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Trombosis, Emboli, Infark

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Trombosis

• Adlh pembentukan b lood c lo t (t rom bus )

dlm PD/jantung• Peristiwa fisiologis pd individu hidup• b lood c lo t (t rom bus ) → mhalangi aliran

darah

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• Trombosis → awal dr mekanisme b l o o dc lo t t ing thd respon adanya kelainan dalamdarah/PD

• Mekanisme clotting → konjugasi antara platelets(trombosit) & plasma darah in conjunction withchemicals carried in blood plasma

• Konjugasi → aktifkan protrombin → trombin →katalis pbentukan fibrinogen → fibrin

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Representation of the Common Pathway

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• Ada 2 jalur :

- intrinsik- ekstrinsik

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• Faktor pembentuk fibrin → prokoagulan

• Untuk mencegah Prokoagulan bekerjaterus menerus → tdp Ant ikoagu lan

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Penyebab Trombosis

• Hipertensi & aterosklerosis → intrinsik →krn adanya pembentukan kolagen

• Aliran darah yg tiba2 jd lambat →platelate (trombosit) kontak dg lapisanendotel → terbtk koagulasi

• Contoh → varises

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Early events in thrombosis

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Types of Thrombi

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Tipe Emboli

• Thromboembolism (embolism of thrombus or blood clot)

• Fat embolism (embolism of fat droplets)

• Air embolism (embolism of air bubbles)

• Gas embolism (embolism of blood gas such as oxygen, nitrogen, helium, etc)

• Septic embolism (embolism of pus containing bacteria)

• Tissue embolism (embolism of small fragments of tissue)

• Foreign body embolism (embolism of foreign materials such as talc and other

tiny objects)

• Amniotic fluid embolism (amniotic fluid, fetal cells, hair or other debris entersthe mother's blood stream via the placental bed of the uterus and triggers anallergic reaction)

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Tipe Jalur Emboli

• Anterograde

• Retrograde

• Paradoxical

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Infark

• Lanjutan dari trombus & emboli → bilaembolus mhalangi PD ke organ/jaringan→ infark

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Normal Infark

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