The radiographic pattern of polyarthritis in Reiter's syndrome

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<ul><li><p>The Radiographic Pattern of Polyarthritis in Reiters Syndrome Stephen D. Sholkoff, Morton G. Glickman and Howard L. Steinbach </p><p>Roentgenographic and scintiphotographic studies of the arthritis of Reiters syndrome demonstrate concurrent involvement of various small joints of the lower extremities often associated with sacroiliitis. The most frequently affected sites are the heels, toes, sacroiliac joints, and ankles and tarsals. Simultaneous involvement of these sites is characteristic of this syndrome. </p><p>Previous articles have enumerated roent- genographic findings in Reiters syndrome (1-7). Predilection for involvement of the sacroiliac joints and the peripheral joints of the lower extremities has been noted; however, the tendency of these sites to be concurrently involved has not been em- phasized. </p><p>To determine the frequency of involve- ment of combinations of joints, we reviewed the roentgenograms and scintiphotographs of our large series of patients who had Reiters syndrome. If it can be shown that certain combinations of joint involvement are characteristic of Reiters syndrome, a presumptive diagnosis might then be justi- fied in the absence of classic clinical signs. </p><p>MATERIALS AND METHODS Between 1966 and 1969, 42 patients with Reiters </p><p>syndrome were examined in the Radiology Depart- </p><p>From the Department of Radiology, Universi ty of California school of Medicine, San Francisco, Calif. </p><p>Supported by NIH Grant GM 01272 from the National Institute of General Medical Sciences, and USPHS Grant AM 02589. </p><p>SI-JZPHEN D. SHOLKOFF, MD: USPHS Research Fel- low in Diagnostic Radiology: M O U ~ N c. CLICKMAN, MD; HOWARD L. WEINBACH, MD: Department of Radi- ology, University of California, School of Medicine, San Francisco, Calif. </p><p>Reprint requests should be addressed to S. D. Sholkoff, MD. </p><p>Submitted for publication July 1970; accepted Nov 18, 1970. </p><p>ment of the University of California Hospital. The methods of roentgenographic and scintiphotographic examinations, including positioning and technical details, were described elsewhere (1, 8). The diag- nosis of Reiters syndrome was established, using the criteria described by Engelman (9). </p><p>All 42 patients were examined roentgenograph- ically. In 17, roentgenograms of all joints were repeated at intervals of 1 4 3 months (median, 15 months). Roentgenographic signs of arthritis (effu- sion, tenosynovitis, erosions, periostitis and ankylo- sis) were judged as present or absent. Scintiphoto- graphs, using an Anger camera and 10 mCi of RmTc-pertechnetate, were taken in 7 patients. They were repeated in 3 patients at 2 weeks, 4% weeks and 2 months (8). None of the patients was younger than 10 years, 4 were 50 years or older, and only 2 were women (I). </p><p>RESULTS The most frequently affected sites were </p><p>the heels, toes, sacroiliac joints, and the ankles and tarsals. The ankles and tarsals were considered together in the tabulation. The frequency with which these four sites were affected simultaneously was as follows: all four sites in 5 patients, three in 7 pa- tients, two in 12 patients, and one in 7 patients. One patient had roentgen evi- dence of polyarthritis without involvement of any of these four sites, and in 10 pa- tients, the results of studies were normal. Of 32 patients with roentgenographically abnormal joints, more than one joint area was involved in 29. </p><p>Calcaneur. Roentgenograms demon- </p><p>Arthritis and Rheumatism, Vol. 14, No. 4 (July-August 1971) 551 </p></li><li><p>fig</p><p> 1. </p><p>Rei</p><p>teh </p><p>synd</p><p>rom</p><p>e in</p><p> you</p><p>ng m</p><p>an w</p><p>ho h</p><p>as s</p><p>hown</p><p> sym</p><p>ptom</p><p>s fo</p><p>r le</p><p>ss th</p><p>an 6</p><p> mon</p><p>ths.