:



Vsebina:

Contents (Syllabus outline):

Vloga genetike v medicini. Struktura in vloga nukleinskih kislin. Geni in kromosomi. Organizacija človeškega genoma, projekt človeškega genoma. Kromosomska teorija dednosti. Medicinska citogenetika. Razširjena Mendlova analiza in osnove populacijske genetike. Razvoj molekularnih markerjev. Strategije genskega mapiranja pri evkariontih. Transkripcijsko uravnavanje genske ekspresije. RNA procesiranje. Mehanizmi zgodnje diferenciacije celic. Genomika. Proteomika. Genetika raka. Gensko zdravljenje. Nove genske tehnologije . Kloniranje.

The role of genetics in medicine Structure and role of nucleic acids Genes and chromosomes Organization of human genome, Human Genome Project Medical cytogenetics Chromosomal mechanisms of inheritance. Mendelian genetics, population genetics and genetic diversity Development of genetic markers. Strategy of gene mapping in eukaryotes. Regulation of gene expression with transcription, RNA processing. Mechanisms of early cell differentiation. Genomics Proteomics Cancer genetics Gene therapy New technologies in genetics. Cloning

Avgust, 2012

Genetika prokariontov: - mehanizmi medvrstnega prenosa genetske informacije (transpozoni, konjugacja, transformacija), - širjenje determinant rezistence in nastanek multirezistentnih bakterij, - kontrolni mehanizmi izražanja genov pri bakterijah, - vloga pri patogenezi (quorum sensing, uravnavanje na nivoju transkripcije in translacije, dvokomponentni sistemi, primeri evolucije uravnavanja virulenčnih dejavnikov kot prilagoditev na gostitelja).

Genetics of prokaryotes - Mechanisms of interspecies transfer of

genetic information (transposons, conjugation, transformation)

- Spreading of resistance and development of multiresistance bacteria

- Control mechanisms of gene expression in bacteria

- The role in pathogenesis (quorum sensing, regulation of transcription and translation, two-component systems, examples of evolutionary regulated virulent mechanisms as adaptation to the host).


1. Thompson & Thompson : Genetics in Medicine, Sixth Edition, W.B.Saunders Company, 2001. 2. Strachan T, Read AP: Human Molecular Genetics 2, BIOS Scientific Publishers Limited, 2000. 3. Winter P.C., Hickey G.I., Fletcher H.L.: Genetics, BIOS Scientific Publishers Limited, 2002. 4. Czepulowski B.: Analyzing Chromosomes, BIOS Scientific Publishers Limited, 2001. 5. Gelehrter T.D., Collins F.S., Ginsburg D.: Principles of Medical Genetics, 2nd ed. Baltimore, Lippincott Williams and Wilkins, 1998. 6. Lewin B: Genes VII, Oxford University Press, 2000. 7. Vogel, Motulsky: Human Genetics, Problems and Approaches, 3rd Ed, Springer,1997. 8. Cox T.M. and Sincler J.:Molecular Biology in Medicine. Blackwell Science, Oxford,1997

Cilji:

Objectives:

Premet ponuja študentu pregledna in nekatera poglobljena znanja o zgradbi, organizaciji ter delovanju prokariontskega in eukariontskega genoma. Študenta seznani z vlogo genetskih faktorjev pri vzrokih humanih bolezni ter prispevku pri multifaktorjalnih boleznih, s kompleksno analizo delovanja in prenosa genetske informacije ter dedovanjem. Poudarek predavanj je na aplikativni vlogi genetike v sodobnih medicinskih tehnikah, diagnostiki in genski terapiji.

The subject offers a review and some extensive knowledge of the structure, organization and action of the prokaryotic and eukaryotic genome. It will acquaint the student with the role of genetic factors in human diseases and with their contribution to multifactorial diseases, with a complex analysis of the action and transfer of genetic information and inheritance. The stress is on the applicative role of genetics in modern medical techniques, diagnosis and gene therapy.



Znanje in razumevanje: Študent si poglobi znanje o genetskih mehanizmih ter razširi poznavanje uporabe genetskih tehnologij v medicini in biotehnologiji. Praktična znanja pridobi pri individualnem delu ob izdelavi raziskovalnega (doktorskega) projekta v genetskem laboratoriju, kjer se seznani z osnovnimi tehnikami genetske analize.

Knowledge and Understanding: The student acquires knowledge of genetic mechanisms and a broader knowledge of the use of genetic technologies in medicine and biotechnology. He/she acquires practical knowledge in individual work in preparing a research (doctoral) project in the genetic lab, where he/she becomes acquainted with the basic techniques of genetic analysis.

Prenesljive/ključne spretnosti in drugi atributi: Ob izdelavi raziskovalnega (doktorskega) projekta se nauči uporabljati metode ter rezultate genetskih analiz v različne aplikativne namene na področju medicinske genetske diagnostike.

Transferable/Key Skills and other attributes: In preparing the research (doctoral) project the student learns to use the methods and results of genetic analyses for various applicative purposes in the field of medical genetic diagnosis.

Metode poučevanja in učenja: Teaching and learning methods:

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predavanja

seminarji

samostojno delo v laboratoriju pod mentorskim vodstvom ob izdelavi raziskovalnega (doktorskega) projekta

Lectures

Seminars

Independent work in the lab, preparation of a research (doctoral) project under the supervision of a mentor

Načini ocenjevanja: Delež (v %) / Weight (in %)

Assessment:

pisni izpit, seminarske naloge raziskovalni (doktorski) projekt

Type (examination, oral, coursework, project): Written examination Tutorial papers Research (doctoral) project

Materialni pogoji za izvedbo predmeta: Material conditions for subject realization:

Predavanja bodo potekala v predavalnicah Medicinske fakultete v Mariboru, laboratorijsko delo pa v Laboratoriju za medicinsko genetiko Splošne bolnišnice Maribor oz. drug ustrezen laboratorij.

Lectures will take place in the lecture rooms of the Maribor University Medical Faculty, lab work will be done at the Maribor Teaching Hospital Laboratory for Medical Genetics or another corresponding laboratory.

Obveznosti študentov:

Students’ commitments:


Pisni izpit Seminarska naloga Raziskovalni projekt

Written examination Tutorial papers Research (doctoral) project


predmeta so obvezna sestavina učnega načrta predmeta kot ga določajo Merila za akreditacijo visokošolskih zavodov in študijskih programov (Ul. RS, št. 101/2004) v 7. členu. Obveznosti študentov ne sodijo k sestavinam opisa predmeta, so pa obvezni del sestavin študijskih programov in zato priporočljiv del obrazca opisa predmetov. Vse nadaljnje sestavine opisa v ležeči pisavi niso obvezne.

Avgust, 2012




Predmet: FARMACEVTSKA BIOTEHNOLOGIJA

Subject Title: PHARMACEUTICAL BIOTECHNOLOGY



Letnik Year

Semester Semester


1 1, 2


Predavanja


Sem. vaje Tutorial

Lab. vaje Lab. work



ECTS

20 40 15 225 10

Nosilec predmeta / Lecturer: Prof. dr. Borut ŠTRUKELJ Prof. dr. Irena MLINARIČ RAŠČAN

Jeziki / Languages:

Predavanja / Lecture: Slovenski, angleški/ Slovene, English

Vaje / Tutorial: Slovenski, angleški/ Slovene, English


Prerequisites:




Tehnologija rekombinantne DNA Vektorji, gostitelji Najpomembnejši rekombinantni biofarmacevtiki Priprava in uporaba monoklonskih protiteles Biotransformacije Ugotavljanje kakovosti in učinkovitosti biofarmacevtikov Celične kulture in prioprava cepiv Sistemi vnosa genov v organizem, Gensko zdravljenje rakavih obolenj Gensko zdravljenje ostalih obolenj Etika in regulativa v medicinski biotehnologiji

Recombinant DNA technology Vectors, host organisms The most relevant recombinant biopharmaceutics Technology of monoclonal antibodies Biotransformations Quality and efficacy assesment of biopharmaceuticals Cell culture and vacccine manufacturing Gene delivery sistems Gene therapy of cancer Gene therapy Ethics and regulatory guidelines in medicinal biotechnology


1. Crommelin J.A., Sindelar R.D.: Pharmaceutical Biotechnology, second edition. Routledge-Taylor&Francis, London, New York, 2003 2. Hunt S.P., Livesey, F.J. : Functional Genomics. Oxford University Press, 2000. 3. Licinio J, Wong MA-Li: Pharmacogenomics. Wiley-VCH, germany, 2002. 4. Kayser O., Muller R.H.: Pharmazeutische biotechnologie WVmbg, Stuttgart, 2000

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Cilji: Objectives:

Snov predmeta, skupaj s seminarskimi vajami, omogoča podiplomskemu študentu pridobiti znanja molekularne biologije, molekularne genetike in predvsem razumevanje novih načinov terapij in tarč, ki izhajajao iz spoznavanja človeškega genoma. Prav tako predmet omogoča spoznavanje najpomembnejših kompleksnih zdravilnih učinkovin iz področja biofarmacevtikov.

The content of the subject is created together with the parallel seminar course, in order to expose the knowledge of molecular biology, molecular genetics and understanding of novel approaches to gene therapy, based on the human genome sequencing programme. Furthermore, the subject enables the student to be acquainted with the most important biopharmaceuticals.



Znanje in razumevanje: Z razumevanjem sestave in delovanja biofarmacevtikov in uporabe genske terapije se poveča praktično znanje o biofarmacevtikih, glavnih terapevtskih učinkih in razumevanje nastajanja neželjenih učinkov.

Knowledge and Understanding: By understanding of the composition and technology of biopharmaceutical drug production, and development and use of the gene therapy, students will expand their practical knowledge and understanding of therapeutical effects as well as of undesired side effects of biopharmaceuticals.

Prenesljive/ključne spretnosti in drugi atributi: Iskanje podatkov po svetovnih bazah podatkov, aplikacija v prakso (iskanje primerov)

Transferable/Key Skills and other attributes: Knowledge of database searching, application into practical work (case studies)



Predavanja, seminarske naloge, E-klepetalnice, samostojno delo

Lectures, tutorials, individual work, E-mail system conversations.



Assessment:

Način (pisni izpit, ustno izpraševanje, naloge, projekt) Pisni projekt Pisni in ustni izpit

Type (examination, oral, coursework, project): Written project Oral and written examination

Materialni pogoji za izvedbo predmeta: Material conditions for subject realization:

Predavalnica z računalnikom, internetna povezava

Lecture hall with the computer, Internet connection



Opravljen seminar Opravljen izpit

Course work with the written project Succesfull written and oral examination


predmeta so obvezna sestavina učnega načrta predmeta kot ga določajo Merila za akreditacijo visokošolskih zavodov in študijskih programov (Ul. RS, št. 101/2004) v 7. členu. Obveznosti študentov ne sodijo k sestavinam opisa predmeta, so pa obvezni del sestavin študijskih programov in zato priporočljiv del obrazca opisa predmetov. Vse nadaljnje sestavine opisa v ležeči pisavi niso obvezni.

Avgust, 2012




Predmet: Raziskovanje v klinični praksi

Subject Title: Research in Clinical Practice



Letnik Year

Semester Semester

Biomedicinska tehnologija Biomedical Technology

1 1 ali 2

Univerzitetna koda predmeta / University subject code:

Predavanja


Sem. Vaje Tutorial

Lab. Vaje Lab. Work

Teren. Vaje Field work

Samost. Delo Individ. Work

ECTS

20 40 15 225 10

Nosilec predmeta / Lecturer: Prof. dr. Ivan Krajnc

Sonosilec predmeta / Co-lecturer:

Jeziki / Languages:

Predavanja / Lecture: Slovenščina / Slovene

Vaje / Tutorial: Slovenščina / Slovene


Prerequisites:




Interdisciplinarni predmet »Raziskovanje v klinični praksi je razdeljen iz 10. sklopov: 1. Klinično preizkušanje zdravil – prof. dr. Jože Drinovec 2. Najnovejši diagnostični in terapevtski dosežki v dermatovenerologiji – doc. dr. Jovan Milojković 3. Evropska organizacija za raziskave in zdravljenje raka – prof. dr. Iztok Takač 4. Raziskave v kirurgiji – doc. dr. Vojko Flis 5. Sistemske vezivno-tkivne bolezni – prof. dr. Ivan Krajnc 6. Analiza slikovnih preiskav v klinični medicini – doc. dr. Marjan Skalicky 7. Epidemiološke metode – temeljno orodje v klinični medicini in javnemu zdravju – doc. dr. Ivan Eržen 8. Raziskovanje in metodologija proučevanja duševnih procesov – izred. prof. dr. Bojan Zalar 9. Statistika v medicini – prof. dr. Gorazd Lešnjak 10. Na dokazih temelječe delo v medicini – izred. prof. dr. Janko Kersnik

Interdisciplinary subject »Research in Clinical Practice« is divided into 10 sections: 1. Clinical medications/drug testing – Prof. Jože Drinovec 2. Most up to date diagnostic and therapeutic achievements in dermatovenerology – Assistant Prof. Jovan Milojković 3. European Organisation for Research and Cancer Treatment – Prof. Iztok Takač 4. Research in surgery – Assistant Prof. Vojko Flis 5. System connective-tissue diseases – Prof. Ivan Krajnc 6. Analyses of image examinations in clinical medicine – Assistant Prof. Marjan Skalicky 7. Epidemiological methods – basic tools in clinical medicine and health system – Assistant Prof. Ivan Eržen 8. Mental processes - research and methodology of investigating – Associate Prof. Bojan Zalar 9. Statistics in medicine – Prof. Gorazd Lešnjak 10. Evidence-based medicine – Associate Prof. Janko Kersnik

