- 1. Tropical Medicine Graduate ProgramGraduate Student
HandbookRevised July, 2008 Department of Tropical Medicine, Medical
Microbiology &PharmacologyJohn A. Burns School of Medicine
University of Hawai`i at Manoa651 Ilalo StreetHonolulu, HI
96813Phone (808) 692-1600 Fax (808) 692-1979 1
2. Revised July, 2008Table of Contents Description of
Department, Graduate Program & Faculty . 3Student
LearningOutcomes 5Student Assessment 6Requiredand Recommended
Courses 10Graduate Program Requirements 12Academic Policies
16Tropical MedicineCourse Descriptions 16Useful Links 19UH Manoa
Campus Map 20 2 3. Revised July, 2008 Map to John A. Burns School
of Medicine (Kaka`ako Campus) 22Graduate Faculty Description &
Contact Information 233 4. Revised July, 2008 Description of the
Department, Graduate Program & FacultyTropical Medicine is the
study of diseases that occur more commonly in the tropical regions
of the world. However, in todays era of globalization and modern
transportation, diseases that were once confined to the tropics
have spread geographically and now play a significant role in the
20th century global resurgence of infectious diseases. As such,
research in the area of tropical medicine and medical microbiology
has greatly increased in importance in the past 20 years. The
Department of Tropical Medicine, Medical Microbiology, and
Pharmacology, at the John A. Burns School of Medicine, University
of Hawaii at Manoa (UHM) offers graduate programs leading to the MS
and PhD in Biomedical Sciences (Tropical Medicine). A major goal of
the department is to provide Asian and Pacific countries the
expertise needed to conduct tropical infectious diseases research.
Tropical medicine faculty conduct studies on infectious organisms
and the diseases they cause, including dengue, West Nile, AIDS,
hepatitis, viral and bacterial encephalitis, malaria, tuberculosis
and Kawasaki disease. The faculty employs a multidisciplinary
approach, including immunology, pathogenesis, epidemiology,
pharmacology, diagnosis, prevention, control, treatment,
socio-ecological systems, human ecology, microbial and vector
ecology, environmental change, and participatory action research to
answer fundamental questions associated with the transmission
dynamics and pathogenesis of these diseases. These studies can be
laboratory-based, field-based, clinic-based, or include a
combination of all three.The field of tropical medicine requires
knowledge of virology, bacteriology, parasitology, entomology,
immunology, cell and molecular biology, epidemiology, ecology,
behavioral science and clinical medicine. In this respect, the
tropical medicine program at UHM provides learning opportunities in
a range of biological disciplines available in few other university
departments. Students also receive vigorous training in scientific
methodology. The department has active research programs with
several community hospitals and collaborates closely with the State
of Hawai`i Department of Health, providing instruction and
expertise in bioterrorism preparedness and diagnosis of infectious
diseases using the latest technology. In addition to local
collaborations, department faculty have partnered with several
international institutions in Southeast Asia and Africa
specializing in infectious disease research.Faculty *Graduate
Faculty*D. J. Gubler, ScD (Chair)arboviruses and vector-borne
disease, epidemiology and control *S. N. Bennett, PhDmolecular
evolution and epidemiology of emerging infectious 4 5. Revised
July, 2008 diseases *S. P. Chang, PhDimmunology, molecular biology,
malaria vaccine development A. Collier, PhD pharmacology,
pharmacokinetics, reproductive pharmacology C. B. Cropp,
MSarbovirology *A. R. Diwan, PhDmedical virology, chemotherapy,
vaccines (retired) *E. Furusawa, MD, PhDviral chemotherapy
(retired) L. Gollin, PhDmedical anthropology and ethnobotany *W. L.
Gosnell, PhDhost parasite interactions, malaria, immunology *G. S.
N. Hui, PhDparasitology, immunology, cell biology P. H. Kaufusi -
pathogenesis of West Nile virus *K. J. Kramer, PhDparasitology,
epidemiology, leptospirosis, HIV serodiagnosis H. Luo, PhD
pathogenesis of arboviruses and polyomaviruses *F. D. Miller,
PhDepidemiology of infectious diseases *V. R. Nerurkar,
PhDpathogenesis of infectious diseases, delineating cellular and
molecular mechanisms underlying microbe-host interaction *D. W.
Taylor, Ph.D. - malaria immunology, maternal and child health *S.
Verma, PhDmolecular, biochemical aspects of viral diseases G. Watt,
MDzoonotic infectious diseases *B. A. Wilcox, PhDecology of
infectious diseases, integrative health research, community
medicine *S. Verma, PhDdiagnosis of Kawasaki syndrome, effect of
selenium deficiency on RNA virus mutations *K. Yamaga,
PhDimmunological mechanisms of diseasesCooperating Graduate Faculty
J. M. Berestecky, PhDenteric bacteria G. Erdem, MDmolecular
epidemiology of group A streptococcal and staphylococcal
infections; complications of strep infections like acute rheumatic
fever A. Imrie, PhDcytotoxic T-cells & HIV J. H. Kim, MDHIV
viral neutralization, cytokine gene therapy in HIV specific
T-cells, HTLV-I and-II mechanisms of Rex protein function S. R.
