To the members of FIFA and the confederations .To the members of FIFA and the confederations Circular

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  • To the members of FIFA and the confederations

    Circular no. 1567

    Zurich, December 2016 ZBO/awe

    WADA Prohibited list 2017 - comes into force January 2017

    Dear Sir or Madam,

    FIFA

    FIFA wishes to remind its member associations, the confederations, as weil as all players, clubs and player support personnel that the World Anti -Doping Code Prohibited List 2017 and Methods issued by WADA will take effect on 1 January 2017. A summary of the modifications to the 2017 Prohibited List, including the 2017 Prohibited list is enclosed.

    FIFA would like to remind all players that it is their duty to ensure that they do not take any forbidden substances and should inform themselves if in doubt regarding produds and substances.

    Thank you very much for your cooperation in this matter. Should you have any questions, please do not hesitate to contact FIFA's anti-doping unit at medical@fifa .org .

    Yours faithfully,

    ;FA 7~ Zvonimir Boban Deputy Secretary General (Football)

    Encl.:

    Copies:

    WADA Prohibited List 2017 WADA summary of modifications 2017

    FIFA Council Medical Committee WADA

    Federation Internationale de Football Association FIFA-Strasse 20 P.O. Box 8044 Zurich Switzerland Tel: +41 (0)43 222 7777 Fax: +41 (0)43 222 7878 wwwJIFA.com

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    Prohibited Substances

    ANABOLIC AGENTS

    Compoundsboldenone,boldione,19-norandrostenedione,andnandrolonehavebeentransferredand19-norandrostenedioladdedtotheS1.bsectionbecausetheycanbeproducedendogenouslyatlowconcentrations.Thischangedoesnotaffecttheprohibitedstatusofthesesubstances.TheinterpretationandreportingoffindingsforthesesubstancesisaddressedinspecificTechnicalDocuments(TD2016IRMSand/orTD2016NA).

    5-androst-2-ene-17-one,commonlyknownasDelta-2or2-androstenone,wasaddedasanexampleofmetaboliteofDHEA,morerecentlyfoundindietarysupplements.

    PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES AND MIMETICS

    ToextendthescopeofErythropoieticStimulatingAgents,GATAinhibitors(e.g.K-11706)andTransformingGrowthFactor-(TGF-)inhibitors(e.g.sotatercept,luspatercept)wereadded.

    TheInternationalNonproprietaryName(INN)ofFG-4592,roxadustat,wasadded.

    MolidustatwasaddedasanotherexampleofHIFstabilizer.

    Cobalt:Itisre-iteratedthatvitaminB12,whichcontainscobalt,isnotprohibited.

    S1

    S2

    BETA-2-AGONISTS

    Thereferencetoisomerswassimplified.

    Examplesofselectiveandnon-selectivebeta-2-agonistswereadded(fenoterol,formoterol,higenamine,indacaterol,olodaterol,procaterol,reproterol,salbutamol,salmeterol,terbutaline,vilanterol).

    HigenamineisdocumentedtobeaconstituentoftheplantTinosporacrispa,whichcanbefoundinsomedietarysupplementsandisanon-selectivebeta-2-agonist.

    Dosingparametersofsalbutamolwererefinedtomakeitclearthatthefull24hourdoseshouldnotbeadministeredatonetime.

    Themaximumdosageforsalmeterolwasstatedaccordingtothemanufacturersrecommendations.

    Studiesareongoingtoestablishanappropriateurinarythresholdconcentrationforinhaledsalmeterol.Atpresent,theTechnicalDocumentTD2015MRPLrecommendsnottoreportsalmeterolbelow10ng/mL.

    HORMONE AND METABOLIC MODULATORS

    Androsta-3,5-diene-7,17-dione(arimistane)wasaddedasanewexampleofaromataseinhibitor.

    Prohibited Methods

    MANIPULATION OF BLOOD AND BLOOD COMPONENTS

    Supplementaloxygenadministeredbyinhalation,butnotintravenously,ispermitted.Toclarifythis,M1.2nowreadsexcludingsupplementaloxygenbyinhalation.

    S3

    S4

    M1

    SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES2017 PROHIBITED LIST

    Substances and methods prohibited at all times (In- and Out-of-Competition)

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    Substances and Methods Prohibited In-Competition

    STIMULANTS

    LisdexamfetaminewasaddedtoS6.a;itisaninactivepro-drugofamfetamine.

    IntheabsenceofanINNformethylhexaneamine,itsInternationalUnionofPureandAppliedChemistry(IUPAC)name,4-methylhexan-2-amine,wasadded.Anumberofothersynonymsexistformethylhexaneamineincluding:1,3-dimethylamylamine,dimethylpentylamine;methylhexamine;methylhexanamine;1,3-dimethylpentylamine.

    RegularfoodconsumptionwillnotyieldsufficientlevelsofphenylethylaminetoresultinanAdverseAnalyticalFinding.

    NARCOTICS

    Nicomorphinewasadded.Itisanopioidanalgesicdrug,whichisconvertedtomorphinefollowingadministration.

    GLUCOCORTICOIDS

    Afterconsiderationofstakeholderscomments,nochangesweremadeinthissectionfor2017.

    S6

    S7

    S9

    MONITORING PROGRAMThefollowingwereaddedtoestablishpatternsofuse:

    Codeine; Concurrentuseofmultiplebeta-2-agonists.

  • THE WORLD ANTI-DOPING CODE

    INTERNATIONALSTANDARD

    PROHIBITED LISTJANUARY 2017

    The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail.

    This List shall come into effect on 1 January 2017

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    IN ACCORDANCE WITH ARTICLE 4.2.2 OF THE WORLD ANTI-DOPING CODE, ALL PROHIBITED SUBSTANCES SHALL BE CONSIDERED AS SPECIFIED SUBSTANCES EXCEPT SUBSTANCES IN CLASSES S1, S2, S4.4, S4.5, S6.A, AND PROHIBITED METHODS M1, M2 AND M3.

    PROHIBITED SUBSTANCES

    SUBSTANCES & METHODSPROHIBITED AT ALL TIMES(IN- AND OUT-OF-COMPETITION)

    NON-APPROVED SUBSTANCESAny pharmacological substance which is not

    addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times.

    ANABOLIC AGENTSAnabolic agents are prohibited.

    1. ANABOLIC ANDROGENIC STEROIDS (AAS)a. Exogenous* AAS, including:

    1-Androstenediol (5-androst-1-ene-3,17-diol);1-Androstenedione (5-androst-1-ene-3,17-dione);1-Testosterone (17-hydroxy-5-androst-1-en-3-one);4-Hydroxytestosterone (4,17-dihydroxyandrost-4-en-3-one);Bolandiol (estr-4-ene-3,17-diol);Bolasterone;Calusterone;Clostebol;Danazol ([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17-ol); Dehydrochlormethyltestosterone (4-chloro-17-hydroxy-

    17-methylandrosta-1,4-dien-3-one);Desoxymethyltestosterone (17-methyl-5-androst-

    2-en-17-ol);Drostanolone;Ethylestrenol (19-norpregna-4-en-17-ol);Fluoxymesterone;Formebolone;Furazabol (17-methyl [1,2,5]oxadiazolo[3',4':2,3]-5-

    androstan-17-ol); Gestrinone;

    S0

    S1

    Mestanolone;Mesterolone;Metandienone (17-hydroxy-17-methylandrosta-1,4-dien-

    3-one);Metenolone;Methandriol;Methasterone (17-hydroxy-2,17-dimethyl-5-

    androstan-3-one); Methyldienolone (17-hydroxy-17-methylestra-4,9-dien-

    3-one);Methyl-1-testosterone (17-hydroxy-17-methyl-5-

    androst-1-en-3-one); Methylnortestosterone (17-hydroxy-17-methylestr-4-en-

    3-one); Methyltestosterone;Metribolone (methyltrienolone, 17-hydroxy-17-

    methylestra-4,9,11-trien-3-one);Mibolerone;Norboletone;Norclostebol;Norethandrolone;Oxabolone;Oxandrolone;Oxymesterone;Oxymetholone;Prostanozol (17-[(tetrahydropyran-2-yl)oxy]-1'H-

    pyrazolo[3,4:2,3]-5-androstane);Quinbolone;Stanozolol;Stenbolone;Tetrahydrogestrinone (17-hydroxy-18a-homo-19-nor-17-

    pregna-4,9,11-trien-3-one);Trenbolone (17-hydroxyestr-4,9,11-trien-3-one);

    and other substances with a similar chemical structure or similar biological effect(s).

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    b. Endogenous** AAS when administered exogenously:

    19-Norandrostenediol (estr-4-ene-3,17-diol);19-Norandrostenedione (estr-4-ene-3,17-dione);Androstenediol (androst-5-ene-3,17-diol);Androstenedione (androst-4-ene-3,17-dione);Boldenone;Boldione (androsta-1,4-diene-3,17-dione);Dihydrotestosterone (17-hydroxy-5-androstan-3-one);Nandrolone (19-nortestosterone);Prasterone (dehydroepiandrosterone, DHEA,

    3-hydroxyandrost-5-en-17-one); Testosterone;

    and their metabolites and isomers, including but not limited to:

    3-Hydroxy-5-androstan-17-one;5-Androst-2-ene-17-one;5-Androstane-3,17-diol;5-Androstane-3,17-diol;5-Androstane-3,17-diol;5-Androstane-3,17-diol;5-Androstane-3,17-diol;7-Hydroxy-DHEA;7-Hydroxy-DHEA;4-Androstenediol (androst-4-ene-3, 17-diol);5-Androstenedione (androst-5-ene-3,17-dione);7-Keto-DHEA;19-Norandrosterone;19-Noretiocholanolone;Androst-4-ene-3,17-diol;Androst-4-ene-3,17-diol;Androst-4-ene-3,17-diol;Androst-5-ene-3,17-diol;Androst-5-ene-3,17-diol;Androst-5-ene-3,17-diol;Androsterone;Epi-dihydrotestosterone;Epitestosterone;Etiocholanolone.

    2. OTHER ANABOLIC AGENTS

    Including, but not limited to: Clenbuterol; Selective androgen receptor modulators (SARMs, e.g.

    andarine and ostarine); Tibolone; Zeranol; Zilpaterol.

    For purposes of this section:* exogenous refers to a substance which is not ordinarily

    produced by the body naturally.** endogenous refers to a substance which is ordinarily produced

    by the body naturally.

    PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS

    The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited:

    1. Erythropoietin-Receptor agonists:1.1 Erythropoiesis-Stimulating Agents (ESAs) including e.g.

    Darbepoietin (dEPO); Erythropoietins (EPO); EPO-Fc; EPO-mimetic peptides (EMP), e.g. CNTO 530 and peginesatide;GATA inhibitors, e.g. K-11706;Methoxy polyethylene glycol-epoetin beta (CERA);Transforming Growth Factor- (TGF-) inhibitors, e.g. sotatercept, luspatercept;

    1.2 Non-erythropoietic EPO-Receptor agonists, e.g. ARA-290; Asialo EPO; Carbamylated EPO.

    2. Hypoxia-inducible factor (HIF) stabilizers, e.g. cobalt, molidustat and roxadustat (FG-4592); and HIF activators, e.g. argon and xenon.

    S2

  • 4

    3. Chori