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The PEP uP Protocol

The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition Provides fuel for cellular metabolism Prevents protein/muscle wasting Decreases ventilator

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Page 1: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

The PEP uP Protocol

Page 2: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

I’M HUNGRY!!

Page 3: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Adequate Nutrition

Provides fuel for cellular metabolism

Prevents protein/muscle wasting

Decreases ventilator time

Helps prevent infection/VAP

Decreases ICU length of stay

Promotes healthy wound healing

Reduces mortality

Page 4: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

GUT disuse causes loss of functional and structural integrity of the GI tract and is associated with increased complications

These changes are time dependent; the longer they are left NPO, the greater the complications.

Page 5: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Our ICU Has Joined the PEP uP Protocol Trial!

Main Objective:

To study the effect of an innovative enteral feeding protocol and nursing education program on the adequacy of enteral feeding delivery

Page 6: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Lots of People are doing it!

20 study sites across North America

Baseline data of current nutrition practices has already been collected on 30 patients in every unit

Half the ICUs have been randomized to implement the new PEP uP Protocol

A further 30 patients per ICU will now be enrolled for a total of 1200 patients

The main outcome is adequacy of enteral feeding delivery, but also:

Safety incidents related to EN

Evaluation of the protocol by nursing

Follow 60 day hospital outcomes, i.e. mortality, LOS, etc.

Page 7: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Main Features the PEP uP Protocol

All patients will receive Peptamen 1.5 initially

All patients will start on Beneprotein®

• 2 packets (14 g) mixed in 120ml water administered bid via NG

All patients will be given metaclopromide on Day 1 of enteral feeding

• 10 mg IV q 6h

……. Reassess formula, protein supplement, and motility agent daily

Page 8: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Get PEPPED UP!

Option 1: Begin Volume-Based feeds.

The 24 hour period begins at XXXXh daily.

Patient is to receive Peptamen 1.5 initially.

The total target volume for Day 1 of EN is based on the patient’s weight in kilograms.

Consult dietitian to reassess 24 hr target volume as soon as possible

Determine hourly rate as per Volume Based Feeding Schedule.

Monitor gastric residual volumes as per Gastric Feeding Flowchart and Volume Based Feeding Schedule .

Page 9: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

What is volume based feeding?

It is based on a 24 hour volume total rather than an hourly rate

The initial infusion rate is determined by dividing the total by 24

The hourly rate may be changed during the day due to interruptions (i.e. tests, surgery) to achieve the 24 hour volume total

During daily rounds nursing report will include the percentage of feeds the patient received the previous day

The goal is to improve nutrition in ICU patients

Page 10: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Get PEPPED UP!Option 2: Trophic feeds

Begin Peptamen 1.5 at 10 mL/h after initial tube placement confirmed. Do not monitor gastric residual volumes.

Reassess ability to transition to Volume-Based feeds next day.

Intended for patient who is:

On vasopressors (regardless of dose) as long as they are adequately resuscitated

Not suitable for high volume enteral feeding (ruptured AAA, surgically place jejunostomy, upper intestinal anastomosis, or impending intubation)

Page 11: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Get PEPPED UP!Option 3: NPO

NPO

Only if contraindication to EN present: bowel perforation, bowel obstruction, proximal high output fistula.

Recent operation and high NG output are not a contraindication to EN.

Reassess ability to transition to Volume-Based feeds next day.

Page 12: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Gastric Feeding Flowchart

No

Place feeding tube or use existinggastric drainage tube.

X-ray to confirm placement (as required)

Elevate head of bed to 45° (or as much as possible) unless contraindicated.

Start feed at initial rate or volume ordered.

Measure gastric residual volumes q4h.Is the residual volume > 300 ml?

NOTE: Do not aspirate small bowel tubes.

Replace 300 mL of aspirate, discard remainder. Reduce rate by 25 mL/h to no less than 10 mL/h.Step 1: Start metoclopramide 10mg IV q 6 hr. If already prescribed, go to Step 2.Step 2: Consider adding erythromycin 200 mg IV q12h (may prolong Qt interval). If 4 doses of erythromycin are ineffective, go to Step 3.Step 3: Consider small bowel feeding tube placement and discontinue motility agents thereafter.

Was the residual volume greater than 300 mL the

last time it was measured?