</p><p> (le</p><p>ft) R</p><p>ight</p><p> foot</p><p>. Pe</p><p>riarti</p><p>cula</p><p>r ero</p><p>sive </p><p>lesio</p><p>ns a</p><p>nd d</p><p>estru</p><p>ctio</p><p>n of</p><p> car</p><p>- til</p><p>age </p><p>are </p><p>wen</p><p> at </p><p>tad-</p><p>met</p><p>atar</p><p>sal </p><p>join</p><p>ts a</p><p>nd i</p><p>nter</p><p>met</p><p>atar</p><p>sal j</p><p>oint</p><p>s. </p><p>Perio</p><p>stiti</p><p>s th</p><p>icken</p><p>s sh</p><p>aft </p><p>of s</p><p>econ</p><p>d m</p><p>etat</p><p>arsa</p><p>l. (ri</p><p>ght) </p><p>Left </p><p>foot</p><p>. Ta</p><p>rsal</p><p>-met</p><p>atar</p><p>sal j</p><p>oint</p><p>s ar</p><p>e in</p><p>tact</p><p>. Th</p><p>ere </p><p>is m</p><p>ild s</p><p>oft </p><p>tissu</p><p>e sw</p><p>ellin</p><p>g Ov</p><p>er gr</p><p>eat t</p><p>oe, </p><p>and </p><p>slig</p><p>ht f</p><p>orm</p><p>atio</p><p>n of</p><p> per</p><p>iost</p><p>ial n</p><p>ew b</p><p>one </p><p>on s</p><p>haft </p><p>of d</p><p>ista</p><p>l pha</p><p>lanx</p><p>. </p></li><li><p>POLYARTHRITIS IN REITERS SYNDROME </p><p>strated arthritis of the heels (19 plantar and 11 posterior, and 7 in both areas, simultaneously) in 23 patients. Associated sacroiliitis was observed in 9. Simultaneous disease of the ankles and tarsals, toes, or sacroiliac joints was evident in all but 4. Heel changes were not an isolated finding in any of the patients. </p><p>Sacroiliac. In only 2 of 17 patients with sacroiliitis was neither toe, tarsal, ankle or heel involved. In 1 of those pa- tients, effusion was present in the knee. Subsequent scintiphotography in this pa- tient demonstrated arthritis of the right ankle. Sacroiliitis was an isolated finding in 1 patient. Only 1 patient with roentgeno- graphically abnormal joints had neither sacroiliitis nor heel involvement. </p><p>Ankle, tarsus. In 13 of 15 patients </p><p>with ankle or tarsal involvement, arthritis was observed in at least one of the other three typical joints. In only 1 of 15 patients was the ankle or tarsus involved alone. </p><p>roes. Of 19 patients with toe involve- ment, 17 had disease in the heel as well, and 10 had sacroiliitis. I n all 19, either sacroiliac or heel disease was evident con- currently. Interestingly, in 14, the inter- phalangeal joint of the great toe was in- volved. In no patient was involvement of the toes the only abnormality. </p><p>Hands. Disease in the hand or wrist was seen in only 7 patients. It was associ- ated with sacroiliitis in 6, and with severe and extensive disease of the feet in 5. </p><p>Scintiphotography. Scintiphotography in 7 patients confirmed the distribution of </p><p>Fig 2. Scintiphotographs of feet in same patient on same day. In right foot, abnormal accumulation of activity corresponds to tarsal-metatarsal joint lesions seen in roentgenogram. In left foot, abnormal accumulation of activity corresponds to interphalangeal joint and metatarsal-phalangeal joint of great toe, indicating active inflammation of these joints. Tarsal-metatarsal joints and distal portion of tarsus are uninvolved. Symmetric accumulation of activity seen over proximal tarsus is due to superimposition of ankle joint in this view. Side view (not shown) demonstrated no abnormal accumulation in left tarsus. </p><p>Arthritis and Rheumatism, Vol. 14, No. 4 (July-August 1971) 553 </p></li><li><p>Fig </p><p>3. Re</p><p>iter's</p><p> syn</p><p>drom</p><p>e in</p><p> you</p><p>ng m</p><p>an w</p><p>ith s</p><p>ympt</p><p>oms </p><p>of a</p><p>bout</p><p> 3 m</p><p>onth</p><p>s' du</p><p>ratio</p><p>n. </p><p>(left)</p><p> Rig</p><p>ht h</p><p>eel. No</p><p> roen</p><p>tgen</p><p>ogra</p><p>phic </p><p>abno</p><p>rmal</p><p>ity. </p><p>(rig</p><p>ht) S</p><p>cintip</p><p>hoto</p><p>grap</p><p>h of</p><p> bot</p><p>h he</p><p>els. C</p><p>obal</p><p>t