Teaching and Learning, Community involvement

Asangla Ao Courses taught: Course number

Course name Co-ordinator No. contact hours for specific courses

ANAT 381 Experimental Basis of Embryology

Nagano 3

BIOL 370 Human genetics applied

Dr. Roberta M Palmour (Dept. of Human genetics)

2

EXMD 629 Reproductive Medicine and Assisted Reproductive Technology

Ao (Joint) 15

SMC6061 Antenatal Genetics (U de M)

Dr. Grant Mitchell

2

GREI-fellowship teaching program

Lecture on ART-PGD

Dr. Reinblatt 2

Total hours 24 Student Supervision: McGill students

Wejdan Aleneji MSc program 2012-2015 Wassim Bedrouni Medical Student 1st year` (June-August-2014)

Involvement in the community:

Successful collaboration with international researchers in Israel which has resulted 15 publications to date and we still continue to collaborate.

Volunteered every year since 2002 to review abstracts for annual conference of ‘European Society of Human Reproduction and Embryology’

Volunteered to review abstracts since 2002 for annual conference of ‘Royan International Twin Congress on Reproductive Biomedicine and congress on Stem Cell Biology and Technology’

Volunteered to review abstracts for CFAS -2012, 2013, 2014 Ad hoc reviewer for multiple journals Volunteer to advice on setting up a new PGD program in University of Bari, Italy, during my

summer vacation and continue the collaboration. Volunteer consultation at the Gunashila Maternity and infertility Hospital, Bangalore, India, in

setting up PGD facility during my winter vacation and continuing the collaboration. Provide opportunities to international visitors to come and observe our PGD program. I teach in a

course at University of Montreal as an external lecturer. Once in an academic year, I give a lecture to MSC students of Genetic counselor, McGill

University. Apart from oral presentation, sometimes the students visit the laboratory to have hands on experience

Medical genetics residents from McGill university and U de M often spend time in the laboratory and during PGD consultation session and it is part of their residency training

REI fellows from Fertility clinic attends PGD consultation session, observe laboratory activities and as observer for PGD cases as part of the fellowship teaching program.

Participate as Thesis examiner and member of graduate supervisory committee of 3 students William Foulkes

Dr. Foulkes has been involved with many activities relating to hereditary cancer. He is often solicited as a resource for the media when expert opinion in this area is required. Nora Wong and Laurence Baret have been involved with many activities relating to hereditary breast and ovarian cancer leading information booth at many events in the community.

Simon Gravel

Course coordinator in HGEN 661: Population genetics. Taught over 50 hours of lecture and computer lab, Winter 2015. Designed and implemented completely new course concept for quantitative genetics. Student evaluations will be available at end of winter semester Guest lectures BCM 2004: _Evolution Moleculaire (UdeM) BSc HGEN 697: Advanced Statistical Concepts PhD Phys 634: Graduate Biophysics PhD Montreal Spring School PhD

Nada Jabado

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. Fontebasso A M, Papillon-Cavanagh S, Schwartzentruber J, Nikbakht H, Gerges N, Fiset P O, Bechet D, Faury D, De Jay N, Ramkissoon L A, Corcoran A, Jones D T, Sturm D, Johann P, Tomita T, Goldman S, Nagib M, Bendel A, Goumnerova L, Bowers D C, Leonard J R, Rubin J B, Alden T, Browd S, Geyer J R, Leary S, Jallo G, Cohen K, Gupta N, Prados M D, Carret A S, Ellezam B, Crevier L, Klekner A, Bognar L, Hauser P, Garami M, Myseros J, Dong Z, Siegel P M, Malkin H, Ligon A H, Albrecht S, Pfister S M, Ligon K L, Majewski J, Jabado N* and Kieran MW (2014). Nat Genet 46(5): 462-466. ISI 29.648 *co-corresponding and co-senior author http://www.ncbi.nlm.nih.gov/pubmed/24705250

Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific

DNMT3B isoform in the embryonal brain tumor ETMR. Kleinman C L, Gerges N, Papillon-Cavanagh S, Sin-Chan P, Pramatarova A, Khuong-Quang D A, Adoue V, Busche S, Caron M, Djambazian H, Bemmo A, Fontebasso A M, Spence T, Schwartzentruber J, Albrecht S, Hauser P, Garami M, Klekner A, Bognar L, Montes J L, Staffa A, Montpetit A, Berube P, Zakrzewska M, Zakrzewski K, Liberski P P, Dong Z, Siegel P M, Duchaine T, Perotti C, Fleming A, Faury D, Remke M, Gallo M, Dirks P, Taylor M D, Sladek R, Pastinen T, Chan J A, Huang A, Majewski J and Jabado N (2014). Nat Genet 46(1): 39-44. ISI 29.648 http://www.ncbi.nlm.nih.gov/pubmed/24316981

Yann Joly

HGEN-660B - GENETICS, ETHICS AND LAW Instructor: Prof. Yann Joly, PhD (DCL), Ad.E. The objectives of this course are to: 1) introduce students to legal, ethical, and policy scholarship in genetics and related “omics” disciplines; 2) promote interdisciplinary collaboration and debate as a means of enriching scientific practices; 3) enable students to develop analytical research skills and to identify and critically evaluate the legal, ethical and policy issues that arise in genetic

research and in clinical genetics. The classes will be taught in seminar style, complemented by thematic class discussions and case studies. Themes covered in this course include, but are not limited to: genetic testing, genetic counseling, personalized medicine, privacy and confidentiality, population genetics, regenerative medicine, commercialization and intellectual property, genetic discrimination, and genetic analysis of social and behavioral traits. Through class lectures, case studies and discussions on a series of selected readings, students will be asked to reflect on the complex relationships between science, law, and ethics. Each member of the class will participate in and contribute to the learning that occurs. Such collaborative learning experience will be reflected in the way that the course is structured and the student’s work is evaluated.

Jacek Majewski

Most Significant Contributions

Kleinman CL*, Gerges N, Papillon-Cavanagh S, …28 others…Majewski J, Jabado N. Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nat Genet. 2014 Jan;46(1):39-44.

We applied integrative genomics approaches to detect a fused transcript most likely driving the progression of a rare childhood tumor. Follow up analysis of downstream targets identified a likely mechanism of action and potential therapeutic targets. This study illustrates the power of combining different levels of genomic data to elucidate disease mechanisms.

Danielle Malo

Involvement in the community: Mentorship program, Faculty of Veterinary Medicine

Tomi Pastinen

Other Professional and Scientific Contributions Co-organizer: IHEC Annual Meeting 2014 Vancouver, BC, Canada

Brent Richards Teaching

2014-15 (Scheduled or completed) Introduction to Clinical Science INDS-301 (CRN 1842) 18 hours Applied Human Genetics. BIOL370. 1.5 hours Advanced statistical concepts in genetics and genomics. HGEN697. 1.5 hours. Endocrinology clinical teaching: 30 hours. On-ward instruction and formal daily teaching for a minimum of one hour with additional bedside teaching. Endocrinology Research Program for Fellows. 1 hour. Instructing Endocrinology Fellows on their research elective.

2013-14 Introduction to Clinical Science INDS-301 (CRN 1842) 18 hours Applied Human Genetics. BIOL370. 1.5 hours

Endocrinology Course INDS-104 (CRN 4400), 8 hours Endocrinology clinical teaching: 30 hours. On-ward instruction and formal daily teaching for a minimum of one hour with additional bedside teaching. Endocrinology Research Program for Fellows. 1 hour. Instructing Endocrinology Fellows on their research elective.