Replace up to 300mL of aspirate, discard remainder. Set rate of EN based on remaining volume and time until X am (max rate 150mL/hr). Reassess motility agents after feeds tolerated at target rate for 24 hours.

Yes

No

Yes

Page 13: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Case studyA 35 year old male was admitted at 0400h following a gunshot wound to chest.

His injuries include massive trauma to right arm, left chest and left shoulder. He experienced 3 intra-operative cardiac arrests.

On  arrival to the ICU he is in pulmonary edema, right heart failure , vasopressin at 0.04 units/hr and his levophed continues to be titrated up to maintain a MAP of 60 mmHg; the current rate is 25 mcg/min.

He is approximately 70Kg and 1.74m tall.

Page 14: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Case studyAdmission

On admission you inform the medical team that the patient is NPO. Which of the following interventions do you anticipate?

• Continue NPO

• Volume based enteral feeds

• Enteral feeds at 25/hr

• Trophic feeds

Page 15: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Case studyDay 1

He is oliguric, and his creatinine and urea continue to rise. What dose of metoclopramide will you administer?

• Metoclopramide 10 mg q6h

• Metoclopramide 5 mg q6h

• Metoclopramide 10 mg q8h

• Metoclopramide not indicated

Page 16: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Levophed and vasopressin are discontinued

His enteral feeds are at 10 ml/hr.

Case studyDay 2

Page 17: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

On morning rounds you inform the medical team that the patient no longer requires vasopressor support and is receiving trophic feeds. What intervention do you anticipate?

• Increase trophic rate from 10 to 20 ml/hr

• Start enteral feeds at 25 ml/hr and increase to target of 70ml/hr

• Start volume feeds at a target goal rate determined by dietitian

• Start volume feeds at 1100 mls over 24 hours

Case studyDay 2 – Morning Rounds

Page 18: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

At 0800 you measured the gastric residual volume and it is 350mls. You replace the aspirate and continue feeding at target goal rate. At 1200 his gastric residuals are measured again and it remains at 350 ml What will you do?

a. Replace 300 ml of aspirate and decrease rate by 50 ml/hr

b. Replace all the aspirate and maintain current feeding rate

c. Replace 300ml of aspirate and decrease rate by 25ml/hr

d. Do not replace aspirate and hold tube feeds

Case studyDay 2 – Gastric Residuals

Page 19: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

He remains stable throughout Day 3

On day 4 of his admission the surgical team informs you at 1000h that they will be taking him back to the OR

They request that he be kept NPO after 2400 hours.

Case studyDays 3 and 4

Page 20: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

The dietitian has determined that his daily volume goal is 1200 ml in 24 hours (starts at 0700 daily) which is a rate of 50ml/hr. Based on the 24 hour volume protocol, what will be his new rate to reach his goal volume by midnight?

• 64 mls/hr

• 75 mls/hr

• 82 mls/hr

• 96 mls/hr

Case studyDay 4 – Returning to OR

Page 21: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

What is the maximum hourly rate that you should infuse on volume based feeding?

a. 125 ml/hr

b. 135 ml/hr

c. 150 ml/hr

d. 160 ml/hr

Case studyHourly Rate?

Page 22: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Your 24 hour intake indicates that he received 1100 ml in the last 24 hours. Based on the daily goal of 1200 ml in 24 hours, what will you report as his nutritional adequacy during morning rounds?

a. 92%

b. 94%

c. 96%

d. 98%

Case studyReporting Daily Nutrition

Page 23: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

He continues to receive 5mg metoclopromide as per the enteral feeding initiation orders. His gastric residuals have been more than 300 ml for 2 consecutive checks. What intervention do you anticipate ?

a. Consider Erythromycin 200 mg Q12h

b. Increase Metoclopramide to 10 mg q4h

c. Increase rate of feeds

d. Hold feeds for 4 hours

Case studyGastric Residuals - Again

Page 24: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

He is scheduled for an MRI at 1400h. The enteral feeds are stopped from 1400 hours to 1700 hours.

His volume target is 1200 ml in 24 hours which is a rate of 50ml/hr. Upon returning to the ICU at 1700h, what will be his new rate for the remaining time  ?

• 60 ml/hr

• 65 ml/hr

• 70 ml/hr

• 75 ml/hr

Case studyOne Week Later

Page 25: The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator

Questions?