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THE PSYCHIATRIC, BEHAVIORAL AND NEURAL CORRELATES

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PowerPoint PresentationEARLY CHILDHOOD OVERCONTROL
[email protected]
Resilient, Undercontrolled, overcontrolled (RUO) types
Five Factor Model: low extraversion, high neuroticism (low openness, elevated conscientiousness and agreeable)
Temperament: “Reactive control”
Behavioral Inhibition (BI): Neural or behavioral indicator
The error-related negativity (ERN)
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“OVERCONTROL”
helps detect and learn from errors
and adapt to changing
AIMS
1) Develop a measure to identify the overcontrolled phenotype in early
childhood (4-7 year olds) [Study 1]
1) In relation to cognitive, social and psychiatric functioning
2) In relation to neural error monitoring (using EEG)
2) Identify the overcontrolled phenotype in middle childhood (8-12 year olds)
[Study 2]
2) In relation to neural error monitoring (using fMRI)
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• Mean Age(SD) = 5.29(1.02)
• 52 healthy community children (below CBCL clinical cut-off of 70)
• Subset completed neural EEG Assessment (n=64)
Gilbert, Barch & Luby, 2019
• Parent report (over the last year):
• “gets upset or has trouble when plans change at short notice”
• “pays a lot of attention to how s/he does things compared with others”
• “gets frustrated when s/he can’t seem to get it right the first time (e.g., when
solving a puzzle, when completing a math problem)”
• ”looks for reassurance that s/he has done well or done the right thing more than
siblings or other kids his/her age”
• Inflexibility/Frustration with Change Subscale α= .86
Gilbert, Barch & Luby, 2019
• Parent report (over the last year):
• “gets upset or has trouble when plans change at short notice”
• “pays a lot of attention to how s/he does things compared with others”
• “gets frustrated when s/he can’t seem to get it right the first time (e.g., when
solving a puzzle, when completing a math problem)”
• ”looks for reassurance that s/he has done well or done the right thing more than
siblings or other kids his/her age”
• Inflexibility/Frustration with Change Subscale α= .86
• Social Concern/Perfectionsim Subscale α= .80
Gilbert, Barch & Luby, 2019
• Parent report (over the last year):
• “gets upset or has trouble when plans change at short notice”
• “pays a lot of attention to how s/he does things compared with others”
• “gets frustrated when s/he can’t seem to get it right the first time (e.g., when solving
a puzzle, when completing a math problem)”
• ”looks for reassurance that s/he has done well or done the right thing more than
siblings or other kids his/her age”
• Inflexibility/Frustration with Change Subscale α= .86
• Social Concern/Perfectionsim Subscale α= .80
• Total Overcontrol α = .88
• Age (r=.17, p=.04) BI (r=.44, p<.001) Depression status t(145)-10.04 (p<.001)
r = .59, p < .01
Gilbert, Barch & Luby, 2019
Measure Assesses
Activation Scale
Functioning (BRIEF)
Gilbert, Barch & Luby, 2019
Plan/Organize .06(.04) .02(.02) .04(.03)
*p < .05; **p < .001
OCYC
Peer Acceptance -.20 -.09 -.26*
Bullied .15 .001 .26*
*p < .05; **p < .001
Gilbert, Barch & Luby, 2019
NEURAL CORRELATES OF OVERCONTROL
• Error Related Negativity (ERN)
• Heightened performance monitoring
symptoms
from Hijack (2012)
Santesso DL, Segalowitz SJ, Schmidt , 2005
Schrijvers et al., 2010; Torpey et al., 2013; Meyer et al., 2018
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Go Trial Nogo Trial
75% trials 25% trials
*Note, when partial correlations controlling for age, BI, depression completed, findings
no longer significant Gilbert, Barch & Luby, 2019
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• It is associated with
• Poor social functioning (peer relations and being bullied)
• Temperament: elevated behavioral inhibition
STUDY 2: PARTICIPANTS
• Mean Age(SD) = 10.23(1.3)
• Via KSADS-PL:
• 38 subset with usable fMRI neuroimaging assessment
Gilbert, Perino, Myers & Sylvester, 2020
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Summary scale
Disorders (SCARED)
Conners 3-Parent Short Parent-reported ADHD symptoms
Child Global Assessment Scale (cgas) Interviewer-rated Overall functioning
Gilbert, Perino, Myers & Sylvester, 2020
Anxiety
Disorder
Social Concern/Perfectionism 2.34(2.4)** 2.35(2.4)
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OCYC
Conners Hyperactivity &
*p < .05; **p < .001
NEUROIMAGING ERROR TASK: MODIFIED POSNER CUEING PARADIGM
Number of errors not associated with overcontrol and didn’t differ by cue type
Gilbert, Perino, Myers & Sylvester, 2020
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ROIs error>correct: Right and Left dACC Right medial PFC
Right and Left insula Right dorsal superior pre-motor cortex
ASSOCIATIONS WITH OVERCONTROL
*controlling for age
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CONCLUSIONS
• Ages 5 – 12
outcomes
• Blunted neural responding to errors
• Overcontrol may be a transdiagnostic mechanistic process
• Could be targeted in intervention (rather than treating specific
symptoms) (i.e., Radically Open Dialectical Behavior Therapy, RO DBT)
THANK YOU!
Colleagues & Collaborators:
John Luby, M.D.
Chad Sylvester, M.D.
Deanna Barch, Ph.D.
Nathan Fox, Ph.D.
Thomas Lynch, Ph.D.
Diana Whalen, Ph.D
EEDP Staff: Danielle Kelly, Ella Sudit, Becky Tillman, Gemma Baugh, Sarah
Engle, Brittany Haus, Alli Hollendar, Alex Puricelli, Megan Dandarund,
Shannon O’Hara and all the wonderful EEDP students
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