Kim, PhDbasic immunology of HIV-1 infection Y. Lu, PhD gene
transfer and gene therapy in HIV-infection, diagnostic virology M.
E. Melish, MDstaphylococcal infection and toxins, clinical
infectious disease, Kawasaki syndrome F. D. Pien, MDclinical
microbiology, diagnostic bacteriology and parasitology, efficacy of
antimicrobial agents R. C. Rudoy, MDclinical aspects of viral and
bacterial diseases B. Shiramizu, MDpathobiology of HIV-associated
disorders E. K. Tam, MDinflammation, immunologic mechanisms of
pulmonary diseases, genetic and environmental determinants of
asthma R. Yanagihara, MDemerging and re-emerging infectious
diseases Q. Yu, MD,PhD HIV-1 vaccines and memory CTL responses 5 6.
Revised July, 2008 Affiliate Graduate Faculty F. Mercier, PhD
neurovirology C. F. T. Uyehara, PhDdevelopmental and cardiovascular
pharmacologyAdministrative Staff Sheila Kawamoto, Administrative
& Fiscal Support Specialist Karen Amii, Clerk
StenographerTropical Medicine Graduate Program Student Learning
OutcomesA. Master of Science in Biomedical Sciences (Tropical
Medicine)1. Demonstrate a fundamental knowledge base in the major
subdisciples ofthe field of Tropical Medicine: bacteriology,
virology, mycology,parasitology, immunology, molecular
epidemiology, and infectiousdisease ecology.2. Demonstrate a
mastery of technical and experimental methodologiesrequired to
conduct research in the field of Tropical Medicine.3. Demonstrate
the ability to plan, execute, interpret, and evaluateexperimental
studies in Tropical Medicine.4. Demonstrate skills required for
instruction, assessment and mentoring ofundergraduate and MS level
students.5. Demonstrate proficiency in written and verbal
communication skills inclassroom lectures and other teaching
formats and in professionalseminars and presentations.6.
Demonstrate sufficient mastery and scientific maturity to assess
the workof peers in related fields.B. Ph.D. in Biomedical Sciences
(Tropical Medicine)1.Demonstrate an advanced knowledge base in the
major subdisciples of the field of Tropical Medicine: bacteriology,
virology, mycology, parasitology, immunology, molecular
epidemiology, and infectious disease ecology.2.Demonstrate a
mastery of technical and experimental methodologies required to
conduct research in the field of Tropical Medicine.6 7. Revised
July, 2008 3.Demonstrate the ability to plan, execute, interpret,
and evaluate experimental studies in Tropical
Medicine.4.Demonstrate skills for instruction, assessment and
mentoring of undergraduate, MS and PhD level students.5.Demonstrate
skills to verbally communicate scientific concepts and results in
classroom lectures and other teaching formats and in professional
seminars and presentations.6.Demonstrate written communication
skills as required in various professional duties including
manuscript preparation for scientific publication, preparation of
research grant applications, preparation of lecture notes,
development of introductory and advanced courses in related
disciplines.7.Demonstrate sufficient mastery and scientific
maturity to assess the work of peers in related fields.8.Develop
administrative skills to manage a research laboratory, supervise
technical and professional staff, and assume responsibilities and
provide leadership as a faculty member. Tropical Medicine Graduate
Program Student Assessment A. Master of Science Degree 1. Course
evaluationsa. Core courses: written examinations at regular
intervals (midtermexams) as well as a final examination at the end
of the courseb. Advanced courses: written exams may be substituted
by termpapers or oral presentations on a subject selected by
student andthe faculty instructorc. Course examinations, papers and
presentations are evaluated bythe faculty instructor 2. Diagnostic
evaluationa. First or second semester of residenceb. Written exam
to evaluate background in infectious diseasemicrobiology &
immunologyc. Used to advise on course of study 3. Master's Plan A
(Thesis)a. Thesis proposal is evaluated and subject to approval by
thesisadvisory committeeb. General (Qualifying) Examination7 8.
Revised July, 2008 A general examination (written and oral) will be
required before a student is advanced to candidacy for a Master of
Science degree. The examination will be given during the third or
fourth semester of residence. The questions will be composed by the
graduate faculty and will be designed to adequately test the
student's basic knowledge of the fields of biomedical sciences and
Tropical Medicine. The results of the oral/written examination will
be used to evaluate the student's progress and to advise him/her on
a course of study to correct any weakness. A student who passes the
examination may be recommended for advancement to candidacy for the
master's degree. A student who fails the general examination may
repeat it once within six months following the date of the first
examination. The exact time of examination will be determined by
mutual agreement between the student and examination committee. The
student will not be considered for candidacy again should he/she
fail the general examination a second time.c. Final Examination A
final oral examination, covering the thesis and related areas, is
required. It will be held at least three weeks before the end of
the term during which the degree is conferred. The student will be
expected to present the work covered in his/her thesis, giving the
purpose, methodology, results, and meaning of the work in a clear,
orderly manner. He/she will be expected to discuss questions
regarding the thesis and demonstrate a sufficient background in
related areas. The final examination will be conducted by the
thesis committee and may be open to all graduate faculty Should the
student fail the final examination, he/she may repeat it only once
at the discretion of the thesis committee. A student who fails the
examination a second time is dismissed from the program. 4.
