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  • TMV MRI SI - pdfs.semanticscholar.org · mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and...
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Page 1 of 6 Supporting Information Tobacco mosaic virus rods and spheres as supramolecular high-relaxivity MRI contrast agents Michael A. Bruckman 1 , Stephen Hern 1 , Kai Jiang 1 , Chris Flask 1,2 , Xin Yu 1,2 , Nicole F. Steinmetz 1,2,3 * Department of 1 Biomedical Engineering, 2 Radiology, 3 Materials Science and Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. * Corresponding author: Prof. Nicole F. Steinmetz, Department of Biomedical Engineering, Radiology, Materials Science and Engineering, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA, phone: 216-368-5590, email: [email protected] Electronic Supplementary Material (ESI) for Journal of Materials Chemistry B This journal is © The Royal Society of Chemistry 2013

TMV MRI SI - pdfs.semanticscholar.org · mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and iGd-SNP at (5) 2x dilution and (6) 4x dilution. Supporting Figure 7 Summary comparing

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Page 1: TMV MRI SI - pdfs.semanticscholar.org · mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and iGd-SNP at (5) 2x dilution and (6) 4x dilution. Supporting Figure 7 Summary comparing

Page 1 of 6

Supporting Information

Tobacco mosaic virus rods and spheres as supramolecular

high-relaxivity MRI contrast agents

Michael A. Bruckman1, Stephen Hern1, Kai Jiang1, Chris Flask1,2, Xin Yu1,2, Nicole F.

Steinmetz1,2,3*

Department of 1Biomedical Engineering, 2Radiology, 3Materials Science and Engineering,

Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.

* Corresponding author: Prof. Nicole F. Steinmetz, Department of Biomedical Engineering,

Radiology, Materials Science and Engineering, Case Western Reserve University School of

Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA, phone: 216-368-5590, email:

[email protected]

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

Page 2: TMV MRI SI - pdfs.semanticscholar.org · mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and iGd-SNP at (5) 2x dilution and (6) 4x dilution. Supporting Figure 7 Summary comparing

Page 2 of 6

Supporting Figure 1 TEM and SEC images of eAlk-TMV, iAlk-TMV and eGd-TMV.

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

Page 3: TMV MRI SI - pdfs.semanticscholar.org · mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and iGd-SNP at (5) 2x dilution and (6) 4x dilution. Supporting Figure 7 Summary comparing

Page 3 of 6

Supporting Figure 2 MALDI-TOF MS of Native-TMV, eAlk-TMV and iAlk-TMV.

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

Page 4: TMV MRI SI - pdfs.semanticscholar.org · mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and iGd-SNP at (5) 2x dilution and (6) 4x dilution. Supporting Figure 7 Summary comparing

Page 4 of 6

Supporting Figure 3 Before (left) and after (right) images of sucrose gradient density

purifications of (from left to right) eAlk-TMV, eGd-TMV, iAlk-TMV, and iGd-TMV.

Supporting Figure 4 Dynamic light scattering data of iGd-SNPs formed from iGd-TMV

used in this paper.

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

Page 5: TMV MRI SI - pdfs.semanticscholar.org · mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and iGd-SNP at (5) 2x dilution and (6) 4x dilution. Supporting Figure 7 Summary comparing

Page 5 of 6

Supporting Figure 5 NanoDSC analysis of native-TMV and iAlk-TMV showing an increase

in stability of iAlk-TMV over native-TMV.

Supporting Figure 6 SDS-PAGE of denatured TMV samples and subsequent lane analysis to

determine the protein concentration of iGd-SNPs. Lane assignments: Native TMV at (1) 1.0

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013

Page 6: TMV MRI SI - pdfs.semanticscholar.org · mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and iGd-SNP at (5) 2x dilution and (6) 4x dilution. Supporting Figure 7 Summary comparing

Page 6 of 6

mg/ml, (2) 0.5 mg/ml, (3) 0.25 mg/ml, (4) 0.125 mg/ml, and iGd-SNP at (5) 2x dilution and

(6) 4x dilution.

Supporting Figure 7 Summary comparing relaxivity per volume (R1/V) of viral nanoparticle

MRI contrast agents. References match paper order.

Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013


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