The Epidemiology of Idiopathic Pulmonary Fibrosis. Vidya Navaratnam University of Nottingham. What is IPF?. Chronic, progressive, fibrotic lung disease of unknown aetiology More common in men Average age of presentation 71 years Median survival 3 years Lots of symptoms - PowerPoint PPT Presentation
The problem with Idiopathic Pulmonary Fibrosis
The Epidemiology of Idiopathic Pulmonary Fibrosis
Vidya NavaratnamUniversity of Nottingham
What is IPF?
Chronic, progressive, fibrotic lung disease of unknown
aetiologyMore common in menAverage age of presentation 71
yearsMedian survival 3 yearsLots of symptoms7 years of life
lost
How common is IPF?
Textbooks in the 1990s
Not a common diseaseDisease of middle aged people
Number of deaths from CFA in England and Wales
Mortality from CFA in seven countries Hubbard et al, Thorax
1996;51:711-16
No direct prevalence data over time, but increased incidence and
prevalence reported from Japan at 2001 ATS (Kudo et al, Sapporro)
incidence increased from 1.23 to 2.03 per 100,000
1992-1999prevalence increased by factor of 2.5
Summary of incidence in early 1990s
StudyRate per 100,000 pyrsNew Mexico3UK death certificates2.8UK
general practice4
Incidence over time - update Gribbin Thorax
2006:61:980
Idiopathic Pulmonary Fibrosis -New
Primary Care Data
CasesCrude incidence rates (95% CI) per 100 000 person years
Rate Ratios (95%CI)Year20001605.77 (4.95 to 6.74)120011796.12 (5.28
to 7.08)1.08 (0.87 to 1.33 )20022036.69 (5.83 to 7.68)1.20 (0.98 to
1.48 )20032217.14 (6.26 to 8.15)1.30 (1.06 to 1.60 )20042538.08
(7.14 to 9.14)1.41 (1.16 to 1.72 )20052608.14 (7.21 to 9.19)1.45
(1.19 to 1.77 )20062437.54 (6.65 to 8.55)1.35 (1.11 to 1.65
)20072949.05 (8.07 to 10.15)1.63 (1.34 to 1.98 )20082618.04 (7.12
to 9.08)1.37 (1.12 to 1.67)p for trend
