www.mayoclinicproceedings.org

@mayoproceedings

Table of Contents March 2013 Volume 88 Number 3

The April online issue of Proceedings will be available by Monday, April 1.Sign up for an alert to the online Table of Contents at www.mayoclinicproceedings.org

Editorial

213 Medical Marriages: Time-Sensitive Bliss

Mary E. Warner, Nafisseh S. Warner, and Lindsay L. Warner

Original Articles

216 The Medical Marriage: A National Survey of the Spouses/Partners of US Physicians

Tait D. Shanafelt, Sonja L. Boone, Lotte N. Dyrbye, Michael R. Oreskovich, Litjen Tan, Colin P. West,Daniel V. Satele, Jeff A. Sloan, and Wayne M. SotileDespite their overall satisfaction, spouses/partners reported that their physician partner frequently came home irritable,too tired to engage in home activities, or preoccupied with work.

226 Comparison of the Effectiveness of Varenicline and Combination Nicotine Replacement Therapyfor Smoking Cessation in Clinical Practice

Leonie S. Brose, Robert West, and John A. StapletonVarenicline was marginally more effective than combination nicotine replacement therapy for smoking cessation in thispopulation, but demographic and intervention characteristics associated with success also predicted varenicline use.

234 Combined Use of the Novel Biomarkers High-Sensitivity Troponin T and ST2 for Heart FailureRisk Stratification vs Conventional Assessment

Josep Lupón, Marta de Antonio, Amparo Galán, Joan Vila, Elisabet Zamora, Agustín Urrutia,and Antoni Bayes-GenisThis study analyzed the prognostic value of the markers NT-proBNP (myocardial stretch), hs-cTnT (myocardialdamage), and hs-ST2 (myocardial fibrosis and remodeling) in patients with chronic heart failure.

244 Fresh Frozen Plasma Dosing for Warfarin Reversal: A Practical Formula

Armin Rashidi and H. Raymond TahhanAbout 1% of patients taking warfarindthe most widely used anticoagulantdexperience fatal hemorrhage each year.This article provides an accurate method to dose fresh frozen plasma for warfarin reversal.

251 Impact of Cardiorespiratory Fitness on the Obesity Paradox in Patients With Heart Failure

Carl J. Lavie, Lawrence P. Cahalin, Paul Chase, Jonathan Myers, Daniel Bensimhon, Mary Ann Peberdy,Euan Ashley, Erin West, Daniel E. Forman, Marco Guazzi, and Ross ArenaCardiorespiratory fitness modifies the relationship between body mass index and survival in overweight and obesepatients with systolic heart failure.

Table of Contents March 2013 Volume 88 Number 3

259 Maximal Estimated Cardiorespiratory Fitness, Cardiometabolic Risk Factors, and MetabolicSyndrome in the Aerobics Center Longitudinal Study

Conrad P. Earnest, Enrique G. Artero, Xuemei Sui, Duck-chul Lee, Timothy S. Church, and Steven N. BlairThe authors found a strong inverse relationship between cardiorespiratory fitness and metabolic syndrome in bothsexes. Waist circumference was the most highly associated individual component.

271 Losartan Added to b-Blockade Therapy for Aortic Root Dilation in Marfan Syndrome: ARandomized, Open-Label Pilot Study

Hsin-Hui Chiu, Mei-Hwan Wu, Jou-Kou Wang, Chun-Wei Lu, Shuenn-Nan Chiu, Chun-An Chen, Ming-Tai Lin,and Fu-Chang HuIn patients with Marfan syndrome, adding losartan, an angiotensin II receptor blockade drug, to b-blockade treatmentwas safe and more effective than b-blockade alone in slowing, or even reversing, aortic root dilation.

277 Measuring Faculty Reflection on Medical Grand Rounds at Mayo Clinic: Associations WithTeaching Experience, Clinical Exposure, and Presenter Effectiveness

Christopher M. Wittich, Jason H. Szostek, Darcy A. Reed, Jeanine L. Kiefer, Paul S. Mueller,Jayawant N. Mandrekar, and Thomas J. BeckmanThese study findings should prompt course directors to encourage the use of interactive and clinically germanepresentations and to consider selecting presenters who are experienced teachers.

Review

285 Mesenteric Venous Thrombosis

Ashwani K. Singal, Patrick S. Kamath, and Ayalew Tefferi

Concise Review for Clinicians–CME Credit Offered

295 Current Issues in Contraception

Mary L. Marnach, Margaret E. Long, and Petra M. Casey

Residents’ Clinic

300 64-Year-Old Man With Dyspnea and Weight Gain

Jae Yoon Park and Furman S. McDonald

Letters to the Editor

305 Off-Label Drug Use: The Bevacizumab Story

Michael W. Stewart; Christopher M. Wittich, Christopher M. Burkle, and William L. Lanier

306 The High Cost of Cancer Drugs and What We Can Do About It

Thomas Rosamond; Mustaqeem Siddiqui and S. Vincent Rajkumar

307 Posttreatment Prostate-Specific Antigen Surveillance After Primary Treatment of Prostate Cancer

Join Y. Luh, Michael W. Harmon, Tony Y. Eng; Jon C. Tilburt, Simon Kim, Manish Kohli, and Mohammed Nahbhan

Table of Contents March 2013 Volume 88 Number 3

Stamp Vignette on Medical Science

e23 Hermann StaudingerdFounder of Polymer Chemistry

Marc A. Shampo, Robert A. Kyle, and David P. Steensma

Art at Mayo Clinic

e25 Down River by Charles Munch

Margaret R. Wentz

Medical Images

e27 Mycosis Fungoides

Barry Ladizinski and Elise A. Olsen

Other Features

e29 Books Received

C3 Professional Opportunities

Please note that articles with an “e” page designation are available onlyin the online version of the Journal at www.mayoclinicproceedings.org

Coming Soon.

Institution-Wide QT Alert System IdentifiesPatients With High Risk of Mortality

Risk Factors for Temporal Lobe Epilepsy inPatients Undergoing Surgical Treatment

Detecting Near-Miss Transfusion Episodes

Supplemental material attached to journal articles has not been edited

Treatment of Scleroderma

Management of Newly Diagnosed SymptomaticMultiple Myeloma

Icon Key

This article has been given “Editor’s Choice” distinction.

An author interview accompanies this article.

This article is online only at www.mayoclinicproceedings.org.

Supplemental material accompanies this article at www.mayoclinicproceedings.org.

“Mayo Clinic Proceedings,” “Mayo,”“Mayo Clinic,” and the triple-shield MayoClinic logo are all registered marks ofMayo Foundation for Medical Educationand Research.

ª 2013 Mayo Foundation for Medical Education and Research

MAYOCLINIC PROCEEDINGS (ISSN 0025-6196) is publishedmonthly

by Elsevier on behalf of Mayo Foundation for Medical Education and

Research. Periodicals postage paid at New York, NY, and additional

mailing offices. POST MASTER: Send address changes to Mayo Clinic

Proceedings Customer Service, 3251 Riverport Lane, Maryland Heights,

MO 63403.

, and the authors take responsibility for the accuracy of a

ll data.