ABSTRACTS

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The Role ofLaw Dose Low biolecular Hepxin (Clerane)in Delayed Type Hypersensitivity - New Data

Arieh Ingber. M.D. Department of Dermatology, Hadassah University Hospital, Ein Kezem. Jerusalem Israel

In order to evaluate the efficacy of Clexan on patch tests reactions a randomize,placebo-cantroUedstudywasperformedonatotalof41 informed volunteers witha history ofcontactdermatitis and positive patchtests.titera 2weelis","va~houTPeriodofcessationofany treatment, thesubjects were patch tested. The patients with positive patchtestsformed thestudy grouP.ThesubiectswerestratiGedand randomizedinto4groupswhichreceived asinglesubcutaneaus injectionof mg, 3 mg, 30mgoflo~molecularheparin(Clerane)or ofaPlacebo.5-7dayslaterachallerlgepatchtestwasdone.andthe challengeresponse wasread 72 hours later. In anadditionalchnicaltrial. 6 patients were selected fortreatment with Clexane because ofsevere,longstanding alleraccontact dermatitls.The results demonstrated the efficacy ofclexane in delayedt,pehypersensiti~ity mediatedbyTH I reactions.

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PROGNOSTIC PATCH TESTING: THE OTHER KIND OF PATCH TEST

Edward M. Jackson, Ph.D.. Jackson Reseach Associates, Inc. Sumner, WA 98390

OBJECT: to review the use of various prognostic patch tests to substantiate the safety and efficacy of cosmetics and skin care products. METHOD A brief summary of three types of patch test will be made: the prophetic patch test. the repeat insult patch test and the cumulative irritancy patch test. The application of these patch test PrOtOCOlS t0 substantiate the safety and efficacy of cosmetics and skin care products will be made. RESULTS A comparison Of prognostic and diagnostic patch test protocols will be presented in a comparison table. CONCLUSION The practicing clinician benefits from a knowledge of prognostic patch testing to aide in the diagnosis of contact dermatitis.

REFERENCE: E.M. Jackson, The biostbtistical significance of panel size in patch testing, AMERICAN JOURNAL OF CONTACT DERMATITIS, 5(4):228-230, 1994.

TRICLOSAN IN LEAVE ON PRODUCTS

Edward M. Jackson, Ph.D. Jackson Research Associates, Inc. SUlNler, WA 98390

OBJECT: to review the new use of triclosan and other biocides in hand and body lotions as a potential source of contact dermatitis. METHOD A review of the contact dermatitis reports from sxposuro to triclosan in consumer products will be made. The legal/ regulatory status of triclosan in liquid making an-antibacterial claim will be noted. The new use of biocides includins triclosan in hand and body lotions will be examined as to their potential to produce contact dermatitis as compared to rinse off products. RESULTS Data will be presented comparing the types and number of products as well as the concentration of various biocides. CONCLUSION While biocides remain on the skin after use of leave on products, their contact dermatitis potential remains unknown and is an important parameter to be aware of for the diagnosis of contact dermatitis to biocides.

REFERENCE: E.M. Jackson, "The Toxicologist's Report:" Are Antimicrobial Soaps in Trouble?, COSMETICS & TOILETRIES, =(12):39-42, 1994.

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ALLERGY TO GALLATES AS A CAUSE OF HAND DERMATlTIS J. &lark Jackson. M.D. and Joseph F. Fowler, Jr., M.D., University of Louisville, Division of Dermatology, Louisville, KY.

$3!!jtc; jrc ;rescrvati.:c; r~~2mr.!y f.>!Xd in foods, cosmetics, and other skin care products. There are three types of gallates; octyl gallate, propyl gallate, and dodecyl gallate. They are rare sensitizers. We present the case of a 36 year old baker with a six month history of hand dermatitis refractory to therapy with topical steroids. He worked with cake icings and flavorings in different cakes. Patch testing revealed relevant positives to flavorings and fragrances as well as octyl and dodecyl gallate. The patient was moved to a different job away from the flavorings and icings and had near complete resolution of his hand dermatitis. We recommend searching for gallates as a cause of allergic contact dermatitis in at risk patients.