Master's Plan B (Non-thesis)a. Research project proposal is
evaluated and subject to approval by the advisory committee.b.
General (Qualifying) Examinatiom 8 9. Revised July, 2008 A general
examination (oral or written) will be requiredbefore a student is
advanced to candidacy for a Master ofScience degree. The
examination will be given during the third semester ofresidence.
The questions will be composed by the graduate faculty andwill be
designed to adequately test the student's generalknowledge of the
biomedical sciences and Tropical Medicine. The results of the oral
examination will be used to evaluatethe student's progress and to
advise him/her on a course ofstudy to correct any weakness. A
student who passes the examination may berecommended for
advancement to candidacy for the master'sdegree. A student who
fails the general examination may repeat itonce within six months
following the date of the firstexamination. The exact time of
examination within that sixmonths may vary and will be determined
by mutualagreement between the student and examination committee. A
student who fails the examination a second time isdismissed from
the program. c. Final Examination A comprehensive written and oral
examination is requiredand will be conducted by the candidate's
advisorycommittee. The final examination will be given at least
three weeksbefore the end of the term during which the degree
isconferred. The student will be required to demonstrate a
basicknowledge of the various fields encompassed by
TropicalMedicine. Should the student fail the final examination,
he/she may bepermitted to repeat it only once at the discretion of
his/heradvisory committee. A student who fails the examination a
second time isirrevocably dropped from the program.B. Ph.D. Degree
1. General diagnostic examinationa. conducted by an advisory
committee representative of the general field of infectious
diseases before the end of the first semester9 10. Revised July,
2008 b. evaluates the student's general knowledge of the field of
tropical medicine and used to outline a course of study to correct
any deficiencies. 2. Qualifying Examination a. Usually administered
after the first year of study b. Examination Committee consists of
graduate faculty representative of the general field of infectious
diseases and will prepare and evaluate the results of the exam. c.
Examination committee determines whether the student has passed or
failed the exam, note any academic weaknesses and recommend an
appropriate course of study. d. The qualifying exam may be repeated
once e. This examination is also used to determine whether to
encourage a student to proceed in a doctoral program or end with a
terminal MS degree. 3. Comprehensive Examination a. The Tropical
Medicine PhD Comprehensive Examination will consist of the
preparation and defense of a research proposal based on the
students dissertation research project. b. This examination should
be administered by the end of the second year of PhD training by
members of the students dissertation committee. c. The exact format
of the proposal is to be specified by the dissertation committee;
however it should generally follow the format of a grant proposal
to a major funding agency such as the National Institutes of Health
or the National Science Foundation. d. The proposal should be
prepared in consultation with the students research advisor but
should include at least one innovative objective that is not
included as part of an existing grant or a proposal developed by
the advisor. e. An oral examination based on the written proposal
will be carried out by the dissertation committee. The content of
this oral examination may include fundamental concepts underlying
the hypotheses addressed in the proposal, technical or experimental
design issues, and any other topics which the committee feels are
pertinent to the students understanding of his/her research area.
f. A majority of the committee must vote to pass the student in
order for student to pass the exam. g. The exam may be repeated
once. h. Failure to pass the comprehensive exam after two attempts
will result in dismissal from the graduate program. 4. Final
Examination and Dissertation Defense10 11. Revised July, 2008 a.
Administered upon completion of the dissertation research in
theform of a seminar presentation, defense and oral examination b.