Peter Roughley Teaching

Dept. Human Genetics, "Biochemical Genetics of Collagen" part of course BIOL-575 (3 h) Faculty of Dentistry, “Cartilage Extracellular Matrix” part of course DENT-669, (3 h)

Eric Shoubridge

TEACHING: Courses

Biology 17-575 Human Biochemical Genetics (6 hrs)

ADMINISTRATION AND OTHER CONTRIBUTIONS:

Chair, Dept. Human Genetics, McGill University (2013-present) Co-Chair: Genetics Axis MUHC Research Institute (2002-present) Editorial Board of Human Molecular Genetics (2004- present). Editorial Board of Translation (2012-present)

Jacquetta Trasler

TEACHING ACTIVITIES Undergraduate: Per Year

549-563B Pharmacology 6 hours (Spring 2014) 599D Pharmacology Independent Studies- Benjamin Fung 25 hours (Fall 2014) HGEN 697 Advanced Readings in Human Genetics 3hours (Spring 2014) 2014-Benjamin Fung, RQR NSERC-CREATE Summer Research Project Award Course Development (Dept. of Pharmacology & Therapeutics)

Silvia Vidal SCHOLARLY AND PROFESSIONAL ACTIVITIES:

Organization of symposia/workshops

2014-2015 NK2015: 15th conference of the Society for Natural Immunity. Fairmont Le Château Montebello, Montebello, Quebec (Canada) May 2-6, 2015

TEACHING: 2013-present MIMM502 Honor’s Research Project 6 hrs contact time 1 student 2013-2014 MIMM498/499

Course coordinator 5 students 2 h contact time MIMM 384D-Term paper project Mentored 3 students 6 h contact time

BOCH300D Introduction to bioinformatics W, 1 hour contact time, 90 students

PHGY 419 Interdepartmental Honor’s Research Project in Immunology 6 hours contact time/student 1 student 2013-14, 2 students 2014-2015 Physiology 552-531B: Selected topics in applied immunology "Cytomegalovirus: Immune system sabotage" W, 3 hours contact time 12 students

PATENTS

Vidal, S. and Leiva-Torres, GA. Application of the human and mouse gene Gnl1 as a marker for susceptibility to viral infection, a model for inflammatory disease and a therapeutic target to modulate NK cells population. Report of Invention filed at the McGill University Commercialization Office, 29/9/2014.

Malo, D. and Vidal, S. A novel in vivo approach to identify key genetic risk factors/ pathways controlling susceptibility and severity of systemic Gram negative infection. Report of Invention filed at the McGill University Commercialization Office, 29/5/2014.

Yojiro Yamanaka

Undergraduate Teaching

Graduate Teaching

Me. Ma’n H. Zawati

HGEN-674 -RESEARCH INTERNSHIP IN GENOMICS AND POLICY Instructor: Me. Ma’n H. Zawati, LL.B., LL.M.

The objectives of this course are to: 1) introduce students to legal, ethical, and policy scholarship in genetics and related “omics” disciplines; 2) promote interdisciplinary collaboration and debate as a means of enriching scientific practices; 3) enable students to develop analytical research skills and to identify and critically evaluate the legal, ethical and policy issues that arise in genetic research and in clinical genetics. The classes will be taught in seminar style, complemented by thematic class discussions and case studies. Themes covered in this course include, but are not limited to: genetic testing, genetic counseling, personalized medicine, privacy and confidentiality, population genetics, regenerative medicine, commercialization and intellectual property, genetic discrimination, and genetic analysis of social and behavioral traits. Through class lectures, case studies and discussions on a series of selected readings, students will be asked to reflect on the complex relationships between science, law, and ethics. Each member of the class will participate in and contribute to the learning that occurs. Such collaborative learning experience will be reflected in the way that the course is structured and the student’s work is

evaluated.

 

2014 Fall HGEN692 1.5hrs 3hrs

2014 Fall EXMD608 1.5hrs 3hrs

2014 Winter EXMD607B *20 2hrs 2hrs 2014 Winter HGEN675

Coordinator 4 6hrs 39hrs

2014 Fall PHGY488 4hrs 6hrs

2014 Winter BIOL568 18 3hrs 3hrs 2014 Winter BIOL416 9 3hrs 7.5hrs