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PharmacoEconomics & Outcomes News 429 - 13 Sep 2003 A proposal allowing ambulance paramedics in the UK to administer two thrombolytic agents for acute myocardial infarction has been put forward by the Medicines and Healthcare products Regulatory Agency, reports Scrip. Paramedics are already allowed to administer streptokinase without the direction of a physician, but the high incidence of allergic reactions associated without the agent and the need for carefully controlled IV infusion make it inadequate for prehospital admission, the agency says. Boehringer Ingelheim’s tenecteplase [‘Metalyse’] and Roche’s reteplase [‘Rapilysin’] avoid these problems. The change is expected to be implemented early in 2004, subject to ministerial approval. UK to allow paramedics to administer two thrombolytics. Scrip : 8, No. 2879/2880, 27-29 Aug 2003 800943452 1 PharmacoEconomics & Outcomes News 13 Sep 2003 No. 429 1173-5503/10/0429-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

Thrombolytics to be administered by UK paramedics

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PharmacoEconomics & Outcomes News 429 - 13 Sep 2003

■ A proposal allowing ambulance paramedics in theUK to administer two thrombolytic agents for acutemyocardial infarction has been put forward by theMedicines and Healthcare products RegulatoryAgency, reports Scrip. Paramedics are already allowedto administer streptokinase without the direction of aphysician, but the high incidence of allergic reactionsassociated without the agent and the need for carefullycontrolled IV infusion make it inadequate forprehospital admission, the agency says. BoehringerIngelheim’s tenecteplase [‘Metalyse’] and Roche’sreteplase [‘Rapilysin’] avoid these problems. Thechange is expected to be implemented early in 2004,subject to ministerial approval.UK to allow paramedics to administer two thrombolytics. Scrip : 8, No.2879/2880, 27-29 Aug 2003 800943452

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PharmacoEconomics & Outcomes News 13 Sep 2003 No. 4291173-5503/10/0429-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved