To the Charter Class of the Skaggs School of Pharmacy ... To the Charter Class of the Skaggs School

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  • To the Charter Class of the Skaggs School of Pharmacy & Pharmaceutical Sciences

    We write to commend you on your superb performanceson the NAPLEX and the California PharmacyJurisprudence Examinations. Not only did all of you passand acquire licensure, but you should also take greatpride in your scores.

    Dr. Manoguerra writes,

    In This IssueLetter to the Charter Class .................................... 1

    Welcome New Faculty ......................................... 2

    Lab News ............................................................ 3 - 6

    SSPPS Recognition .............................................. 7

    2007 White Coat Ceremony .................................. 8

    We cant do a formal statistical analysis since we donthave the distribution of all of the student scores, onlythe UCSD scores. Nevertheless, if we make someassumptions about score distribution, we think you areover two standard deviations above the national meanand close to the two standard deviations for theCalifornia mean. Hence, we feel that you and yourclassmates have distinguished yourselves, not only inthe mastery of the didactic materials documented bythe examinations, but also in your interfacing with theother health science professions, in presentation skills,and selection of quality internships and career options,etc.

    Please keep in touch, and we look forward to yourvisiting us when it is convenient. You will find thePharmaceutical Sciences Building now populated withmany more students, a more fully equipped building anda continuation of the excitement about commitment topharmacy education that you engendered as our charterclass. We will be planning a second advanced student-alumni party for next May and hope that those of you inthe area can again join us. Successes of this natureclearly document that the University of California madea great investment in you and in starting a professionalpharmacy program at UCSD. Continuation of theirsupport will pay dividends in healthcare andpharmaceutical research across the State for years tocome.

    Again, the founding faculty of 2002-2003 and Deanssend our congratulations and our best wishes forcontinued success.

    Fall 2007

    SSPPS Volunteers ................................................ 9

    Student News ...................................................... 10

    SSPPS News ....................................................... 11

    More Student News .................................................... 12-17

    Alumni News .............................................................. 18

    Library Corner / Thank You ................................... 19

    Let me share some interesting and excitinginformation we recently received from theNational Association of Boards of Pharmacy, whoadministers the North American PharmacistLicensure Examination (NAPLEX). They sent ussummary data on our Class of 2006 performanceon the exam. The first group of 17 SSPPSgraduates who took the exam between May 1 andAugust 31, 2006 scored an average of 125.65 outof a possible 150 points. The California stateaverage was 113.4 and the national average was107.02. For the 7 students that took the exambetween September 1 and December 31, 2006, theaverage score was 121.14. The state average was101.39 and the national average was 93.18. Thepassing rate for our graduates was 100%."

    There are very few objective measures that wecan use to validate that what we are providing tothe students is adequately preparing them for thelicensure exam and professional practice. This isone measure that appears to tell us that we areon the right track. Keep up the outstanding work.When we receive the data for the Class of 2007, Iwill share that with you as well.

  • Page 2 Newsletter

    SSPPS Welcome New Faculty

    Welcome Grace Kuo, Pharm.D., MPHBy Charles Daniels, R.Ph., Ph.D.

    Welcome Joseph D. Ma, Pharm.D.By Jan Hirsch, R.Ph., Ph.D.

    Dr. Joseph D. Ma joined the faculty of the UCSDSkaggs School of Pharmacy and PharmaceuticalSciences (SSPPS) in August 2007 as an AssistantProfessor of Clinical Pharmacy. Dr. Ma also has anappointment in the Moores UCSD Cancer Center.

    At SSPPS Dr. Ma will be co-chair of the winter quarter212B Therapeutics course and provide lectures in thearea of oncology. At the Moores Cancer Center he isin the Clinical Trials Office (CTO) workingcollaboratively with oncologists to implement an earlyphase clinical trial team to assist in the developmentand management of phase I clinical trials in oncology.His research interests overall are related toexamining inter- and intra-individual pharmacokineticand pharmacodynamic variability in specialpopulations.

    Dr. Ma received his Pharmacy Doctorate from theUniversity of California, San Francisco and thencompleted a 2-yearpost doctoralfellowship in clinicalpharmacology/drugmetabolism atBassett Healthcare,Cooperstown, NY.Prior to joiningSSPPS, Dr. Maworked with Amgen,Inc. (Thousand Oaks,CA) in the EarlyDevelopmentDepartment where he

    was responsible for phase I protocol development andstudy operational and managerial functions.

    When not working, Joe enjoys being outdoors now thathe is ocean side once again. He is originally fromOrange County so he has been spending timereacquainting himself with the sunny weather and localbeaches. His passion is running and he is currentlytraining for a half marathon. He plans to run in theAvia Orange County half marathon in January. Joinhim!

    Skaggs School of Pharmacy and Pharmaceutical Sciencesis proud to introduce Grace Kuo, Pharm.D. as a memberof the Clinical Pharmacy Faculty. Dr. Kuo joins UCSD fromBaylor College of Medicine, Department of Family andCommunity Medicine where she demonstrated abilitiesas a researcher, teacher, and clinician. Grace completedher pharmacy education at Massachusetts College ofPharmacy and Allied Health Sciences (B.S.), the OregonState University and Oregon Health Sciences University(Pharm.D.), and an ASHP Accredited Residency inPrimary Care Pharmacy at the National Institutes ofHealth Clinical Center. Grace received her master ofpublic health degree from the University of Texas HealthScience Center at Houston and is currently a PhDcandidate in health services research and healtheconomics. Dr. Kuo is expected to mix her researchinterests in patient safety and patient care with apractice in the primary care clinics and her teachingduties.

    SSPP

    S

  • Class of 2011 White Coat Ceremony

    Class of 2011 White Coat CeremonyLab NewsSS

    PPS

    Page 3

    NMR Facility in the Pharmacuetical Sciences Building

    By Ariane Jansma, Handel Laboratory

    If you havent been down to the PSB basement recently, there have been lots of changes in the past few months.The Skaggs School of Pharmacy is very excited to welcome two new 600 MHz NMR systems to the school. Equippedwith state-of-the-art probes and consoles, this facility is set up to answer structure questions on compoundsranging from small molecules to natural products to multi-domain proteins.

    So how are we able to use these NMR spectrometers to answer structure questions? The basic principle of NMRinvolves the idea that certain nuclei are spinning charged particles and when placed in a magnetic field, will alignwith that field (figure 1A). If we represent these nuclei as a vector, we can see that applying a pulse of energy willtip them out of alignment and the manner by which they precess back to equilibrium is based on their molecularenvironment (figure 1B). We can use this information to determine regiochemistry, stereochemistry, through-spaceproximity, and ultimately molecular structure.

    Magnetic Field

    A

    Apply Energy Nuclei Precess

    to Equilibrium

    B

    Figure 1: Basic principles of NMR

    One application of NMR to multi-domain proteins is to use through-space correlations (NOEs) to determine both thetertiary and quaternary structure. For example, we can look specifically at a dimer interface by using labelingstrategies in combination with filtered NMR experiments. Often when using NMR to study proteins, it is necessaryto label them with magnetically active nuclei (13C and 15N) in order to achieve sufficient sensitivity. If we make asample of 1:1 13C and 15N protein, we can use filtered experiments that allow us to measure correlations specificallybetween protons connected to 13C and protons connected to 15N (Figure 2). This HCNH-NOE can ultimately allow usto map a protein dimer interface.

    Continued on next page

  • Figure 2: Application of filtered NOE experiments to a protein dimer

    Lab NewsSS

    PPS

    Page 4

    This is just one of many examples of how we can use NMR to examine molecular structure. In the Handel lab, we arefocused on structure and function of proteins, specifically chemokines and their receptors. However, there are alsosome very exciting NMR projects going on with our natural products groups and future newsletters will feature theirresearch.

    Meanwhile, come and visit us at the NMR facility in the PSB basement and have a look at these cutting edge andexciting spectrometers.

    13C Labeled 15N Labeled

    MCP-1

    N

    N

    Handel, T., Domaille, P. Biochem.,

    15N 13C NOE

  • Page 5Lab NewsSS

    PPS

    BioBridge is a collaboration of university scientists, public schooleducators, museums, and local industry focused on linking the scientificand educational communities by bringing research discoveries directly intohigh school classrooms through co-developed teacher-researcher labactivities.

    BioBridge was originated by Dr.Jeremy Babendure in RogerTsiens lab to develop integratedscience activities based on therainbow fluorescent proteinprobes. BioBridge partners

    realized that for activities to suc