The examination and dissertation committee will consist offaculty
within the graduate program with expertise in the
variousprogrammatic disciplines as well as an external
memberrepresenting the UHM academic community at large c. Committee
evaluation is based on the following criteria: i. Students
proficiency in the area of specialization withinthe field of
Tropical Medicine as commensurate with theexpectations of the
specific degreeii. Whether or not the student has produced a body
of workwhich is on par with program expectations for the
specificdegree iii. Whether or not the student has effectively
communicatedand defended this body of work d. A majority of the
committee must vote to pass the student inorder for student to pass
the exam. e. The exam may be repeated once. f. Failure to pass the
final examination after two attempts willresult in dismissal from
the graduate program.Required and Recommended CoursesThe required
and/or recommended courses are divided into three groups.GROUP I -
Core Courses: All students are required to have a background of
undergraduate courses in medical microbiology, organic chemistry
and biochemistry, physics, and mathematics. An introductory course
in Immunology (e.g. MICR 461) will be required of students who do
not have an adequate background in immunology.All students are
required to take: TRMD 604Infectious Disease Micro ITRMD
605Infectious Disease Micro IITRMD 606Tropical Medicine Research
RotationsCMB 621 Molecular Biology of Cell I (MS and PhD)CMB 622
Molecular Biology of Cell II (PhD only)CMB 626 orResearch
EthicsMICR 614TRMD 690 Tropical Medicine Seminar (each semester)11
12. Revised July, 2008 GROUP II - Tropical Medicine elective
courses to be selected by the student and his/her graduate
committee according to the student's interests and needs. TRMD607
NeurovirologyTRMD609 Advances in Medical ImmunologyTRMD650 Advanced
Ecology of Infectious DiseasesTRMD652 Advanced Genetics &
Evolution of InfectiousDiseasesTRMD653 Bioinformatics for
Infectious DiseasesTRMD671 Advanced Medical ParasitologyTRMD672
Advanced Medical VirologyTRMD673 Advanced Medical
BacteriologyTRMD695 Plan B Masters ProjectTRMD699 Directed
Reading/ResearchTRMD700 Thesis ResearchTRMD705 Special Topics in
Tropical MedicineTRMD800 Dissertation ResearchGROUP III - Courses
available in related fields: Elective courses available in related
fields of study include: Asian Studies 600 Asian Studies Seminar
Biochemistry 441Basic Biochemistry 643Bioenergetics &
Carbohydrates 644Metabolic Biochemistry Cell & Molecular
Biology625 Advanced Topics in Genetics680 Molecular Genetics650
Population Genetics654 Genetics Seminar671 Techniques in Genetics
Entomology* 486 Insect-Microbe Interactions661 Medical and
Veterinary Entomology671 Insect Ecology675 Biological Control of
Pests686 Insect Transmission of Plant Pathogens*Plant &
Environmental Protection Sciences Geography410Human Role in
Environmental Change12 13. Revised July, 2008 411 Human Dimensions
of Global Environmental Change 488 Geographic Information Systems
654 Seminar in Geography of S.E. Asia 665 Seminar in Geography of
the PacificInterdisciplinary Studies 650 Principles of Applied
Evolutionary Ecology 651LLaboratory in Applied Evolutionary
EcologyMicrobiology 461Immunology463Microbiology of
Pathogens470Microbial Pathogenesis490Animal Virology625Advanced
Immunology630Microbial Genome632Advanced Microbial
Physiology655Advanced Virology661Bioinformatics & Comparative
Genomics680Advances in Microbial Ecology681Host-Parasite
Relationships685Molecular and Cellular Bacterial
PathogenesisPharmacology 601General Pharmacology602Systematic
PharmacologyPublic Health 655 Biostatistics I 656 Biostatistics II
658 Computer Applications in Public Health 661 Epidemiological
Study Design Critique 663 Principles of Epidemiology I 664
Principles of Epidemiology II 666 Seminar in Infectious Disease
ControlZoology 621 Evolutionary Ecology 631 Biometry 632 Advanced
Biometry 652 Population Biology 690 Conservation Biology 13 14.
Revised July, 2008 Tropical Medicine Graduate Program
RequirementsMasters Plan A (Thesis) 1)Preliminary Conference with
graduate program chair appointment of interim advisor diagnostic
evaluation with entire faculty Complete relevant sections of
Pre-Candidacy Progress Form I Preliminary Conference Transfer of
credits (if applicable) Identification and remediation plan for
deficiencies (if applicable) 2)General (Qualifying) Examination
second semester of residence written/oral exam with questions
composed by advisory committee (3 members: advisor + 2 other T3M
faculty) test general knowledge of biomedical sciences used to
evaluate, advise on course of study to correct weaknesses may be
repeated once pass: advancement to candidacy Completion and
submission of Pre-Candidacy Progress Form I to Graduate Division
3)Coursework requirements 30 credit hours 18 hrs approved course
work excluding 699 and thesis 700 at least 12 hrs in courses
numbered 600-798 participation in TM690, Journal Club (TM699-1 cr)
every semester registration in thesis 700 during last semester; at
least 9 cr. hrs ofthesis 700 4)Masters Thesis Committee Selection
of permanent advisor by end of first year (chair of thesis
committee) Appointment of two other members of T3M faculty to
committee 5)Thesis proposal Submission of research topic and thesis
proposal to committee by end of third semester Thesis proposal
should be presented as a departmental seminar Approval of thesis
topic by committee Obtain certification, approvals and guidance as
needed: Committee on Human Studies www.hawaii.edu/irb/; 539-3955
Environmental Health & Safety Office www.hawaii.edu/ehso/;
956-8660 Institutional Animal Care and Use Committee
www.hawaii.edu/ansc/IACUC/; 956-444614 15. Revised July, 2008
Advancement to thesis stageSubmission of Advance to Candidacy Form
II to Graduate Division (must be submitted prior to registering for
Thesis 700) 6) Final ExaminationResearch seminar and oral
examination covering thesis research and related areasConducted by
thesis committee; open to all graduate faculty 7) Judgement of
ThesisEvaluation of final oral exam and written thesis by thesis