m</p><p>arke</p><p>r abo</p><p>ve t</p><p>anus</p><p> indi</p><p>cate</p><p>s rig</p><p>ht fo</p><p>ot. </p><p>Ther</p><p>e is</p><p> abn</p><p>orm</p><p>al a</p><p>ccum</p><p>ulat</p><p>ion </p><p>of a</p><p>ctiv</p><p>ity c</p><p>orre</p><p>spon</p><p>ding</p><p> to </p><p>plan</p><p>tar </p><p>surfa</p><p>ce o</p><p>f rig</p><p>ht c</p><p>alcan</p><p>eus. </p><p>Left </p><p>calca</p><p>neus</p><p> sho</p><p>rn n</p><p>o ab</p><p>norm</p><p>ality</p><p>. In</p><p> bot</p><p>h fe</p><p>et, </p><p>abno</p><p>rmal</p><p> acc</p><p>umul</p><p>atio</p><p>n of</p><p> act</p><p>ivity</p><p> is s</p><p>een </p><p>in m</p><p>etat</p><p>arsa</p><p>l-pha</p><p>lang</p><p>eal r</p><p>egio</p><p>ns. </p></li><li><p>POLYARTHRITIS IN REITERS SYNDROME </p><p>active arthritis, as shown on roentgeno- grams (Fig 1, 2). In 5 of 7 patients, scinti- photography also demonstrated arthritic activity in joints that appeared normal on roentgenograms (Fig 3). In occasional joints, arthritic activity not suspected clinically or roentgenographically, was demonstrated by scintipho tography . </p><p>DISCUSS 10 N The most helpful observation in our </p><p>analysis of these cases of Reiters syndrome was the concurrent, usually asymmetric, in- volvement of the various small joints of the lower extremities accompanied with sacro- iliitis. In 26 of 33 patients, at least 2 of these joints were involved, and in 13 pa- tients, 3 or more joints were affected simul- taneously. This report emphasizes the fre- quency with which the heels, toes (particu- larly the interphalangeal joint of the great toe), sacroiliac joints, ankles and tarsals are affected concurrently in Reiters syndrome. For example, only I patient with abnormal joints had neither heel nor sacroiliac dis- ease. The joint structure can only respond to insult in a limited number of ways, re- gardless of etiology. Hence, a presumptive diagnosis may be inferred on the basis of the distribution of arthritis, rather than on characteristic articular changes. </p><p>The patterns of involvement, as modified by the scintiphotographs, were even more characteristic of this disease. Scintiphotog- raphy has not been used extensively in clinical evaluation of arthritis, and was performed in only a few of the patients </p><p>included in this report. I t is, however, a more sensitive indicator of early joint in- flammation than is roentgenography (6). Therefore, scintiphotography may be su- perior to roentgenography in depicting con- current involvement of several joints, with a pattern characteristic of Reiters syn- drome. </p><p>1. </p><p>2. </p><p>3. </p><p>4. </p><p>5. </p><p>6. </p><p>7. </p><p>8. </p><p>9. </p><p>REFERENCES Sholkoff SD, Glickman MG, Steinbach HL: Roentgenology of Reiters syndrome. Radi- </p><p>Csonka G Reiters syndrome. Ergebn Inn Med Kinderheilk 23:125-189, 1965 Mason RM, Murray RS, Oates JK, et al: A comparative radiological study of Reiters disease, rheumatoid arthritis and ankylos- ing spondylitis. J Bone Joint Surg (Lon- don) 41B:137-148, 1959 Murray RS, Oates JK, Young AC: Radio- logical changes in Reiters syndrome and arthritis associated with urethritis. J Fac Radiol 937-43, 1958 Peterson CC Jr, Silbiger M L Reiters syn- drome and psoriatic arthritis; their roent- gen spectra and some interesting similari- ties. Amer J Roentgen 101:860-871, 1967 Reynolds DF, Csonka GW: Radiological aspects of Reiters syndrome (venereal ar- thritis). J Fac Radiol 9:44-49, 1958 Weldon WV, Scalettar R: Roentgen changes in Reiters syndrome. Amer J Roentgen 86: 344-350, 1961 Sholkoff SD, Glickman M G Scintiphoto- graphic evaluation of arthritis activity. In- vest Radiol 4207-214, 1969 Engelman EP, Weber HM: Reiters syn- drome. Clin Orthop 57:19-29. 1968 </p><p>ology 97~497-504, 1970 </p><p>Mhritb 8d Rheumatism, Val. 14, NO. 4 (Juh-Aupd 1971) 555 </p></li></ul>