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1. Klinično preizkušanje zdravil Ko so končane raziskave na živalih, celicah in tkivih, je mogoče sklepati na učinkovitost in varnost nove učinkovine orientacijsko v bioloških sistemih. Pri kliničnem raziskovanju oz. preizkušanju zdravil so štiri faze, po tretji pride do registracije zdravila, četrta faza pa vključuje vse raziskave od tedaj naprej. Za registracijo zdravila je potrebna kemijska analiza zdravila, pri generičnih zdravilih pa klinične farmakokinetične raziskave. Smernice za klinično preizkušanje zdravil so zajete v principih dobre klinične prakse oz. mednarodnih konferenc za harmonizacijo. Partnerji v klinični raziskavi so: državni organ oz. ministrstvo za zdravje oz. urad za zdravila in etična komisija; raziskovalci, praviloma zdravniki, največkrat v univerzitetnih ustanovah; sponzor oz. plačnik raziskave, ki je lastnik rezultatov in odgovoren za nadzor. Tipi kliničnih raziskav so: odprta, enojno slepa, dvojno slepa, randomizirana, nerandomizirana, sekvencijska, raziskava v primerjavi s skupino placebo, raziskava z dvema ali več terapevtskimi skupinami, raziskave v enem ali v več centrih, raziskava z zgodovinsko kontrolno skupino, z majhnim številom preiskovancev ali velika klinična raziskava, metaanaliza. Statistična obdelava rezultatov v kliničnih raziskavah z zdravili. Hranjenje rezultatov kliničnih raziskav. Publiciranje kliničnih raziskav. 2. Najnovejši diagnostični in terapevtski dosežki v dermatovenerologiji

dermatoimunihistopatološka diagnostika v dermatologiji;

diagnostični postopki in zdravljenje spolno prenosljivih okužb;

diagnostika in zdravljenje kožnih oblik Lymske bolezni;

sodobna diagnostika genodermatoz;

fototerapija;

biološka zdravila v dermatologiji.

3. Evropska organizacija za raziskave in zdravljenje raka Evropska organizacija za raziskave in zdravljenje raka (EORTC) je mednarodna raziskovalna organizacija s sedežem v Bruslju, ki je bila ustanovljena leta 1962. Namenjena je napredku multidisciplinarnih raziskav na področju raka in je povezana z vodilnimi raziskovalnimi ustanovami, ki delujejo na področju biomedicine. V ta namen razvija, izvaja, koordinira in vzpodbuja eksperimentalne in klinične raziskave raka v

1. Clinical drug testing When researches on animals, cells and tissues had been finished, it is possible to come to conclusion about safety and efficiency of new substance to biological systems. In clinical research, or testing of drugs there are four phases, after the third, a drug can be registered; the fourth phase includes all researches after this point. For registration of the drug, chemical analysis of the drug is needed, and for generic drugs clinical pharmacokinetics researches are needed. Directions for clinical drug testing are included in the principles of good clinical practice, i.e. international conferences on harmonisation. Partners in clinical practice are: public institution or Ministry for Health, Office for Drugs or Ethical Commission, researchers, usually doctors, most often at university institutions, sponsor or financier of the research who is owner of the results and responsible for supervision. Types of clinical researches are: open, single-blind, double-blind, randomized, nonrandomized, sequential, research in comparison with placebo group, research with two or more therapeutic groups, research in one or more centres, research with control group from the past, with small group of patients or extensive clinical research, meta-analysis. Stastical analysis of results in clinical drug researches. Clinical researches results keeping. Publicising of clinical researches. 2. The newest diagnostic and therapeutic achievements in dermatovenerology

dermato-imunohistopatological diagnostic in dermatology,

diagnostic procedures and treatment of sexually transmissive infections,

diagnostic and treatment of dermatological forms of Lyam disease,

modern diagnostic of genodermatoses,

phototherapy,

biologic drugs in dermatology.

3. European Organisation for Research and Treatment of cancer European Organisation for Research and Treatment of Cancer (EORTC), with headquarters in Brussels, was founded in the year 1962. Its goal is making headway with multidisciplinary researches in the field of cancer. It is linked with leading researching institution in the field of biomedicine. For this purpose it develops, carries out and stimulates experimental and clinical researches on cancer in Europe. Final goal of EORTC is to improve standards of cancer treatment using new drugs and innovative

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Evropi. Končni cilj EORTC je, s pomočjo razvoja novih zdravil in drugih inovativnih postopkov, preskušanja bolj učinkovitih načinov zdravljenja, kirurgije in obsevanja, izboljšati standarde zdravljenja raka v Evropi. V ta namen povezuje v omrežje številne znanstvenike, klinike in ustanove, ki organizirajo laboratorijske in klinične raziskave vseh vrst rakov. 4. Raziskave v kirurgiji Znanstveno-raziskovalna dejavnost v kirurgiji je postavila temelj sodobne kirurgije. Sodobna kirurgija temelji na izsledkih številnih vej naravoslovnih znanosti in je z njimi tesno prepletena. Po zadnjih petletnih izsledkih Angleške kraljeve kirurške šole in Evropske akademije za kirurške raziskave poteka okoli ¾ raziskav iz področja kirurgije na posameznih temeljnih področjih sodobne biomedicine (molekularna genetika, biologija celice, tkivni inženiring, biomateriali, ipd), četrtina projektov pa je povezana s kliničnim raziskovanjem. Cilji evropske akademije za raziskave na področju kirurgije so:

Prispevati k izboljšanju medicinske oskrbe bolnika in njegove rehabilitacije.

Razčlenjevati, razvijati in uvajati nove in sodobne kirurške postopke.

Spoznavati temeljne vzroke kirurških bolezni in njihovo zdravljenje.

Spodbujati vseživljenjsko učenje kirurških veščin in klinične kirurgije ter razumevanje raziskovalnih metodologij

Temeljni kurikularni moduli uvajanja v področje kirurških raziskav so:

Etični koncepti v sodobni klinični in eksperimentalni kirurgiji

Temeljni znanstveno-filozofski koncepti kirurškega raziskovanja

Temeljne metodologije

Klinične randomizirane raziskave v kirurgiji

Virtualni koncepti v kirurgiji

Biotehnološki koncepti v kirurgiji

Eksperimentalna kirurgija

Umetni organi v kirurgiji

Računalniško modeliranje

Molekularna biologija, genetika v kirurgiji in izvorne celice

Tkivni inženiring

Pedagoška metodologija učenja kirurških veščin

Moduli so usklajeni s kurikularno shemo Evropske akademije za kirurške raziskave. 5. Sistemske vezivno-tkivne bolezni Sinonimi za te bolezni so tudi:

mezenhimopatije,

oziroma difuzno-vezivno-tkivne bolezni,

procedures, testing of efficient way of treatments, surgery and radiation. For this purpose, organisation is trying to create a net of scientists, clinics and institutions involved into laboratory and clinical researches of all kinds of cancers. 4. Researches in surgery Scientific research activity in surgery established basis of modern surgery. Modern surgery is founded on the results of the numerous branches of science and is tightly interweaving with them. According to the five-year results of the English Royal Surgeon School and European Academy for Surgeon Researches, about ¾ of the researches in the field of surgery are carried out in the basic fields of modern biomedicine (molecular genetic, biology of cell, tissue engineering, biomaterials etc), ¼ of the projects are linked with clinical research. Aims of the European Academy for Researches in Surgery are:

to contribute to improvement of the medical care and patient's rehabilitation.

to analyse, develop and introduce new and modern surgical procedures.

to find out the basic causes of the surgical diseases and their treatments.

to stimulate lifelong learning of surgical skills and clinical surgery, understanding of researching methodologies.