committeeSubmission of Masters Thesis Evaluation Form III to
Graduate DivisionMasters Plan B (Non-thesis) 1)Preliminary
Conference with graduate program chair appointment of interim
advisor diagnostic evaluation with entire faculty Complete relevant
sections of Pre-Candidacy Progress Form I Preliminary Conference
Transfer of credits (if applicable) Identification and remediation
plan for deficiencies (if applicable) 2)General (Qualifying)
Examination second semester of residence questions composed by
advisory committee test general knowledge of biomedical sciences
used to evaluate, advise on course of study to correct weaknesses
may be repeated once pass: advancement to candidacy Completion and
internal filing of Pre-Candidacy Progress Form I 3)Coursework
requirements 30 credit hours 18 hrs approved course work excluding
699 and thesis 700 at least 18 hrs in courses numbered 600-798
participation in seminar (TM690), Journal Club (TM699-1 cr) every
semester at least 1 semester 699 research but no more than 9 cr of
TM699 4)Masters Committee permanent advisor; selected by end of
first year two other members of T3M faculty 5)Study Program and
Research Project proposal meet with committee to decide on study
program before end of second semester additional courses research
project proposal Obtain certification, approvals and guidance as
needed:15 16. Revised July, 2008 Committee on Human Studies
www.hawaii.edu/irb/; 539-3955 Environmental Health & Safety
Officewww.hawaii.edu/ehso/; 956-8660 Institutional Animal Care and
Use Committeewww.hawaii.edu/ansc/IACUC/; 956-4446Completion and
internal filing of modified Advance to Candidacy Form II 6) Final
examinationComprehensive written and oral examination; demonstrate
basic knowledge of the various fields encompassed by Tropical
MedicineTo be conducted by candidates advisory committeeTo be given
at least three weeks before the end of the term in which the degree
is conferredPresentation of research seminar and written paper
covering research projectCompletion and internal filing of modified
Progress Report Form IIIDoctor of Philosophy 1)Preliminary
Conference with graduate program chair appointment of interim
advisor remedy all undergraduate deficiencies completion of
relevant sections of Pre-Candidacy Progress Form I 2)General
(Qualifying) Examination end of second semester of residence
written exam, approx. 3-4 hours covering tropical medicine &
medical microbiology, molecular and cell biology questions composed
by examination committee appointed by graduate program chair;
should be more detailed, challenging than MS general exam determine
whether to encourage student to proceed to Ph.D. used to evaluate,
advise on course of study to correct weaknesses pass: advancement
to candidacy, submission of Pre-Candidacy Progress Form I to
Graduate Division 3)Coursework requirements No specific course
credit requirements except that candidates who have not had
equivalent courses should take the core courses: TRMD 605 and 606,
and CMB 621 and 622 in order to pass the qualifying examination and
a Research Ethics course Candidates will be required to enroll in
courses which, in the opinion of their advisors, are essential for
a comprehensive background in Tropical Medicine and to prepare them
for a research career 16 17. Revised July, 2008 Candidates must
gain teaching experience by assisting in one course fortwo or more
semesters 4)Doctoral Committee 4 members of graduate faculty
representing various infectious diseasesubdisciplines, and 1
outside member: one faculty from another field of study and
fromoutside departments graduate faculty selected after candidate
passes general exam & admitted to candidacy meeting of student
with doctoral committee at least once per semester toassess
progress 5)Dissertation independent research, original contribution
to Tropical Medicine preparation, approval, etc. to follow Graduate
Division guidelines approval of research topic by committee before
end of third semester 6)Comprehensive Examination preparation and
defense of a written research proposal in grant proposalformat
conducted by students doctoral committee tests broad knowledge and
basic understanding of Tropical Medicine andchosen minor fields;
also evaluates ability to use knowledge to develop aresearch plan
and solve problems in a logical manner pass: advancement to
candidacy for Ph.D. degree submission of Advance to Candidacy Form
II to Graduate Division Helpful resources for preparation of
research proposalNIH:
http://deainfo.nci.nih.gov/extra/extdocs/gntapp.htmNIH:
http://www.niaid.nih.gov/ncn/grants/app/default.htmNIH:
http://www2.hawaii.edu/~sandrac/TRMD_Comprehensive_Exam_Propo
sal_Guidelines.dochttps://laulima.hawaii.edu/access/content/user/sandrac/TRMD%20Comprehensive%20Exam%20Proposal%20Guidelines.docNSF:
http://www.cs.cmu.edu/~sfinger/advice/advice.htmlGeneral:
http://www.learnerassociates.net/proposal/ 7)Final Examination
defense of the research dissertation, related subjects conducted by
students doctoral committee taken at least 6 wks before end of
semester in which degree granted 8)Judgement of Dissertation review
of written dissertation by doctoral committee submission of
Dissertation Evaluation Form III to Graduate DivisionMS/PhD Student
Progress Forms: I. Preliminary Conference, General/Qualifying Exam,
Pre-Candidacy Progress17 18. Revised July, 2008 II.Formation of
Masters Committee/Dissertation Committee, Approval of
Thesis/Dissertation Topic, Results of Comprehensive Exam (PhD
only), Advancementto Candidacy III. Final Oral Examination/Defense
of Thesis/Dissertation, Judgment ofThesis/DissertationAcademic
PoliciesUndergraduate and graduate students in the School of
Medicine must adhere to the academic policies of UH Manoa. A
summary description of these policies may be found in the online
catalog: http://www.catalog.hawaii.edu/about-uh/campus-
policies/campus-policies.htm.Tropical Medicine and Medical
Microbiology (TRMD) Course DescriptionsTRMD 499 Reading and
Research (V) Directed reading and research in laboratory;
diagnostic aspects of bacterial, parasitic, and viral infections.
