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ThromboJytics and intracranial haemorrhage

THERAPY

Reported frequencies of the risk of intracranial haemorrhage after thrombolytic treatment following acute myocardial infarction in large trials have varied between 0.3 and 0.8%. Thus, Dr P Urban and colleagues from the Hopital Cantonal Universitaire, Geneva, Switzerland, have expressed concern at the high incidence of intracranial haemorrhage in patients from their hospital who received alteplase l00mg following acute myocardial infarction. They found that the incidence of in-hospital stroke was 3.4% (12/358) and 10 of these cases were found to be secondary to intracranial haemorrhage.

Over 90% of the patients in this series were not treated as part of a randomised evaluation. Thus, it may be that the high overall incidence of intracranial haemorrhage in this report ' ••• ,.,. ll«llNUiy .....-16 t. trw frepaq of ;IItI'tlelWllUll ~ tIIIOCUdM ",it" t"rtJIIIbolyJu tluul t. IfIDIY OJIthllinic ,k", dniHtl from IMgl-6C11k

"",h;-u.tlY clillbl tritIb'. Urban P, Reynard C. Meier B. Thrombolysis and risk of intracranial blecdina. Lancet 339: 817,28 Mar 1992 '''''

II Apr 1992INPHARMAe ISSN 0156-2703/92/041 HlO20/$1.00/0 Ie Ads ...... , ... 1III1Jd