Basic curricular introductory modules into the surgical researches are:

Ethical concepts in modern clinical and experimental surgery

Basic scientific-philosophic concepts of surgery research

Fundamental methodologies

Clinical randomised researches in surgery

Virtual concepts in surgery

Biotechnological concepts in surgery

Experimental surgery

Artificial organs in surgery

Computerised modelling

Molecular biology, genetics in surgery and original cells

Tissue engineering

Pedagogical methodology of learning about surgical skills

Modules are in concordance with curricular scheme of the European Academy of Surgical Research. 5. System connective-tissue diseases Synonyms for these diseases are also:

mesenhympathies,

or diffuse-connective-tissue diseases.

Avgust, 2012

Sem prištevamo sistemski lupus eritematozus, druge oblike lupusnega sindroma, sjögrenov sindrom, sistemsko sklerozo, polimiozitis, dermatomiozitis, prekrivajoči se sindrom. Te bolezni so po kliničnih in laboratorijskih značilnostih zelo podobne, ob enem pa dovolj različne, da jih lahko ločimo med seboj. Skupne značilnosti so:

avtoimunska patogeneza,

prisotnost genov HLA-DR lokusa. Prizadenejo lahko različne organe, značilna in specifična so serumska avtoprotitelesa, nekatere bolezni so tudi posledica vpliva raznih zdravil. 6. Analiza slikovnih preiskav v klinični medicini Poudarek je na bolniku in raziskovalcu prijaznih metodah, kar je tudi v skladu z navodilom Etične komisije, vsekakor pa se ne bo mogoče v poglobljenem delu izogniti obremenilnih preiskav in preiskav, ki imajo določen riziko, tako za bolnika, kot za raziskovalca. Osnovna slikovna prijazna preiskava je dokazano ultrazvočna analiza z uporabo kontrastov. V našem terciarnem programu klinične medicine je tudi endoskopski ultrazvok, tako s kontrasti, kot možnostjo pridobitve cisto - histo materiala, kakor tudi aplikaciji določenih kemičnih in drugih bioloških agensov v izbrano tarčo. Komplementarno bi vsekakor bila tudi vključena v raziskovalne namene kompjuterizirana tomografija, dodana s pozistronsko emisijsko tomografijo (PETCT), ki pogosto v predlagani klinični praksi dopolni znanstveno raziskovanje in objektivno analizira rezultate. Posebno področje bi bilo namenjeno magnetnoresonančni analizi, med drugim tudi uporaba določenih predproceduralnih in poproceduralnih računalniških dodelav. Prav tako se prišteva k slikovnim preiskavam izvide nuklearno medicinskih pregledov. Vse te standardne slikovne metode bi dopolnil s slikovno arhivo endoskopskih preiskav. Aktivnosti na področju video konferenc v raziskovalne namene klinične prakse - postaviti mesto in težo aktivnostim na nivoju video konferenc. 7. Epidemiološke metode – temeljno orodje v klinični medicini in javnemu zdravju V okviru tega sklopa bo predstavljena epidemiologija kot temeljna znanost ki omogoča opis, in kvantifikacijo določenih zdravstvenih problemov ter proučevanje vzrokov za pojav le teh. V okviru predmeta se bodo študenti seznanili s temeljnimi epidemiološkimi metodami in postopki. Predstavljeni bodo principi in namen posameznih epidemioloških študij ter možnosti in omejitve teh študij ter tipične vrste študij v okviru

Here belong System Lupus Erythematosus, other forms of lupus syndrome, Sjögren syndrome, systemic sclerosis, polymyositis, dermatomiositis, and overlapping syndrome. These diseases are similar according to their clinical and laboratory features, but at the same time enough different to be distinguished. Common characteristics are:

autoimmune pathogenesis,

presence of the HLA -DR locus genes. Diseases can affect different organs, one of the features is presence of specific serum auto antibodies, and some diseases are also consequences of the influence of different medications. 6. Analysis of the images in the clinical medicine Accent is on the patient – researcher friendly methods, in concordance with the instructions issued by the Ethical Commission. However, it will not be possible to avoid overwhelming researching and a research involving risk for the patient and a researcher. It has been proved that the only patient-friendly image examination is ultrasound analysis using contrasts. Our tertiary program of clinical medicine deals with usage of endoscopic ultrasound using contrast as possibilities of gaining cysto-hysto material, and applications of specific chemical and other biological agenses into chosen target. Complementarily, computerised tomography plus positron emission tomography ((PETCT) are often suggested in clinical practice to supplement scientific research and objective result analyses. Special field is dedicated to magnet resonance analyses, and other pre procedural and post procedural computerised analyses. Images are also nuclear medical examinations. All this standard image methodes are supplemented with archived endoscopic examination images. Activities in the field of video conferences for clinical practice research purposes – activities should gain their proper weight at the level of video conferences. 7. Epidemiological methods – basic tool in clinical medicine in public health system Within this frame, epidemiology as basic science which enables description, quantification of certain health problems and research of their causes will be presented. Students will introduce basic epidemiological methods and procedures. Principles and purposes of the epidemiological studies, abilities and limitations of these studies, and typical kinds of studies within descriptive and analytical epidemiology. Special accent will be put

Avgust, 2012

deskriptivne in analitične epidemiologije. Poseben poudarek bo namenjen naslednjim področjem:

merjenje pojavov v epidemiologiji;

merjenje in mere pogostosti pojavov;

mere povezanosti med pojavi;

mere potencialnega učinka pojavov na zdravje ljudi;

interpretacija rezultatov epidemioloških raziskav;

potek epidemioloških raziskav;

orodja za epidemiološko raziskovanje;

etični vidiki epidemiološkega raziskovanja. 8. Raziskovanje in metodologija proučevanja duševnih procesov Raziskovalne strategije:

- študije posameznih primerov (osnovna vrednost, ponovljive meritve, spremenljivost variable v časovnem obdobju, model A-B-B-A, interakcijski model, evalvacija nespremenljivih procedur, ocena psihofarmakološkega efekta)

- primerjava skupin v psihiatričnem raziskovanju (primerljivost skupin pri eksperimentalnih in neeksperimentalnih študijah, družinske študije)