Pre: consent.TRMD 500 Masters Plan B/C Studies (1) Enrollment for
degree completion. Pre: masters Plan B or C candidate and
consent.TRMD 512 Unit II Concurrent Elective (1) Elective course
for first-year medical students. CR/NC only. Pre: BIOM 551 and
consent.TRMD 513 Unit III Concurrent Elective (1) Elective course
for first-year medical students. CR/NC only. Pre: BIOM 551 and
consent.TRMD 514 Unit IV Concurrent Elective (1) Elective course
for second-year medical students. CR/NC only. Pre: BIOM 551 and
consent.TRMD 515 Unit V Concurrent Elective (1) Elective course for
second-year medical students. CR/NC only. Pre: BIOM 551 and
consent.TRMD 525 Unit V Block Elective (1) Required elective for
second-year medical students; objectives to be determined by
contract. One option is a review of USMLE step. CR/NC only. Pre:
BIOM 551.TRMD 545 Topics in Tropical Medicine (V) Elective for
fourth-year medical students for advanced study of selected topics
within the field of tropical medicine and medical microbiology.
Pre: fourth-year standing.18 19. Revised July, 2008 TRMD 595
(Alpha) Selected Topics in Infectious Diseases (1) Elective for
medical students; (B) infectious diseases; (C) parasitology; (D)
epidemiology; (E) immunology. MD majors only. CR/NC only. Pre: MDED
554 or consent. Fall only.TRMD 599 (Alpha) Selected Research Topics
in Infectious Diseases (1) Research elective for medical students;
(B) infectious diseases; (C) parasitology; (D) epidemiology; (E)
immunology. MD majors only. CR/NC only. Pre: MDED 554 or consent.
Fall only.TRMD 604 Infectious Disease Micro I (3) Pathogenesis,
epidemiology, immunobiology of infectious diseases caused by
bacterial and fungal pathogens; principles of host- pathogen
interactions; public health aspects of infectious diseases.
Repeatable one time. A-F only. Pre: MICR 351 or consent.
(Cross-listed as PH 665)TRMD 605 Infectious Disease Micro II (3)
Pathogenesis, epidemiology, immunobiology of infectious diseases
caused by viruses and parasites; principles of host-pathogen
interactions; public health aspects of infectious diseases.
Repeatable one time. A-F only. Pre: MICR 351 and TRMD 604; or
consent. (Cross-listed as PH 667)TRMD 606 Tropical Medicine
Laboratory Rotations (V) Practical experience in use of equipment
and procedures in infectious disease and immunology research;
introduction to research in tropical medicine. Repeatable unlimited
times. Pre: 604 (or concurrent), or consent. (Cross-listed as PH
668)TRMD 607 Neurovirology (1) Seminar course on neuroinvasive
viruses giving basics of viruses causing nervous system diseases
and discussing recent advances in the research field of
neurovirology. Pre: MICR 351 or equivalent; or consent. Fall
only.TRMD 609 Advances In Medical Immunology (3)
Presentations/discussions of current literature concerning recent
advances in immunology relevant to disease and to disease
processes. Pre: consent. (Alt. years: spring) TRMD 650 Advanced
Epidemiological Ecology of Infectious Diseases (2) Applications of
population biology, pathogen/host life history, and population
genetics to infectious disease epidemiology, including micro- and
macroparasites, and implications to disease control and prevention
of strategies. A-F only. Pre: 604 (or concurrent) and 605 (or
concurrent), or consent. (Alt. years: spring)19 20. Revised July,
2008 TRMD 652 Advanced Genetics and Evolution of Infectious
Diseases (2) An evolutionary perspective to examine the interactive
responses between infectious agents and the immune system. Topics
will include natural selection, life history evolution, population
genetics of pathogens and hosts, and anti-microbial resistance. A-F
only. Pre: 604 (or concurrent) and 605 (or concurrent), or consent.
(Alt. years: spring) TRMD 653 Bioinformatics for Infectious
Diseases (1) Combined lecture/computer lab course on bioinformatic
tools used in genomics, including sequence assembly, search
algorithms, alignment, phylogenetics, and molecular
evolution/epidemiology. Focus will be on infectious disease
examples. Open to nonmajors. A-F only. Pre: 604 (or concurrent) and
605 (or concurrent) or consent. Fall only.TRMD 671 Advanced Medical
Parasitology (2) Consideration of ultrastructure, physiology,
biochemistry, in-vitro cultivation and host-parasite relationship
of parasites of medical importance. A-F only. Pre: consent. (Alt.
years: fall)TRMD 672 Advanced Medical Virology (2) In-depth study
of the major groups of viruses pathogenic for human; virus
replication, host range, pathogenesis, immunology, and
epidemiology. Pre: 605 or equivalent, or consent. (Alt. years:
fall)TRMD 673 Advanced Medical Bacteriology (2) Role of bacteria in
infectious diseases, with emphasis on clinical aspects and
identification of etiological agents. Pre: 605 or equivalent, or
consent.TRMD 690 Seminar in Tropical Medicine and Public Health (1)
Weekly discussion and reports on current advances in tropical
medicine and public health. (Cross-listed as PH 755)TRMD 695 Plan B
Masters Project (3) Independent study for students working on a
Plan B Masters project. A grade of Satisfactory (S) is assigned
when the project is satisfactorily completed. Pre: graduate
standing in TRMD.TRMD 699 Directed Research (V) Directed research
in medical microbiology (bacteriology, parasitology, virology).
