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Save 20% on The Laboratory Zebrafish, published by CRC Press in December 2010.
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Claudia HarperAmgen Inc., Cambridge, MA, USA
Christian LawrenceChildren’s Hospital Boston, MA, USA
Series:Laboratory Animal Pocket Reference
Series editor:Mark A. Suckow
The first of its kind – an all inclusive scientific treatment of thebiology, care, and management of this important animal model
Second only to the mouse and rat, the zebrafish is the most popular animal model in biomedicalresearch. Rapid embryonic development and transparent organogenesis give zebrafish uniqueadvantages in the study of biological pathways, vertebrate development, carcinogenicity,drug development, genomics, gene function, mutagenesis screening, and toxicology.
In the relatively brief span of only a few decades, the zebrafish hasgone from being a hobby fish to a mainstream model animal employed by scientists to study everything from stem cells to thebasis of behavioral changes induced by drug addiction. This rapidadvance has been fueled largely by numerous and impressive advances in technology, along with detailed characterization ofthe animal on a genetic and molecular level.
However, there are few accepted and established standards forhusbandry, management, and care for the fish in laboratory settingsand even fewer comprehensive and constantly reliable resources.
This handbook provides managers, veterinarians, investigators, technicians, and regulatorypersonnel with a concise yet thorough reference on zebrafish biology, care, husbandry, andmanagement. It arms those fish workers with scientifically grounded principles and fundamentalinformation that can be used to design sound fish care programs.
Like other books in the Laboratory Animal Pocket Reference Series, this guide covers all aspectspertaining to the use of these organisms, including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures,veterinary care, and water quality management.
Co-authored by former presidents of the Zebrafish Husbandry Association
Catalog no. K10378, December 2010, 274 pp., SoftcoverISBN: 978-1-4398-0743-9, $59.95 / £38.99
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91Color
Illustrations
11ColorTables
From Zebrafish Anatomy: Danio rerio poster. Copyright 2007, AALAS.
Photo courtesy of Christian Mossiman.
Photo courtesy of Dr. Trace Peterson, Oregon State University.
Photo courtesy of Aquatic Habitats, Inc.
Hu, N. et al. 2001. The Anatomical Record, 264, 1–12. Reprinted with permission of John Wiley & Sons, Inc.
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About The AuthorsClaudia Harper, DVM, Dipl. ACLAM is currentlya director at Amgen. Dr. Harper was previouslya senior clinical veterinarian at MassachusettsGeneral Hospital Center for Comparative Medicine, and a senior scientist at PharmaMarUSA. She completed her veterinary degree atTufts University and was a post-doctoral fellowin the Division of Comparative Medicine at theMassachusetts Institute of Technology. Her experience includes research and clinical and diagnostic work with aquatic biomedical researchmodels in academia and the pharmaceutical industry. She played a key role at MIT in identi-fying, naming, and describing the aquatic Helicobacter cetorum. She has presented originalresearch and given lectures nationally and inter-nationally, and has authored and co-authorednumerous scientific articles.
Dr. Harper’s clinical experience in aquatic animalhealth includes working with biomedical researchmodels and aquaculture species. She was thefish health columnist for Aquaculture Magazinefrom 2002 until 2007 and is the co-founder anda past president of the Zebrafish Husbandry Association (ZHA).
Christian Lawrence, M.S.manages the AquaticResources Program at Children’s Hospital Boston,which is home to one of the largest and mostactive zebrafish research programs in the world.He earned his master of science in biology fromthe University of Massachusetts–Boston in 2006,where his graduate research focused on the environmental and genetic controls of sexualdifferentiation in the zebrafish. He also has abachelor of science in wildlife conservation biology from Arizona State University and abachelor of arts in communications from SetonHall University.
Mr. Lawrence has worked with and managedzebrafish for nearly 10 years, spending time atHarvard University, the Marine Biological Labo-ratory, and Brigham and Women’s Hospital before moving on to Children’s Hospital Bostonin 2008. He has authored a number of scientificpapers on the biology, husbandry, and manage-ment of zebrafish. He is past president of theZebrafish Husbandry Association (ZHA) and currently serves as the coordinator of the ZHAworking groups program.
Features:• Provides a quick reference source for
technicians, investigators, veterinarians,managers, and regulatory personnel
• Presents basic information and common procedures in detail
• Covers a broad range of topics including husbandry, regulatory compliance, technical procedures,veterinary care, and water qualitymanagement
• Discusses the use of zebrafish to study biological pathways, vertebrate development, carcinogenicity, drugdevelopment, genomics, gene function, mutagenesis screening, and toxicology
This handbook is organized into seven chapters: • Biology
• Husbandry
• Life Support Systems
• Management
• Veterinary Care
• Experimental Methodology
• Resources
The final chapter, Resources, provides the zebrafishuser with lists of sources of additional informationon the zebrafish model, as well as key references,professional organizations, and suppliers ofequipment and supplies used in zebrafish husbandry and care.