- korelacijski pristop (korelacija in vzročnost, psihometrika, reliabilnost presoje, epidemiologija)

Ocenjevalne metode: - strukturirani in nestrukturirani vprašalniki

(intervju, SCID [strukturirani klinični intervju za DSM – IV], CIDI [sestavljeni mednarodni diagnostični intervju [WHO]], CBCL [Child behaviour checklist])

- fiziološko in vedenjsko ocenjevanje (periferne psihofiziološke meritve, opazovanje vedenja, ocenjevanje vedenja / kognitivni procesi)

- biološki markerji - domnevni markerji afektivnih

bolezni: neuroendokrine ugotovitve, monoamini in njihovi metaboliti v telesnih tekočinah, periferni modeli aktivnosti centralnega živčnega sistema, študije spanja

- domnevni markerji za shizofrenijo: študije cerebrospinalnih tekočin, aktivnost MAO

- domnevni markerji za anksioznost - domnevni markerji za alkoholizem

Epidemiološko raziskovanje duševnih motenj (prevalenca, klasifikacija, vzorčenje)

on the following fields:

measurement of the phenomena in epidemiology;

measurement and incidence measures of the phenomena,

measurements of the association /linkage of the phenomenon,

measurement of the potential effect of the phenomena on the people's health,

interpretation of the results of the epidemiological research,

course of the epidemiological researches,

tools for epidemiological researches,

ethical aspects of epidemiological research. 8. Research and methodology of mental processes researching Researching strategies:

- case studies (basic value, repeated measurements, interval variable, model A-B-B-A, interactive model, evaluation of invariable procedures, assessments of the psychopharmacological effect)

- comparison of groups in psychiatric research (comparability of groups in experimental and nonexsperimental studies, family studies)

- correlation approach (correlation and causality, psychometric, reliability of judgement, epidemiology).

Assessment methods: - Structured and nonstructured

questionnaires (interviews, SCID [structured clinical interview for DSM – IV], CIDI [composed international diagnostic interview [WHO]], CBCL [Child behaviour checklist])

- Physiological and behavioural assessment (peripheral psycho physiological measurements, behaviour monitoring, assessment of behaviour / cognitive process)

- Biological markers - presumed markers for the affective

diseases: neuroendokrin findings, monoamines and their metabolites in body liquids, peripheral models of the activities of the central nervous system, studies about sleep

- presumed markers for schizophrenia: studies about cerebrospinal liquids, activities MAO

- presumed markers for anxiety - presumed markers for alcoholism.

Epidemiologic research of mental disturbances (prevalence, classification, sampling) Psychopharmacology research (animal models,

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Psihofarmakološko raziskovanje (živalski modeli, proučevanja na relaciji zdravilo: placebo, proučevanja na relaciji zdravilo: zdravilo, multicentrične študije) Raziskovanje na področju psihoterapije Raziskovanje na področju vedenjske medicine

- kardiovaskularne motnje - psihološki dejavniki pri raku - kronične respiratorne težave - bolečinski sindromi)

Raziskovanje specialnih populacij:

- starostniki - otroci

9. Statistika v medicini Uporabnost in pasti uporabe statistike. Osnovno o multivariatnih statističnih metodah. Soodvisne in prikrite spremenljivke. 10. Na dokazih temelječe delo v medicini Na dokazih temelječe delo v medicini predstavlja pomembno spremembo v načinu dela, učenja, poučevanja in raziskovanja zdravnikov. Opredeljeno je kot uporaba trenutno razpoložljivih najboljših dokazov v odločanju o oskrbi posameznih bolnikov. Dokaz sam po sebi ni dovolj za kakovostno oskrbo bolnika. Poudarjeno je, da prakticiranje na dokazih temelječe medicine zahteva njeno povezavo s kliničnim strokovnim znanjem, kar vključuje naslednje pomembne elemente: − strokovno jemanje anamneze in izvedbo

telesnega pregleda; − poznavanje bolnika, družine in skupnosti, kar

omogoča odločanje o zdravljenju v kontekstu bolnika;

− odnos z bolnikom, ki upošteva njegove predstave in vrednote;

− praktično znanje o dostopnosti virov v skupnosti.

Brez kliničnega strokovnega znanja, postane delo v praksi tiranizirano z zunanjimi dokazi, kajti še tako odlični zunanji dokazi so lahko povsem neprimerni za določenega bolnika. In brez trenutno najboljših zunanjih dokazov, postane delo v praksi hitro zastarelo in v škodo bolnikov.

research on the relation drug : placebo, drug : drug, multicentric study) Research in psychotherapy Research in the behavioural medicine

- cardiovascular disorders - psychological factors in cancer - chronic and respiratory difficulties - pain syndromes)

Research in special populations:

- the elderly - children

9. Statistics in medicine Applicability and pitfalls of the use of statistics. Basics of multivariate statistic methods. Dependent and hidden variables 10. Evidence-based medicine work Evidence based work in medicine is an important change in the doctor's way of work, learning, teaching and researching. It is defined as use of momentarily available best evidences in patient's health care decision making. Evidence by itself is not sufficient for patient’s quality health care. It is pointed out that practicing of evidence based medicine demands liaison with clinical professional knowledge, taking into consideration important elements, as follows: professional history taking and physical examination; − information about patient, family and

community, treatment of the patient in patient's context.

− relationship with patient, considering their believes and values;

− practical knowledge about availability of supportive sources in the community.

Without clinical professional knowledge, practice becomes tyrannised by external evidences, but even excellent external evidences can be totally inadequate for particular patient. However, without momentarily best external evidences, work in practice soon becomes out of date and harmful to the patient.


1. Klinično preizkušanje zdravil

Zakon o zdravilih. Ur List RS št. 31, 24.3.2006.

Bennett PN, Brown MJ. Clinical pharmacology. Ninth ed.London: Clirchill Livinstone, 2003.

Gallin JI. Principles and practice of clinical research. Amsterdam: Academic Press, 2002.

Brunton LL, Lazo JS, Parker KL. Goodman & Gilman's The pharmacological basis of therapeutics. 19th ed. New York: McGraw-Hill, 2006.

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2. Najnovejši diagnostični in terapevtski dosežki v dermatovenerologiji

Dermatology, Braun-Falco O et al. 3rd ed., Springer 2005

Rook' s Textbook of dermatology, 7th ed. Blackwell Publishing company 2004

Philip H McKee, Eduardo Calonje anf Scott R Granter. Pathology og the skin, Elsevier Mosby 2006

Human Molecular Genetics 2. 2nd ed. Tom Strachan & Andrew P. Read.Oxford, UK BIOS Scientific Publishers Ltd

Human genetics: problems and approaches, 3rd ed. F.Vogel, A.G.Motulski. Springer 1997

Jean L. Bolognia, e tal. Dermatology, 3rd ed. St. Louis, Mosby 2003 3. Evropska organizacija za raziskave in zdravljenje raka

EORTC Investigator's handbook. Brussels, EORTC: 2002. 4. Raziskave v kirurgiji

O'Leary JP, Tabuencal A. The Physiologic Basis of Surgery. Lippincott Williams & Wilkins, 4 edition. 2007.

Jeppson B eds. Animal Modelling in Surgical Research. Taylor & Francis, 1 edition,1997.

Haves WA. Principles and Methods of Toxicology. CRC; 4 edition ,2001.

Krinke GJ, Bullock GR, Bunton T. The Laboratory Rat (Handbook of Experimental Animals). Academic Press; 1st edition, 2000.

5. Sistemske vezivno-tkivne bolezni

Ruddy S, Harris ED, Sledge CB, Budd RC, Sergent JS, editors. Kelleyś textbook of rheumatology. 6th ed. Philadelphia, New York, London, St. Louis, Sidney, Toronto: W B Saunders Company; 2001: 1145-52

Ronald A. Asherson, Ricard Cervera, Jean-Charles Piette, Yehuda Shoenfeld, editors. The Antiphospholipid Syndrome II – Autoimmune Thrombosis. Amsterdam: Elsevider; 2002.

Kocijančič A, Mrevlje F, Štajer D. Interna medicina. Ljubljana, 2005. 6. Analiza slikovnih preiskav v klinični medicini

Wilfred M Weinstein, Cj Hawkey, Jaime Bosch: Clinical Gastroenterology and hepatology, , 2005.

Eckhart G. Hahn, Jürgen F. Inische Gastroenterologie in 2 Bäden, auflage 1996

Mark Feldman, Lawrence S. Fridman, Lawrence J. Brandt: Gastrointestinal and Liver Disease, 2006

Robert H. Hawes, Paul Fockens: Endosonography, 2006, Elsevier Inc. All rights reserved. 7. Epidemiološke metode – temeljno orodje v klinični medicini in javnemu zdravju

Premik M. Uvod epidemiologijo. Ljubljana: Medicinska fakulteta, Inštitut za socialno medicino, 1998.

Zaletel-Kragelj L, Eržen I, Premik M. Uvod v javno zdravje. Ljubljana: Medicinska fakulteta UL, 2007.

Brownson RC, Baker EA, Leet T, Gillespie KN. Evidence based public health. Oxford, New York: Oxford University Press, 2003.

Izbrana poglavja iz učbenika: Detels R, McEwen J, Beaglehole R, Tanaka H, eds. Oxford textbook of public health. Oxford: Oxford University Press, 2002.

R. Beaglehole, R. Bonita, T. Kjelldstrom Basic Epidemiology. World Health Organisation (WHO). 1994

Greenberg, R.S. Daniels, F.W. Flanders, J.W. Eley, J.R. Boring: Medica1 Epidemiology, Appleton&Lange, East Norwalk, 1993.

Lilienfeld AM, Lilienfeld ED. Foundations of Epidemiogy, Oxford, New York: Oxford University Press, 1980.

8. Raziskovanje in metodologija proučevanja duševnih procesov

Chris Freeman. Resarch methods in Psychiatry. Gaskell; 3 Rev Ed; 2006.

Jon S. Bailey, Mary R. Burch. Research Methods in Applied Behavior Analysis. Sage Publications, 2002.

Alac C. Repp, Robert Horner. Functional Analysis of Problem Behavior: From Effective Assessment to Effective Support (The Wadsworth Special Educator Series). Wadsworth Publishing; 1 edition,1999.

http://www.amazon.com/exec/obidos/search-handle-url/103-1289169-9143801?%5Fencoding=UTF8&search-type=ss&index=books&field-author=J.%20Patrick%20O%27Leary

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Robert Sommer, Barbara Sommer. A Practical Guide to Behavioral Research: Tools and Techniques. Oxford University Press, USA; 5 edition , 2001

Jonathon Green. Research and Innovation on the Road to Modern Child Psychiatry. Gaskell, 2001).

Robert G. Hadley, Lynda K. Mitchell. Counseling Research and Program Evaluation. Wadsworth Publishing; 1 edition , 1994.

Alan E. Kazdin. Single-Case Research Designs: Methods for Clinical and Applied Settings. Oxford University Press; 1982.

9. Statistika v medicini

Kirkwood B. R., Sterne J. A. C., Essential medical statistics. Blackwell, Oxford 2003 (2nd ed.). Riffenburgh R. H., Statistics in medicine. Elsevier, London 2006 (2nd ed.).

Ramsey F. L., Schafer D. W., The statistical sleuth (a course in methods of data analysis). Thomson, London 1997

10. Na dokazih temelječe delo v medicini

Kersnik J, (ur.). Znanstveno utemeljena medicina, (Zbirka PiP). Ljubljana: Združenje zdravnikov družinske medicine, Slovensko zdravniško društvo, 2000.

Kersnik J. Osnove družinske medicine. Maribor: Medicinska fakulteta 2007: 249-60.

Kersnik J. Kakovost v splošni medicini, (Zbirka PiP). 1. natis. Ljubljana: Sekcija za splošno medicino SZD, 1998: 3-34. (http://www.drmed.org/strok/ssi/kakovost/kakovost.htm)

Cilji:

Objectives:

1. Klinično preizkušanje zdravil Udeleženci bodo sposobni razumevati rezultate drugih raziskovalcev kliničnih študij z zdravili, sodelovati aktivno pri kliničnih raziskavah in pripraviti načrt manjše raziskave v enem centru, vključno z izdelavo poročila in statistične obdelave. 2. Najnovejši diagnostični in terapevtski dosežki v dermatovenerologiji Podrobno poznavanje sodobnih postopkov v diagnostiki nekaterih kožnih bolezni ter novejših možnosti zdravljenja teh bolezni. 3. Evropska organizacija za raziskave in zdravljenje raka Osvojiti znanje o strukturi in delovanju EORTC na področju laboratorijskih in kliničnih raziskav. 4. Raziskave v kirurgiji Seznanitev s temeljnimi znanstveno-filozofskimi koncepti kirurškega raziskovanja, seznanitev s temeljnimi metodologijami, izdelava projektne naloge na enem izmed raziskovalnih področij sodobne kirurgije. 5. Sistemske vezivno-tkivne bolezni Podrobno poznavanje vrste sistemskih vezivno-tkivnih bolezni, tako klinično sliko kot laboratorijske specifične znake. 6. Analiza slikovnih preiskav v klinični medicini Seznanitev slušateljev s pristopi in problemi pri