Pre: consent.TRMD 700 Thesis Research (V) Research for masters
thesis. Approval of department faculty required.TRMD 705 Special
Topics in Tropical Medicine (1) Advanced instruction in frontiers
of tropical medicine and public health. Repeatable. (Cross-listed
as PH 756) 20 21. Revised July, 2008 TRMD 800 Dissertation Research
(V) Research for doctoral thesis. Approval of department faculty is
required. Useful LinksAsia-Pacific Institute of Tropical Medicine
& Infectious Diseases:http://apitmid.hawaii.edu/Graduate
Division: http://www.hawaii.edu/graduate/Graduate Division forms
and manuals:
http://www.hawaii.edu/graduate/download/list.htm#masterUH Manoa
online catalog: http://www.catalog.hawaii.edu/Get a UH username:
https://sunsys.its.hawaii.edu/acctmgmt/Course Registration:
http://www.hawaii.edu/myuh/manoa/International Student Services:
http://www.hawaii.edu/issmanoa/Graduate Student Organization:
http://gso.hawaii.edu/JABSOM:
http://jabsom.hawaii.edu/jabsom/JABSOM Health Sciences library:
http://www.hawaii.edu/hslibJABSOM 2004-2005 Bulletin (catalog):
http://hawaiimed.hawaii.edu/medical_ed/0405bltn.pdf21 22. Revised
July, 2008 Map to John A. Burns School of Medicine, Kakaako campus
651 Ilalo St., Honolulu, HI 96813
http://jabsom.hawaii.edu/jabsom/about/map.php 22 23. UH Manoa
Campus Map 23 24. Revised July, 200824 25. GRADUATE FACULTY IN THE
DEPARTMENT OF TROPICAL MEDICINENameRank and Department Research
InterestsShannon N. Bennett, Ph.D. (Univ. of British Assistant
Professor Dengue virus molecular epidemiology and evolution,
parasitic Colombia, Canada), [email protected] Medicine
nematodes of marine fishesMalaria immunity & vaccine
development, biomarkers of severe Sandra Perreira Chang, Ph.D.
(Oregon Health Professor dengue virus infection, immunology of
latent M. tuberculosis Sciences University),
[email protected] Medicine infection, molecular biology of
M. tuberculosis drug resistanceAbbie Collier, Ph.D. (Univ. of
Auckland Medical Pharmacokinetics, pharmacodynamics, molecular
studies of Assistant Professor School), [email protected]
metabolism, reproductive pharmacology and teratogenesis
PharmacologyArwind R. Diwan, Ph.D. (Univ. of London,Professor
Chemotherapy of viral diseases; viral vaccines; oncogenic School of
Hygiene & Tropical Medicine), Tropical Medicine (retired)
viruses; slow virus infections; hepatitis; AIDS
[email protected] Furusawa, M.D., Ph.D. (Osaka,
Japan),Professor Pharmacology of natural products, viral and cancer
956-3168Pharmacology (retired)chemotherapyWilliam L. Gosnell, Ph.D.
(Univ. of Hawaii),Junior Researcher Host parasite interactions,
malaria, TB immunology [email protected] MedicineDuane
Gubler, ScD. (Johns Hopkins Bloomberg Professor & Chairperson
Vector-borne diseases including dengue and West Nile virus School
of Public Health) [email protected] Tropical MedicineGeorge S.N.
Hui, Ph.D. (Univ. of Hawaii), ResearcherImmunology of parasitic
infections, immunomodulators for [email protected] Tropical Medicine
parasite vaccines, cell biology of protozoan parasitesKenton J.
Kramer, Ph.D. (Univ. of Hawaii),Associate Professor Parasitic
diseases of the Pacific; amebic infections in Hawaii;
[email protected] Tropical Medicine Community Medicine Program for
Health Promotion; epidemiologic/immunologic methods of malaria
controlF. DeWolfe Miller, Ph.D. (Univ. of Michigan), Professor
Infectious disease epidemiology [email protected]
MedicineVivek R. Nerurkar, Ph.D. (Univ. of Bombay,Professor
Pathogenesis of infectious diseases; cellular & molecular
India), [email protected] Tropical Medicine mechanisms underlying
microbe-host interaction.25 26. Revised July, 2008Leslie Q. Tam,
Ph.D. (Univ. of Hawaii), Professor, Tropical MedicineP. falciparum
merozoite surface & rhoptry antigens; bacterial cell
[email protected] (emeritus)wall adjuvantsDiane Wallace Taylor, Ph.D.
