The Epidemiology of Idiopathic Pulmonary Fibrosis

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The Epidemiology of Idiopathic Pulmonary Fibrosis. Vidya Navaratnam University of Nottingham. What is IPF?. Chronic, progressive, fibrotic lung disease of unknown aetiology More common in men Average age of presentation 71 years Median survival 3 years Lots of symptoms - PowerPoint PPT Presentation

Text of The Epidemiology of Idiopathic Pulmonary Fibrosis

The problem with Idiopathic Pulmonary Fibrosis

The Epidemiology of Idiopathic Pulmonary Fibrosis
Vidya NavaratnamUniversity of Nottingham

What is IPF?
Chronic, progressive, fibrotic lung disease of unknown aetiologyMore common in menAverage age of presentation 71 yearsMedian survival 3 yearsLots of symptoms7 years of life lost

How common is IPF?

Textbooks in the 1990s
Not a common diseaseDisease of middle aged people


Number of deaths from CFA in England and Wales

Mortality from CFA in seven countries Hubbard et al, Thorax 1996;51:711-16

No direct prevalence data over time, but increased incidence and prevalence reported from Japan at 2001 ATS (Kudo et al, Sapporro) incidence increased from 1.23 to 2.03 per 100,000 1992-1999prevalence increased by factor of 2.5

Summary of incidence in early 1990s

StudyRate per 100,000 pyrsNew Mexico3UK death certificates2.8UK general practice4

Incidence over time - update Gribbin Thorax 2006:61:980

Idiopathic Pulmonary Fibrosis -New

Primary Care Data

CasesCrude incidence rates (95% CI) per 100 000 person years Rate Ratios (95%CI)Year20001605.77 (4.95 to 6.74)120011796.12 (5.28 to 7.08)1.08 (0.87 to 1.33 )20022036.69 (5.83 to 7.68)1.20 (0.98 to 1.48 )20032217.14 (6.26 to 8.15)1.30 (1.06 to 1.60 )20042538.08 (7.14 to 9.14)1.41 (1.16 to 1.72 )20052608.14 (7.21 to 9.19)1.45 (1.19 to 1.77 )20062437.54 (6.65 to 8.55)1.35 (1.11 to 1.65 )20072949.05 (8.07 to 10.15)1.63 (1.34 to 1.98 )20082618.04 (7.12 to 9.08)1.37 (1.12 to 1.67)p for trend