1. Clinical drug testing Participants will be able to understand results of the other clinical studies on drugs take active part in clinical research and prepare plan for the smaller research in one centre, including report and statistical analysis. 2. Latest diagnostic and therapeutical achievements in dermatovenerology Thorough knowledge about modern procedures in diagnostic of some skin diseases and advanced possibilities of their treatments. 3. European Organisation for Researches and Cancer Treatment Knowledge about structure and functioning of EORTC in the field of laboratory and clinical research. 4. Researches in surgery Basic scientific-philosophic concepts of surgery research, learning about basic methodologies, carrying out project in one of the modern surgery research fields. 5. System connective- tissue diseases In detail knowledge about kinds of the system connective tissue diseases, clinical picture and laboratory specific signs. 6. Analysis of images in clinical medicine Approaches and problems in data collecting for

http://www.amazon.com/exec/obidos/search-handle-url/105-8552081-5574816?%5Fencoding=UTF8&search-type=ss&index=books&field-author=Jonathon%20Greenhttp://www.drmed.org/strok/ssi/kakovost/kakovost.htm

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pridobivanju podatkov za razlago slikovnih raziskav, spoznavanje osnovnih značilnosti posameznih vrst slikovnih raziskav in analiz, seznanitev z veliko obremenjenostjo ponavljanja slikovnih analiz v Sloveniji – njihovo dupliciranje. Slušatelji bodo usposobljeni za pridobivanje različnih slikovnih gradiv in dokumentov po medmrežju medicinskega depoja varovanega z ključnimi vstopnimi kodami. Nadaljevanje slikovnih metod vsebuje tudi diferencialno analizo uspešnosti različnih diagnostičnih postopkov in posledičnih terapevtskih zaključkov. 7. Epidemiološke metode – temeljno orodje v klinični medicini in javnemu zdravju Seznanitev slušateljev s pristopi in problemi pri pridobivanju podatkov za epidemiološke raziskave, spoznavanje osnovnih značilnosti posameznih vrst epidemioloških raziskav, seznanitev z velikimi javno zdravstvenimi problemi v Sloveniji. Poleg tega bodo slušatelji usposobljeni za uporabo različnih meril za oceno teže posameznih bolezni ter analizo uspešnosti različnih diagnostičnih in terapevtskih metod. 8. Raziskovanje in metodologija proučevanja duševnih procesov Spoznavati merske procese na področju duševnosti in posebnosti merjenja duševnih aktivnosti (strukturirani in nestrukturirani parametri). Specifičnost metodoloških pristopov pri duševnih procesih. 9. Statistika v medicini Jasna predstava o možnostih uporabe sodobnih statističnih metod pri raziskovanju v medicini in širše. 10. Na dokazih temelječe delo v medicini − poznati koncept, vlogo in merila na dokazih

temelječe medicine − znati oceniti kakovost strokovne literature

explanation of images, essential characteristics of specific kinds of images and analyse, information on providing too many doubled /repeated images in Slovenia. Listeners will be enabled to gain different material, images and documents on the Intranet from the medical depot, which is protected by the key entrance codes. Continuation of the image interpretative methods contains also differential analyse of the efficiency of the different diagnostic procedures and final therapeutic results. 7. Epidemiological methods – basic tool in clinical medicine and public health system Approaches and problems of data gaining for epidemiological research, basic characteristics of some epidemiological researches. Information about large public health problems in Slovenia. Attendants become competent to use different measures/criteria for assessment of the severity of some disease and to carry out outcome analysis of different diagnostic and therapeutic methods. 8. Research and methodology of mental processes investigation Measurement of mental processes and activities and their specificities (structural and non structural parameters.) Specificity of methodological approaches in mental processes. 9. Statistic in medicine Possibilities of application of modern statistical methods in medical research and wider. 10. Evidence-based work in medicine − learning about concepts, role and measures of

the evidence based medicine − assessment of the professional literature quality



Znanje in razumevanje: 1. Klinično preizkušanje zdravil Znanje: Prijava raziskave etični komisiji, izdelava protokola manjše klinične raziskave, izdelava poročila in priprava ekspertnega mnenja. Razumevanje: Razumevanje metaanalize, kompleksnih raziskav z zdravili in kompleksnejših statističnih prikazov. 2. Najnovejši diagnostični in terapevtski dosežki v dermatovenerologiji

Lažje razumevanje patofizioloških procesov pojava nekaterih kožnih bolezni.

Sodobne možnosti zdravljenja nekaterih

Knowledge and Understanding: 1. Clinical drug testing Knowledge: Application of the research to Ethical Commission, smaller clinical research protocol, report and preparation of the expert opinion. Met analyse, complex research with drugs and more complex statistics account. 2. Up to date diagnostic and therapeutic achievements in dermatovenerology

understanding of patophysiological processes in some skin diseases,

modern possibilities of treatment of some skin diseases and understanding of the

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kožnih bolezni in razumevanje mehanizmov zdravljenja.

3. Evropska organizacija za raziskave in zdravljenje raka Osnovno znanje in razumevanje poslanstva EORTC in principov laboratorijskih in kliničnih raziskav na področju raka. 4. Raziskave v kirurgiji Praktično in teoretično znanje za samostojno raziskovalno delo. 5. Sistemske vezivno-tkivne bolezni Znanje patofiziologije avtoimunskih procesov pri vnetnih obolenjih. 6. Analiza slikovnih preiskav v klinični medicini je v znanstveno-raziskovalnem smislu ena osnovnih kliničnih dokumentiranih, primerljivih in analitskih metod, ki bodo kandidate v podiplomskem raziskovanju utemeljeno utrdile v njihovih hipotezah oz. predvidenih rezultatih raziskav. 7. Epidemiološke metode – temeljno orodje v klinični medicini in javnemu zdravju Slušatelji poznajo in razumejo pristope in probleme pri pridobivanju podatkov za epidemiološke raziskave, osnovne značilnosti posameznih vrst epidemioloških raziskav, poznajo pristope, probleme in rešitve pri ocenjevanju pomena posameznih postopkov na področju diagnosticiranja in zdravljenja posameznih bolezni ali stanj. 8. Raziskovanje in metodologija proučevanja duševnih procesov Pridobljeno znanje bo vplivalo na razumevanje duševnih procesov, kandidati bodo spoznali drugačnost in specifičnost mentalnih parametrov, ter se naučili obvladovati variable, ki v laični populaciji predstavljajo relativne entitete. Spoznali bodo, da je na področju duševnosti zelo kompleksna in eksaktna metodologija proučevanja zaradi specifičnosti narave variabel. 9. Statistika v medicini Poznavanje osnovnih multivariatnih metod. 10. Na dokazih temelječe delo v medicini Znanje o teoriji na dokazih temelječe medicine in merilih za izbiro kakovostne medicinske literature.

treatment mechanisms. 3. European Organisation for Researches and Cancer Treatment Elementary knowledge and understanding of the EORTC and principals of the laboratory and clinical research in the field of cancer. 4. Researches in surgery Practical and theoretical knowledge for independent research work. 5. System connective-tissue diseases Pathophysiology of autoimmune processes in inflammatory diseases. 6. Image analysis in clinical medicine From the point of scientific research this is one of the elementary clinical document based, comparative and analytical methods, which will enable candidates to become competent in examination results. 7. Epidemiological methods – elemental tool in clinical medicine and public health Attendants get to know and understand procedures and problems of epidemiological research data collecting, basic features of some epidemiologic researches, understand approaches, problems and solutions of assessment of the meaning of the procedures in the field of diagnostic and treatment of some diseases and states. 8. Investigation and methodology of mental processes research Acquired knowledge will influence on mental processes understanding and specificity of mental parameters, competences with variables, in laymen presented as relative entities. Students will recognise that specificity of the variables in the field of mental health makes research methodology very complex and exact. 9. Statistics in medicine Knowledge about elementary multivariate methods. 10. Evidence-based work in medicine Knowledge on theory evidence-based medicine and criteria for quality literature choice in medicine.

Prenesljive/ključne spretnosti in drugi atributi: 1. Klinično preizkušanje zdravil Sposobnost ocenjevati kakovost, ustreznost in novosti pri kliničnih raziskavah z zdravili.

Transferable/Key Skills and other attributes: 1. Clinical testing of drugs Quality assessment ability in adequacy and novelties in clinical drug researches.

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2. Najnovejši diagnostični in terapevtski dosežki v dermatovenerologiji Evalvacija pridobljenih rezultatov, njihova korelacija s klinično sliko ter pomen teh pri zdravljenju. 3. Evropska organizacija za raziskave in zdravljenje raka Poznavanje pomena EORTC pri izvajanju raziskav na področju zdravljenja raka. 4. Raziskave v kirurgiji Praktično znanje za vodenje raziskav. 5. Sistemske vezivno-tkivne bolezni Analiza in evalvacija testov, s pomočjo katerih ocenjujemo avtoimunska dogajanja. 6. Analiza slikovnih preiskav v klinični medicini Študentje lahko s pridom direktno sodelujejo v proučevanju različnosti posameznih slikovnih algoritmov značilnih za posamezne bolezenske sindrome in analizirajo uspešnost obvladovanja posameznih bolezni na analizi najbolj povednih slikovnih metod. Pridobljeno znanje je lahko aplicirano tudi za ocenitev učinkovitega zdravljenja. Nadaljnja analiza omogoča tudi možnost diferenciranja korektnosti in strokovne zanesljivosti posameznim nosilcev slikovnih diagnostično terapevtskih metod. 7. Epidemiološke metode – temeljno orodje v klinični medicini in javnemu zdravju Slušatelji lahko s pridobljenim znanjem sodelujejo pri proučevanju razširjenost zdravstvenih problemov kot tudi pri analizi uspešnosti obvladovanja posameznih bolezni in stanj ter pri ocenjevanju učinkovitost zdravljenja. Pridobljeno znanje lahko uporabijo pri zagotavljanju kakovosti posameznih procesov dela. 8. Raziskovanje in metodologija proučevanja duševnih procesov Poznavanje raziskovanja na področju duševnosti pripomore pri vsakršnem proučevanju drugih problemov, ko se pojavijo manj enoznačni, latentni ali manj razumljivi pojavi. Duševnost se v marsičem prepleta s telesnim, poznavanje raziskovanja na področju duševnosti pa poleg poznavanja raziskovanja na področju drugih medicinskih strok omogoča interaktivnejše, kompleksnejše in pogosto bolj reliabilne pristope k obravnavi problemov v medicini. 9. Statistika v medicini Uporaba statistike kot orodja pri raziskavah, razumevanje rezultatov in tolmačenje.

2. Up to date diagnostic and therapeutic achievements in dermatovenerology Evaluation of acquired results, their correlation with clinical picture and their importance in treatment. 3. European Organisation for Researches and Treatment of Cancer Importance of EORTC in carrying out of researches in the cancer treatment field. 4. Researches in surgery Practical knowledge and conducting of research. 5. System connective-tissue diseases Analyse and evaluation of assessment tests for autoimmune happenings. 6. Image analysis in clinical medicine Students are enabled to take part in researching of differences in algorithms which are characteristic of particular disease syndrome and to analyse efficiency of treatment of the diseases according to the analyses of the most explicable image methods. This knowledge is applicable for assessment of efficient treatment. Analyses also give possibility of differentiating of correctness and professional reliability of the particular carrier of image diagnostic therapeutic methods. 7. Epidemiological methods – basic tools in clinical medicine and public health system Gained knowledge should enable students to participate in researching about extension of health problems and analysis of the efficiency of prevention of the particular diseases states and treatment efficiency. Acquired knowledge should enable student to ensure work quality process. 8. Researching and methodology of investigation into mental process Knowledge about researching in the mental field enable us to study about other problems/issues, when we have to deal with less obvious, characteristic, latent or less understandable issues. State of mind is in interconnection with physical state. Knowledge about researching in the field of mentality, as well as other medical fields enable more interactive, complex and often more reliable approaches to problem solving in medicine. 9. Statistic in medicine Use of statistics as tools in researches, understanding of results and their interpretation.

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10. Na dokazih temelječe delo v medicini Kandidati bodo znali poiskati kakovostne vire z dokazi za svoje področje dela.

10. Evidence-based based work in medicine Candidates will be able to look for the evidence quality sources for their field of work.



Delo v majhnih skupinah, samostojno raziskovalno delo

Work in small groups, independent research work

Načini ocenjevanja: Delež (v %) / Weight (in %)

Assessment:

Način (pisni izpit, ustno izpraševanje, naloge, projekt) Izpit

100%

Type (examination, oral, coursework, project) Project work, seminar assignment Exam

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C.) IZBIRNI PREDMETI / OPTIONAL SUBJECTS




Predmet: Bio-keramika

Subject Title: Bio-ceramics



Letnik Year

Semester Semester

Podiplomski študijski program Post graduate education program

Bio-medicinske tehnologije Bio-medical tehnology

2 3 ali 4

Univerzitetna koda predmeta / University subject code:

Predavanja


Sem. vaje Tutorial

Lab. vaje Lab. work



ECTS

15 20 10 105 5

Nosilec predmeta / Lecturer: Prof. dr. Tomaž KOSMAČ Prof. dr. Miha DROFENIK

Jeziki / Languages:

Predavanja / Lecture: Slovenščina/slovene

Vaje / Tutorial: Slovenščina/slovene


Prerequisites:

Kandidat mora doseči 300 ECTS na predhodnem študiju.

Graduate degree 300 ECTS


Uvod: razlogi, ki narekujejo uporabo bio-keramičnih materialov v medicini, definicija in klasifikacija, pregled pomembnejših bio-keramičnih materialov, njihovih karakterističnih lastnosti in njihove uporabe v medicini. Keramika in keramične tehnologije, ki so potrebne za razumevanje fizikalnih, kemijskih in bioloških lastnosti keramičnih m

Documents

UM 2012.pdf · 2019. 2. 11. · Avgust, 2012 A.) OBVEZNI PREDMET / OBLIGATORY SUBJECT MEDICINSKA FAKULTETA UČNI NAČRT PREDMETA / COURSE SYLLABUS Predmet: Biomedicinska Informatika