(University ofAdjunct Professor Maternal and neonatal immunity to
malaria Hawaii), [email protected] MedicineSaguna
Verma, Ph.D. (Devi Ahilya University,Assistant ResearcherDiagnosis
of Kawasaki syndrome, effect of selenium deficiency India),
[email protected] Medicine on RNA virus
mutations,Professor Population biology; human-ecosystem
interaction; ecological Bruce Wilcox, Ph.D. (Univ. of California
San Tropical Medicine and Diego), [email protected] human health
linkagesKaren M. Yamaga, Ph.D. (Univ. of Hawaii), Professor
Immunological mechanisms of diseases; pathogenesis of
[email protected] Tropical Medicine rheumatoid arthritis
COOPERATING GRADUATE FACULTYJohn Berestecky, Ph.D. (Univ. of
Hawaii), Associate Professor Epidemiology & pathogenesis of
Campylobacter enteritis, [email protected] Community immune
response of Hawaiian Green Turtles, identification of College plant
pathogens using monoclonal antibodiesMona Bomgaars, MD Hansens
Disease Branch Hansens disease and international health
[email protected] State Dept. of Health (retired)Frederick M.
Burkle, Jr., M.D., M.P.H.Clinical Professor, Dept. ofInternational
emergency and disaster medicine (University of Vermont College of
Medicine, Surgery Univ. California Berkeley) Adjunct Tropical
MedicineGuliz Erdem, M.D. (Hacettepe University Assistant Professor
Molecular epidemiology of group A streptococcal & Faculty of
Medicine, Turkey), [email protected]. of Pediatrics
staphylococcal infections; complications of strep infections like
acute rheumatic fever.Allison Imrie, Ph.D. (Univ. of New South
Wales, Assistant Professor, Dept. of HIV-1and dengue virus
pathogenesis; evaluation of anti- Sydney, Australia),
[email protected] Public Health Sciencesretroviral drugs on
host metabolism; effects of HIV-1 infection on the neurological
system 26 27. Revised July, 2008Claude Jourdan-Le Saux, Ph.D.
(UniversiteAssistant Researcher, Dept.Human genetic disorders,
asthma, interleukins and pulmonary dAix-Marseille, France),of Cell
and Molecularfunction. [email protected] Biology HIV viral
neutralization, Cytokine gene therapy in HIV specific Jerome H.
Kim, M.D. (Yale University School of Clinical Associate Professor,
T-cells, Molecular mechanisms of apoptosis in HIV infection,
Medicine)Dept. of Medicine HTLV-I and -II mechanisms of Rex protein
function, [email protected] tuberculosis (clinical syndromes)
(on leave)Yuanan (Ron) Lu, Ph.D. (Univ. of Hawaii),Professor, Dept.
of Public Gene therapy for HIV-1 infection, gene transfer
approaches for [email protected] SciencesneuroAIDS,
immunodiagnosis of herpesvirus infection of green turtles,
aquaculture virologyMarian E. Melish, M.D. (Univ. of Rochester),
Professor, Dept. of Pediatrics Staphylococcal infection and toxins;
clinical infectious disease; [email protected] Kawasaki's
syndromeFrederic Mercier, Ph.D. (University of Assistant
Researcher,Neurovirology, neurogenesis and neural stem cellsBrain
Montpellier II, France) [email protected] Medicineanatomy
and cytoarchitectureFrancis D. Pien, M.D. (Univ. of Chicago)
Associate ProfessorClinical microbiology with special reference to
diagnosticDept. of Medicinebacteriology & parasitology;
evaluation of antimicrobial agents Silvia Ratto Kim, Ph.D.
(University of Genoa,Associate Researcher,Basic immunology of HIV-1
infection Italy)Hawaii AIDS Clinical [email protected] (on
leave)Research ProgramBruce Shiramizu, M.D. (Univ. of Utah, Salt
LakeProfessor, Depts. of Pathobiology of HIV-associated disorders
City)Medicine and PediatricsRaul C. Rudoy, M.D. (Cayetano Heredia
Univ., Professor, Dept. of Pediatrics Clinical aspects of viral and
bacterial disease in pediatrics Peru), [email protected]
K. Tam, M.D. (Univ. of California, San ProfessorGenetic &
environmental determinants of respiratory disease Francisco),
[email protected]. of Medicine(eg. asthma); volcanic air
pollution & modulators of respiratory health;genetics &
tobacco smoke in lung disease.Richard Yanagihara, M.D. (Univ. of
Cincinnati),Professor, Dept. of Pediatrics Transdisciplinary
investigations of emerging & re-emerging
[email protected] diseases; use of infectious
agents to trace ancient & recent movements of human
populations.27 28. Revised July, 2008Qigui Yu, M.D., PhD (Wuannan
Medical School, Assistant Professor, Dept. of HIV-1 Vaccines, HIV-1
specific CTL memory responses Fourth Military Medical
University)Medicine28
